AMPK
Les inhibiteurs de l'AMPK sont des composés qui ciblent et inhibent la Protéine Kinase Activée par l'AMP (AMPK), une enzyme jouant un rôle crucial dans l'homéostasie énergétique cellulaire. L'AMPK est activée en réponse à de faibles niveaux d'énergie dans les cellules et aide à réguler des processus tels que l'absorption du glucose, l'oxydation des acides gras et la biogenèse mitochondriale. Inhiber l'AMPK est important pour étudier son rôle dans les maladies métaboliques, le cancer et le vieillissement. Chez CymitQuimica, nous proposons une gamme d'inhibiteurs de l'AMPK pour soutenir vos recherches sur le métabolisme, l'oncologie et les maladies liées à l'âge.
171 produits trouvés pour "AMPK"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
XY221
XY221 (Compound 16o) selectively inhibits BRD4 BD2 with an IC50 of 5.8 nM. It demonstrates high selectivity for pan-BD2 and BRD4 BD2 domains, being 667 times more selective than for BRD4 BD1, and 9-32 times more selective than for BRD2/3/T BD2. XY221 can induce apoptosis in MV4-11 cells and exhibits anti-cancer activity.Formule :C32H34FN3O5Couleur et forme :SolidMasse moléculaire :559.628AMPK-IN-6
AMPK-IN-6 (compound 13a) is a potent AMPK inhibitor with an IC50 value of 0.093 µM. It induces apoptosis and suppresses autophagy. Additionally, AMPK-IN-6 exhibits antiproliferative activity and holds potential for research into pulmonary arterial hypertension.Formule :C18H20FN5OCouleur et forme :SolidMasse moléculaire :341.383Flindersine
CAS :Flindersine is a useful organic compound for research related to life sciences. The catalog number is T124718 and the CAS number is 523-64-8.Formule :C14H13NO2Couleur et forme :SolidMasse moléculaire :227.263AMARA peptide
CAS :AMARA peptide: a minimal substrate for SIK, AMPK, and other protein kinases; contains AMPK phosphorylation site.Formule :C62H115N27O17SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1542.81NUAK1-IN-2
NUAK1-IN-2 (Compound 24) is an inhibitor of NUAK1 with an IC50 of 3.162 nM, as well as an inhibitor of CDK2/4/6. It is applicable in research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.Formule :C24H30N6OCouleur et forme :SolidMasse moléculaire :418.535STO-609 acetate
CAS :STO-609 acetate is selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki: 80/15 ng/ml, for CaM-KKα/KKβ); competes for theFormule :C19H10N2O3·C2H4O2Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :374.35ALKBH1-IN-3 prodrug
ALKBH1-IN-4 prodrug (Compound 29E) is a prodrug of an inhibitor targeting the DNA N6-methyladenine demethylase enzyme ALKBH1. It works by significantly increasing the cellular abundance of 6mA and enhancing the AMPK signaling pathway, which suppresses the vitality of gastric cancer cells. ALKBH1-IN-4 prodrug displays excellent cellular activity and favorable metabolic exposure in vivo, making it a promising candidate for research in gastric cancer-related areas.
Couleur et forme :Odour SolidSAMS
CAS :SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).Formule :C74H131N29O18S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1779.15ALKBH1-IN-3
ALKBH1-IN-3 is an effective inhibitor of the DNA N6-methyladenosine (6mA) demethylase ALKBH1. This compound enhances the abundance of 6mA in gastric cancer cell lines HGC27 and AGS, simultaneously inhibiting cell viability and upregulating the AMP-activated protein kinase (AMPK) signaling pathway. ALKBH1-IN-3 holds potential for use in cancer research, including studies on gastric cancer.Couleur et forme :Odour SolidGlycometabolism Compound Library
xnum glycometabolism-related comounds, can be used for HTS and HCT;
Couleur et forme :Odour SolidKanglexin
CAS :Kanglexin is an orally active novel anthraquinone compound. It inhibits NLRP3 inflammasome activation and pyroptosis, offering cardioprotective benefits. By stimulating the FGFR1/ERK signaling pathway, Kanglexin promotes angiogenesis and accelerates wound healing in diabetes. Additionally, it has lipid-lowering effects and inhibits vascular smooth muscle cell dedifferentiation, making it a potential compound for studying hyperlipidemia, fatty liver, and atherosclerosis.Formule :C21H18O8Masse moléculaire :398.36Anti-Phospho-AMPKα (Thr172) Antibody (3O988)
Anti-Phospho-AMPKα (Thr172) Antibody (3O988) is a Rabbit antibody targeting Phospho-AMPKα (Thr172). Anti-Phospho-AMPKα (Thr172) Antibody (3O988) can be used in WB.Couleur et forme :Odour LiquidMetformin-d6 hydrochloride
CAS :Metformin-d6 hydrochloride (Metformin-d6 hydrochloride) is a deuteride of Metformin, which can be used to study Metformin metabolism in vivo.Formule :C4H12ClN5Degré de pureté :98.1%Couleur et forme :SolidMasse moléculaire :171.66Teneligliptin hydrobromide hydrate
CAS :Teneligliptin hydrobromide hydrate: potent, long-lasting DPP-4 inhibitor with ~1 nM IC50.Formule :C22H33BrN6O2SCouleur et forme :SolidMasse moléculaire :525.51Pyraclostrobin (Standard)
CAS :Pyraclostrobin (Standard) is the standard substance of Pyraclostrobin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Pyraclostrobin is one of the most heavily used fungicides that inhibits mitochondrial complex III of fungal and mammalian cells.Formule :C19H18ClN3O4Couleur et forme :SolidMasse moléculaire :387.826-Azuridine
CAS :6-Azauridine is a purine analog with antitumor effects, inhibiting DNA synthesis and inducing apoptosis in lymphatic cancers.
Formule :C8H11N3O6Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :245.19BC1618
CAS :BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitor that stimulates Ampk-dependent signaling.Formule :C24H24F3NO2Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :415.45Metformin
CAS :Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability.
Formule :C4H11N5Degré de pureté :99.77% - >99.99%Couleur et forme :SolidMasse moléculaire :129.16COH-SR4
CAS :COH-SR4 (COH-SR4 (Mitochondria uncoupler SR4)) is a uncoupler of mitochondrial oxidative phosphorylation.Formule :C13H8Cl4N2ODegré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :350.03Kahweol
CAS :Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaBFormule :C20H26O3Degré de pureté :99.26% - 99.86%Couleur et forme :Off-White To Yellow SolidMasse moléculaire :314.42
