PI3K
Les inhibiteurs de PI3K sont des composés qui bloquent l'activité des phosphoinositide 3-kinases (PI3Ks), une famille d'enzymes impliquées dans un large éventail de processus cellulaires, y compris la croissance, la prolifération, la survie et le métabolisme. La voie PI3K/Akt/mTOR est souvent dérégulée dans le cancer, ce qui fait de PI3K une cible clé pour la thérapie anticancéreuse. Les inhibiteurs de PI3K sont des outils essentiels pour étudier la transduction du signal, la biologie du cancer et le développement de thérapies ciblées. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de PI3K pour soutenir vos recherches en signalisation cellulaire, en oncologie et en développement thérapeutique.
242 produits trouvés pour "PI3K"
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PI3K-IN-6
CAS :<p>PI3K-IN-6 is an oral active and highly selective inhibitor of phosphoinositide 3-kinase (PI3K) β/δ(IC50 values of 7.8 nM/5.3 nM , respectively).</p>Formule :C17H14Cl2FN9ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :450.26PI3Kα-IN-13
CAS :<p>PI3Kα-IN-13 (Compound 18a), a PI3Kα inhibitor with an IC50 of 2.5 nM, effectively induces apoptosis and hampers the proliferation of various cancer cell lines,</p>Formule :C21H19N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :389.41PI4KIII β inhibitor 3
CAS :<p>PI4KIII beta inhibitor 3 is a novel and high effective inhibitor of PI4KIIIβ (IC50 of 5.7 nM).</p>Formule :C22H22N8OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :446.53CAL-130 Hydrochloride
CAS :<p>CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).</p>Formule :C23H23ClN8OCouleur et forme :SolidMasse moléculaire :462.94AZD3458
CAS :<p>AZD3458 is a potent and remarkably selective inhibitor of PI3Kγ (PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ with pIC50s of 9.1, 5.1, <4.5, and 6.5 , respectively).</p>Formule :C20H23N3O4S2Couleur et forme :SolidMasse moléculaire :433.54PI3K-IN-10
CAS :<p>PI3K-IN-10 is a potent inhibitor of pan-PI3K .</p>Formule :C23H19ClN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :430.89PI3Kα/mTOR-IN-1
CAS :<p>PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR.</p>Formule :C16H18N6ODegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :310.35PI3Kγ inhibitor 1
CAS :<p>PI3Kγ inhibitor 1 is a inhibitor of PI3Kδ and PI3Kγ.</p>Formule :C32H26N8O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :586.67ON 146040
CAS :<p>ON 146040 is an effective inhibitor of PI3K isoforms with IC50s of 14 and 20 nM for PI3Kα and PI3Kδ, respectively.</p>Formule :C24H23N7O3SDegré de pureté :97.39%Couleur et forme :SolidMasse moléculaire :489.55PI3K-IN-38
CAS :<p>PI3K-IN-38: oral PI3K inhibitor, IC50 of 0.541 µM, anticancer, anti-inflammatory, halts tumors in vivo.</p>Formule :C20H24N6O2Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :380.44CHMFL-PI3KD-317
CAS :<p>CHMFL-PI3KD-317: potent PI3Kδ inhibitor, IC50=6 nM, orally active, >10x selective vs. PI3K isoforms, anti-cancer.</p>Formule :C21H24ClN5O3S2Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :494.03AZ044
CAS :<p>AZ044 is a potent, selective inhibitor of type III phosphatidylinositol-4-kinase alpha-subtype (PI4KIIIalpha).</p>Formule :C24H27N3O3SDegré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :437.55TGX-115
CAS :<p>TGX-115 inhibits PI 3-K p110β (IC50=0.13μM) & p110δ (IC50=0.63μM), treats various cardiovascular diseases.</p>Formule :C20H20N2O3Degré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :336.38SRX3207
CAS :<p>SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.</p>Formule :C29H29N7O3SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :555.65PQR514
CAS :<p>PQR514: more potent pan-PI3K inhibitor than predecessor PQR309, exhibits strong anticancer activity in vitro and in OVCAR-3 model.</p>Formule :C16H20F2N8O2Degré de pureté :98.77% - 99.19%Couleur et forme :SolidMasse moléculaire :394.38GS-9901
CAS :<p>GS-9901 is a selective, orally active and potent PI3Kδ inhibitor (IC50: 1 nM) for the study of non-Hodgkin's lymphoma and chronic lymphocytic leukemia.</p>Formule :C22H17ClFN9ODegré de pureté :98.60% - 99.92%Couleur et forme :SolidMasse moléculaire :477.88NVP-BAG956
CAS :<p>NVP-BAG956 is an ATP-competitive PI3K inhibitor (IC50s: 34/56/112/444 nM for PI3Kδ/PI3Kα/PI3Kγ/PI3Kβ).</p>Formule :C28H21N5Degré de pureté :99.25% - 99.80%Couleur et forme :SolidMasse moléculaire :427.5PI3Kγ inhibitor 2
CAS :<p>PI3Kγ inhibitor 2 is an orally bioavailable inhibitor of PI3Kγ(Ki of 4 nM).</p>Formule :C20H18F3N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :433.38LAS191954
CAS :<p>LAS191954 is a selective, potent and orally active PI3Kδ inhibitor for inflammatory diseases treatment(IC50 : 2.6 nM).</p>Formule :C20H15N9ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :397.39Ginsenoside Rk1
CAS :<p>Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.</p>Formule :C42H70O12Degré de pureté :98.46% - 99.13%Couleur et forme :SolidMasse moléculaire :767GNE-490
CAS :<p>GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.</p>Formule :C18H22N6O2SDegré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :386.47CAL-130 Racemate
CAS :<p>CAL-130 Racemate is the racemate of CAL-130. CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).</p>Formule :C23H22N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.47PIK-inhibitors
CAS :<p>PIK-inhibitors (MDK34597) is a pan PI3K inhibitors, an analog of PI-103.</p>Formule :C19H17N5O2Degré de pureté :96.98%Couleur et forme :SolidMasse moléculaire :347.37MSC2360844
CAS :<p>MSC2360844 is a potent, orally active and selective inhibitor of PI3Kδ(IC50 of 145 nM).</p>Formule :C26H27FN4O5SDegré de pureté :99.54% - 99.9%Couleur et forme :SolidMasse moléculaire :526.58NVP-QAV-572
CAS :<p>NVP-QAV-572 is a inhibitor of PI3K(IC50 of 10 nM).</p>Formule :C17H19F2N7O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.5Zandelisib
CAS :<p>Zandelisib is an inhibitor of phosphatidylinositol 3-kinase (PI3K)(p110δ, IC50 of 3.5 nM), and with antineoplastic activity.</p>Formule :C31H38F2N8ODegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :576.68PI3Kδ-IN-17
CAS :<p>PI3Kδ-IN-17 (Compound S5) is a potent PI3K δ inhibitor, exhibiting an IC50 value of 2.82 nM and demonstrates significant efficacy in suppressing the</p>Formule :C23H24F3N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :487.48SAR-260301
CAS :<p>SAR-260301 is an orally available and selective inhibitor of PI3Kβ (IC50: 23 nM).</p>Formule :C19H22N4O3Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :354.4PI3Kδ-IN-1
CAS :<p>PI3Kδ-IN-1 is an efficacious PI3Kδ inhibitor (IC50 of 1.7 nM).</p>Formule :C22H20F3N7O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :471.44mTOR inhibitor 9d
CAS :<p>mTOR inhibitor 9d is a dual inhibitor of the protein kinases mTOR and PI3K with an mTOR IC50 value of 0.31 nm, and can be used for the treatment of leukemia,</p>Formule :C21H23N5O3SDegré de pureté :99.08%Couleur et forme :SoildMasse moléculaire :425.5MIPS-21335
CAS :<p>MIPS-21335 is a potent PI3KC2α inhibitor with an IC50 value of 7 nM and additionally exhibits inhibitory activity against PI3KC2β, p110α, p110β, and p110δ with</p>Formule :C24H21N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :487.47PKI-402
CAS :<p>PKI-402 is a potent PI3K and mTOR inhibitor. PKI-402 inhibits PI3Kα, mTOR, PI3Kβ, PI3Kδ and PI3Kγ with IC50s of 2, 3, 7, 14 and 16 nM, respectively.</p>Formule :C29H34N10O3Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :570.65GSK-F1
CAS :<p>GSK-F1 (PI4KA inhibitor-F1) is a novel potent PI4KA inhibitor.</p>Formule :C27H18F5N5O4SDegré de pureté :97.03%Couleur et forme :SolidMasse moléculaire :603.52GDC-0349
CAS :<p>GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.</p>Formule :C24H32N6O3Degré de pureté :96.00% - 98.17%Couleur et forme :SolidMasse moléculaire :452.55PF-04979064
CAS :<p>PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).</p>Formule :C24H26N6O3Degré de pureté :98.20% - ≥98%Couleur et forme :SolidMasse moléculaire :446.5VVD-699
CAS :<p>VVD-699 is a covalent inhibitor of RAS-PI3K. It forms a covalent bond with cysteine at position 242 within the RAS-binding domain of PI3Kp110α, thereby obstructing the ability of RAS to activate PI3K. VVD-699 is capable of inhibiting the growth of tumors with RAS mutations and HER2 overexpression. It is applicable in research related to RAS mutation-associated cancers, such as those involving H358 lung cancer cells, A549 cells, and FaDu cells.</p>Formule :C25H30ClFN2O6S2Couleur et forme :SolidMasse moléculaire :573.097PI3Kδ-IN-23
CAS :<p>PI3Kδ-IN-23 (compound A11) is a potent inhibitor of PI3Kδ, with an IC50 of 0.27 nM. It binds to PI3Kδ through covalent interaction with Lys779 and plays a significant role in cancer research.</p>Formule :C30H30N6O5Couleur et forme :SolidMasse moléculaire :554.596UNI418
CAS :<p>UNI418 is a dual inhibitor targeting PIKfyve and PIP5K1C, exhibiting antiviral activity against SARS-CoV-2 (EC50=1.4 μM). It inhibits the endocytosis of the virus mediated by ACE2 by suppressing PIP5K1C (IC50=60.1 nM; Kd=61 nM). Additionally, UNI418 impedes the entry of SARS-CoV-2 into host cells by inhibiting the proteolytic activation regulated by PIKfyve (Kd=0.78 nM).</p>Formule :C22H16N6Couleur et forme :SolidMasse moléculaire :364.40PI3kδ inhibitor 1
CAS :<p>PI3kδ inhibitor 1 is a selective inhibitor of PI3Kδ (IC50 of 3.8 nM).</p>Formule :C28H33FN6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :504.60Sonolisib
CAS :<p>Sonolisib is an irreversible and pan-isoform inhibitor of PI3K (IC50=0.1 nM (p110α), 1.0 nM (p120γ), 2.9 nM (p110δ)).</p>Formule :C29H35NO8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :525.59PI3Kδ-IN-13
CAS :<p>PI3Kδ-IN-13 (compound 89), with an IC50 value of 2.6 nM, is an inhibitor of PI3Kδ, applicable for researching diseases involving cell proliferation, including</p>Formule :C27H39N7O4S2Couleur et forme :SolidMasse moléculaire :589.77Duvelisib (R enantiomer)
CAS :<p>Duvelisib R enantiomer (IPI-145 R enantiomer) is an enantiomer of Duvelisib with lower activity. Duvelisib is a PI3K inhibitor.</p>Formule :C22H17ClN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :416.86
