PI3K
Les inhibiteurs de PI3K sont des composés qui bloquent l'activité des phosphoinositide 3-kinases (PI3Ks), une famille d'enzymes impliquées dans un large éventail de processus cellulaires, y compris la croissance, la prolifération, la survie et le métabolisme. La voie PI3K/Akt/mTOR est souvent dérégulée dans le cancer, ce qui fait de PI3K une cible clé pour la thérapie anticancéreuse. Les inhibiteurs de PI3K sont des outils essentiels pour étudier la transduction du signal, la biologie du cancer et le développement de thérapies ciblées. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de PI3K pour soutenir vos recherches en signalisation cellulaire, en oncologie et en développement thérapeutique.
231 produits trouvés pour "PI3K".
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Tenalisib
CAS :Tenalisib (RP6530) (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.)Formule :C23H18FN5O2Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :415.42Ref: TM-T13119
1mg35,00€2mg50,00€5mg77,00€1mL*10mM (DMSO)84,00€10mg105,00€25mg178,00€50mg289,00€100mg434,00€CGS 15943
CAS :CGS 15943 is an orally bioavailable non-xanthine antagonist of Adenosine Receptor.Formule :C13H8ClN5ODegré de pureté :97.4%Couleur et forme :SolidMasse moléculaire :285.69Ref: TM-T14944
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg82,00€25mg147,00€50mg222,00€100mg334,00€200mg494,00€WYE-687
CAS :WYE-687 is a selective mTOR inhibitor (IC50: 7 nM), over 100x more selective for mTOR than PI3Kα/γ, affecting mTORC1/pS6K and mTORC2/P-AKT(S473).Formule :C28H32N8O3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :528.61Inavolisib
CAS :Inavolisib (GDC-0077) is an orally available selective PI3Kα inhibitor with an IC50 value of 0.038 nM.Cost-effective and quality-assured.Formule :C18H19F2N5O4Degré de pureté :97.36% - 99.90%Couleur et forme :SolidMasse moléculaire :407.37Ref: TM-T15375
1mg84,00€5mg200,00€10mg353,00€1mL*10mM (DMSO)383,00€25mg602,00€50mg982,00€100mg1.603,00€200mg2.142,00€IPI-3063
CAS :IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).Formule :C25H25N7O2Degré de pureté :98.00%Couleur et forme :SolidMasse moléculaire :455.51Ref: TM-T15592
1mg44,00€2mg60,00€5mg99,00€1mL*10mM (DMSO)107,00€10mg166,00€25mg323,00€50mg447,00€100mg610,00€Recilisib
CAS :Recilisib (ON 01210) is a radioprotectant,can activate AKT, PI3K activities in cells.Formule :C16H13ClO4SDegré de pureté :98.85% - 98.96%Couleur et forme :SolidMasse moléculaire :336.79Ref: TM-T13862
1mg43,00€2mg56,00€5mg93,00€1mL*10mM (DMSO)100,00€10mg113,00€25mg177,00€50mg295,00€100mg477,00€200mg677,00€Parsaclisib
CAS :Parsaclisib (INCB050465) is a potent and selective inhibitor of PI3Kδ(IC50 of 1 nM at 1 mM ATP)Formule :C20H22ClFN6O2Degré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :432.88Ref: TM-T12367
1mg138,00€5mg289,00€1mL*10mM (DMSO)318,00€10mg434,00€25mg763,00€50mg1.054,00€100mg1.423,00€Copanlisib dihydrochloride
CAS :Copanlisib dihydrochloride: ATP-competitive PI3K inhibitor, potent for PI3Kα/δ/β/γ, antitumor, 2000x selectivity over other kinases except mTOR.Formule :C23H30Cl2N8O4Degré de pureté :99.05% - 99.16%Couleur et forme :SolidMasse moléculaire :553.44PI4KIIIbeta-IN-9
CAS :PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ(IC50 of 7 nM). .Formule :C23H25N3O5S2Degré de pureté :97.18%Couleur et forme :SolidMasse moléculaire :487.59Ref: TM-T12469
1mg75,00€5mg178,00€1mL*10mM (DMSO)197,00€10mg268,00€25mg485,00€50mg677,00€100mg888,00€NSC781406
CAS :NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).Formule :C29H27F2N5O5S2Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :627.68Ref: TM-T16355
2mg39,00€5mg60,00€1mL*10mM (DMSO)84,00€10mg87,00€25mg159,00€50mg231,00€100mg355,00€200mg505,00€Sophocarpine monohydrate
CAS :Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.Formule :C15H22N2ODegré de pureté :99.55%Couleur et forme :White SolidMasse moléculaire :246.35P110δ-IN-1
CAS :P110δ-IN-1 (PWT-143) is an effective and selective inhibitor of P110δ (IC50: 8.4 nM).Formule :C31H40N8O3SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :604.77Pictilisib dimethanesulfonate
CAS :Pictilisib dimethanesulfonate (GDC-0941 2 MeSO3H salt) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) andFormule :C25H35N7O9S4Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :705.85Safingol hydrochloride
CAS :Safingol hydrochloride (L-threo-dihydrosphingosine hydrochloride) is a PKC-specific inhibitor that inhibits PKC and PI3k and induces cancer cell death.Formule :C18H40ClNO2Degré de pureté :99.71% - 99.87%Couleur et forme :SoildMasse moléculaire :337.969PI4KIIIbeta-IN-10
CAS :PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM).Formule :C22H25N3O5S2Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :475.58Ref: TM-T12468
1mg75,00€5mg156,00€1mL*10mM (DMSO)164,00€10mg241,00€25mg399,00€50mg532,00€100mg750,00€200mg1.009,00€Thioridazine hydrochloride
CAS :Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4Formule :C21H27ClN2S2Degré de pureté :99.55% - 99.95%Couleur et forme :White SolidMasse moléculaire :407.04STX-478
CAS :STX-478 (compound 80), an orally administered, CNS-penetrant allosteric mutant-selective PI3Kα inhibitor, demonstrates significant and sustained tumorFormule :C16H12F5N5O2Degré de pureté :98.31% - 99.78%Couleur et forme :SolidMasse moléculaire :401.29Ref: TM-T78211
1mg84,00€5mg177,00€1mL*10mM (DMSO)195,00€10mg286,00€25mg512,00€50mg772,00€100mg1.153,00€PI3Kα-IN-12
PI3Kα-IN-12 (compound 13), a potent and selective PI3Kα inhibitor (IC50: 1.2 nM), effectively suppresses HCT-116 and U87-MG cell proliferation with IC50 values
Formule :C28H36F2N10O5S3Couleur et forme :SolidMasse moléculaire :726.84PI5P4Ks-IN-2
CAS :PI5P4Ks-IN-2 inhibits PI5P4K isoforms α, β, γ, γ+ with IC50 <4.3, <4.6, 6.2, 0.32 µM, respectively.Formule :C22H23N5Degré de pureté :98.97% - 99.35%Couleur et forme :SoildMasse moléculaire :357.45Ref: TM-T72032
1mg92,00€5mg192,00€1mL*10mM (DMSO)210,00€10mg285,00€25mg482,00€50mg632,00€100mg827,00€PI3Kδ-IN-14
PI3Kδ-IN-14 (Compound (S)-29), a selective PI3Kδ inhibitor with an IC50 of 0.8 nM and a Kd of 84.8 nM, targets the ATP-binding site within the kinase domain ofFormule :C26H20ClFN8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :514.94PI3K-AKT-mTOR Compound Library
A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved withCouleur et forme :Odour SolidRef: TM-L1300
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderPI3Kδ-IN-12
PI3Kδ-IN-12 (compound 13), a PI3Kδ inhibitor with a pIC50 of 5.8, exhibits differential binding affinities with pKi values of 8.0 for PI3Kδ, 6.5 for PI3Kγ, 6.4Formule :C20H15Cl2N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :444.27PI3Kδ-IN-18
Se15, a selective PI3Kδ inhibitor, exhibits potency with an IC50 value of less than 0.1nM and is utilized in autoimmune research [1].Degré de pureté :98%Couleur et forme :Odour SolidD-106669
CAS :D-106669 (comppun 150) is a potent inhibitor of PI3Kα, with an IC50 value of 0.129 μM, and plays a significant role in cancer research.Formule :C17H18N6OCouleur et forme :SolidMasse moléculaire :322.36PI3K-IN-47
PI3K-IN-47 (Compound 27) is a potent bivalent inhibitor targeting the phosphoinositide 3-kinases (PI3K) family, exhibiting inhibitory concentration (IC50)Formule :C50H46F4N8O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1027.07Duvelisib (R enantiomer) hydrochloride
Duvelisib (R enantiomer) hydrochloride (INK1197 R enantiomer HCl) is a PI3K inhibitor.Formule :C22H18Cl2N6ODegré de pureté :99.86% - 99.88%Couleur et forme :White SolidMasse moléculaire :453.32Ref: TM-T11129L
1mg296,00€5mg718,00€1mL*10mM (DMSO)895,00€10mg982,00€25mg1.485,00€50mg2.008,00€100mg2.637,00€Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Couleur et forme :Odour SolidRef: TM-L1600
1mgÀ demander10μL*10mM (DMSO)À demander20μL*10mM (DMSO)À demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderPITCOIN4
PITCOIN4 is a Class II Alpha PI3K-C2α inhibitor with high selectivity, demonstrating nanomolar inhibition of PI3K-C2α and exhibiting over 100-fold selectivityDegré de pureté :98%Couleur et forme :Odour SolidIHMT-PI3K-455
IHMT-PI3K-455 (Compound 15u) is a potent, selective PI3Kγ/δ dual inhibitor, demonstrating oral activity, with IC50 values of 7.1 nM for PI3Kγ and 0.57 nM forFormule :C26H21F2N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :517.49PI3K-IN-41
PI3K-IN-41 (compound 2), a photocaged PI3K inhibitor (IC50=18.92 nM) with anticancer properties, demonstrates potent PI3K inhibition following UV lightFormule :C45H39F2N5O12SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :911.88PI3K-IN-46
CAS :PI3K-IN-46 is a specific inhibitor of PI3Kγ.Formule :C13H9N3OSDegré de pureté :97.26%Couleur et forme :SolidMasse moléculaire :255.3Ref: TM-T64392
1mg62,00€1mL*10mM (DMSO)133,00€5mg149,00€10mg213,00€25mg319,00€50mg450,00€100mg605,00€740 Y-P(TFA)
740 Y-P(TFA)(1236188-16-1 free base) (740YPDGFR(TFA)) is a potent and cell-permeable activator of PI3K.Formule :C143H223F3N43O41PS3Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :3384.73PROTAC PI3Kα degrader-1
PROTACPI3Kα degrader-1 is a PI3Kα-targeting PROTAC degrader (DC50= 0.08 μM) that demonstrates notable selectivity in degrading PI3Kα over the PI3Kβ, PI3Kγ, and PI3Kδ isoforms. It degrades PI3Kα effectively in a time- and concentration-dependent manner and significantly inhibits the phosphorylation of AKT at the Ser473 site. Additionally, PROTACPI3Kα degrader-1 exhibits significant in vivo anticancer efficacy in HGC-27 and DOHH2 xenograft models.Couleur et forme :Odour SolidPROTAC PI3K/110β degrader-1
CAS :PROTACPI3K/110β degrader-1 (J-9) acts as a PROTAC degrader specifically targeting PI3K/110β.Formule :C51H65N9O9SCouleur et forme :SolidMasse moléculaire :980.18740 Y-P acetate
740 Y-P acetate (740YPDGFR acetate) is a potent and cell-permeable PI3K activator.740 Y-P acetate tends to bind to GST fusion proteins containing the N- and C-Formule :C143H226N43O41PS3Degré de pureté :99.92%Couleur et forme :SoildMasse moléculaire :3330.79IHMT-PI3Kδ-372 S-isomer
CAS :IHMT-PI3Kδ-372 S-isomer is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM.Formule :C26H23F2N7O2Degré de pureté :99.97%Couleur et forme :White SolidMasse moléculaire :503.5Ref: TM-T60196
1mg109,00€2mg163,00€5mg241,00€1mL*10mM (DMSO)294,00€10mg354,00€25mg532,00€50mg745,00€100mg1.018,00€BAY1082439
CAS :BAY1082439, an orally bioavailable, selective inhibitor of PI3Kα/β/δ, demonstrates high efficacy in inhibiting the growth of Pten-null prostate cancer [1][2].Formule :C25H30N6O5Degré de pureté :98%Couleur et forme :White SolidMasse moléculaire :494.54(3S)-GSK-F1
CAS :(3S)-GSK-F1 is a selective small molecule inhibitor of Type III Phosphatidylinositol 4‑Kinase Alpha (PI4KIIIα), pIC50=8.3.Formule :C27H18F5N5O4SDegré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :603.52Ref: TM-T67837
1mg70,00€5mg133,00€1mL*10mM (DMSO)182,00€10mg210,00€25mg371,00€50mg532,00€100mg837,00€PI3Kα-IN-25
PI3Kα-IN-25 (Compound Djh1) is a selective inhibitor of PI3Kα, suitable for research in triple-negative breast cancer.Formule :C21H19ClN4O4Couleur et forme :SolidMasse moléculaire :426.853GSK2292767 FA
GSK2292767 FA: potent PI3Kδ inhibitor, pIC50=10.1, 500x selectivity, for respiratory research.Formule :C25H30N6O7SDegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :558.61ARUK2001607
CAS :ARUK2001607 selectively inhibits PI5P4Kγ (Kd=7.1 nM) with high selectivity over 150+ kinases.Formule :C14H13N3O2S2Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :319.40Umbralisib R-enantiomer
CAS :Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202.Formule :C31H24F3N5O3Degré de pureté :97.34%Couleur et forme :SolidMasse moléculaire :571.55Ref: TM-T13140
1mg177,00€5mg432,00€1mL*10mM (DMSO)532,00€10mg620,00€25mg1.108,00€50mg1.431,00€100mg1.783,00€FDA-Approved Kinase Inhibitor Library
A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.Couleur et forme :LiquidRef: TM-L1610
1mgÀ demander10μL*10mM (DMSO)À demander20μL*10mM (DMSO)À demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderPI3K-IN-57
PI3K-IN-57 (Compound 4a) is a PI3K inhibitor that shows strong inhibitory effects on the proliferation of HeLa tumor ectopic xenografts in vivo. It holds promise for anticancer agent research.Couleur et forme :Odour SolidIHMT-PI3K-315
IHMT-PI3K-315 (20e) serves as a potent, selective inhibitor of PI3Kγ/δ, exhibiting IC 50 values of 4.0 nM for PI3Kγ and 9.1 nM for PI3Kδ. Additionally, it demonstrates antitumor activity.Formule :C22H20F2N6O4Couleur et forme :SolidMasse moléculaire :470.43GSK251
CAS :GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode.Formule :C29H37FN6O4SDegré de pureté :99.8%Couleur et forme :White SolidMasse moléculaire :584.71Penetratin-PI3Kγ(126-150)
Penetratin-PI3Kγ(126-150) is a peptide inhibitor of PI3Kγ that plays a significant role in respiratory diseases.Formule :C229H362N76O57SCouleur et forme :SolidMasse moléculaire :5120.74849PF-06843195
CAS :PF-06843195 is a potent and selective PI3Kα inhibitor prevents it catalyzing the conversion of PIP2 to PIP3, inhibit the activation of AKT, anti-tumor .Formule :C20H25F3N8O4Degré de pureté :98.01%Couleur et forme :White SolidMasse moléculaire :498.46TGX-221
CAS :TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.Formule :C21H24N4O2Degré de pureté :99.60% - >99.99%Couleur et forme :White SolidMasse moléculaire :364.44Periplocin
CAS :Periplocin fights lung cancer, induces apoptosis, stunts growth via beta-catenin/Tcf, and treats rheumatoid arthritis/traditional ailments.Formule :C36H56O13Degré de pureté :99.66% - 99.96%Couleur et forme :White SolidMasse moléculaire :696.82Ref: TM-T5S1982
1mg34,00€5mg73,00€10mg101,00€1mL*10mM (DMSO)102,00€25mg167,00€50mg240,00€100mg355,00€500mg845,00€
