PI3K
Les inhibiteurs de PI3K sont des composés qui bloquent l'activité des phosphoinositide 3-kinases (PI3Ks), une famille d'enzymes impliquées dans un large éventail de processus cellulaires, y compris la croissance, la prolifération, la survie et le métabolisme. La voie PI3K/Akt/mTOR est souvent dérégulée dans le cancer, ce qui fait de PI3K une cible clé pour la thérapie anticancéreuse. Les inhibiteurs de PI3K sont des outils essentiels pour étudier la transduction du signal, la biologie du cancer et le développement de thérapies ciblées. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de PI3K pour soutenir vos recherches en signalisation cellulaire, en oncologie et en développement thérapeutique.
242 produits trouvés pour "PI3K"
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PF-06843195
CAS :<p>PF-06843195 is a potent and selective PI3Kα inhibitor prevents it catalyzing the conversion of PIP2 to PIP3, inhibit the activation of AKT, anti-tumor .</p>Formule :C20H25F3N8O4Degré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :498.46VS-5584
CAS :<p>VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.</p>Formule :C17H22N8ODegré de pureté :97.82% - 99.54%Couleur et forme :SolidMasse moléculaire :354.41Apitolisib
CAS :<p>Apitolisib (RG 7422) is a PI3K inhibitor, used in cancer trials, targeting PI3Kα, β, δ, γ (IC50= 5, 27, 7, 14 nM).</p>Formule :C23H30N8O3SDegré de pureté :98.28% - 99.64%Couleur et forme :SolidMasse moléculaire :498.6PIK-108
CAS :<p>PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).</p>Formule :C22H24N2O3Degré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :364.44PIK-75 hydrochloride
CAS :<p>PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor, isoform-specific mutants at Ser773, and potently inhibits DNA-PK with IC50 of 2 nM in cell-free assay.</p>Formule :C16H14BrN5O4S·HClDegré de pureté :97.82%Couleur et forme :SolidMasse moléculaire :488.74YS-49
CAS :<p>YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).</p>Formule :C20H20BrNO2Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :386.28Brevianamide F
CAS :<p>Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines.</p>Formule :C16H17N3O2Degré de pureté :97.30% - 98.82%Couleur et forme :SolidMasse moléculaire :283.33Alpelisib
CAS :<p>Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity.</p>Formule :C19H22F3N5O2SDegré de pureté :98% - 99.73%Couleur et forme :SolidMasse moléculaire :441.47Glaucocalyxin A
CAS :<p>Glaucocalyxin A improves drug delivery, activates apoptosis, inhibits cell growth, with potential as an antiplatelet agent.</p>Formule :C20H28O4Degré de pureté :99.55% - 99.80%Couleur et forme :SolidMasse moléculaire :332.43Flupentixol dihydrochloride
CAS :<p>Flupentixol dihydrochloride is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders.</p>Formule :C23H27Cl2F3N2OSDegré de pureté :98.76% - >99.99%Couleur et forme :White Or Off-White SolidMasse moléculaire :507.43Rigosertib
CAS :<p>Rigosertib, a multi-kinase inhibitor targeting PLK1 (IC50: 9 nM), induces apoptosis and G2/M arrest by disrupting PI3K/Akt.</p>Formule :C21H25NO8SDegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :451.49NIBR-17
CAS :<p>NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.</p>Formule :C18H20N8O2Degré de pureté :97.79%Couleur et forme :SolidMasse moléculaire :380.41-Deoxynojirimycin hydrochloride
CAS :<p>1-Deoxynojirimycin hydrochloride (Moranoline) is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves.</p>Formule :C6H14ClNO4Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :199.63Omipalisib
CAS :<p>Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.</p>Formule :C25H17F2N5O3SDegré de pureté :98% - 99.8%Couleur et forme :SolidMasse moléculaire :505.5Erucic acid
CAS :<p>Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ).</p>Formule :C22H42O2Degré de pureté :99.64%Couleur et forme :Needles From Alcohol Liquid OthersolidMasse moléculaire :338.57AZD-7648
CAS :<p>AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.</p>Formule :C18H20N8O2Degré de pureté :99.03% - 99.85%Couleur et forme :SolidMasse moléculaire :380.4Desmethylglycitein
CAS :<p>Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has</p>Formule :C15H10O5Degré de pureté :97.93%Couleur et forme :SolidMasse moléculaire :270.24Taurolithocholic acid sodium salt
CAS :<p>Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, but</p>Formule :C26H44NNaO5SDegré de pureté :99.79% - 99.93%Couleur et forme :SolidMasse moléculaire :505.69ZSTK474
CAS :<p>PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potential</p>Formule :C19H21F2N7O2Degré de pureté :98.29% - 99.95%Couleur et forme :White PowderMasse moléculaire :417.41PI-103
CAS :<p>PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).</p>Formule :C19H16N4O3Degré de pureté :97.79% - 99.3%Couleur et forme :SolidMasse moléculaire :348.36TG 100713
CAS :<p>TG 100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.</p>Formule :C12H10N6ODegré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :254.25BEBT-908
CAS :<p>BEBT-908 (PI3Kα inhibitor 1) is a selective PI3Kα inhibitor (IC50 <0.1 μM). BEBT-908 also inhibits HDAC (0.1 μM≤IC50≤1 μM).</p>Formule :C23H25N9O3SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :507.573-Methyladenine
CAS :<p>3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM).</p>Formule :C6H7N5Degré de pureté :98.02% - 99.65%Couleur et forme :SolidMasse moléculaire :149.15Flavanomarein
CAS :<p>Flavanomarein: Antioxidant with radical scavenging, lipid peroxidation inhibition, and lipid-lowering in HepG2 cells.</p>Formule :C21H22O11Degré de pureté :98.63% - 99.54%Couleur et forme :SolidMasse moléculaire :450.39Eganelisib
CAS :<p>Eganelisib (IPI-549) is an inhibitor of PI3Kγ (IC50 = 16, 3,200, 3,500, and >8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively)</p>Formule :C30H24N8O2Degré de pureté :99.04% - 99.28%Couleur et forme :SolidMasse moléculaire :528.56SKI V
CAS :<p>SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM),</p>Formule :C15H10O4Degré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :254.24Idelalisib
CAS :<p>Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM).</p>Formule :C22H18FN7ODegré de pureté :98% - 99.39%Couleur et forme :SolidMasse moléculaire :415.421-Deoxynojirimycin
CAS :<p>1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.</p>Formule :C6H13NO4Degré de pureté :99.65% - 99.98%Couleur et forme :White-Beige Solid CrystallineMasse moléculaire :163.17Vps34-PIK-III
CAS :<p>Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.</p>Formule :C17H17N7Degré de pureté :98.39% - 98.43%Couleur et forme :SolidMasse moléculaire :319.36Bimiralisib
CAS :<p>Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity.</p>Formule :C17H20F3N7O2Degré de pureté :97.58% - 98.92%Couleur et forme :SolidMasse moléculaire :411.38GNE-493
CAS :<p>GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for</p>Formule :C17H20N6O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :372.44NIH-12848
CAS :<p>NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.</p>Formule :C20H14F3N3SDegré de pureté :99.84% - 99.9%Couleur et forme :SolidMasse moléculaire :385.41Sapanisertib
CAS :<p>Sapanisertib (INK 128) is an oral raptor-mTOR and rictor-mTOR inhibitor with potential cancer-fighting properties.</p>Formule :C15H15N7ODegré de pureté :99.19% - >99.99%Couleur et forme :SolidMasse moléculaire :309.33PF-04691502
CAS :<p>PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.</p>Formule :C22H27N5O4Degré de pureté :96.27% - ≥95%Couleur et forme :SolidMasse moléculaire :425.48BGT226
CAS :<p>BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.</p>Formule :C28H25F3N6O2Degré de pureté :95.74% - 99.51%Couleur et forme :SolidMasse moléculaire :534.53Fimepinostat
CAS :<p>Fimepinostat (CUDC 907) is an orally bioavailable inhibitor of both PI3K class I and pan-HDAC enzymes, with potential antineoplastic activity.</p>Formule :C23H24N8O4SDegré de pureté :98.27% - 99.87%Couleur et forme :SolidMasse moléculaire :508.55Rigosertib sodium
CAS :<p>Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.</p>Formule :C21H24NNaO8SDegré de pureté :98% - 99.37%Couleur et forme :SolidMasse moléculaire :473.47TASP0415914
CAS :<p>TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). T</p>Formule :C13H17N5O3SDegré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :323.37Arnicolide D
CAS :<p>Arnicolide D is a sesquiterpene lactone.</p>Formule :C19H24O5Degré de pureté :96.66%Couleur et forme :SolidMasse moléculaire :332.39PI-3065
CAS :<p>PI-3065 is a novel potent and selective PI3K p110δ inhibitor.</p>Formule :C27H31FN6OSDegré de pureté :99.84% - ≥95%Couleur et forme :SolidMasse moléculaire :506.64Wortmannin
CAS :<p>Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible.</p>Formule :C23H24O8Degré de pureté :95.84% - 99.76%Couleur et forme :White SolidMasse moléculaire :428.43GDC0084
CAS :<p>GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity.</p>Formule :C18H22N8O2Degré de pureté :99.72% - 99.87%Couleur et forme :SolidMasse moléculaire :382.42AS-252424
CAS :<p>AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.</p>Formule :C14H8FNO4SDegré de pureté :99.06% - 99.09%Couleur et forme :SolidMasse moléculaire :305.28Hederacolchiside A1
CAS :<p>Hederacolchiside A1 exhibits anti-leishmanial and anticancer activities by disrupting cell membranes and inducing apoptosis via the PI3K/Akt/mTOR pathway.</p>Formule :C47H76O16Degré de pureté :98.76% - 99.92%Couleur et forme :SolidMasse moléculaire :897.1PI3K-IN-1
CAS :<p>PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.</p>Formule :C31H29N5O6SDegré de pureté :97.03% - 98%Couleur et forme :SolidMasse moléculaire :599.66PF-4989216
CAS :<p>PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.</p>Formule :C18H13FN6OSDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :380.4Leniolisib
CAS :<p>Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).</p>Formule :C21H25F3N6O2Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :450.46Copanlisib
CAS :<p>Copanlisib (BAY 80-6946), a PI3K inhibitor, may block tumor growth and improve cancer treatment efficacy.</p>Formule :C23H28N8O4Degré de pureté :99% - 99.88%Couleur et forme :SolidMasse moléculaire :480.52(E)-Akt inhibitor-IV
CAS :<p>(E)-Akt inhibitor-IV ((E)-AKTIV) ((E)-AKTIV) is an inhibitor of PI3K-Akt.</p>Formule :C31H29IN4SDegré de pureté :99.74% - 99.9%Couleur et forme :SolidMasse moléculaire :616.56BQR-695
CAS :<p>BQR-695 (NVP-BQR695) is a PI4K inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.</p>Formule :C19H20N4O3Degré de pureté :98.91% - 99.69%Couleur et forme :SolidMasse moléculaire :352.39
