ATM/ATR
Les inhibiteurs de l'ATM (Ataxia Telangiectasia Mutated) et de l'ATR (ATM and Rad3-related) ciblent des kinases clés impliquées dans la réponse aux dommages de l'ADN (DDR), activées en réponse aux cassures double brin de l'ADN et au stress de réplication. Ces inhibiteurs perturbent la capacité des kinases à détecter et réparer les dommages de l'ADN, ce qui peut entraîner une instabilité génomique accrue et la mort cellulaire, en particulier dans les cellules cancéreuses qui dépendent de mécanismes de réparation de l'ADN robustes pour survivre. Les inhibiteurs de l'ATM/ATR sont des outils cruciaux dans la recherche et la thérapie contre le cancer, notamment en combinaison avec des agents endommageant l'ADN. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de l'ATM/ATR de haute qualité pour soutenir vos recherches sur la réponse aux dommages de l'ADN, la biologie du cancer et le développement thérapeutique.
71 produits trouvés pour "ATM/ATR"
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Elimusertib hydrochloride(1876467-74-1 free base)
<p>Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumor</p>Formule :C20H22ClN7ODegré de pureté :98.8% - 99.03%Couleur et forme :SolidMasse moléculaire :411.89Garcinone C
CAS :<p>Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.</p>Formule :C23H26O7Degré de pureté :99.13% - 99.92%Couleur et forme :SolidMasse moléculaire :414.45FEN1-IN-1
CAS :<p>FEN1-IN-1 (LNT-1), a FEN1 active site inhibitor, partly works by coordinating Mg2+ ions.</p>Formule :C15H12N2O5SDegré de pureté :99.65% - 99.80%Couleur et forme :SolidMasse moléculaire :332.33GJ071 oxalate
CAS :<p>GJ071 oxalate is a Nonsense suppressor that induces readthrough by inserting amino acids at premature termination codons.</p>Formule :C20H29N3O7SDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :455.53Berzosertib
CAS :<p>Berzosertib (VE-822) is an ATR inhibitor (Ki<0.2 nM) that also inhibits ATM (Ki=34 nM). Berzosertib has antitumor activity. Cost-effective and quality-assured.</p>Formule :C24H25N5O3SDegré de pureté :97.34% - >99.99%Couleur et forme :SolidMasse moléculaire :463.55Hexapeptide-11
CAS :<p>Hexapeptide-11 is a novel proteostasis network modulator in human diploid fibroblasts.</p>Formule :C36H48N6O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :676.8ATM Inhibitor-8
<p>ATM Inhibitor-8 (Compound 10r) is a potent, selective, and orally active inhibitor of ATM, exhibiting anti-tumor activity [1], characterized by an IC50 value of</p>Formule :C26H34N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.59ATM Inhibitor-9
<p>ATM Inhibitor-9 (Compd 7a) is a potent inhibitor of ATM kinase, exhibiting an IC50 value of 5 nM, and is utilized in cancer research [1].</p>Formule :C25H32N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.56CA-M11
<p>CA-M11 (compound CA-M11) is capable of entering the liver's bile salt transport system to release Mirin.</p>Formule :C34H46N2O6SCouleur et forme :SolidMasse moléculaire :610.80Abd110
CAS :<p>Abd110 (compound 42i), a Lenalidomide-based PROTAC ATR kinase degrader, selectively reduces levels of ATR and phospho-ATR while not impacting the related kinases ATM and DNA-PKcs [1].</p>Formule :C41H42N8O7SCouleur et forme :SolidMasse moléculaire :790.89Antitumor agent-28
CAS :<p>Antitumor agent-28 inhibits ATM kinase, blocking ATM disease progression and showing anti-cancer effects.</p>Formule :C25H32N6O4SCouleur et forme :SolidMasse moléculaire :512.63GJ103 sodium salt
CAS :<p>GJ103 sodium salt, a GJ072 analog, lowers surface tension, viscosity, and pH in aqueous solutions, aiding molecular movement.</p>Formule :C16H13N4NaO3SDegré de pureté :99.70% - 99.91%Couleur et forme :SolidMasse moléculaire :364.36Ceralasertib
CAS :<p>Ceralasertib (AZD6738) is an ATR kinase inhibitor (IC50=1 nM) with selective and oral activity. Ceralasertib has antitumor activity. Cost effective and quality assured.</p>Formule :C20H24N6O2SDegré de pureté :98% - 99.99%Couleur et forme :SolidMasse moléculaire :412.51AZD0156
CAS :<p>AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.</p>Formule :C26H31N5O3Degré de pureté :99.13% - 99.87%Couleur et forme :SolidMasse moléculaire :461.56CP-466722
CAS :<p>CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells.</p>Formule :C17H15N7O2Degré de pureté :99.1% - 99.14%Couleur et forme :SolidMasse moléculaire :349.35KU-55933
CAS :<p>KU-55933 (ATM Kinase Inhibitor) is an ATM inhibitor that is selective and ATP-competitive. KU-55933 has antitumor effects. Cost-effective and quality-assured.</p>Formule :C21H17NO3S2Degré de pureté :97.21% - >99.99%Couleur et forme :SolidMasse moléculaire :395.49AZ20
CAS :<p>AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.</p>Formule :C21H24N4O3SDegré de pureté :98% - 99.69%Couleur et forme :SolidMasse moléculaire :412.51NU6027
CAS :<p>NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-</p>Formule :C11H17N5O2Degré de pureté :98.36%Couleur et forme :SolidMasse moléculaire :251.29PIK-93
CAS :<p>PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.</p>Formule :C14H16ClN3O4S2Degré de pureté :97.72%Couleur et forme :SolidMasse moléculaire :389.88AZD-7648
CAS :<p>AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.</p>Formule :C18H20N8O2Degré de pureté :99.03% - 99.85%Couleur et forme :SolidMasse moléculaire :380.4CGK733
CAS :<p>CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.</p>Formule :C23H18Cl3FN4O3SDegré de pureté :98% - 99.67%Couleur et forme :SolidMasse moléculaire :555.84Adefovir dipivoxil
CAS :<p>Adefovir dipivoxil (GS 0840) is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity against</p>Formule :C20H32N5O8PDegré de pureté :98% - 99.80%Couleur et forme :It Has Broad-Spectrum Antiviral ActivityMasse moléculaire :501.47KU60019
CAS :<p>Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50: 6.3 nM). It is much less effective or without effect against a panel of 229 other kinases.</p>Formule :C30H33N3O5SDegré de pureté :95.9% - 99.36%Couleur et forme :SolidMasse moléculaire :547.67VE-821
CAS :<p>VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays).</p>Formule :C18H16N4O3SDegré de pureté :97.19% - 99.97%Couleur et forme :SolidMasse moléculaire :368.41AZ32
CAS :<p>AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.</p>Formule :C20H16N4ODegré de pureté :98.68% - 99.68%Couleur et forme :SolidMasse moléculaire :328.37Elimusertib
CAS :<p>Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in</p>Formule :C20H21N7ODegré de pureté :98.72% - 99.84%Couleur et forme :SolidMasse moléculaire :375.43Dactolisib
CAS :<p>Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).</p>Formule :C30H23N5ODegré de pureté :97.64% - 99.85%Couleur et forme :SolidMasse moléculaire :469.54azd1390
CAS :<p>AZD1390: Potent ATM inhibitor (IC50: 0.78 nM), >10,000-fold selectivity vs. PIKK enzymes.</p>Formule :C27H32FN5O2Degré de pureté :97.41% - 99.72%Couleur et forme :SolidMasse moléculaire :477.57ETP-46464
CAS :<p>ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).</p>Formule :C30H22N4O2Degré de pureté :97.76%Couleur et forme :SolidMasse moléculaire :470.52Mirin
CAS :<p>Mirin is a Mre11-Rad50-Nbs1 (MRN) complex inhibitor and also inhibits Mre11-associated exonuclease activity.Mirin induces cell cycle arrest in G1 phase.</p>Formule :C10H8N2O2SDegré de pureté :99.24%Couleur et forme :SolidMasse moléculaire :220.25ART0380
CAS :<p>ART0380 is a potent, antitumor, selective, orally available, ATP-competitive ATR kinase inhibitor for the study of ataxia telangiectasia mutated (ATM) cancer.</p>Formule :C18H24N6O2SDegré de pureté :99.06% - >99.99%Couleur et forme :SolidMasse moléculaire :388.49SKLB-197
CAS :<p>SKLB-197 targets ATR, inhibiting it at 0.013 μM, and is inactive on 402 other kinases, showing potent antitumor effects on ATM-deficient tumors.</p>Formule :C25H24N6OCouleur et forme :SolidMasse moléculaire :424.5ATR-IN-10
CAS :<p>ATR-IN-10 is a potent and highly selective inhibitor of ATR kinase (IC50: 2.978 μM).</p>Formule :C27H24N4OCouleur et forme :SolidMasse moléculaire :420.51Ceralasertib formate
CAS :<p>Ceralasertib: an oral ATR kinase inhibitor that blocks CHK1 phosphorylation, disrupts DNA repair, and triggers tumor cell apoptosis.</p>Formule :C21H26N6O4SCouleur et forme :SolidMasse moléculaire :458.54ATR-IN-15
CAS :<p>ATR-IN-15, an ATR kinase inhibitor, has an IC50 of 8 nM and also targets LoVo cells, DNA-PK, and PI3K with higher IC50 values.</p>Formule :C19H22N8OCouleur et forme :SolidMasse moléculaire :378.43Gartisertib
CAS :<p>Gartisertib (VX-803) is an ATR inhibitor with anti-tumor activity, inhibiting the anti-proliferative effects induced in ccRCC cells.</p>Formule :C25H29F2N9O3Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :541.55ATR-IN-16
CAS :<p>ATR-IN-16 (compound 46) is an ATR kinase inhibitor with potent anticancer effects in LoVo cells, IC50 of 410 nM.</p>Formule :C19H25N7OCouleur et forme :SolidMasse moléculaire :367.45ATR-IN-23
CAS :<p>ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces</p>Formule :C20H22N6O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.56ATR-IN-6
CAS :<p>ATR-IN-6: potent ATR kinase inhibitor for cancer treatment, referenced in patent WO2021233376A1 as compound A22.</p>Formule :C28H28FN7O2Couleur et forme :SolidMasse moléculaire :513.57ATR-IN-18
CAS :<p>ATR-IN-18: oral ATR inhibitor, IC50 0.69 nM; halts LoVo cell growth, IC50 37.34 nM; anti-tumor.</p>Formule :C19H22F3N7O5SCouleur et forme :SolidMasse moléculaire :517.48ATR-IN-29
CAS :<p>ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].</p>Formule :C19H22N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :378.43ATR-IN-13
CAS :<p>ATR-IN-13 is a potent inhibitor of ATR kinases (IC50: 2 nM) and can be used to study ATR kinase-mediated diseases (e.g. proliferative diseases, cancer).</p>Formule :C24H24FN9OCouleur et forme :SolidMasse moléculaire :473.51AZ 5704
CAS :<p>ATM kinase inhibitor with 0.6 nM IC50, >600-fold selective, enhances irinotecan effects, oral use.</p>Formule :C23H23FN6O2Couleur et forme :SolidMasse moléculaire :434.47ATR-IN-8
CAS :<p>ATR-IN-8 is a potent inhibitor of ATR. ATR-IN-8 has shown potential research value in cancer diseases.</p>Formule :C20H22N6O2SCouleur et forme :SolidMasse moléculaire :410.49ATR-IN-22
CAS :<p>ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1 μM and</p>Formule :C25H31N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :445.56ATR-IN-20
<p>ATR-IN-20: potent ATR inhibitor, IC50=3nM; inhibits mTOR, IC50=18nM; selective vs PI3Kα, ATM, DNA-PK; good pharmacokinetics; anticancer.</p>Formule :C29H31N5O4SCouleur et forme :SolidMasse moléculaire :545.65ATR-IN-5
CAS :<p>ATR-IN-5 is a potent inhibitor of ATR, a member of the PIKK family of proteins involved in genome stability and DNA damage repair.</p>Formule :C27H32F3N9OCouleur et forme :SolidMasse moléculaire :555.6(S)-Ceralasertib
CAS :<p>(S)-Ceralasertib: Potent, selective ATR inhibitor with strong preclinical physicochemical and PK profiles.</p>Formule :C20H24N6O2SCouleur et forme :SolidMasse moléculaire :412.51ATR-IN-21
CAS :<p>ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].</p>Formule :C23H27N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :417.51ATM-IN-1
CAS :<p>ATM-IN-1 is a potent inhibitor of ATM. ATM-IN-1 has shown research potential in cancer and neurological diseases.</p>Formule :C30H36N6O3Couleur et forme :SolidMasse moléculaire :528.65Camonsertib
CAS :<p>Camonsertib (RP-3500) is a novel, potent and selective ATR kinase inhibitor (ATRi) that exhibits potent antitumor effects with an IC50: 1.00 nM in biochemical assays.Cost-effective and quality-assured.</p>Formule :C21H26N6O3Degré de pureté :99.6% - 99.93%Couleur et forme :SolidMasse moléculaire :410.47AZ31
CAS :<p>AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM,</p>Formule :C24H28N4O3Degré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :420.5Lartesertib
CAS :<p>Lartesertib (ATM Inhibitor-5) is an inhibitor of the serine/threonine protein kinase ATM with potential anticancer activity and can be used to study lung cancer</p>Formule :C23H21FN6O3Degré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :448.45ATR-IN-17
CAS :<p>ATR-IN-17 is a potent inhibitor of ATR kinase with good anti-cancer effects in LoVo cells (IC50: 1 nM).</p>Formule :C22H28N6O2SCouleur et forme :SolidMasse moléculaire :440.56ATM Inhibitor-4
<p>ATM Inhibitor -4: selective, potent (IC50: 0.32 nM), inhibits PI3K family, stable, stops mTOR at 1 μM.</p>Formule :C26H29FN6O3Couleur et forme :SolidMasse moléculaire :492.55ATM Inhibitor-2
<p>ATM Inhibitor -2 is a potent and selective inhibitor of ATM (IC50<1 nM).</p>Formule :C26H31N7O3Couleur et forme :SolidMasse moléculaire :489.57ATM Inhibitor-3
<p>ATM Inhibitor-3 selectively inhibits ATM (IC50: 0.71 nM), targets PI3K kinase family, and is metabolically stable.</p>Formule :C25H29FN6O3Couleur et forme :SolidMasse moléculaire :480.53Decarbamoylmitomycin C
CAS :<p>Decarbamoylmitomycin C, an analog of Mitomycin C (MC), functions as a DNA alkylating agent. It is capable of activating chromatin relaxation by the ataxia-telangiectasia and Rad3-related protein (ATR) in a p53-independent manner.</p>Formule :C14H17N3O4Couleur et forme :SolidMasse moléculaire :291.302WSD0628
CAS :<p>WSD0628 is a brain-penetrant and potent ATM inhibitor with a significant radiosensitizing effect [1].</p>Formule :C23H23F2N5O2Couleur et forme :SolidMasse moléculaire :439.46ATM Inhibitor-1
CAS :<p>ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity.</p>Formule :C27H36N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :492.61ATR-IN-14
CAS :<p>ATR-IN-14: potent ATR kinase inhibitor; 98.03% inhibition at 25 nM; IC50 of 64 nM in LoVo cells.</p>Formule :C20H20FN7OCouleur et forme :SolidMasse moléculaire :393.42KU 59403
CAS :<p>KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).</p>Formule :C29H32N4O4S2Degré de pureté :99.10%Couleur et forme :SolidMasse moléculaire :564.72ATR kinase-IN-2
CAS :<p>ATRkinase-IN-2 (Compound I-G-27) is an inhibitor of the ATR protein kinase, with a Ki value ranging from 0.01 to 1 μΜ. It is utilized in tumor research.</p>Formule :C24H29F2N9O2Couleur et forme :SolidMasse moléculaire :513.54ATM Inhibitor-11
CAS :<p>ATMInhibitor-11 (Compound 1) is an inhibitor of ATM with an IC50 of 0.32 nM. It also inhibits KAP1 phosphorylation with an IC50 of 0.97 nM. This compound exhibits high exposure in the brain, heart, and plasma of ICR mice. Furthermore, ATMInhibitor-11 demonstrates antitumor activity in the NCI-H441 xenograft mouse model.</p>Formule :C27H33FN6O2Couleur et forme :SolidMasse moléculaire :492.59ATR kinase-IN-3
CAS :<p>ATRkinase-IN-3 (Compound I-G-28) is an inhibitor of the ATR protein kinase, exhibiting a Ki value ranging from 0.01 to 1 μM, and is utilized in cancer research.</p>Formule :C24H27F2N9O2Couleur et forme :SolidMasse moléculaire :511.53ATR-IN-12
<p>ATR-IN-12, a potent ATR kinase inhibitor with IC50 of 0.007 μM, shows promise for drug development.</p>Formule :C22H27N5O3SCouleur et forme :SolidMasse moléculaire :441.55ATR-IN-19
CAS :<p>ATR-IN-19 (Compound 15 R-configure) is an ATR inhibitor [1].</p>Formule :C18H19N7OSCouleur et forme :SolidMasse moléculaire :381.45(S)-WSD0628
CAS :<p>(S)-WSD0628 is the S isomer of WSD0628 and serves as an ATM inhibitor, effectively suppressing ATM phosphorylation in MCF-7 cells with an IC50 of less than 100 nM. This compound also demonstrates radiosensitizing activity and is capable of penetrating the blood-brain barrier.</p>Formule :C23H23F2N5O2Couleur et forme :SolidMasse moléculaire :439.458ATR-IN-11
<p>ATR-IN-11, a potent ATR kinase inhibitor, shows promise as a lead for DNA damage response-targeted cancer drugs.</p>Formule :C25H30N6O2Couleur et forme :SolidMasse moléculaire :446.54KU-60019
CAS :<p>KU-60019 is a specific inhibitor of ATM kinase (IC50: 6.3 nM).</p>Formule :C30H33N3O5SDegré de pureté :98.05% - 98.50%Couleur et forme :SolidMasse moléculaire :547.67ATR-IN-24
CAS :<p>ATR-IN-24 (Compound 1) is an ATR inhibitor with demonstrated anticancer activity [1].</p>Formule :C23H26N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :418.49
