mTOR
Les inhibiteurs de mTOR sont des composés qui inhibent l'activité de la Cible de la Rapamycine chez les Mammifères (mTOR), un régulateur central de la croissance cellulaire, de la prolifération, du métabolisme et de la survie. La voie mTOR est fréquemment altérée dans le cancer et d'autres maladies, ce qui en fait une cible critique pour l'intervention thérapeutique. Les inhibiteurs de mTOR sont largement utilisés dans la recherche liée au cancer, au vieillissement et aux troubles métaboliques. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de mTOR pour soutenir vos recherches en transduction de signaux, oncologie et développement thérapeutique.
161 produits trouvés pour "mTOR"
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PQR620
CAS :PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2.Formule :C21H25F2N7O2Degré de pureté :97.61%Couleur et forme :SolidMasse moléculaire :445.47DMH-25
CAS :<p>DMH25 is a novel covalent and potent inhibitor of mTOR and shows in vivo antitumor activity against triple-negative breast cancer cells.</p>Formule :C15H8Br3NO3Degré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :489.94Ridaforolimus
CAS :<p>Ridaforolimus (AP23573) 是亲脂性大环内酯类抗生素雷帕霉素的小分子非前药类似物，具有潜在的抗肿瘤活性。它是一种有效和选择性的 mTOR 抑制剂，在 HT-1080 细胞中抑制 S6 磷酸化的 IC50值为 0.2 nM。</p>Formule :C53H84NO14PDegré de pureté :90.00% - 98.55%Couleur et forme :Off-White SolidMasse moléculaire :990.21DIM-C-pPhOH
CAS :CDIM8 (DIM-C-pPhOH) opposes NR4A1, halts TGF-β breast cancer migration, induces ROS/ER stress, and mimics Nur77 RNAi in pancreatic cancer.Formule :C23H18N2ODegré de pureté :98.61%Couleur et forme :SolidMasse moléculaire :338.4CC-115
CAS :CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).Formule :C16H16N8ODegré de pureté :86.79% - 99.01%Couleur et forme :SolidMasse moléculaire :336.35PQR530
CAS :PQR530, a potent dual PI3K/mTORC1/2 inhibitor, blocks PKB and pS6 phosphorylation (IC50: 0.07 μM) and has antitumor properties.Formule :C18H23F2N7O2Degré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :407.42PKCβ inhibitor 1
CAS :<p>PKCβ inhibitor 1 (KUN79359)(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2,</p>Formule :C24H21N5O2Degré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :411.46KU-0060648
CAS :KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ.Formule :C33H34N4O4SDegré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :582.71Desmethyl-VS-5584
CAS :Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.Formule :C16H20N8ODegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :340.38MHY-1685
CAS :<p>MHY-1685 is a mammalian target of rapamycin (mTOR) inhibitor and a senescence inhibitor that can rejuvenate senile hCSCs by modulating autophagy.</p>Formule :C11H8N2O4Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :232.19DS-7423
CAS :<p>DS-7423: a dual PI3K/mTOR inhibitor; IC50s—PI3Kα: 15.6 nM, mTOR: 34.9 nM, PI3Kβ: 1,143 nM, PI3Kγ: 249 nM, PI3Kδ: 262 nM.</p>Formule :C22H27F3N10O2Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :520.51Gedatolisib
CAS :Gedatolisib (PF-05212384) is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signalingFormule :C32H41N9O4Degré de pureté :98% - 99.36%Couleur et forme :SolidMasse moléculaire :615.73ETP-46464
CAS :ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).Formule :C30H22N4O2Degré de pureté :97.76%Couleur et forme :SolidMasse moléculaire :470.52BGT226 maleate
CAS :<p>BGT226 maleate (NVP-BGT226) is a class I PI3K/mTOR inhibitor for PI3Kα/β/γ (IC50: 4/63/38 nM) .</p>Formule :C28H25F3N6O2·C4H4O4Degré de pureté :97.75% - 98.78%Couleur et forme :SolidMasse moléculaire :650.6LY 303511
CAS :LY303511, an inactive analogue of LY294002, is a mTOR inhibitor and no inhibition for PI3-K.Formule :C19H18N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :306.36PI3K/mTOR Inhibitor-13
CAS :PI3K/mTOR Inhibitor-13, an oral dual blocker of PI3K and mTOR, may treat sexual diseases, solid tumors, and IPF.Formule :C20H13F2N5O3SCouleur et forme :SolidMasse moléculaire :441.41PI3K/mTOR Inhibitor-3
CAS :PI3K/mTOR Inhibitor-3, a potent dual-action anti-cancer imidazoline, targets PI3K and mTOR.Formule :C22H23N5OCouleur et forme :SolidMasse moléculaire :373.45PI3-Kinase α Inhibitor 2
CAS :Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 andFormule :C16H15N3O2SCouleur et forme :SolidMasse moléculaire :313.37JR-AB2-011
CAS :JR-AB2-011: selective mTORC2 inhibitor, IC50 = 0.36μM, blocks Rictor-mTOR, Ki = 0.19μM, cytotoxic in glioblastoma.Formule :C17H14Cl2FN3OSDegré de pureté :98.33% - 98.33%Couleur et forme :SolidMasse moléculaire :398.28eCF-309
CAS :eCF-309 is a potent mTOR inhibitor with IC50 value of 15 nM.Formule :C18H21N7O3Couleur et forme :SolidMasse moléculaire :383.4OXA-01
CAS :OXA-01 is a potent mTORC1 and mTORC2 inhibitor, with IC 50 values of 29 nM and 7 nM, respectively [1]. OXA-01 demonstrates broad anti-tumor activity.Formule :C21H20ClN5O2Couleur et forme :SolidMasse moléculaire :409.87P-2281
CAS :P-2281 is an mTOR inhibitor with anticancer and anti-inflammatory properties.P-2281 inhibits dextran sulfate sodium (DSS)-induced colitis by suppressing T-cellFormule :C9H8ClN3ODegré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :209.63PI-540
CAS :PI-540 is a potent and selective inhibitor of class 1A phosphatidylinositide 3-kinases (PI3K).Formule :C22H27N5O2SCouleur et forme :SolidMasse moléculaire :425.55PP30
CAS :PP30 is an inhibitor of mTORC1 and mTORC2. It is selective within the PI3K family, inhibiting other PI3Ks only at high concentrations.Formule :C18H19N7OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :381.45PI3K/mTOR Inhibitor-4
CAS :Oral PI3K/mTOR Inhibitor-4 targets PI3Kα, γ, δ, mTOR; IC50s: 0.63, 22, 9.2, 13.85 nM. Used in cancer research.Formule :C27H22FN3O6SCouleur et forme :SolidMasse moléculaire :535.54PI3K/mTOR Inhibitor-8
CAS :PI3K/mTOR Inhibitor-8: Dual PI3Kα (IC50: 0.46 nM) & mTOR (IC50: 12 nM) inhibitor; blocks G1/S phase & induces apoptosis in HCT-116 cells.Formule :C23H22N8O4SCouleur et forme :SolidMasse moléculaire :506.54PKI-179 hydrochloride
CAS :PKI-179: oral PI3K/mTOR inhibitor; IC50: PI3Kα/β/δ/γ (8-74 nM), PI3Kα mutants (11-14 nM), mTOR (0.42 nM); selective; inhibits cancer cell growth.Formule :C25H29ClN8O3Couleur et forme :SolidMasse moléculaire :525PI3K/mTOR Inhibitor-2
CAS :Potent PI3K/mTOR Inhibitor-2 targets PI3Kα/β/δ/γ & mTOR (IC50: 3.4, 34, 16,1, 4.7 nM); exhibits antitumor effects.Formule :C20H13ClF2N4O4SDegré de pureté :96.16%Couleur et forme :SolidMasse moléculaire :478.86PKI-179
CAS :PKI-179: Dual PI3K/mTOR inhibitor, orally active, IC50s: 0.42-77 nM, targets E545K and H1047R, antitumor in vivo.Formule :C25H28N8O3Couleur et forme :SolidMasse moléculaire :488.54QNN33358
CAS :QNN33358 is an alkylacylglycerol acts as a protein kinase C (PKC) inhibitor and diacylglycerol (DAG) antagonist.Formule :C21H42O4Couleur et forme :SolidMasse moléculaire :358.56WJD008
CAS :WJD008 inhibits PI3K/mTOR, blocks cancer cell growth, and has tumor-fighting properties.Formule :C19H21N5O2Couleur et forme :SolidMasse moléculaire :351.4FT-1518
CAS :FT-1518 is an orally available, selective and potent mTORC1 and mTORC2 inhibitor with anticancer and antitumor activity for cancer research.Formule :C20H26N8ODegré de pureté :98.34% - 98.80%Couleur et forme :SolidMasse moléculaire :394.47NVP-BBD130
CAS :NVP-BBD130 is a stable, ATP-competitive, potent, orally active inhibitor of PI3K and mTOR.Formule :C28H21N5OCouleur et forme :SolidMasse moléculaire :443.5PI3Ka-IN-5
CAS :PI3Ka-IN-5 is a potent PI3Kα/mTOR inhibitor, with an IC 50 of 0.7 nM and 3.3 nM, respectively. PI3Ka-IN-5 can be used for the research of colorectal cancer .Formule :C30H35N9O5Couleur et forme :SolidMasse moléculaire :601.66mTOR inhibitor-2
CAS :mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM).Formule :C23H21N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :411.46AP1867
CAS :AP1867 (FK506-binding protein) is a synthetic FKBP12 F36V-directed ligand coupled to THOX derivatives, facilitating targeted protein interactions and intracellular modulation studies.Formule :C38H47NO11Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :693.78PI3K/mTOR Inhibitor-9
CAS :PI3K/mTOR Inhibitor-9 acts on mTOR (38 nM IC50) and PI3Kα/γ (6.6 nM IC50), PI3Kδ (0.8 nM IC50).Formule :C23H27N7O2Couleur et forme :SolidMasse moléculaire :433.51PI3K/mTOR Inhibitor-12
CAS :PI3K/mTOR Inhibitor-12: oral, potent, selective; IC50: PI3Kα 0.06 nM, mTOR 3.12 nM; strong antitumor; less liver toxicity.Formule :C27H27F2N9O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :611.62PI3K/mTOR Inhibitor-7
CAS :Potent PI3K/mTOR inhibitor, 4.7x stronger than gedatolisib; IC50: 1.4 μM (PI3K), 0.3 μM (mTOR); impacts PI3K/Akt/mTOR pathway; research in cancer.Formule :C29H33N9O4Couleur et forme :SolidMasse moléculaire :571.63PI3K/mTOR Inhibitor-5
CAS :PI3K/mTOR Inhibitor-5 is a potent dual inhibitor of PI3K and mTOR, displaying IC50 values of 86.9 nM (for PI3K) and 14.6 nM (for mTOR), respectively.Formule :C32H40N10O3Couleur et forme :SolidMasse moléculaire :612.73MTI-31
CAS :MTI-31 (LXI-15029) is a potent oral mTORC1/2 inhibitor with a Kd of 0.20 nM, >5,000-fold selectivity, and an IC50 of 39 nM.Formule :C26H30N6O3Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :474.55mTOR inhibitor-11
CAS :mTOR inhibitor-11 (Compound 9) is a brain-penetrant compound capable of inhibiting mTOR with an IC50 of 21 nM for pS6.Formule :C21H26N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :394.47mTOR inhibitor 9b
CAS :mTOR inhibitor 9b is an enzyme inhibitor of protein kinase mTOR he phosphatidylinositol 3-kinase PIK3CA with IC50s of 0.76 nm and 1.262 µM, respectively.mTORFormule :C21H23N5O2SDegré de pureté :99.89%Couleur et forme :SoildMasse moléculaire :409.5PI3K/mTOR Inhibitor-14
CAS :PI3K/mTOR Inhibitor-14 (compound Y-2) serves as a dual inhibitor of PI3K and mTOR, exhibiting IC50 values of 171.4 nM and 10.1 nM , respectively, andFormule :C28H30N8O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :558.66mTOR inhibitor-3
CAS :<p>mTOR inhibitor-3 is a selective mTOR inhibitor (Ki= 1.5 nM). mTOR inhibitor-3 inhibits mTORC1 and mTORC2 in cellular and in vivo experiments.</p>Formule :C25H30N8O2Degré de pureté :99% - 99.64%Couleur et forme :SolidMasse moléculaire :474.56PI3K/mTOR Inhibitor-1
CAS :PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual inhibitor of PI3K/mTOR (PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ/mTOR with IC50s of 20/376/204/46/186 nM)Formule :C18H22FN5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :407.46mTOR inhibitor 9d
CAS :mTOR inhibitor 9d is a dual inhibitor of the protein kinases mTOR and PI3K with an mTOR IC50 value of 0.31 nm, and can be used for the treatment of leukemia,Formule :C21H23N5O3SDegré de pureté :98.91%Couleur et forme :SoildMasse moléculaire :425.5WYE-132
CAS :WYE-125132: potent mTOR inhibitor, IC50 0.19 nM, selective over PI3Ks/hSMG1/ATR.Formule :C27H33N7O4Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :519.6WYE-23
CAS :WYE-23 is an inhibitor of mammalian target of rapamycin (mTOR).Formule :C26H32N8O4Couleur et forme :SolidMasse moléculaire :520.58GNE-490
CAS :GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.Formule :C18H22N6O2SDegré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :386.47PI3K/mTOR Inhibitor-6
CAS :Potent, stable PI3K/mTOR Inhibitor-6 surpasses gedatolisib in gastric fluid; 10 μM hinders PI3K/Akt/mTOR pathway, aids cancer research.Formule :C30H34N10O4Couleur et forme :SolidMasse moléculaire :598.66Rheb inhibitor NR1
CAS :Rheb inhibitor NR1 is a Rheb inhibitor and selective mTORC1 inhibitor that promotes phosphorylation of S473pAKT.Formule :C25H19BrCl2N2O3SDegré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :578.3WAY-600
CAS :<p>WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308).</p>Formule :C28H30N8ODegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :494.59GDC-0349
CAS :<p>GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.</p>Formule :C24H32N6O3Degré de pureté :96.00% - 98.17%Couleur et forme :SolidMasse moléculaire :452.55PKI-402
CAS :PKI-402 is a potent PI3K and mTOR inhibitor. PKI-402 inhibits PI3Kα, mTOR, PI3Kβ, PI3Kδ and PI3Kγ with IC50s of 2, 3, 7, 14 and 16 nM, respectively.Formule :C29H34N10O3Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :570.65PF-04979064
CAS :<p>PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).</p>Formule :C24H26N6O3Degré de pureté :98.20% - ≥98%Couleur et forme :SolidMasse moléculaire :446.54-FPBUA
CAS :<p>4-FPBUA, a semi-synthetic analog of lichen acid, enhances the functionality of cell-based blood-brain barriers (BBB) and increases the transport of β-amyloid (Aβ) in monolayer cells. Additionally, it acts as an inhibitor of mTOR, enhancing cellular autophagy (Autophagy) which can reverse BBB disruption in vivo, making it relevant for research in Alzheimer's disease.</p>Formule :C31H23FO7Couleur et forme :SolidMasse moléculaire :526.51PI3K-IN-37
CAS :PI3K-IN-37 inhibits PI3K α/β/δ (IC50: 6/8/4 nM) and mTOR (IC50: 4 nM).Formule :C25H26N6O2Couleur et forme :SolidMasse moléculaire :442.51PD-M6
CAS :PD-M6 is an mTOR PROTAC degrader with a DC50 of 4.8 μM, which facilitates the ubiquitination and degradation of mTOR. It inhibits the proliferation of cancer cell lines HeLa, MCF-7, and HepG2 with IC50 values of 11.3, 2.58, and 3.23 μM, respectively, and induces autophagy. Additionally, PD-M6 specifically targets the degradation of the key protein LAMTOR1 in the mTOR signaling pathway.Formule :C30H39N9O6Couleur et forme :SolidMasse moléculaire :621.69AZD 3147
CAS :<p>AZD 3147 inhibits mTORC1 (40.7 nM), mTORC2 (5.75 nM), and PI3Kα/β/δ/γ (912/5495/9333/6310 nM IC50s).</p>Formule :C24H31N5O4S2Degré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :517.66mTORC1-IN-1
<p>mTORC1-IN-1 (T1), a rapamycin homologue (rapalog) and selective inhibitor of mTORC1, controls cell growth and metabolism, with implications in various diseases</p>Degré de pureté :98%Couleur et forme :Odour Solid
