mTOR
Les inhibiteurs de mTOR sont des composés qui inhibent l'activité de la Cible de la Rapamycine chez les Mammifères (mTOR), un régulateur central de la croissance cellulaire, de la prolifération, du métabolisme et de la survie. La voie mTOR est fréquemment altérée dans le cancer et d'autres maladies, ce qui en fait une cible critique pour l'intervention thérapeutique. Les inhibiteurs de mTOR sont largement utilisés dans la recherche liée au cancer, au vieillissement et aux troubles métaboliques. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de mTOR pour soutenir vos recherches en transduction de signaux, oncologie et développement thérapeutique.
144 produits trouvés pour "mTOR"
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Salidroside
CAS :<p>Salidroside is a bioactive phenolic glycoside compound isolated from Rhodiola rosea and is a prolyl endopeptidase inhibitor.Cost-effective and quality-assured.</p>Formule :C14H20O7Degré de pureté :97.81%Couleur et forme :Red-Brown Fine PowderMasse moléculaire :300.3Corynoxine
CAS :<p>Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla.</p>Formule :C22H28N2O4Degré de pureté :96.83% - 99.93%Couleur et forme :SolidMasse moléculaire :384.47Mito-LND
CAS :<p>Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.</p>Formule :C43H45BrCl2N3OPDegré de pureté :97.25% - 98.34%Couleur et forme :SolidMasse moléculaire :801.62GNE-317
CAS :<p>GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).</p>Formule :C19H22N6O3SDegré de pureté :98.42% - 99.54%Couleur et forme :SolidMasse moléculaire :414.48Everolimus
CAS :<p>Everolimus (SDZ-RAD) is a potent mTOR inhibitor that binds to FKBP-12. It is used alone or in combination with calcineurin inhibitors.</p>Formule :C53H83NO14Degré de pureté :97.76% - 99.78%Couleur et forme :Off-White To Light Yellow PowdMasse moléculaire :958.2225(R,S)-Ruscogenin
CAS :<p>25(R,S)-Ruscogenin is able to regulate the PI3K/Akt/mTOR signalling pathway, and hinder the metastasis of hepatocellular carcinoma.</p>Formule :C27H42O4Degré de pureté :99.32% - 99.89%Couleur et forme :SolidMasse moléculaire :430.62AZD-8055
CAS :<p>AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms.</p>Formule :C25H31N5O4Degré de pureté :98% - 99.69%Couleur et forme :SolidMasse moléculaire :465.54NV-5138 hydrochloride
<p>NV-5138 hydrochloride: a leucine analog, oral brain mTORC1 activator via Sestrin2, for antidepressant research.</p>Formule :C7H14ClF2NO2Couleur et forme :SolidMasse moléculaire :217.64Palomid 529
CAS :<p>Palomid 529 (SG 00529) has been used in trials studying the treatment of Age-Related Macular Degeneration.</p>Formule :C24H22O6Degré de pureté :98.40% - 98.59%Couleur et forme :SolidMasse moléculaire :406.43KU-0063794
CAS :<p>KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2.</p>Formule :C25H31N5O4Degré de pureté :98.21% - >99.99%Couleur et forme :SolidMasse moléculaire :465.54WYE-687 dihydrochloride
CAS :<p>WYE-687 dihydrochloride is an mTOR inhibitor with IC50 of 7 nM, also targeting PI3Kα (81 nM) and PI3Kγ (3.11 μM).</p>Formule :C28H34Cl2N8O3Couleur et forme :SolidMasse moléculaire :601.53SC99
CAS :<p>SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.</p>Formule :C15H8Cl2FN3ODegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :336.15L-Leucine
CAS :<p>L-Leucine is an essential amino acid vital for protein synthesis, metabolism, muscle and bone repair, blood sugar control, and wound healing.</p>Formule :C6H13NO2Degré de pureté :99.83%Couleur et forme :White Solid CrystallineMasse moléculaire :131.17Vistusertib
CAS :<p>Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.</p>Formule :C25H30N6O3Degré de pureté :97.08% - 99.06%Couleur et forme :SolidMasse moléculaire :462.54Onatasertib
CAS :<p>Onatasertib (CC223) is an orally available mTOR inhibitor with potential antitumor activity.</p>Formule :C21H27N5O3Degré de pureté :99.14% - 99.97%Couleur et forme :SolidMasse moléculaire :397.47Voxtalisib
CAS :<p>Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.</p>Formule :C13H14N6ODegré de pureté :98.21% - 99.69%Couleur et forme :SolidMasse moléculaire :270.29PP121
CAS :<p>PP-121 inhibits PDGFR, Hck, mTOR, VEGFR2, Src, Abl, and DNA-PK with IC50 values ranging from 2 to 60 nM.</p>Formule :C17H17N7Degré de pureté :98.45% - 99.67%Couleur et forme :SolidMasse moléculaire :319.36Polyphyllin I
CAS :<p>Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax,</p>Formule :C44H70O16Degré de pureté :98% - 99.5%Couleur et forme :SolidMasse moléculaire :855.02Torin 1
CAS :<p>Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.</p>Formule :C35H28F3N5O2Degré de pureté :98.3% - 99.33%Couleur et forme :SolidMasse moléculaire :607.62G5-7
CAS :<p>G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.</p>Formule :C22H19F2NO3Degré de pureté :97.3%Couleur et forme :SolidMasse moléculaire :383.39Apitolisib
CAS :<p>Apitolisib (RG 7422) is a PI3K inhibitor, used in cancer trials, targeting PI3Kα, β, δ, γ (IC50= 5, 27, 7, 14 nM).</p>Formule :C23H30N8O3SDegré de pureté :98.28% - 99.64%Couleur et forme :SolidMasse moléculaire :498.6Daphnetin
CAS :<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Formule :C9H6O4Degré de pureté :97.47% - 99.8%Couleur et forme :SolidMasse moléculaire :178.14GSK1059615
CAS :<p>GSK1059615 has been used in trials studying the treatment of Lymphoma, Solid Tumours, Endometrial Cancer, Solid Tumor Cancer, and Metastatic Breast Cancer.</p>Formule :C18H11N3O2SDegré de pureté :99.3% - ≥95%Couleur et forme :SolidMasse moléculaire :333.36Sapanisertib
CAS :<p>Sapanisertib (INK 128) is an oral raptor-mTOR and rictor-mTOR inhibitor with potential cancer-fighting properties.</p>Formule :C15H15N7ODegré de pureté :99.19% - >99.99%Couleur et forme :SolidMasse moléculaire :309.33Hederacolchiside A1
CAS :<p>Hederacolchiside A1 exhibits anti-leishmanial and anticancer activities by disrupting cell membranes and inducing apoptosis via the PI3K/Akt/mTOR pathway.</p>Formule :C47H76O16Degré de pureté :98.76% - 99.92%Couleur et forme :SolidMasse moléculaire :897.1Arnicolide D
CAS :<p>Arnicolide D is a sesquiterpene lactone.</p>Formule :C19H24O5Degré de pureté :96.66%Couleur et forme :SolidMasse moléculaire :332.39Torkinib
CAS :<p>Torkinib (PP 242) (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).</p>Formule :C16H16N6ODegré de pureté :99.11%Couleur et forme :SolidMasse moléculaire :308.34Temsirolimus
CAS :<p>Temsirolimus (CCI-779) is a specific mTOR inhibitor ( IC50: 1.76 μM), used in the treatment of advanced renal cell cancer.</p>Formule :C56H87NO16Degré de pureté :97.76% - >99.99%Couleur et forme :White Crystalline PowderMasse moléculaire :1030.29Rotundic acid
CAS :<p>Rotundic acid fights various cancers: HepG2, A375, NCI-H446, MCF-7, and HT-29.</p>Formule :C30H48O5Degré de pureté :96.91% - 99.97%Couleur et forme :SolidMasse moléculaire :488.7TMBIM6 antagonist-1
CAS :<p>TMBIM6 antagonist-1 (BAX-inhibitor-1) is a bax inhibitor</p>Formule :C15H12N2O3Degré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :268.27Zotarolimus
CAS :<p>Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).</p>Formule :C52H79N5O12Degré de pureté :95% - 98.01%Couleur et forme :SolidMasse moléculaire :966.21(+)-Usnic acid
CAS :<p>(+)-Usnic acid (D-Usnic Acid) is a naturally occurring dibenzofuran derivative found in several lichen species.</p>Formule :C18H16O7Degré de pureté :98.22%Couleur et forme :SolidMasse moléculaire :344.32CZ415
CAS :<p>CZ415 is a potent and highly selective mTOR inhibitor.</p>Formule :C22H29N5O4SDegré de pureté :97.54% - 98.36%Couleur et forme :SolidMasse moléculaire :459.56VS-5584
CAS :<p>VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.</p>Formule :C17H22N8ODegré de pureté :97.82% - 99.54%Couleur et forme :SolidMasse moléculaire :354.41Dihydromyricetin
CAS :<p>Dihydromyricetin, a flavonoid from Ampelopsis, is an antioxidant that blocks dihydropyrimidinase (IC50: 48 μM) and activates autophagy via mTOR inhibition.</p>Formule :C15H12O8Degré de pureté :96.68% - 98.229%Couleur et forme :SolidMasse moléculaire :320.25MHY1485
CAS :<p>MHY1485 is an mTOR activator that is cell-permeable. MHY1485 inhibits autophagosome and lysosome fusion, thereby inhibiting autophagy. Cost-effective and quality-assured.</p>Formule :C17H21N7O4Degré de pureté :97.74% - >99.99%Couleur et forme :SolidMasse moléculaire :387.39ETP-45658
CAS :<p>ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively).</p>Formule :C16H17N5O2Degré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :311.34Dactolisib
CAS :<p>Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).</p>Formule :C30H23N5ODegré de pureté :97.64% - 99.85%Couleur et forme :SolidMasse moléculaire :469.54PQR620
CAS :<p>PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2.</p>Formule :C21H25F2N7O2Degré de pureté :97.61%Couleur et forme :SolidMasse moléculaire :445.47DMH-25
CAS :<p>DMH25 is a novel covalent and potent inhibitor of mTOR and shows in vivo antitumor activity against triple-negative breast cancer cells.</p>Formule :C15H8Br3NO3Degré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :489.94Ridaforolimus
CAS :<p>Ridaforolimus (AP23573) 是亲脂性大环内酯类抗生素雷帕霉素的小分子非前药类似物，具有潜在的抗肿瘤活性。它是一种有效和选择性的 mTOR 抑制剂，在 HT-1080 细胞中抑制 S6 磷酸化的 IC50值为 0.2 nM。</p>Formule :C53H84NO14PDegré de pureté :90.00% - 98.55%Couleur et forme :Off-White SolidMasse moléculaire :990.21DIM-C-pPhOH
CAS :<p>CDIM8 (DIM-C-pPhOH) opposes NR4A1, halts TGF-β breast cancer migration, induces ROS/ER stress, and mimics Nur77 RNAi in pancreatic cancer.</p>Formule :C23H18N2ODegré de pureté :98.61%Couleur et forme :SolidMasse moléculaire :338.4CC-115
CAS :<p>CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).</p>Formule :C16H16N8ODegré de pureté :86.79% - 99.01%Couleur et forme :SolidMasse moléculaire :336.35PQR530
CAS :<p>PQR530, a potent dual PI3K/mTORC1/2 inhibitor, blocks PKB and pS6 phosphorylation (IC50: 0.07 μM) and has antitumor properties.</p>Formule :C18H23F2N7O2Degré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :407.42PKCβ inhibitor 1
CAS :<p>PKCβ inhibitor 1 (KUN79359)(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2,</p>Formule :C24H21N5O2Degré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :411.46KU-0060648
CAS :<p>KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ.</p>Formule :C33H34N4O4SDegré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :582.71Desmethyl-VS-5584
CAS :<p>Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.</p>Formule :C16H20N8ODegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :340.38MHY-1685
CAS :<p>MHY-1685 is a mammalian target of rapamycin (mTOR) inhibitor and a senescence inhibitor that can rejuvenate senile hCSCs by modulating autophagy.</p>Formule :C11H8N2O4Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :232.19DS-7423
CAS :<p>DS-7423: a dual PI3K/mTOR inhibitor; IC50s—PI3Kα: 15.6 nM, mTOR: 34.9 nM, PI3Kβ: 1,143 nM, PI3Kγ: 249 nM, PI3Kδ: 262 nM.</p>Formule :C22H27F3N10O2Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :520.51Gedatolisib
CAS :<p>Gedatolisib (PF-05212384) is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signaling</p>Formule :C32H41N9O4Degré de pureté :98% - 99.36%Couleur et forme :SolidMasse moléculaire :615.73
