mTOR
Les inhibiteurs de mTOR sont des composés qui inhibent l'activité de la Cible de la Rapamycine chez les Mammifères (mTOR), un régulateur central de la croissance cellulaire, de la prolifération, du métabolisme et de la survie. La voie mTOR est fréquemment altérée dans le cancer et d'autres maladies, ce qui en fait une cible critique pour l'intervention thérapeutique. Les inhibiteurs de mTOR sont largement utilisés dans la recherche liée au cancer, au vieillissement et aux troubles métaboliques. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de mTOR pour soutenir vos recherches en transduction de signaux, oncologie et développement thérapeutique.
163 produits trouvés pour "mTOR"
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NV-5138 hydrochloride
NV-5138 hydrochloride: a leucine analog, oral brain mTORC1 activator via Sestrin2, for antidepressant research.Formule :C7H14ClF2NO2Couleur et forme :SolidMasse moléculaire :217.64Gedatolisib
CAS :Gedatolisib (PF-05212384) is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signalingFormule :C32H41N9O4Degré de pureté :98% - 99.36%Couleur et forme :SolidMasse moléculaire :615.73XL388
CAS :XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.Formule :C23H22FN3O4SDegré de pureté :99.39% - 99.53%Couleur et forme :SolidMasse moléculaire :455.5DS-7423
CAS :DS-7423: a dual PI3K/mTOR inhibitor; IC50s—PI3Kα: 15.6 nM, mTOR: 34.9 nM, PI3Kβ: 1,143 nM, PI3Kγ: 249 nM, PI3Kδ: 262 nM.Formule :C22H27F3N10O2Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :520.51Ref: TM-T36083
1mg110,00€5mg268,00€1mL*10mM (DMSO)304,00€10mg409,00€25mg670,00€50mg888,00€100mg1.305,00€Palomid 529
CAS :Palomid 529 (SG 00529) has been used in trials studying the treatment of Age-Related Macular Degeneration.Formule :C24H22O6Degré de pureté :98.40% - 98.59%Couleur et forme :SolidMasse moléculaire :406.43Arnicolide D
CAS :Arnicolide D is a sesquiterpene lactone.Formule :C19H24O5Degré de pureté :96.66% - 99.93%Couleur et forme :SolidMasse moléculaire :332.39mTOR inhibitor-1
CAS :C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.Formule :C16H15BrN2O3Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :363.21GNE-493
CAS :GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM forFormule :C17H20N6O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :372.44KU-0063794
CAS :KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2.Formule :C25H31N5O4Degré de pureté :98.21% - >99.99%Couleur et forme :SolidMasse moléculaire :465.54Cyclovirobuxine D
CAS :Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla.Formule :C26H46N2ODegré de pureté :97.78% - 98%Couleur et forme :SolidMasse moléculaire :402.66OSI-027
CAS :OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM.Formule :C21H22N6O3Degré de pureté :97.42%Couleur et forme :SolidMasse moléculaire :406.44Ref: TM-T6319
1mg39,00€2mg50,00€5mg81,00€1mL*10mM (DMSO)84,00€10mg131,00€25mg235,00€50mg369,00€100mg537,00€PF-04691502
CAS :PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.Formule :C22H27N5O4Degré de pureté :96.27% - ≥95%Couleur et forme :SolidMasse moléculaire :425.48Ref: TM-T6251
1mg34,00€2mg43,00€5mg63,00€1mL*10mM (DMSO)65,00€10mg88,00€25mg117,00€50mg187,00€100mg333,00€WYE-687 dihydrochloride
CAS :WYE-687 dihydrochloride is an mTOR inhibitor with IC50 of 7 nM, also targeting PI3Kα (81 nM) and PI3Kγ (3.11 μM).Formule :C28H34Cl2N8O3Couleur et forme :SolidMasse moléculaire :601.53MHY-1685
CAS :MHY-1685 is a mammalian target of rapamycin (mTOR) inhibitor and a senescence inhibitor that can rejuvenate senile hCSCs by modulating autophagy.Formule :C11H8N2O4Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :232.19Desmethyl-VS-5584
CAS :Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.Formule :C16H20N8ODegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :340.38Samotolisib
CAS :Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.Formule :C23H26N4O3Degré de pureté :98.41% - 99.69%Couleur et forme :SolidMasse moléculaire :406.48KU-0060648
CAS :KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ.Formule :C33H34N4O4SDegré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :582.71PI-103
CAS :PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).Formule :C19H16N4O3Degré de pureté :97.79% - 99.3%Couleur et forme :SolidMasse moléculaire :348.36LY-2584702 free base
CAS :LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).Formule :C21H19F4N7Degré de pureté :98.72% - 99.51%Couleur et forme :SolidMasse moléculaire :445.42Ref: TM-T6159
1mg44,00€2mg56,00€5mg108,00€10mg140,00€25mg299,00€50mg404,00€100mg592,00€500mg1.243,00€WYE-354
CAS :WYE-354 is a selective mTOR inhibitor (IC50=5 nM), targeting mTORC1/C2 over PI3Kα (>100x) and PI3Kγ (>500x), sparing P-AKT(T308).Formule :C24H29N7O5Degré de pureté :97.86% - 99.61%Couleur et forme :SolidMasse moléculaire :495.53Bimiralisib
CAS :Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity.Formule :C17H20F3N7O2Degré de pureté :97.58% - 98.92%Couleur et forme :SolidMasse moléculaire :411.38Omipalisib
CAS :Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.Formule :C25H17F2N5O3SDegré de pureté :98% - 99.8%Couleur et forme :SolidMasse moléculaire :505.5Sapanisertib
CAS :Sapanisertib (INK 128) is an oral raptor-mTOR and rictor-mTOR inhibitor with potential cancer-fighting properties.Formule :C15H15N7ODegré de pureté :99.19% - >99.99%Couleur et forme :SolidMasse moléculaire :309.33Ref: TM-T1838
1mg40,00€2mg51,00€5mg85,00€1mL*10mM (DMSO)88,00€10mg96,00€25mg160,00€50mg235,00€100mg350,00€500mg838,00€Everolimus
CAS :Everolimus (SDZ-RAD) is a potent mTOR inhibitor that binds to FKBP-12. It is used alone or in combination with calcineurin inhibitors.
Formule :C53H83NO14Degré de pureté :97.76% - 99.78%Couleur et forme :Off-White To Light Yellow PowdMasse moléculaire :958.22SC99
CAS :SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Formule :C15H8Cl2FN3ODegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :336.15Ref: TM-T8719
1mg43,00€5mg87,00€1mL*10mM (DMSO)94,00€10mg133,00€25mg227,00€50mg344,00€100mg429,00€200mg597,00€L-Leucine
CAS :L-Leucine is an essential amino acid vital for protein synthesis, metabolism, muscle and bone repair, blood sugar control, and wound healing.Formule :C6H13NO2Degré de pureté :99.83%Couleur et forme :White Solid CrystallineMasse moléculaire :131.17Torin 2
CAS :Torin 2: mTOR inhibitor, IC50=0.25 nM, 800x more selective than PI3K, with EC50=28/35/118 nM for ATM/ATR/DNA-PK.Formule :C24H15F3N4ODegré de pureté :98.31% - 99.32%Couleur et forme :SolidMasse moléculaire :432.4Vistusertib
CAS :Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.Formule :C25H30N6O3Degré de pureté :97.08% - 99.06%Couleur et forme :SolidMasse moléculaire :462.54Ref: TM-T1961
1mg34,00€5mg71,00€1mL*10mM (DMSO)79,00€10mg111,00€25mg170,00€50mg225,00€100mg358,00€200mg530,00€PKCβ inhibitor 1
CAS :PKCβ inhibitor 1 (KUN79359)(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2,Formule :C24H21N5O2Degré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :411.46Ref: TM-T8376
500µg37,00€1mg52,00€5mg101,00€1mL*10mM (DMSO)110,00€10mg177,00€25mg391,00€50mg692,00€100mg945,00€Onatasertib
CAS :Onatasertib (CC223) is an orally available mTOR inhibitor with potential antitumor activity.Formule :C21H27N5O3Degré de pureté :99.14% - 99.93%Couleur et forme :SolidMasse moléculaire :397.47Voxtalisib
CAS :Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.Formule :C13H14N6ODegré de pureté :98.21% - 99.69%Couleur et forme :SolidMasse moléculaire :270.29Ref: TM-T7014
1mg35,00€2mg50,00€5mg74,00€1mL*10mM (DMSO)74,00€10mg117,00€25mg226,00€50mg364,00€100mg532,00€PP121
CAS :PP-121 inhibits PDGFR, Hck, mTOR, VEGFR2, Src, Abl, and DNA-PK with IC50 values ranging from 2 to 60 nM.Formule :C17H17N7Degré de pureté :98.45% - 99.93%Couleur et forme :SolidMasse moléculaire :319.36Polyphyllin I
CAS :Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax,Formule :C44H70O16Degré de pureté :98% - 99.5%Couleur et forme :SolidMasse moléculaire :855.02Torin 1
CAS :Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.Formule :C35H28F3N5O2Degré de pureté :98.3% - 99.33%Couleur et forme :SolidMasse moléculaire :607.62G5-7
CAS :G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.Formule :C22H19F2NO3Degré de pureté :97.3%Couleur et forme :SolidMasse moléculaire :383.39Ref: TM-T8742
1mg35,00€5mg71,00€1mL*10mM (DMSO)78,00€10mg96,00€25mg172,00€50mg248,00€100mg348,00€200mg470,00€Apitolisib
CAS :Apitolisib (RG 7422) is a PI3K inhibitor, used in cancer trials, targeting PI3Kα, β, δ, γ (IC50= 5, 27, 7, 14 nM).Formule :C23H30N8O3SDegré de pureté :98.28% - 99.64%Couleur et forme :SolidMasse moléculaire :498.6Torkinib
CAS :Torkinib (PP 242) (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).Formule :C16H16N6ODegré de pureté :99.11%Couleur et forme :SolidMasse moléculaire :308.34Ref: TM-T2414
5mg54,00€1mL*10mM (DMSO)59,00€10mg71,00€25mg90,00€50mg129,00€100mg215,00€200mg319,00€500mg530,00€DIM-C-pPhOH
CAS :CDIM8 (DIM-C-pPhOH) opposes NR4A1, halts TGF-β breast cancer migration, induces ROS/ER stress, and mimics Nur77 RNAi in pancreatic cancer.Formule :C23H18N2ODegré de pureté :98.61% - 99.93%Couleur et forme :SolidMasse moléculaire :338.4Ref: TM-T4400
2mg42,00€1mL*10mM (DMSO)56,00€5mg62,00€10mg79,00€25mg144,00€50mg215,00€100mg356,00€200mg469,00€Daphnetin
CAS :Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),
Formule :C9H6O4Degré de pureté :97.47% - 99.8%Couleur et forme :SolidMasse moléculaire :178.14D-α-Hydroxyglutaric acid disodium
CAS :D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-Hydroxyglutarate) is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM.Formule :C5H6Na2O5Degré de pureté :97.16%Couleur et forme :SolidMasse moléculaire :192.08GSK1059615
CAS :GSK1059615 has been used in trials studying the treatment of Lymphoma, Solid Tumours, Endometrial Cancer, Solid Tumor Cancer, and Metastatic Breast Cancer.Formule :C18H11N3O2SDegré de pureté :99.3% - ≥95%Couleur et forme :SolidMasse moléculaire :333.36TMBIM6 antagonist-1
CAS :TMBIM6 antagonist-1 (BAX-inhibitor-1) is a bax inhibitorFormule :C15H12N2O3Degré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :268.27Ref: TM-T8649
1mg88,00€2mg114,00€5mg177,00€1mL*10mM (DMSO)190,00€10mg299,00€25mg537,00€50mg767,00€100mg1.054,00€500mg2.115,00€Zotarolimus
CAS :Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).Formule :C52H79N5O12Degré de pureté :95% - 98.01%Couleur et forme :SolidMasse moléculaire :966.21(+)-Usnic acid
CAS :(+)-Usnic acid (D-Usnic Acid) is a naturally occurring dibenzofuran derivative found in several lichen species.Formule :C18H16O7Degré de pureté :98.22%Couleur et forme :SolidMasse moléculaire :344.32CZ415
CAS :CZ415 is a potent and highly selective mTOR inhibitor.Formule :C22H29N5O4SDegré de pureté :97.54% - 98.36%Couleur et forme :SolidMasse moléculaire :459.56Ref: TM-T3514
1mg39,00€2mg49,00€5mg71,00€1mL*10mM (DMSO)72,00€10mg104,00€25mg212,00€50mg319,00€100mg447,00€200mg618,00€VS-5584
CAS :VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.Formule :C17H22N8ODegré de pureté :97.82% - 99.54%Couleur et forme :SolidMasse moléculaire :354.41Dihydromyricetin
CAS :Dihydromyricetin, a flavonoid from Ampelopsis, is an antioxidant that blocks dihydropyrimidinase (IC50: 48 μM) and activates autophagy via mTOR inhibition.Formule :C15H12O8Degré de pureté :96.68% - 98.229%Couleur et forme :SolidMasse moléculaire :320.25MHY1485
CAS :MHY1485 is an mTOR activator that is cell-permeable. MHY1485 inhibits autophagosome and lysosome fusion, thereby inhibiting autophagy. Cost-effective and quality-assured.Formule :C17H21N7O4Degré de pureté :97.74% - >99.99%Couleur et forme :SolidMasse moléculaire :387.39DMH-25
CAS :DMH25 is a novel covalent and potent inhibitor of mTOR and shows in vivo antitumor activity against triple-negative breast cancer cells.
Formule :C15H8Br3NO3Degré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :489.94ETP-45658
CAS :ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively).Formule :C16H17N5O2Degré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :311.34Ref: TM-T25399
1mg50,00€5mg105,00€1mL*10mM (DMSO)117,00€10mg172,00€25mg299,00€50mg485,00€100mg708,00€
