Oligosaccharides

<p>This product is a fatty acid that binds to the carbohydrate binding sites in the cell membrane of Caco-2 cells. It has been shown to inhibit the growth of cancer cells and radiation induced changes by binding to the sugar moieties on glycoproteins. This product also inhibits the production of glycoconjugates, which are important for cell-cell interactions and biological function. The disaccharide form has been found to be a diagnostic agent for cancer cells, with a structural formula that can be seen in the figure below.</p>

<p>Sulpho Lewisa Na is a complex carbohydrate that has been modified with fluorination and methylation. This product is custom synthesized, high purity, and has a CAS number. It is available for synthesis in various lengths of saccharides with a variety of modifications. Sulpho Lewisa Na can be used in the following applications: glycosylations, click modification, and methylation.</p>

Difucosyl-para-lacto-N-hexaose-APD-HSA is a complex carbohydrate that is a custom synthesis. It has been modified by the addition of difucosyl groups to the para position of lactose and by the attachment of an APD moiety to the N-acetyl group of hexitol. The molecular weight is approximately 1,000 Da. This product is used in glycosylation reactions, such as polysaccharide synthesis, and in fluorination reactions. Difucosyl-para-lacto-N-hexaose-APD-HSA can be found under CAS No. 366511-00-7 and is soluble in water and DMSO.

<p>The maltose solution we offer is a 20% solution in water and of high purity and can be customized to meet your needs.</p>

Hyaluronate rhodamine is a synthetic, high-purity, fluorinated, hydrophilic oligosaccharide. It is a complex carbohydrate with a molecular weight of 1500kDa and a very low viscosity. Hyaluronate rhodamine has been modified to include Click chemistry that provides the potential for site-specific modification on the sugar backbone. The fluorination process can be customized to produce the desired degree of substitution (DS) and functionalization for specific applications. This product has been glycosylated and polysaccharide modified to create an oligosaccharide that is suitable for use in therapeutic and diagnostic applications.

2, 3, 6, 2', 3', 4', 6'-Hepta-O-acetyl-D-maltose is a fluorinated monosaccharide that is used in the synthesis of glycosides. It has a CAS number of 56285-96-2 and can be custom synthesized. This product is an oligosaccharide that can be modified by glycosylation, methylation, or click modification. It is a complex carbohydrate with a high purity and can be used in the modification of sugars.

<p>Heparin derived dp24 saccharide ammonium salt is a complex carbohydrate and a saccharide. It is used for the modification of polysaccharides and oligosaccharides. The compound has been shown to reduce blood coagulation by preventing the binding of calcium ions to thrombin, which then blocks the conversion of fibrinogen to fibrin. Heparin derived dp24 saccharide ammonium salt has high purity and can be custom synthesized with high quality. The compound is also methylated, glycosylated, or click-modified.</p>

<p>GM3-ganglioside NBD (ammonium salt) has a core disaccharide structure (Galβ1,4Glc) with sialic acid linked α2,3 to the galactose residue with nitrobenzoxadiazole (NBD) linked β to position 1 on the reducing terminal glucose residue, in place of the ceramide fatty acid (Ledeen, 2009). Ganglioside GM3 is strongly associated with human tumors, such as, lung, brain, and melanomas, where it is frequently found to be overexpressed. GM3 ganglioside is seen as a possible tumor-associated carbohydrate antigen for cancer immunotherapy (Changping, 2019). GM3 ganglioside is implicated in various other diseases involving chronic inflammation, such as: insulin resistance, leptin resistance, T-cell function, and immune disorders (e.g. allergic asthma). It has also been shown to play an essential role in murine and human auditory systems, and is a common pathological feature of GM3S deficiency is deafness (Inokuchi, 2018).</p>

Lacto-N-neotetraosa-APD-HSA is a synthetic monosaccharide that is structurally similar to tetrasaccharide and pentasaccharide. It can be synthesized by click chemistry and has been modified by fluorination and acetylation. Lacto-N-neotetraosa-APD-HSA has a high purity and is an excellent candidate for applications in the food industry, such as sugar substitutes.

1,3,4,6-Tetra-O-acetyl-2-(6-deoxy-a-L-galactopyranosyl)-a-D-galactopyranose is a glycoside, which is a type of carbohydrate that contains both an alcohol and a sugar. It is synthesized by the reaction of 1,3,4,6-tetra-O-acetyl mannitol with 6 deoxyglucuronic acid. This product can be used as a custom synthesis for pharmaceuticals or in other fields. The purity of this product is greater than 98%.

<p>Useful for raising antibodies to Blood Group B</p>

4-Methoxyphenyl 4-O-(2,4,6-tri-O-benzyl-b-D-galactopyranosyl)-2,3,6-tri-O-benzyl-b-D-glucopyranoside is a suppressor of genes that has been shown to be active in the treatment of leukemia. It suppresses transcription by inhibiting histone H3 acetylation and DNA replication by binding to the dna replication complex at sites of replication. The suppression of genes may be due to its ability to inhibit translation by blocking signal sequences and hybridization with complementary mRNA.

<p>A mixture of sodium trigalacturonate &amp; tetragalacturonate (α-1,4 sodium galacturonotriose + α-1,4 sodium galacturonotetraose) is derived from pectin or pectic acid, by enzymatic or partial acid hydrolysis (Combo, 2012). It is used in galacturonic acid metabolism research as a substrate to identify, differentiate, and characterize endo- and exopolygalacturonase(s), and gluconase(s) (Jayani, 2005). The addition of very short fragments of homogalacturonan, tri-galacturonate, and tetra-galacturonate oligosaccharides, restore development in dark-grown, de-etiolated seedling mutants, suggesting that they are unable to generate de-methylesterified pectin fragments. A model of spatiotemporally separated photoreceptive and signal-responsive cell types has been proposed, that contains overlapping subsets of the regulatory network of light-dependent seedling development (Sinclair, 2017).</p>

Methyl 2-O-allyl-3-O-(2,3,4,6-tetra-O-acetyl-a-D-mannopyranosyl)-a-D-mannopyranoside is a modification of the carbohydrate that is synthesized by an acetylation of the mannose residue. It has been synthesized as a potential therapeutic agent for cancer treatment. Methyl 2-O-allyl 3,4,6 tetra O acetyl a D mannoside (MAA) is an oligosaccharide which consists of three monosaccharides: mannose (1), allose (2) and glucose (3). The modification of MAA involves the addition of methyl groups to the allyl group on position 1. This modification can be done through fluorination or methylation. Methylated derivatives have shown anti tumor activity in vivo and in vitro studies. The complex carbohydrate has high purity and

Methyl 3-O-(2,3,4,6-tetra-O-acetyl-b-D-glucopyranosyl)-4,6-O-benzylidene-2-O-benzoyl-a-D-glucopyranoside is a custom synthesis that has been fluorinated and methylated. This product is a monosaccharide with a CAS No. 7123893 2. It is an oligosaccharide that can be used in the synthesis of saccharides and polysaccharides. Methyl 3 O (2 3 4 6 tetra O acetyl b D glucopyranosyl) 4 6 O benzylidene 2 O benzoyl a D glucopyranoside has been synthesized by glycosylation of sugar. This product can also be used to modify and functionalize complex carbohydrates.

1,6-Anhydro-2,3-O-isopropylidene-4-O-(2,3,4,6-tetra-O-acetyl-a-D-mannopyranosyl)-b-D-mannopyranose is a methylated saccharide that has been modified with a click reaction. This product is available for custom synthesis and modification. It is an oligosaccharide with high purity and can be synthesized or modified to be glycosylated or fluorinated. The CAS number for this product is 67591 05 3.

NA2F N-Glycan is a custom synthesized, high purity and monosaccharide glycoprotein. NA2F N-Glycan has been fluorinated and methylated to produce NA2F N-Glycan. The product is a complex carbohydrate that is comprised of an oligosaccharide and polysaccharide. NA2F N-Glycan is synthesized from the sugar saccharide, which is a hexose made up of six carbon atoms that are bonded to each other in a ring.

Benzyl 4- O- b- D- glucosaminyl-b- D- xylopyranoside is an oligosaccharide that is synthesized by the glycosylation of benzyl 4-O- b -D-glucosaminyl b -D -xylopyranoside with a monosaccharide. The synthesis of this compound is achieved through the modification of the parent compound with a fluorination, methylation, or glycosylation. Benzyl 4- O- b -D- glucosaminyl b -D -xylopyranoside can be found in complex carbohydrates, such as cellulose and starch.

Sialylglycan is a glycan that is found on the surface of cells and is important in cell-cell interactions. It is involved in the binding of influenza virus to its receptor, and sialylglycan has been shown to be bifunctional, meaning it can act as both an antigen and an antibody. Sialylglycan oligosaccharides are found in muscle tissue, which is where influenza viruses are most likely to attach. The molecule's fluorimetric properties have also been used to study outbreaks of avian influenza. Sialylglycan has been used for gene analysis by attaching fluorescent tags to the molecule that can be detected using fluorescence microscopy techniques. In vivo assays have also been performed with sialylglycan as a model antigen.

<p>3-Cyclohexylpropyl-4-O-(a-D-glucopyranosyl)-b-D-glucopyranoside is a solubilized form of epidermal growth factor (EGF) that binds to the epidermal growth factor receptor. It has been shown to stimulate epidermal growth and increase the rate of cellular proliferation in human epidermis. 3-Cyclohexylpropyl-4-O-(a-D-glucopyranosyl)-b-D-glucopyranoside may also have structural roles in mitochondrial matrix, ligand binding, and energy metabolism. Further study is needed to determine the role of this drug in these processes.</p>