Composés polycycliques

1-Methylindole-2-Carboxylic Acid is a chemical that belongs to the group of phenylacetic acid compounds. It has been shown to inhibit lymphocyte activation and t-cell proliferation in vitro, which may be due to its ability to interfere with the production of interleukin. 1-Methylindole-2-Carboxylic Acid also has an antitumor effect on animals and can reduce the tumor burden by inhibiting DNA synthesis, protein synthesis, and mineralization. The molecular modeling studies have shown that 1-Methylindole-2-Carboxylic Acid binds in the active site of protein kinase C as a competitive inhibitor and prevents ATP from binding to the enzyme.

3-(2-Diisopropylaminoethyl)indole hydrochloride is an inhibitor of the enzyme monoamine oxidase (MAO). MAO is responsible for the degradation of monoamines such as serotonin, dopamine, and norepinephrine. 3-(2-Diisopropylaminoethyl)indole hydrochloride inhibits these enzymes in order to increase the levels of these neurotransmitters in the brain. These effects are observed with a sectional study on the host plant species. 3-(2-Diisopropylaminoethyl)indole hydrochloride has been shown to have low potency for inhibiting 5-HT1A and 5-HT2A receptors in rat studies, but it is not active against 5-HT2C receptors. This drug was used to measure urinary serotonin and dopamine levels in human urine samples.

2-Bromo-1H-imidazole is an environmental pollutant that has been detected in the atmosphere, water, and soil. It is used as a pesticide and has been found to be an impurity in biphenyl. 2-Bromo-1H-imidazole can be used as a substrate for the Suzuki coupling reaction or as a starting material for the synthesis of imidazole derivatives. The compound spontaneously fragments under acidic conditions to form nitric acid and hydrogen bromide. 2-Bromo-1H-imidazole has been shown to inhibit hepatitis C virus (HCV) replication and induce cancer cell apoptosis in vitro.
2-Bromo-1H-imidazole is also known to cause DNA fragmentation in cells through oxidation by reactive oxygen species or through spontaneous decomposition of the molecule into acid, bromine radicals, and ammonia.

Please enquire for more information about Indole-3-acetyl-L-alanine acid methyl ester including the price, delivery time and more detailed product information at the technical inquiry form on this page

6-Fluoroindole-3-acetic acid is a molecule that has been synthesized by the reaction of 6-fluoroindole with acetic anhydride. When mixed with acetonitrile, the fluorescence of 6-fluoroindole-3-acetic acid can be seen in the solution. The fluorescence intensity is proportional to the concentration of this molecule. 6-Fluoroindole-3-acetic acid is used as a template molecule for fluorescence labeling experiments. It interacts with hormones and can be used to identify their conformations and interactions. This compound has been shown to have anticancer properties in mice, and it may also be effective against cancer cells in humans. It has also been shown to inhibit the growth of pisum sativum (pea).

3-Aminoquinuclidine dihydrochloride (3-AQDH) is a chiral quinuclidine derivative that is an acetylcholine receptor agonist. It has been shown to bind to the α7 nicotinic acetylcholine receptor with high affinity and selectivity. 3-AQDH has also been shown to crosslink the cholinergic receptor, which may lead to increased sensitivity of the receptor. The binding constants between 3-AQDH and the α7 nicotinic acetylcholine receptors are very high and it has been shown to be enantiopure in its synthesis. 3-AQDH also has a hydrophilic interaction chromatography profile, which separates it from other compounds. This agent may have potential use as a drug for treating Alzheimer's disease and Parkinson's disease due to its ability to inhibit acetylcholinesterase activity.

5,7-Dimethoxyindole is a potent inhibitor of the enzyme oxidase. 5,7-Dimethoxyindole has been shown to inhibit the growth of a number of fungi, including Phytophthora infestans and Cryptococcus neoformans. The molecular modeling studies have shown that this molecule can form an H-bond with the acceptor in the active site of the enzyme and prevent access by substrate. This inhibition has been shown to be competitive with respect to ferrous ions and noncompetitive with respect to other cofactors. 5,7-Dimethoxyindole also inhibits integrase enzymes, which are involved in DNA integration during viral replication. 5,7-Dimethoxyindole was found to bind to a pharmacophore model for integrase inhibitors and formylation reactions. This compound is also magnetic due to its high electron density at the methoxy group.

Tert-Butyl 2,5-diazabicyclo[2.2.1]heptane-2-carboxylate hydrochloride (TBDAHC) is a fine chemical that is an intermediate for the synthesis of other compounds. TBDAHC is a versatile building block that can be used in research chemicals, reaction components, and specialty chemicals. It is also a useful scaffold for making complex compounds and useful building blocks. The compound has high quality and can be used as a reagent in organic chemistry.

Quinoline-2,8-diol is a bacterial strain that can be used to remove fatty acids from wastewater. The recombinant cytochrome P450 in this strain can degrade fatty acids, which are carcinogenic and have been shown to cause hepatic steatosis. In addition, the quinoline-2,8-diol strain has shown an ability to inhibit xenograft tumor growth in mice by activating cytochrome P450 and inducing apoptosis. This bacterial strain also has the potential to produce xanthurenic acid from tyrosine. Xanthurenic acid is toxic and has been shown to inhibit polymerase chain reaction (PCR) amplification of DNA. Quinoline-2,8-diol may be used as a model for experimental studies of xanthurenic acid's effects on energy metabolism and DNA synthesis.

Thiamine monophosphate chloride dihydrate is a form of the vitamin thiamine. It has been used in control analysis to measure the activity of enzymes that require thiamine as a cofactor, such as transketolase and pyruvate kinase. Thiamine monophosphate chloride dihydrate has also been studied in biochemical properties, where it was found that this compound can be cleaved by picolinic acid to form thiazole phosphate. The matrix effect is an important factor in polymerase chain reactions and has been shown to be dependent on the presence of dinucleotide phosphate. This compound is an essential component of energy metabolism and plays a role in protein synthesis. Thiamine monophosphate chloride dihydrate also has toxicological studies, including a model system using wild-type strains of yeast. These studies have shown that this compound leads to physiological effects such as inhibition of glycolysis and lactic acid production.

6-Ethylmercaptopurine is a purine analogue that inhibits the synthesis of DNA. It is used as an inhibitor of protein synthesis and in the treatment of inflammatory bowel disease. 6-Ethylmercaptopurine has been shown to inhibit the activity of ATPase, which may be responsible for its ability to suppress the proliferation of cells. This drug can also act as an analog to adenosine, which can be used to determine ATP levels in a cell or tissue sample by measuring the amount of p-nitrophenyl phosphate produced. 6-Ethylmercaptopurine has been shown to block phosphatase activity, which may lead to inflammation in some cases.
6-Ethylmercaptopurine has a molecular weight of 194.2 g/mol and an optimum pH of 4.5

5-Bromo-6-chloro-1H-indole is a fine chemical that is used as a building block for research chemicals, reagents, and speciality chemicals. It is soluble in chloroform and benzene, but insoluble in water. This product can be used as a reaction component or a useful intermediate in the production of complex compounds. 5-Bromo-6-chloro-1H-indole has been reported to be an effective scaffold for the synthesis of many novel compounds with potential applications such as pharmaceuticals, agrochemicals, and dyes.

4,4'-Bis(methoxycarbonyl)-2,2'-bipyridine is a ligand that can be used in cross-coupling reactions. It has been shown to bind to metal ions and form complexes with the ligands. 4,4'-Bis(methoxycarbonyl)-2,2'-bipyridine has a constant value for maximizing the yield of the reaction and is luminescent. This product also has photophysical properties that allow it to be utilized in voltammetry studies. The transfer of this product can be optimized by using chromophores or catalysis. 4,4'-Bis(methoxycarbonyl)-2,2'-bipyridine provides a means for cross-coupling reactions using electrochemical studies and dichroism.

2-Boc-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid is a useful scaffold with a high quality. It can be used as a building block in the synthesis of complex compounds and fine chemicals. 2-Boc-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid is also a useful intermediate and reagent in organic synthesis. This compound has CAS number 362492-00-0.

2,2'-Bipyridine-6-carboxylic acid is a reagent that is used in organic synthesis as a reaction component and building block for the synthesis of heterocyclic compounds. 2,2'-Bipyridine-6-carboxylic acid is also used as a precursor to produce other compounds. 2,2'-Bipyridine-6-carboxylic acid has been shown to be useful in the synthesis of complex compounds with diverse structures, making it a versatile building block. It can also be used as an intermediate in the synthesis of various drugs and speciality chemicals.

6-Iodoisatin is a potential anticancer agent that has been shown to inhibit the growth of murine melanoma cells in vitro. The mechanism of action is not yet fully understood, but it seems that 6-iodoisatin may inhibit the synthesis of melanin and its cross-coupling reaction. This compound also exhibits affinity for tumour cells and can be radiolabeled with a radionuclide such as iodine-131 (I) or iodine-123 (I). 6-Iodoisatin has been shown to have a high biodistribution profile in mice. It accumulates in melanoma tumours at an amount that is ten times higher than that observed in other tissues.

Please enquire for more information about 1-(2-Chloropropanoyl)indoline including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 3-(4-Bromophenyl)-5-(hydroxyimino)-7,7-dimethyl-6,7,8-trihydrocinnoline including the price, delivery time and more detailed product information at the technical inquiry form on this page

2-Oxoindoline-3-hydrazone (2OIH) is a heterocyclic compound that has been reported to have anticancer activity. 2OIH is an intramolecular hydrogen bond acceptor, which may account for its anticancer activity. It has been shown to be effective against cancer cells in mammalian cell lines and in vitro studies of human carcinoma cell lines. This compound also showed anticancer activity against bacteria such as Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus). The geometric isomers of 2OIH have been studied using nmr spectra, and the carbonyl group has been identified as the source of its anti-cancer properties. Structural analysis has revealed that the hydroxyl group on the indole moiety is important for the anti-cancer properties of this molecule.

Applications 2-​Quinolinecarboxylic acid can be found in the studying of ligands for the purpose of copper-catalyzed Ullmann reactions with aryl ethers and aryl iodides.

Applications 3-Cyanoindole (cas# 5457-28-3) is a compound useful in organic synthesis.

Applications Methyl 2-(1-(5-Fluoropentyl)-1H-indole-3-carboxamido)-3-phenylpropanoate is a useful intermediate for organic synthesis. It is a derivative of I-AMB (I110000(M)), which is an analog of 5-fluoro AMB that was developed on an indole base instead of the indazole base typically associated with AB-PINACA.
References Shevyrin, V., et al.: Chem. Heterocyclic Comp., 50, 583 (2014)

Applications 5-Chloroindole-2-carboxylic Acid is used in the synthesis of 4-(3-aminomethylphenyl)piperidine-1-carboxamides as potent, selective, and orally bioavailable inhibitors of βII tryptase. It is also a reagent used to prepare indole amides with possible antihistaminic activities.
References Levell, J., et al.: Bioorg. Med. Chem., 13, 2859 (2005); Battaglia, S., et al.: Eur. J. Med. Chem., 34, 93 (1999)

Applications 5-[(1R)-2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-(phenylmethoxy)-2(1H)-quinolinone is used as a reactant in the preparation of Indacaterol (I499745), a β-adrenoreceptor agonist.
References Baur, Francois, et al.: J. of Med. Chem., 53(9), 3675-3684 (2010)

Applications 1,2,3,4-Tetrahydroquinolin-3-amine (cas# 40615-02-9) is a useful research chemical.

Applications 1,4-Diazabicyclo[2.2.2]octane bis(sulfur dioxide) adduct (cas# 119752-83-9) is a useful research chemical.

Applications 3-(ETHOXYCARBONYL)BICYCLO[1.1.1]PENTANE-1-CARBOXYLIC ACID (cas# 1823373-90-5) is a useful research chemical.

Applications 2-Azabicyclo[2.2.2]octan-3-one (cas# 3306-69-2) is a useful research chemical.

Applications Protected nucleoside.
References Elzein, E., et al.: Bioorg. Med. Chem. Lett., 17, 161 (2007), Franchetti, P., et al.: J. Med. Chem., 52, 2393 (2009),

Applications 4-Isoquinolin-4-yl-benzylamine is an analog of amino isoquinolin (A611600). Amino isoquinolin ( A611600) is used for synthesis of Rho kinase inhibitors.
References Kimura, K; Science, 273, 245 (1996);Amano, M; J Biol Chem 274, 32418 (1999)Gassel, M; J Mol Biol, 329, 1021 (2003);

Applications 5-Nitroisoindoline is used as a reagent in organic synthesis of several compounds including that of biphenylcarboxamidoisoindoline derivatives, which act as apolipoprotein B secretion inhibitors, and of benzenesulfonamides which may act as antipsychotic agents.
References Yamada, H., et al.: Preparation of biphenylcarboxamidoisoindoline derivatives as apolipoprotein B secretion inhibitors, WO Patent 2002014277, Feb 21, 2002; Cooper, D., et al.: Preparation of benzenesulfonamides as antipsychotic agents, WO Patent 2003068732, Aug 21, 2003;

Applications 2-tert-Butyl-1H-indole (cas# 1805-65-8) is a useful research chemical.