Composés polycycliques

Applications 1R,3S,5R)-2-(tert-Butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic Acid acts as a reagent in the preparation of fused bicycles end-capped with peptide derivatives as HCV inhibitors. Synthesis of (tert-butoxycarbonyl)azabicyclohexanecarboxylic acid via stereoselective cyclopropanation of pyrroline
References Wang, G., et al.: Tetrahedron Lett., 54, 6722 (2013); Belema, M., et al.: From U.S. Pat. Appl. Publ. (2012), US 20120195857 A1 20120802

Applications 2-Azabicyclo[2.2.2]octan-3-one (cas# 3306-69-2) is a useful research chemical.

Applications 3-(ETHOXYCARBONYL)BICYCLO[1.1.1]PENTANE-1-CARBOXYLIC ACID (cas# 1823373-90-5) is a useful research chemical.

Applications 4,4'-Di-tert-butyl-2,2'-bipyridine acts as a reagent in the preparation, antiproliferative and cytotoxic activity of apoptotic ruthenium nitrogen heterocyclic complexes via combinatorial library synthesis.
References Mulcahy, S. P., et al.: Dalton Trans., 39, 177 (2010)

Applications 5-Chloroindole-2-carboxylic Acid is used in the synthesis of 4-(3-aminomethylphenyl)piperidine-1-carboxamides as potent, selective, and orally bioavailable inhibitors of βII tryptase. It is also a reagent used to prepare indole amides with possible antihistaminic activities.
References Levell, J., et al.: Bioorg. Med. Chem., 13, 2859 (2005); Battaglia, S., et al.: Eur. J. Med. Chem., 34, 93 (1999)

Applications alpha-Furil Dioxime (cas# 23789-34-6) is a useful research chemical.

Stability Hygroscopic
Applications 3-Bromo-4-fluoro-1H-indazole (cas# 885521-60-8) is a useful research chemical.

Applications Indole derivative with anticancer activity.
References Lavrenov, S. et al.: Bioorgan. Med. Chem. 18, 6905 (2010)

Stability Store under Argon
Applications 3,6-Thioxanthenediamine-10,10-dioxide (cas# 10215-25-5) is a compound useful in organic synthesis.

Stability Light Sensitive
Applications 3,3'-Bipyridine-6,6'-dicarbonitrile

Applications 2,4-Dimethylquinoline, �� 95.0% (cas# 1198-37-4) is a useful research chemical.

Applications Indole derivative as substrate-binding; N297Q and I300V mutants of cytochrome P 450 2A6 display expansion of substrate specificity of cytochrome P 450 2A6 to oxidize substituted indoles.
References Gotoh, O., et al.: J. Biol. Chem., 267, 83 (1992), Guengerich, F., et al.: Chem. Res. Toxicol., 14, 611 (2001), Kim, D., et al.: Biochemistry, 43, 981 (2004),

Applications 5-Fluoroindole-3-butyric Acid is used in preparation of Aminochroman and Aminotetralin derivatives, which are useful in the treatment of serotonin-mediated disorders.
References Hatzenbuhler, N., et al.: PCT Int. Appl., (2005);

Applications 2-(1-Cyanoethyl)indole-13C215N is an isotope labelled intermediate for the synthesis of pharmaceutical actives, intermediates and fine chemicals.
References Pezzuto, J.M., et al.: Biochem., 20, 298 (1981), Takeda, K., et al.: Chem. Pharm. Bull., 29, 1280 (1981),

Applications 1,2,3,4,5,6,7,8-OCTAHYDROPHENANTHRENE (cas# 5325-97-3) is a useful research chemical.

Applications 2-(quinolin-4-yl)ethan-1-amine (cas# 860720-12-3) is a useful research chemical.

Applications 6-fluoroquinoline-8-carboxylic acid (cas# 1306605-84-4) is a useful research chemical.

Applications 1,2,3,4-Tetrahydroisoquinoline-6,7-diol hydrobromide (cas# 52768-23-7) is a useful research chemical.

Applications Methyl indoline-5-carboxylate

Applications (2R,3aS,7aS)-Octahydroindole-2-carboxylic Acid Hydrochloride is an intermediate in the synthesis of Perindoprilat (P287530), an angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive.
References Vincent, M., et al.: Drug Design Disc., 9, 11 (1992), Pascard, C., et al.: J. Med. Chem., 34, 663 (1991)

Applications 3,5-Diphenylpyrazole (cas# 1145-01-3) is a useful research chemical.

Applications 1-Benzylindole-5-boronic Acid Pinacol Ester acts as a reagent in the synthesis of 3,3-difluoro-2-oxindoles via electrophilic fluorination of indoles using N-fluorobenzenesulfonimide. Preparation of triazolopyridine compounds as JAK kinase inhibitors useful in the treatment of neurodegenerative and inflammatory diseases.
References : Lim, Y., et al.: Org. Lett., 14, 5676; Menet, C., et al.: PCT Int. Appl. (2010), WO 2010010190 A1 20100128.

Applications 5-Nitroisoindoline is used as a reagent in organic synthesis of several compounds including that of biphenylcarboxamidoisoindoline derivatives, which act as apolipoprotein B secretion inhibitors, and of benzenesulfonamides which may act as antipsychotic agents.
References Yamada, H., et al.: Preparation of biphenylcarboxamidoisoindoline derivatives as apolipoprotein B secretion inhibitors, WO Patent 2002014277, Feb 21, 2002; Cooper, D., et al.: Preparation of benzenesulfonamides as antipsychotic agents, WO Patent 2003068732, Aug 21, 2003;

Applications 6-Bromo-2-(4-bromophenyl)indole (cas# 28718-96-9) is a compound useful in organic synthesis.

Applications Oxyquinoline Sulfate is used as a food preservative.
References Gendy, A. et al.: Aud. J. Basic. App. Sci., 6, 260 (2012); Abou El-Ghait, E. et al.: Res. J. Agri. Biol. Sci., 8, 261 (2012);

Applications 1H-Indole-3-carboxylic acid hydrazide

Applications Quinoline-3-sulfonyl Chloride (cas# 159182-40-8) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 7-Phenyl-7H-purine (cas# 18346-05-9) is a compound useful in organic synthesis.

Applications 6-hydroxyquinoline-2-carboxylic acid (cas# 75434-18-3) is a useful research chemical.

Applications 1-benzyl-1,2,3,4-tetrahydroisoquinoline hydrochloride (cas# 155413-72-2) is a useful research chemical.

Applications 3-Cyanoindole (cas# 5457-28-3) is a compound useful in organic synthesis.

Applications 4-Isoquinolin-4-yl-benzylamine is an analog of amino isoquinolin (A611600). Amino isoquinolin ( A611600) is used for synthesis of Rho kinase inhibitors.
References Kimura, K; Science, 273, 245 (1996);Amano, M; J Biol Chem 274, 32418 (1999)Gassel, M; J Mol Biol, 329, 1021 (2003);

Applications 7-BROMOMETHYLQUINOLINE HYDROBROMIDE (cas# 188874-61-5) is a useful research chemical.

Applications 2-(2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL)ACETIC ACID (cas# 61164-71-4) is a useful research chemical.

Applications 9-Oxo-9H-thioxanthene-2-carboxylic acid (cas# 25095-94-7) is a useful research chemical.

Applications N’,N’-Dimethylindole-2-carboxamide (cas# 7511-14-0) is a compound useful in organic synthesis.

Applications 4-Chloro-8-(trifluoromethyl)quinoline is used as a reagent for the potent CRTh2 (DP2) receptor antagonists discovery which is used for treatment of asthma, allergic rhinitis and other inflammatory diseases.
References Birkinshaw, T.N., et al.: Bioorg. Med. Chem. Lett., 16, 4287 (2006)

Applications 4-Fluoro-1H-indazole

Applications 3,5-Dichloro-4-pyridone-1-acetic acid

Applications 4-Chloro-7-(trifluoromethyl)quinoline is a reagent in the preparation of piperazinylquinolines as breast cancer inhibitors.
References Solomon, V., et al.: Bioorg. Med. Chem., 18, 1563 (2010);

Applications 5,7-Dichloro-3,4-dihydro-2H-isoquinolin-1-one (cas# 885273-81-4) is a useful research chemical.

Applications 8-aza-9-boratricyclo[8.4.0.0,2,7]tetradeca-1(14),2,4,6,10,12-hexaen-9-ol (cas# 17012-25-8) is a useful research chemical.

Stability Hygroscopic
Applications 2-(1,3-Dioxo-3,4-dihydroisoquinolin-2(1H)-yl)acetic Acid (cas# 52208-61-4) is a useful research chemical.

Applications 4-Hydroxymethylbicyclo[2.2.2]octane-1-carboxylic Acid Isopropylamide is a useful synthetic intermediate.

Applications 1,8,8-trimethyl-3-azabicyclo[3.2.1]octane hydrochloride is a useful research chemical, a camphidine derivative with multiple synthetic applications.
References Rubinstein, K., et al.: Acta Chem. Scand., 17, 2061 (1963); Manzoor-I-Khuda, M., et al.: Pak. J. Sci. Ind. Res., 10, 97 (1967)

Applications 3-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)propanoic Acid (cas# 923163-76-2) is a useful research chemical.

Applications 6-Chloro-3,4-dihydro-4-hydroxy-3-(phenylsulfonyl)-4-(trifluoromethyl)-2(1H)-quinolinone is an intermediate in the synthesis of novel quinolinones as HIV-1 reverse transcriptase inhibitors.
References Patel, M., et al.: Bioorg. Med. Chem. Lett., 11, 1943 (2001);

Applications 6-Propylamino-7-deazapurine (cas# 60972-21-6) is a compound useful in organic synthesis.

Applications Methyl 4-formylbicyclo[2.2.2]octane-1-carboxylate (cas# 94994-25-9) is a useful research chemical.

Applications (1R,6R)-2,8-Diazabicyclo[4.3.0]nonane is a chiral reagent used in the synthesis of pyrrolopyrimidine derivatives as dual DNA gyrase B and topoisomerase IV inhibitors and potential antibacterial agents.
References Bioorg. Med. Chem. Lett., 23, 1529 (2013);

Applications 2’,3’,5’-Tri-O-benzoyl Xanthine-13C5 is an intermediate used in the synthesis of Xanthosine-13C5 (X742102), which is the labeled analogue of Xanthosine (X742100), the deamination product of Guanosine. It is also a potential biomarker for detecting radiation exposure.
References Magasanik, B, et al.: J. Bio. Chem., 206, 83 (1954);

Applications 4-Ethyl-2(1H)-quinolinone has been use as a reactant in the preparation of 6-bisalkylamino-2-quinolinones as selective androgen receptor modulators.
References Van Oeveren, A., et. al.: Bioorg. Med. Chem. Lett., 17, 1527 (2007)

Applications Indoline-2-carboxylic acid is used in the synthesis of D-43787, which is a novel immunomodulating compound; antiasthmatic and immunosuppressant.
References Blackham, A., et al.: Clin. Exp. Immunol., 86, 224 (1991), Barnes, P., et al.: Clin. Sci., 1998, 94, 557 (1998), Cohn, L., et al.: Pharmacol. Ther., 88, 187 (2000), Asanuma, F., et al.: Inflamm. Res., 50, 136 (2001), Zenke, G., et al.: J. Immunol., 166, 7165 (2001),

Applications 7-Phenoxyquinolin-2(1H)-one is a useful research chemical.

Applications 2-azaspiro[4.5]decane-1,3-dione (cas# 1197-80-4) is related to gabapentin (G117250).

Applications (2R,3aR,7aR)-rel-OctahydroIndole-2-carboxylic Acid is a reactant in the preparation of Perindoprilat (P287530), an angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive.
References Blankley, C.J., et. al.: J. Med. Chem., 30, 992 (1987)

Applications 5,7-Dichloro-4-hydroxyquinoline is an intermediate in synthesizing Quinoxyfen-d4 (Q765502), an isotope labelled Quinoxyfen acts as an agricultural fungicide.
References Corrales, M., et al.: Food Chem. Toxicol., 48, 3471 (2010); Lagunas-Allue, L., et al.: Anal. Bioanal. Chem., 398, 1509 (2010); Wong, J., et al.: J. Agric. Food Chem., 58, 5897 (2010)

Applications 4,7-difluoro-1H-indole-2-carboxylic acid (cas# 247564-67-6) is a useful research chemical.

Applications 2-Chloroquinolin-6-ol can be used for hair dye compositions.
References Lagrange, A., et.al., PCT Int. Appl., 87, (2012);

Applications 2,3,3-Trimethylindolenine-5-sulfonic Acid, Potassium Salt (cas# 184351-56-2) is a compound useful in organic synthesis.

Applications 6-Hydroxyquinoline-(1H)-2-one (cas# 19315-93-6) is a compound useful in organic synthesis.