Composés polycycliques

Applications 5-Amino-2H-isoquinolin-1-one is a reactant used in the synthesis of glucoorticoid receptor agonists as well as PARP inhibitors used in the treatment of tumors.
References Berger, M. et al.: Bioorg. Med. Chem. Lett., 27, 437 (2017); Goodfellow, E. et al.: Bioorg. Med. Chem. Lett., 27, 688 (2017);

Applications An intermediate in the preparation of Azasetron.
References Baker, S., et al.: Bioorg. Med. Chem. Lett., 15, 4727 (2005), Odzak, R., et al.: Bioorg. Chem., 34, 90 (2006), Anand, R., et al.: J. Med. Chem., 52, 1602 (2009),

Applications 3-Hydroxy-2,3-dihydro-1H-indol-2-one is a useful reagent for the distereoselective preparation of spiro[furo[3,4-c]chromene-1,3'-indoline]triones.
References Lei, C. W., et al.: Org. Biomol. Chem., 18, 845 (2020)

Applications 5,7-Dichloro-3,4-dihydro-2H-isoquinolin-1-one (cas# 885273-81-4) is a useful research chemical.

Applications 1,2,3,4-Tetrahydroisoquinoline-6,7-diol hydrobromide (cas# 52768-23-7) is a useful research chemical.

Applications 6-fluoroquinoline-8-carboxylic acid (cas# 1306605-84-4) is a useful research chemical.

Applications 7-chloro-4-hydroxyquinoline-3-carboxylic acid (cas# 86-47-5) is a useful research chemical.

Applications 2-(quinolin-4-yl)ethan-1-amine (cas# 860720-12-3) is a useful research chemical.

Applications 8-Hydroxyquinoline Copper Salt is used in the formulation of biocide microcapsules towards stabilized iodine-​containing compounds for protection of technical materials from degradation by microorganisms.
References Boettcher, A., et al.: PCT Int. Appl. (2012), WO 2012076699 A1 20120614

Applications 2-(prop-2-yn-1-yl)-1,2,3,4-tetrahydroisoquinoline-1,3-dione (cas# 410538-30-6) is a useful research chemical.

Applications 6-Hydroxyquinoline-(1H)-2-one (cas# 19315-93-6) is a compound useful in organic synthesis.

Applications 3-(4-Aminobutyl)-1H-indole-5-carbonitrile could be a useful reagent for preparing CNS agents.
References Boettcher, H., et al.: Ger. Offen. (1992), DE 4101686 A1

Applications 1,2,3,4,5,6,7,8-OCTAHYDROPHENANTHRENE (cas# 5325-97-3) is a useful research chemical.

Applications 6-​Benzyloxy-​7-​methoxy-​3,​4-​dihydro-​isoquinoline is a reactant used in the synthesis of VMAT2 imaging agents.
References Liu, C. et al.: Chiral., 25, 215 (2013);

Applications 2,3,3-Trimethylindolenine-5-sulfonic Acid, Potassium Salt (cas# 184351-56-2) is a compound useful in organic synthesis.

Applications 4-Hydroxymethylbicyclo[2.2.2]octane-1-carboxylic Acid Methylamide is a useful synthetic intermediate.

Applications 2-(1-Cyanoethyl)indole-13C215N is an isotope labelled intermediate for the synthesis of pharmaceutical actives, intermediates and fine chemicals.
References Pezzuto, J.M., et al.: Biochem., 20, 298 (1981), Takeda, K., et al.: Chem. Pharm. Bull., 29, 1280 (1981),

Applications 2-Oxa-7-azaspiro[3.5]nonane is an intermediate used to prepare benzothienoazepine derivatives as potent respiratory syncytial virus RNA polymerase inhibitors. It is also used to prepare 1,7-Diazacarbazole derivatives as inhibitors of checkpoint kinase 1.
References Xiong, H., et al.: Bioorg. Med. Chem. Lett., 23, 6789 (2013); Gazzard, L., et al.: J. Med. Chem., 58, 5053 (2015)

Applications Indole derivative as substrate-binding; N297Q and I300V mutants of cytochrome P 450 2A6 display expansion of substrate specificity of cytochrome P 450 2A6 to oxidize substituted indoles.
References Gotoh, O., et al.: J. Biol. Chem., 267, 83 (1992), Guengerich, F., et al.: Chem. Res. Toxicol., 14, 611 (2001), Kim, D., et al.: Biochemistry, 43, 981 (2004),

Applications 4-Chloro-7-(trifluoromethyl)quinoline is a reagent in the preparation of piperazinylquinolines as breast cancer inhibitors.
References Solomon, V., et al.: Bioorg. Med. Chem., 18, 1563 (2010);

Applications 2-Chloroquinolin-6-ol can be used for hair dye compositions.
References Lagrange, A., et.al., PCT Int. Appl., 87, (2012);

Applications 5,7-Dichloro-4-hydroxyquinoline is an intermediate in synthesizing Quinoxyfen-d4 (Q765502), an isotope labelled Quinoxyfen acts as an agricultural fungicide.
References Corrales, M., et al.: Food Chem. Toxicol., 48, 3471 (2010); Lagunas-Allue, L., et al.: Anal. Bioanal. Chem., 398, 1509 (2010); Wong, J., et al.: J. Agric. Food Chem., 58, 5897 (2010)

Applications 2-azaspiro[4.5]decane-1,3-dione (cas# 1197-80-4) is related to gabapentin (G117250).

Applications 5-Chloroisoquinoline (cas# 5430-45-5) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 2,4-Dimethylquinoline, �� 95.0% (cas# 1198-37-4) is a useful research chemical.

Applications 4,5,6,7-tetrahydro-1H-indazole-6-carboxylic acid (cas# 1354950-72-3) is a useful research chemical.

Applications 4,7-difluoro-1H-indole-2-carboxylic acid (cas# 247564-67-6) is a useful research chemical.

Applications Methyl 4-formylbicyclo[2.2.2]octane-1-carboxylate (cas# 94994-25-9) is a useful research chemical.

Stability Light Sensitive
Applications 3,3'-Bipyridine-6,6'-dicarbonitrile

Applications tert-Butyl 1,6-Diazaspiro[3.4]octane-1-carboxylate is a reactant in the preparation of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors.
References Sippy, K.B., et. al.: Bioorg. Med. Chem. Lett., 19, 1682 (2009)

Applications methyl 8,8-dioxo-8lambda6-thia-2,3,5,7-tetraazatricyclo[7.4.0.0,2,6]trideca-1(13),3,5,9,11-pentaene-4-carboxylate (cas# 1311315-62-4) is a useful research chemical.

Applications 3-(quinolin-2-yl)propanoic acid (cas# 39111-94-9) is a useful research chemical for biological study. In particular it has been used in identifying structure-activity relationship of HDAC6 zinc-finger ubiquitin binding domain inhibitors.
References Ferreira, F., et al.: J. Med. Chem, 61, 4517 (2018)

Applications 4,8-DICHLOROQUINOLINE (cas# 21617-12-9) is a useful research chemical.

Applications 4,4'-Diamino-2,2'-bipyridine is a bidendate chelator.

Applications octahydro-1H-indole-2-carboxamide (cas# 1105694-34-5) is a useful research chemical.

Applications 1-(5-Fluoropentyl)-1H-indole-3-carbonyl Chloride is an intermediate for the synthesis of Methyl 2-(1-(5-Fluoropentyl)-1H-indole-3-carboxamido)-3-phenylpropanoate (M224944), which is a useful intermediate for organic synthesis.

Applications Indole derivative with anticancer activity.
References Lavrenov, S. et al.: Bioorgan. Med. Chem. 18, 6905 (2010)

Applications tert-​Butyl 6-​Hydroxy-​2-​azaspiro[3.3]​heptane-​2-​carboxylate is a reactant used in the synthesis of pharmaceuticals such as CNS penetrant CXCR2 antagonists for the potential treatment of CNS demyelinating.
References Xu, H. et al.: ACS Med. Chem. Lett., 7, 397 (2016);

Stability Hygroscopic
Applications 3-Bromo-4-fluoro-1H-indazole (cas# 885521-60-8) is a useful research chemical.

Applications 3,5-Dichloro-4-pyridone-1-acetic acid

Applications 5,7-Dibromoquinolin-8-ol

Applications 2-​Quinolinecarboxylic acid can be found in the studying of ligands for the purpose of copper-catalyzed Ullmann reactions with aryl ethers and aryl iodides.

Applications 7-Bromoisoquinoline (cas# 58794-09-5) is a compound useful in organic synthesis. It can be used for the preparation of estrone cortistatin analogs via Suzuki-Miyaura coupling. It could also be used for the preparation of pyrazolopyrimidinamine derivatives.
References Sato, Y., et al.: Biosci., Biotechnol., Biochem., 72, 2992 (2008), Apsel, B., et al.: Nat. Chem. Biol., 4, 691 (2008)

Applications alpha-Furil Dioxime (cas# 23789-34-6) is a useful research chemical.

Applications 3-Mercaptoindole (cas# 480-94-4) is a compound useful in organic synthesis.
References Harris, R.L.N.: Tetrahedron Letters, 51, 4465 (1969)

Applications 3-AMINOQUINOLINE (cas# 580-17-6) is a useful research chemical.

Applications 3-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)propanoic Acid (cas# 923163-76-2) is a useful research chemical.

Applications A useful intermediate for the synthesis of pharmaceutical actives, intermediates and fine chemicals.
References Pezzuto, J.M., et al.: Biochem., 20, 298 (1981), Takeda, K., et al.: Chem. Pharm. Bull., 29, 1280 (1981),