Composés polycycliques

Applications 1H-Indole-d5-3-acetamide is the isotope labelled analogue of Indole-3-acetamide, a compound that is converted to indole-3-acetic acid by indole-3-acetamide hydrolase in auxin biosynthesis in plants.
References Mano, Y., et al.: J. Exp. Bot., 61, 25 (2010);

Applications 9-oxo-9H-Thioxanthene-4-carboxylic acid (cas# 51762-56-2) is a useful research chemical.

Applications 5-Hydroxyquinoline-3-carboxylic acid (cas# 911108-90-2) is a useful research chemical.

Applications 4,8-DICHLOROQUINOLINE (cas# 21617-12-9) is a useful research chemical.

Applications 2-Oxa-7-azaspiro[3.5]nonane is an intermediate used to prepare benzothienoazepine derivatives as potent respiratory syncytial virus RNA polymerase inhibitors. It is also used to prepare 1,7-Diazacarbazole derivatives as inhibitors of checkpoint kinase 1.
References Xiong, H., et al.: Bioorg. Med. Chem. Lett., 23, 6789 (2013); Gazzard, L., et al.: J. Med. Chem., 58, 5053 (2015)

Applications 3-(2-Deoxy-5-O-phosphono-β-D-erythro-pentofuranosyl)-3,4-dihydro-5H-imidazo[2,1-i]purine-5-thione is used in the synthesis of azidoetheno analogs of deoxyadenosine as nucleotide photo-affinity probes.
References Flaherty, D. et al.: Nucleos. Nucleot., 14, 65 (1995);

Stability Hygrscopic
Applications 2,2'-Biquinoline-4,4-dicarboxylic acid disodium salt

Applications Methyl quinoline-4-carboxylate (cas# 21233-61-4) is a useful research chemical.

Applications Ethyl 4,6,8-trichloroquinoline-3-carboxylate

Applications 6-Fluoroquinoline, is a versatile building block used in the synthesis of various chemical compounds.

Applications 2,6-Dichloro-9-nitroso-9H-purine is a compound useful in organic synthesis.

Applications 4-Hydroxy-quinoline-6-carboxylic acid

Stability Hygroscopic
Applications 7-(4-Chlorobutoxy)-3,4-dihydro-2(1H)-quinolinone is used in the synthesis of aripiprazole, an antipsychotic oral drug used in the treatment of Schizophrenia.
References Bonacorsi, S. et al.: J. Label. Comp. Radiopharm., 49, 1 (2006); Morita, Seiji; K. et al.: Tetrahedron, 54, 4811 (1998);

Applications tert-Butyl 1,6-Diazaspiro[3.4]octane-1-carboxylate is a reactant in the preparation of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors.
References Sippy, K.B., et. al.: Bioorg. Med. Chem. Lett., 19, 1682 (2009)

Applications 3-(quinolin-2-yl)propanoic acid (cas# 39111-94-9) is a useful research chemical for biological study. In particular it has been used in identifying structure-activity relationship of HDAC6 zinc-finger ubiquitin binding domain inhibitors.
References Ferreira, F., et al.: J. Med. Chem, 61, 4517 (2018)

Applications 6-Hydroxyindole-2-carboxylic acid (cas# 40047-23-2) is a useful research chemical.

Anomelin is a synthetic anticancer compound, which is derived from complex organic synthesis methodologies. This compound is typically produced through careful laboratory processes due to its intricate chemical structure, which is crafted to target specific molecular pathways involved in cancer cell proliferation.

Prenyletin methyl ether is a flavonoid compound, which is a naturally occurring polyphenolic molecule sourced primarily from specific plant species. This compound exerts its effects through a variety of biochemical interactions, notably influencing cellular signaling pathways, including antioxidative and anti-inflammatory processes.

5-Hydroxyquinolin-2(1H)-one is a chalcone that can be synthesized from 2,5-dihydroxybenzaldehyde and quinoline. It is a bacteriostatic agent that inhibits bacterial growth by binding to the 50S ribosomal subunit, blocking the formation of an antibiotic-substrate complex with the enzyme cell wall synthesis that is required for cell wall biosynthesis, inhibiting protein synthesis and cell division. 5-Hydroxyquinolin-2(1H)-one has shown activity against methicillin resistant Staphylococcus aureus (MRSA) and methicillin resistant Enterococcus faecium. 5-Hydroxyquinolin-2(1H)-one also represses the expression of DNA topoisomerase II genes, which may be associated with its inhibitory effects on bacterial growth.

6-Bromo-2,3-dihydro-1H-indole is a natural product that has been shown to inhibit cancer cell growth in vitro. In the presence of 6-bromoindole, cells are unable to proliferate and undergo apoptosis. This compound also shows anti-cancer activity against human leukemia cells. The mechanism of action for this molecule is not yet known but may be related to its ability to activate the caspase enzyme family or its ability to bind to DNA. 6-Bromoindole has been shown to have anti-inflammatory properties through inhibition of prostaglandin synthesis in animal models.

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1,1'-Bicyclo[1,1,1]pentane-1,3-dicarboxylic acid monomethyl ester is a chemical compound used in research and as a building block for complex compounds. It is a high quality and versatile compound that has a wide range of uses in the production of fine chemicals. This compound is an intermediate for the synthesis of 1,4-benzodioxan. CAS No. 83249-10-9

8-Bromoisoquinoline is a bifunctional alkylating agent that is used to synthesize esters and amides. It is commonly used for the synthesis of amino acids, peptides, and other biologically active molecules. 8-Bromoisoquinoline has been shown to have a synergistic effect with hydroxyalkyl carbamates, which may be due to its ability to form an ionic bond with the carboxylic acid in these compounds. This chemical can also react with nitro groups and serve as a chlorinating agent, as well as react with anions such as phosphate and acetate. 8-Bromoisoquinoline can be synthesized by reacting ethyl bromoacetate with tetrahydroisoquinolinium chloride in hydrochloric acid or isopropyl alcohol.

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4-Hydroxy-7-methoxyquinoline is an anti-malarial drug that belongs to the class of trimethyl, trifluoromethyl group. It is a cyclic compound and its synthesis starts with cyclization of the methyl derivative, which forms a ring. This product is used in clinical practice as an inhibitor of malarial protozoa and has been shown to have mechanistic effects on the cytochrome bc1 complex containing red blood cells. 4-Hydroxy-7-methoxyquinoline also inhibits the growth of bacteria by binding to the enzyme methionine synthase, which is involved in the biosynthesis of methionine from homocysteine. The product also has an inhibitory effect on DNA synthesis and protein synthesis.

Pangelin is a novel biochemical agent, which is meticulously derived from a unique microbial source with advanced bioconversion techniques. This product functions primarily through a targeted enzymatic mechanism that modulates specific biochemical pathways, ensuring high specificity and efficacy in its action. The enzymatic process engages with targeted substrates to yield predictable and controlled outcomes, making it a potentially valuable tool in biochemical research and applications.

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8-Cyclopentyl-1,3-dimethylxanthine (CPT) is a xanthine derivative that binds to the adenosine receptor and inhibits the phosphodiesterase enzyme. CPT is used in vivo as a model for measuring locomotor activity, dopamine receptors, adenosine receptors, and glutamate receptors. The binding of CPT to these receptors can lead to bronchoconstriction by stimulating the release of vasoactive substances from airway cells and increasing the sensitivity of airway cells to bronchoconstrictor stimuli. This drug also has been shown to inhibit calcium ion influx into cytosol and increase intracellular levels of cAMP.

4-Hydroxy-3-nitro-2(1H)-quinolinone is a quinoline derivative that has been shown to have anticancer activity against cancer cells. It can be used for the treatment of various types of cancer, including lung cancer, breast cancer, and colon cancer. This drug inhibits the growth of cancer cells by blocking the cycle at the G1 phase and inducing apoptosis. It also disrupts mitochondrial membrane potential, leading to an increase in reactive oxygen species and DNA damage. 4-Hydroxy-3-nitro-2(1H)-quinolinone is an epidermal growth factor receptor (EGFR) antagonist and blocks epidermal growth factor signaling through its inhibition of EGFR tyrosine kinase activity. It also downregulates TNFα expression in tumor cells by inhibiting NFκB activation.

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7-Azaindole-5-carboxylic acid methyl ester is an ester derivative that can be synthesized from the reaction of acetyl chloride and diazotization. 7-Azaindole-5-carboxylic acid methyl ester has been used in research for its biological activity, specifically as a cytotoxic agent. It has also been shown to inhibit the growth of cancer cells by alkylation reactions and cyclization reactions. 7-Azaindole-5-carboxylic acid methyl ester has been shown to have antitumor properties with a mechanism that is not yet fully understood.