Composés polycycliques

<p>Applications 8,8-dimethyl-2-oxabicyclo[4.2.0]octan-7-amine (cas# 1342540-54-8) is a useful research chemical.<br></p>

<p>Applications Dichloroquinoline derivatives for use as herbicides.<br></p>

<p>Applications Quinoline-4-carboxylic acid (cas# 486-74-8) is a useful research chemical.<br></p>

<p>Stability Light Sensitive<br>Applications 3,3'-Bipyridine-6,6'-dicarbonitrile<br></p>

<p>Stability Store under Argon<br>Applications 3,6-Thioxanthenediamine-10,10-dioxide (cas# 10215-25-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(pyridin-3-yl)pyrido[2,3-d]pyrimidine has been used in the preparation of divalent transition metal aminonicotinaldehyde chloride complexes, antimicrobial, antioxidant and antitumor activities, electrochemical and molecular docking with EGFR protein.<br>References Konakanchi R., et al., Res. Chem. Intermed., 44, 27-53 (2018)<br></p>

<p>Applications 2,3,3-Trimethylindolenine is an indole derivative used in the preparation of cyanine dye labelleing reagents and other imaging agents.<br>References Mujumdar, R. et al.: Cytometry, 10, 3 (1989); Mushkalko, I.L. et al.: Ukr. Khim. Zhur., 52, 509 (1986);<br></p>

<p>Applications 4,4'-Diamino-2,2'-bipyridine is a bidendate chelator.<br></p>

<p>Applications Indole derivative with anticancer activity.<br>References Lavrenov, S. et al.: Bioorgan. Med. Chem. 18, 6905 (2010)<br></p>

<p>Applications (1R,​4S)​-1,​3,​3-​Trimethylbicyclo[2.2.1]​heptan-​2-​one also known more commonly as (-)-Fenchone is a chiral intermediate of Fenchone and is currently being used for studies ranging from inhibitory effects of monoterpenes on human TRPA1 and odorant receptor of the malaria vector Anopheles gambiae.<br>References Rahman, S., et al. J. Biol. Chem., 292, 18916-23 (2017); Takaishi, M., et al.: J Physio. Sci., 64, 47-57 (2014)<br></p>

<p>Stability Hygroscopic<br>Applications 5-Amino-6-nitroquinoline is a reagent used in the synthesis of benzodiazepine sulfonamide-based bombesin receptor 3 agonists. It is also used in the synthesis of quinoxalinediones.<br>References Liu, P. et al.: ACS. Med. Chem. Lett., 2, 933 (2011); Bigge, C. et al.: J. Med. Chem., 38, 5720 (1995);<br></p>

<p>Applications 5-[(1R)-2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-(phenylmethoxy)-2(1H)-quinolinone is used as a reactant in the preparation of Indacaterol (I499745), a β-adrenoreceptor agonist.<br>References Baur, Francois, et al.: J. of Med. Chem., 53(9), 3675-3684 (2010)<br></p>

<p>Applications tert-Butyl 6-amino-3,4-dihydroquinoline-1(2H)-carboxylate (cas# 1152923-36-8) is a useful research chemical.<br></p>

<p>Applications 6-Fluoroquinoline, is a versatile building block used in the synthesis of various chemical compounds.<br></p>

<p>Applications 5,6,7,8-TETRAHYDROISOQUINOLIN-1-AMINE (cas# 75704-51-7) is a useful research chemical.<br></p>

<p>Applications 2,6-Dichloro-9-nitroso-9H-purine is a compound useful in organic synthesis.<br></p>

<p>Applications 3-(ETHOXYCARBONYL)BICYCLO[1.1.1]PENTANE-1-CARBOXYLIC ACID (cas# 1823373-90-5) is a useful research chemical.<br></p>

<p>Applications 2-Azabicyclo[2.2.2]octan-3-one (cas# 3306-69-2) is a useful research chemical.<br></p>

<p>Applications 2-(chloroacetyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (cas# 111631-72-2) is a useful research chemical.<br></p>

<p>Applications 1R,3S,5R)-2-(tert-Butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic Acid acts as a reagent in the preparation of fused bicycles end-capped with peptide derivatives as HCV inhibitors. Synthesis of (tert-butoxycarbonyl)azabicyclohexanecarboxylic acid via stereoselective cyclopropanation of pyrroline<br>References Wang, G., et al.: Tetrahedron Lett., 54, 6722 (2013); Belema, M., et al.: From U.S. Pat. Appl. Publ. (2012), US 20120195857 A1 20120802<br></p>

<p>Applications 4-Hydroxy-quinoline-6-carboxylic acid<br></p>

<p>Applications 4-Chloro-6,7-dimethoxyquinoline, can be used as an intermediate for the synthesis of various pharmaceutical and biologically active compounds. It is used for the preparation of Tivozanib (T447205), and Cabozantinib (C051500), acting as anticancer agents.<br>References Fu, Y., Zhongguo Xinyao Zazhi, 22, 26 (2013); Liu, M., Adv. Mat. Res., 396, 1490 (2012); Camp, R., et al.: Cancer, 86, 2259 (1999);<br></p>

<p>Applications An indolinone derivative used for the preparation of p38α inhibitors as potential antiinflammatories.<br>References Eastwood, P., et al.: Bioorg. Med. Chem. Lett., 21, 5270 (2011),<br></p>

<p>Applications An indole derivative used in synthesis of matrix metalloprotease inhibitors.<br>References Somei, M., et al.: Nat. Prod. Rep., 22, 73 (2005),<br></p>

<p>Applications Protected nucleoside.<br>References Elzein, E., et al.: Bioorg. Med. Chem. Lett., 17, 161 (2007), Franchetti, P., et al.: J. Med. Chem., 52, 2393 (2009),<br></p>

<p>Applications Indole derivative, as antiviral and antitumor agent.<br>References Borza, I., et al.: J. Med. Chem., 50, 901 (2007), Lefoix, M., et al.: Bioorg. Med. Chem., 16, 5303 (2008), Frost, J., et al.: J. Med. Chem., 51, 1904 (2008),<br></p>

<p>Applications 5-Amino-8-fluoroquinoline is an intermediate for organic synthesis. It functions as a reagent in the preparation of pyridoquinolinones and pyridoquinolinecarboxylates as bactericides.<br>References Lee, J. K., et al.: Bull. Korean Chem. Soc., 17, 90 (1996)<br></p>

<p>Applications 7-Chloro-3-isoquinolinemethanol is an intermediate in the preparation of pyrrolopyrimidinones as P2X3 receptor antagonists.<br>References Bayrakdarian, M., et al.: PCT Int. Appl. (2008), WO 2008136756 A1 20081113;<br></p>

<p>Applications 1-Hydroxyisoquinoline (cas# 491-30-5) is a compound useful in organic synthesis.<br></p>

<p>Applications m-Toluquinoline is a reagent used in the preparation of diarylmethylpiperazines as potent opioid receptor agonists with improved side effects. Also used in the preparation of novel pyrazine compounds derived from 2-phenylquinolin-7-yl which act as potent insulin-like growth factor-I receptor inhibitors.<br>References Plobeck, N. et al.: J. Med. Chem., 43, 3878 (2000); Mulvihill, M. et al.: Bioorg Med. Chem. Lett., 16, 1359 (2008);<br></p>

<p>Applications 2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine (cas# 16321-99-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,6-Dichloropurine-9-β-D-riboside (cas# 13276-52-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester is used in the synthesis of antibacterials.<br>References Phillips, O. et al.: Exp. Opin. Ther. Pat., 19, 529 (2009);<br></p>

<p>Applications 1-Ethyl-5-fluoroindoline-2,3-dione (cas# 776-47-6) is a useful research chemical.<br></p>

<p>Applications Tricyclohexylchlorotin is used as in the synthesis of organotin derivatives of 2-thiophene carboxylic acid as enzyme inhibitors and antibacterial agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Abbas, S. et al.: J. Organometal. Chem., 724, 255 (2003); Zia-ur-Rehman et al.: J. Coord. Chem., 65, 3238 (2012);<br></p>

<p>Applications 9-(Trimethylsilyl)-2,6-bis[(trimethylsilyl)oxy]-9H-purine is an intermediate used in the synthesis of Xanthosine-13C5 (X742102), which is the labeled analogue of Xanthosine (X742100), the deamination product of Guanosine. It is also a potential biomarker for detecting radiation exposure.<br>References Magasanik, B, et al.: J. Bio. Chem., 206, 83 (1954);<br></p>

<p>Applications 4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline-1,3-dione (cas# 5488-36-8) is a useful research chemical.<br></p>

<p>Applications 2-[(Dimethylamino)methyl]indole (cas# 3978-16-3) is a compound useful in organic synthesis.<br>References Inion, H., et al.: Eur. J. Med. Chem., 10, 276 (1975),<br></p>

<p>Applications 2-chloro-1-{1H,2H,3H,4H,5H-pyrido[4,3-b]indol-2-yl}ethan-1-one (cas# 1087784-16-4) is a useful research chemical.<br></p>

<p>Applications 4,4'-Dicyano-2,2'-bipyridine is a photosensitizers for solar fuel generation<br>References Mills, I. N., et al.: Polyhedron, 82, 104 (2014)<br></p>

<p>Stability Hygroscopic<br>Applications 3-Oxo-2,3-dihydro-1H-indazole-5-carboxylic acid (cas# 787580-93-2) is a useful research chemical.<br></p>

<p>Applications 2,3-dihydrobenzo[g]quinolin-4(1H)-one (cas# 21516-07-4) is a useful research chemical.<br></p>

<p>Applications 5-(2-Bromo-1-oxobutyl)-8-hydroxy-2(1H)-quinolinone is an intermediate in the synthesis of metabolites of procaterol hydrochloride (Meptin) (P155490), a β2-adrenergic agonist used in the treatment of asthma.<br>References Yoshizaki, S., et al.: Chem. Pharma. Bull., 26, 1611 (1978);<br></p>

<p>Applications 9,10-Phenanthrenequinone is used in the formation of spirophosphoranes containing acyclic 5-methyl-2-phenyl-2H-1,2,3-diazaphosphol-4-yl substituent.<br>References Mironov, V. F., et al.: Russ. J. Electrochem., 88, 430-438 (2018)<br></p>

<p>Applications 5-Nitro-1H-quinolin-2-one is used in the synthetic preparation of novel antileishmanial agents for Leishmania donovani promastigotes.<br>References Paloque, L., et al.: Europ. J. Med. Chem., 54, 75 (2012);<br></p>

<p>Applications Ethyl 2-Aminoindole-3-carboxylate (cas# 6433-72-3) is a compound useful in organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications 2-AMINO-1,2,3,4-TETRAHYDROISOQUINOLINE-1,3-DIONE (cas# 22177-46-4) is a useful research chemical.<br></p>

<p>Applications 2-Deuteroindole is a useful reagent in the preparation of deuterated labeled indoles.<br>References Lautie, M. F., et al.: J. Label. Compd. Radiopharm., 16, 735 (1979); Ibaceta-Lizana, J. S. L., et al.: J. Chem. Soc. Perkin Trans 2., 9, 1221 (1987)<br></p>

<p>Applications N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide is used in synthesis of an antitumor agent, neratinib (N390090).<br>References Zhang, P., et al.: Zhongguo Yaowu Huaxue Zazhi, 18, 355 (2008);<br></p>

<p>Applications 2-amino-N-(quinolin-8-yl)acetamide (cas# 587832-36-8) is a useful research chemical.<br></p>

<p>Applications 2,5-Dimethyl-2,3-dihydro-1H-indole (cas# 90874-56-9) is a useful research chemical.<br></p>

<p>Applications 2,2'-Bipyridine-4,4'-dicarboxamide<br></p>

<p>Applications 5-Aminotricyclo[3.3.1.13,7]decane-1,3-diol is an intermediate used in the synthesis of Hydroxy Vildagliptin (V305035), which is an impurity of Vildagliptin (V305000). Vildagliptin is a DPP-​4 enzyme inhibitor, has anti-oxidant properties and used as an apoptotic agent on pancreatic cancer . Vildagliptin is used to treat type 2 diabetes mellitus (T2DM) and improve the endothelial function of patients.<br>References Amritha, C.A., et al.: J. Clin. Diagn. Res., 9, FC14 (2015); Cosenso-Martin, L.N., et al.: Diabetol. Metab. Syndr., 7, 70/1 (2015)<br></p>

<p>Applications 2,6-Diazaspiro[3.3]heptane-2-carboxylic Acid tert-Butyl Ester Hemioxylate is preparation of pyrimidine derivatives and related heterocycles as CDK inhibitors for treatment of diseases.<br>References Katamreddy, S. R., et al.: PCT Int. Appl. (2020), WO 2020140055 A1<br></p>

<p>Applications tert-​Butyl 5-​(4,​4,​5,​5-​tetramethyl-​1,​3,​2-​dioxaborolan-​2-​yl)​isoindoline-​2-​carboxylate is a reactant in the synthesis of tyrosine kinase inhibitors in the treatment of proliferative diseases.<br>References WO Patent 2014089324 (2014); CN 104016979 (2014);<br></p>