Composés polycycliques

<p>4-Methylindole is an anthranilic acid derivative that inhibits the polymerase chain reaction (PCR) by binding to the polymerase and preventing DNA replication. 4-Methylindole has been shown to inhibit the production of human liver proteins in vitro, but its effects on other tissues have not been determined. 4-Methylindole is a low toxicity compound that is metabolized by hydrolysis, which can be reversed with acid or base. It also binds to and irreversibly oxidizes human protein, which may be due to its reversible oxidation properties. This chemical has been found in capsicum annuum, which produces it as a natural defense against herbivores.</p>

<p>5-Chloroindole-3-acetonitrile is a chemical compound that can be used as a reaction component, reagent, or useful scaffold in the synthesis of complex compounds. 5-Chloroindole-3-acetonitrile is also a fine chemical with many uses as a high quality research chemical and versatile building block. It is commercially available from various suppliers and its CAS number is 81630-83-3.</p>

<p>Isomeric 4-methylisoquinoline is a molecule that is structurally similar to protopine and berberine chloride. It has been shown to be an effective photosensitizer for the production of reactive oxygen species (ROS) in cells, which can lead to DNA damage and cell death. The functional groups on this molecule are the chloro group, which is a halogen, and the isoquinoline ring system with two methyl groups. The chemistry of this compound involves alkylation, yielding a new compound with one less methyl group than the original molecule. This process is called enamine formation.</p>

<p>2-Phenyl-quinoline is a naturally occurring compound that exhibits antimicrobial activity. It has been shown to inhibit the growth of bacteria by interfering with the synthesis of ATP, which is necessary for bacterial cell division. 2-Phenyl-quinoline also possesses antioxidative properties and has been shown to have inhibitory effects on a number of bacterial strains. 2-Phenyl-quinoline has been shown to induce necrotic cell death in S. aureus strains, as well as anti-inflammatory and antinociceptive properties.</p>

<p>Xanthine is a reactive, oxidized form of purine. It is found in the human body as a product of xanthine oxidase (XO) metabolism of xanthine and hypoxanthine. Xanthine is known to have antioxidant properties and has been shown to inhibit the activity of xanthine oxidase in vitro. Xanthine, when combined with other anticancer drugs such as doxorubicin, can be used as an anticancer agent. This drug has been shown to cause oxidative injury in humans and animal models at physiological levels.</p>

<p>1-Methylindole-6-carboxylic acid is a versatile building block that is used in the synthesis of more complex compounds. It can be used as a reagent, speciality chemical, and useful building block for pharmaceuticals and other research chemicals. 1-Methylindole-6-carboxylic acid has been shown to be an effective intermediate for the production of a number of different compounds. The compound can also act as a reaction component or scaffold for chemical reactions.</p>

<p>Dichloro[9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene]palladium(II) is a fine chemical that can be used as a building block in the synthesis of compounds with diverse structures. It is a research chemical and reagent that has been found to be useful in the synthesis of complex organic compounds. This compound is also versatile enough to be used as an intermediate or scaffold in the synthesis of many different types of organic compounds.</p>

<p>5-Acetoxy-6-methoxyindole is a fine chemical, useful building block, and research chemical with CAS No. 112919-69-4. It is a versatile building block and reaction component that can be used as a reagent or speciality chemical in the synthesis of other complex compounds. 5-Acetoxy-6-methoxyindole is also used as an intermediate in the synthesis of drugs and pharmaceuticals. This compound has high purity, making it a high quality product with many uses.</p>

<p>Acridone is a potent antimicrobial agent that inhibits bacteria by binding to the duplex DNA. Acridone has been shown to have inhibitory properties against wastewater treatment, which may be due to its ability to bind with the bacterial dna and inhibit the replication of bacterial cells. Acridone also has genotoxic activity, as it has been shown to react with nuclei in carcinoma cell lines and cause DNA strand breakage. Acridone is a fluorescent probe that can be used for electrochemical impedance spectroscopy (EIS). It binds to the complementary sequence of double-stranded DNA and causes an increase in the impedance of a solution when exposed to an electric current. This property can be used for analytical methods such as gel electrophoresis or chromatography.</p>

<p>Please enquire for more information about 2-[(3-Phenoxyphenyl)methylene]-2H-1,4-benzothiazin-3(4H)-one including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 5-methyl-3-(phenylmethylthio)-1,2,4-triazino[5,6-b]indole including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 5-methyl-3-methylthio-1,2,4-triazino[5,6-b]indole including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 3-(3,4,5-Trimethoxybenzoylhydrazidyl)-2-oxoindoline including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 3-(4-phenoxyphenyl)spiro[1,3-thiazolidine-2,3'-indoline]-4,7-dione including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 3-(2-(4-Bromophenyl)-6,6-dimethyl-4-oxo-5,6,7-trihydroindolyl)benzoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 3-((4-Methoxyphenyl)methylene)-1,4-dihydro-4-thiaquinolin-2-one including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 3-(4-Bromophenyl)-5-(hydroxyimino)-7,7-dimethyl-6,7,8-trihydrocinnoline including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 4-(2,6,6-Trimethyl-4-oxo-5,6,7-trihydroindolyl)benzoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 1-(2-Chloropropanoyl)indoline including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2-Oxoindoline-3-hydrazone (2OIH) is a heterocyclic compound that has been reported to have anticancer activity. 2OIH is an intramolecular hydrogen bond acceptor, which may account for its anticancer activity. It has been shown to be effective against cancer cells in mammalian cell lines and in vitro studies of human carcinoma cell lines. This compound also showed anticancer activity against bacteria such as Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus). The geometric isomers of 2OIH have been studied using nmr spectra, and the carbonyl group has been identified as the source of its anti-cancer properties. Structural analysis has revealed that the hydroxyl group on the indole moiety is important for the anti-cancer properties of this molecule.</p>

<p>Please enquire for more information about Ethyl 4-oxo-7-(benzyloxy)hydroquinoline-3-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>5-Iodoisatin is a cross-coupling agent that has an inhibitory effect on tumor tissue. It is also used for the synthesis of conjugated drugs and pharmacological research. 5-Iodoisatin, which forms a ternary complex with copper and iodide, inhibits the growth of colorectal carcinoma cells by interfering with their DNA replication and protein production. 5-Iodoisatin can be converted to its active form through the formation of a ternary complex with copper and iodide ions. This inhibition is due to its ability to interact with DNA, RNA polymerase, and other proteins involved in transcription, translation, and replication processes. 5-Iodoisatin is metabolized through conjugation with glucuronic acid or sulfate in the liver; it binds to human mitochondrial DNA and can enter cells via passive diffusion. The carbonyl group in this drug may play an important role in its interaction with cancer cells.</p>

<p>Please enquire for more information about 2,10-diaza-5,5,13-trimethyl-9-(4-(isopropyl)phenyl)tricyclo[9.4.0.0&lt;3,8&gt;]pentadeca-1(11),3(8),12,14-tetraen-7-one including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Decursidin is a chemical compound, classified as a coumarin derivative, which is a bioactive constituent derived from the roots of the Angelica gigas plant. This compound is prominent for its pharmacological activities, attributed to its distinct chemical structure.</p>

<p>Please enquire for more information about 4-(2-(4-Bromophenyl)-6,6-dimethyl-4-oxo-5,6,7-trihydroindolyl)benzoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 3-(2,6,6-Trimethyl-4-oxo-5,6,7-trihydroindolyl)propanoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1-Methylisatin, 3-thiosemicarbazide (MTST) is an antimicrobial agent that has been shown to be effective against a broad range of microorganisms. MTST inhibits the growth of bacteria and fungi by binding to the fatty acid moieties of membrane lipids, which disrupts the integrity of the cell membrane. This disruption can lead to bacterial death. MTST also has antiviral properties that are due to its ability to inhibit virus replication by binding with receptor binding sites on the virus surface. 1-Methylisatin, 3-thiosemicarbazide has been shown to be an effective treatment for autoimmune diseases such as multiple sclerosis and rheumatoid arthritis in animal models.</p>

<p>Applications 2-amino-N-(quinolin-8-yl)acetamide (cas# 587832-36-8) is a useful research chemical.<br></p>

<p>Stability Store under Argon<br>Applications 3,6-Thioxanthenediamine-10,10-dioxide (cas# 10215-25-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Chloro-1-hydroxy-7-isoquinolinesulfonyl Chloride (cas# 223671-81-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL)ACETIC ACID (cas# 61164-71-4) is a useful research chemical.<br></p>

<p>Applications (2R,3aR,7aR)-Octahydroindole-2-carboxylic Acid Hydrochloride is an intermediate in the synthesis of Perindoprilat (P287530), an angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive.<br>References Vincent, M., et al.: Drug Design Disc., 9, 11 (1992), Pascard, C., et al.: J. Med. Chem., 34, 663 (1991)<br></p>

<p>Stability Light Sensitive<br>Applications Reacts with aldehydes to produce highly fluorescent imidazole derivatives. A fluorometric labeling reagent.<br></p>

<p>Applications (2R,3aS,7aS)-Octahydroindole-2-carboxylic Acid Hydrochloride is an intermediate in the synthesis of Perindoprilat (P287530), an angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive.<br>References Vincent, M., et al.: Drug Design Disc., 9, 11 (1992), Pascard, C., et al.: J. Med. Chem., 34, 663 (1991)<br></p>

<p>Applications 2-tert-Butyl-1H-indole (cas# 1805-65-8) is a useful research chemical.<br></p>

<p>Applications (Z)-9-(2-Propen-1-ylidene)-2-(trifluoromethyl)-9H-thioxanthene is an intermediate used in the synthesis of (E/Z)-Flupentixol-d4 Dihydrochloride (F597982), which is a neuroleptic agent related structurally to thiothixene. Antipsychotic; neuroleptic agent; dopamine receptor antagonist.<br>References Nielsen, et al.: Acta Pharmacol. Toxicol., 32, 363 (1973), Post, M.L., et al.: Nature, 256, 342 (1975), Peuch, et al.: Neuropharmacology, 20, 1279 (1981),<br></p>

<p>Applications 4-Fluoro-7-azaindole (cas# 640735-23-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Chloro-5-isoquinolinesulfonic Acid (cas# 105627-80-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Azabicyclo[2.2.2]octan-3-one (cas# 3306-69-2) is a useful research chemical.<br></p>

<p>Applications Protected nucleoside.<br>References Elzein, E., et al.: Bioorg. Med. Chem. Lett., 17, 161 (2007), Franchetti, P., et al.: J. Med. Chem., 52, 2393 (2009),<br></p>

<p>Applications 7-Bromo-2,3-dihydro-1H-indole is a compound useful in organic synthesis.<br></p>

<p>Applications Indole derivative with anticancer activity.<br>References Lavrenov, S. et al.: Bioorgan. Med. Chem. 18, 6905 (2010)<br></p>