Composés polycycliques

<p>N-Acetylimidazole is a drug that belongs to the class of glycol esters. It is an inhibitor of the enzyme acetylcholinesterase and has been used in the treatment of autoimmune diseases, such as myasthenia gravis. N-Acetylimidazole can inhibit the activity of other enzymes, such as p-nitrophenyl phosphate oxidase, which may be responsible for its anti-inflammatory properties. This drug has been shown to inhibit microbial growth in vitro by inhibiting the synthesis of choline and acetylcholine in the body. N-Acetylimidazole also inhibits bacterial growth by acting as a substrate molecule for bacterial enzymes that catalyze transfer reactions, including phosphotransferases and hydrolases.</p>

<p>Selinidin is a phytochemical compound, which is derived from the natural source of the Brunsvigia bosmaniae plant. As a bioactive constituent of this plant, it is characterized by its unique structure and chemical properties, enabling it to interact with a variety of cellular targets, primarily through modulation of inflammatory pathways. The mode of action of Selinidin involves the inhibition of pro-inflammatory cytokines and mediators, thereby reducing inflammation and oxidative stress at the cellular level.</p>

<p>2-Hydroxyquinoline-4-carboxylic acid is a carboxylate that is structurally classified as a multidrug. It has been shown to inhibit bacterial efflux pumps and target enzymes, such as cancer cells and multidrug resistant bacteria. 2-Hydroxyquinoline-4-carboxylic acid also has potent antibacterial activity against Streptococcus faecalis, an opportunistic pathogen that causes infections in the urinary tract and on skin wounds. The fluorescence properties of this compound can be used for fluorescent labeling of biomolecules or for sensing applications.</p>

<p>Please enquire for more information about 3-{[(3,4-Dichlorophenyl)amino]carbonyl}bicyclo[2.2.1]hept-5-ene-2-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1,2,3,4,5,6-Hexahydro-1,5-methano-pyrido-[1,2-a][1,5]diazocin-8-one is a cholinergic drug that is used as a research tool in vitro. It has been shown to increase the concentration of acetylcholine in the synapse. It is also known as cytisine and varenicline. 1,2,3,4,5,6-Hexahydro-1,5-methano-pyrido-[1,2-a][1,5]diazocin-8-one binds to nicotinic receptors and stimulates them. This increased activity of nicotinic receptors leads to the release of acetylcholine (ACh), which is an important neurotransmitter in the brain. 1,2,3,4 5 6 hexahydro - 1 5</p>

<p>3-Bromoquinoline is a brominated quinoline derivative that can be synthesized by cross-coupling reactions. The compound's chemical structure is similar to the 3-azidoquinoline, which was studied in quantum theory and molecular modeling. The 3-bromoquinoline molecule has been shown to exist in two different coordination geometries: octahedral and trigonal bipyramidal. In the octahedral geometry, the 3-bromoquinoline molecule is bound to three bromine atoms and one nitrogen atom, with an intramolecular hydrogen bond between the nitrogen atom and the quinoline ring system. The trigonal bipyramidal geometry also features an intramolecular hydrogen bond between the nitrogen atom and quinoline ring system, as well as a halogen bonding interaction with one of the three bromine atoms.</p>

<p>Please enquire for more information about Calipteryxin including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Oxypeucedanin methanolate is a naturally occurring furanocoumarin, which is a type of organic compound found predominantly in several citrus plants. This compound is derived from the peels and essential oils of these plants, highlighting its botanical source that is rich in phytochemicals.</p>

<p>1,2-Dihydrobenzene (1,2-DH) is a molecule that has the chemical formula C6H6. It is a colorless liquid with boiling point of 147°C and melting point of -11°C. 1,2-DH has been shown to form hydrogen bonds with water molecules. This compound is also insoluble in water, which may be due to its dehydrating properties. When catalyzed by an acid or base, 1,2-DH undergoes dehydration reactions. Acidic or basic conditions are required for this reaction to occur and the resulting product can be determined by x-ray diffraction studies. 1,2-DH has been shown to form coordination complexes with metal ions such as copper (Cu) and zinc (Zn). These complexes have been shown to have ligand binding properties that lead to supramolecular structures. Intermolecular hydrogen bonding interactions between 1,2-DH molecules have also been observed during</p>

<p>Please enquire for more information about 2,3,4,5-Tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Methyl 3-formyl-4,6-dimethoxy-1-methyl-1H-indole-2-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Daphnetin-8-methyl ether is a naturally derived coumarin compound, which is predominantly sourced from the Daphne genus of plants, among other botanical species known for their therapeutic potential. This compound is recognized for its biochemical interaction with key cellular pathways, particularly through the modulation of enzymes and receptors associated with inflammatory and oxidative stress responses.</p>

<p>Please enquire for more information about 1-(2-Methoxyethyl)-1H-indole-3-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1,1'-Dimethyl-4,4'-bipyridinium dichloride hydrate is a bipyridine with a divalent chloride. It has been shown to have synergic effects in the presence of dextran sulfate and paraquat. This compound has good photochemical properties, which are used for wastewater treatment and surface methodology. 1,1'-Dimethyl-4,4'-bipyridinium dichloride hydrate also has toxicological studies that show it does not cause any cellular toxicity or mitochondrial membrane potential changes. It also reduces potassium dichromate toxicity in glomerular filtration rate studies. This compound can be used as an analytical method for other bipyridines.</p>

<p>1H-Cyclopenta[l]phenanthrene is a five-membered cyclic hydrocarbon that binds to phosphine and is used in the synthesis of ferrocenes. It is also unsymmetrical and anion-forming. 1H-Cyclopenta[l]phenanthrene can be protonated at carbon, which makes it a good ligand. 1H-Cyclopenta[l]phenanthrene has been shown to react with carbonyls, imines, and ethylene to form organometallic complexes.</p>

<p>Please enquire for more information about 7-Azaspiro[4.5]decane including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Umbelliprenin is a naturally occurring prenylated coumarin, which is primarily isolated from plants in the Apiaceae family. These plants are rich sources of various biologically active compounds. The mode of action of umbelliprenin is attributed to its ability to modulate multiple cellular pathways, including apoptosis and cell cycle arrest. This modulation is largely due to its interaction with reactive oxygen species and various signaling molecules within the cell.</p>

<p>Please enquire for more information about 5-Bromo-3-chloro-1H-indazole including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Oxypeucedanin hydrate is a natural furanocoumarin compound, which is derived from various plant sources, such as citrus fruits and members of the Apiaceae family. As a secondary metabolite, it plays a role in plant defense mechanisms against herbivores and pathogens.</p>

<p>Please enquire for more information about 3-(Bromomethyl)-1-methyl-1H-indazole including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>7-Methylquinoline is an organic compound that can be used to synthesize antimalarial drugs. It is a quinoline derivative with a methyl group at the 7th position. The structure of 7-methylquinoline contains a nitrogen atom and hydrogen atoms, which are bonded to fluorine, chlorine, and bromine atoms. This molecule has been shown to be stable in the presence of Friedel-Crafts catalysts and chloride ions. The reaction mechanism for 7-methylquinoline is intramolecular hydrogen transfer from the chloroform molecule to the quinoline ring system. The formation rate for this compound is slow because it requires two steps: nucleophilic substitution and electrophilic addition reactions.</p>

<p>Please enquire for more information about Ethyl 3-{[(1E)-(dimethylamino)methylene]amino}-5-methoxy-1-methyl-1H-indole-2-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>4,7-Dihydroxy-1,10-phenanthroline is an organometallic compound that has been shown to inhibit the growth of tumour cells. It is a protonated molecule and can be classified as a reactive intermediate. The reaction mechanism for this intermediate is nucleophilic attack by the hydroxy group on the carbon atom adjacent to the aromatic ring. This results in the formation of a cationic intermediate, which undergoes protonation to form the final product. 4,7-Dihydroxy-1,10-phenanthroline has been found to have anti-tumor effects against l1210 murine leukemia cell lines.</p>

<p>Please enquire for more information about 7-Benzyl-1H-Purine-2,6(3H,7H)-Dione including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Ethyl 5-fluoroindole-2-carboxylate is a cytotoxic compound that belongs to the class of organic compounds called aryl rings. It has been shown to inhibit tumor growth in vitro and in vivo through the inhibition of protein synthesis. The molecular docking studies have shown that this compound binds to the enzyme SMMC-7721 cell, which is involved in DNA transcription and replication. It also inhibits activity of other enzymes, such as kinases and phosphatases, which are involved in cellular processes such as proliferation and differentiation. Ethyl 5-fluoroindole-2-carboxylate may be used for the treatment of blood cancer or monosugar diseases, such as diabetes mellitus or hyperlipidemia.</p>

<p>3-Acetyl-5-hydroxymethyl-7-hydroxycoumarin is a synthetic coumarin derivative, which is a class of organic compounds often found in natural products. These compounds are derived from plant sources and are known for their significant biochemical effects and aromatic properties. The mode of action of 3-Acetyl-5-hydroxymethyl-7-hydroxycoumarin involves interactions at the molecular level, where it can exhibit various biological activities, such as antioxidant and antimicrobial effects. Due to the hydroxyl and acetyl functional groups present, it can participate in redox reactions and binding interactions, affecting biochemical pathways.</p>

<p>3-Isoquinolinecarboxylic acid is a molecule with a reactive group that can form cyclic structures. It has been shown that 3-Isoquinolinecarboxylic acid is an apoptotic agent in human macrophages and induces the release of picolinic acid from these cells. This molecule also has a high affinity for α7 nicotinic acetylcholine receptors, which are present on the surface of nerve cells. 3-Isoquinolinecarboxylic acid can be synthesized by condensing picolinic acid, an aromatic aminoacid, with an appropriate amine. The synthesis of this heterocycle is catalyzed by an enzyme called quinolinate synthase. The product of this reaction is oxidized to form 3-isoquinolyl carboxylic acid. The final step in the synthesis involves the oxidative cleavage of a disulfide bond using hydrogen peroxide, yielding 3-isoquinoly</p>

<p>1,3-Diethyl-8-phenylxanthine is a p2y receptor antagonist that inhibits bacterial growth by interfering with the energy metabolism of the cell. It is an analytical reagent that can be used to measure specific DNA sequences and has been shown to have genotoxic effects on cultured human cells. 1,3-Diethyl-8-phenylxanthine has also been shown to inhibit the growth of infectious bacteria such as staphylococcus aureus and Mycobacterium tuberculosis in vitro. This compound may be used as a potential biomarker for the identification of antimicrobial peptides that are active against Mycobacterium tuberculosis in humans.</p>

<p>4-Bromoisoquinoline is an aryl halide that can be used in the cross-coupling reaction with other aryl halides. It has been shown to have anticancer activity and to inhibit the growth of tumour cell lines in vitro. This compound is also efficient for inhibiting leukemia cells. 4-Bromoisoquinoline has been shown to have an inhibitory effect on cancer cells through the inhibition of DNA synthesis and RNA transcription, as well as by inducing apoptosis. The mechanism of action may be due to its ability to bind to aromatic hydrocarbons and halides, which leads to thermodynamic changes and vibrational energy transfer.</p>

<p>Please enquire for more information about 4-Aminobicyclo[2.2.2]octan-1-ol hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2-Iodo-1H-imidazole is an asymmetric molecule that is synthesized by a Suzuki coupling reaction between malonic acid and tautomers of 2-iodo-1H-imidazole. This molecule inhibits the activity of inhibitor molecules, such as nitrogen atoms, which are used in pesticide production. It also has pesticidal activity and can be used to treat cancer or autoimmune diseases. 2-Iodo-1H-imidazole is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid.</p>

<p>Praeruptorin E is a natural furanocoumarin, which is derived from the roots of Peucedanum praeruptorum, a plant commonly used in traditional Chinese medicine. As a bioactive compound, Praeruptorin E exhibits significant pharmacological activities, particularly in cardiovascular, anti-inflammatory, and cytoprotective domains.</p>

<p>Please enquire for more information about 2-Oxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(2R)-1-[2-[(3-Hydroxytricyclo[3.3.1.1(3,7)]dec-1-yl)amino]acetyl]-2-pyrrolidinecarbonitrile is a drug that belongs to the class of DPP-IV inhibitors and is used for the treatment of type 2 diabetes mellitus. It has been shown to be effective in reducing postprandial blood glucose levels in patients with type 2 diabetes mellitus. The mechanism of action of this drug is not fully understood, but it may have an effect on insulin release from pancreatic beta cells and/or inhibition of gastric emptying or intestinal absorption of glucose. This drug has been shown to reduce tubulointerstitial injury in diabetic rats and can be used as a combination therapy for type 2 diabetes mellitus. There are no known clinically relevant interactions between (2R)-1-[2-[(3-Hydroxytricyclo</p>

<p>cis-Isokhellactone is a bioactive compound that belongs to the class of sesquiterpene lactones, which is isolated from plants in the genus Khella. With a well-characterized molecular structure, this compound exhibits significant binding affinity for cellular targets that are crucial in the regulation of cell proliferation and apoptosis. The mode of action involves the modulation of signaling pathways involved in cell cycle regulation and the induction of apoptosis in neoplastic cells.</p>

<p>Tert-butyl(8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate (tBAA) is a heterocycle that has been modified to enhance its pharmacokinetic properties. Tert-butyl(8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate was designed to be metabolically stable and have a high bioavailability and isosteric properties with phosphatidylinositol, which it uses as a substrate in the catalytic cycle. This modification also increased tBAA's stability in vivo, leading to an increase in efficacy. The covalent attachment of the phenyl ring on the tertiary amine nitrogen of tBAA provides additional protection against hepatic metabolism by CYP450 enzymes, making it more potent than other compounds with similar structures that are not covalently attached to the amine group.</p>

<p>Pranferol is a phytochemical compound, which is derived from natural plant sources. It possesses unique immunomodulatory properties, affecting cellular pathways that regulate immune responses. The bioactive components in Pranferol interact with specific receptors on immune cells, modulating signaling cascades and gene expression to enhance or suppress specific immune functions depending on the physiological context.</p>

<p>4-Amino-3-bromoisoquinoline is an isocyanide that reacts with nucleophilic heteroatoms such as the amino group. It also reacts with bromine to form a bromopyridine. The nitrile group of 4-amino-3-bromoisoquinoline can be reduced with sodium borohydride to produce 4-aminoquinoline. This compound has shown potential for use in chemotherapy and treating bacterial infections.</p>

<p>Please enquire for more information about 2,3-Dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 4-(Methoxycarbonyl)bicyclo[2.1.1]hexane-1-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2-Hydroxy-4-methylquinoline is an organic compound that has a chelate ring. It is soluble in deionized water and reacts with metal ions to form a fluorescent product. The molecule also has antibacterial activity, which may be due to its ability to inhibit the growth of bacteria by acting as a metal ion chelator. 2-Hydroxy-4-methylquinoline can react with halides and ammonium persulfate to form isomeric products, such as 4,5-dihydroxyquinoline, which have been shown to have antimicrobial properties. 2-Hydroxy-4-methylquinoline can also react with phosphorus oxychloride and alkylating agents such as chloroethane or chloroform to form substituted derivatives.</p>

<p>5-Nitrosoquinolin-8-ol is a chemical inhibitor that can be used in the study of enzyme function. It reacts with the active site of the enzymes and prevents them from carrying out their normal functions. 5-Nitrosoquinolin-8-ol has been shown to inhibit the growth of cancer cells and to have antiinflammatory properties. 5-Nitrosoquinolin-8-ol has been shown to bind to sephadex G-100 and potassium dichromate, which are both types of ion exchangers. The redox potential for this compound is -0.84 V. This means it will not react easily with other compounds, which makes it a good candidate for use as an inhibitor in biochemical studies. The nitrogen atoms in this compound are reactive, which means they can form covalent bonds with other molecules in a reaction called nitrosation. Structural biology is a branch of science that deals with studying the three dimensional structure of biological mac</p>

<p>Please enquire for more information about 1-Benzyl-5-ethoxy-1H-indole-3-carbaldehyde including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>7-Geranyloxycoumarin is a naturally occurring coumarin derivative, which is primarily sourced from plant species in the Rutaceae family. It is a bioactive compound known for its presence in various essential oils and its contribution to the properties of these plant extracts. The mode of action of 7-Geranyloxycoumarin involves interactions at the cellular level, including enzyme inhibition and modulation of signal transduction pathways, which can lead to diverse pharmacological effects.</p>

<p>Please enquire for more information about 9-[(5-Amino-1,3,4-thiadiazol-2-yl)methyl]-1,3-dimethyl-3,9-dihydro-1H-purine-2,6-dione including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>8-Bromo-2-methylquinoline is a naphthalene derivative that has an oxidant function. It can be used as a solvent for chlorobenzene and as a catalyst for the production of bipyridines and piperazine. 8-Bromo-2-methylquinoline is also used as a ligand in the preparation of metal complexes. This compound reacts with methyl groups, chlorine, and halides to form methyl quinolines and dichloromethanes. 8-Bromo-2-methylquinoline may react with fatty acids to form polyunsaturated acid esters or with polyunsaturated fatty acids to form polyethers.</p>

<p>1,2,3,4-Tetrahydro-4,8-dihydroxy-2-methyl-isoquinoline is a chemical compound that has been used as an intermediate in the synthesis of pharmaceuticals. It is also a useful building block for the production of other chemicals. This compound is soluble in water. 1,2,3,4-Tetrahydro-4,8-dihydroxy-2-methyl-isoquinoline has shown to be a versatile and high quality reagent with many research applications.</p>

<p>3-Hydroxyisoquinoline is a non-nucleoside inhibitor of cyclic nucleotide phosphodiesterase (cNMP) that is used in the treatment of nervous system diseases. 3-Hydroxyisoquinoline has been shown to have an inhibitory effect on cyclic nucleotide phosphodiesterase and can be used for the treatment of neurological disorders such as Parkinson’s disease, Alzheimer’s disease, and epilepsy. It also has anti-inflammatory properties and can be used to treat pain. 3-Hydroxyisoquinoline has a photoelectron spectrum that peaks at 5.6 eV, with a strong absorption band at 2.1 eV due to hydrogen bonding. This compound is also able to absorb radiation in the form of light emission with an emission peak at 4.8 eV, with a maximum intensity around 830 nm and a half-life of 0.2 s. 3-Hydroxyisoquinoline is able to</p>

<p>4-Hydroxy-3-nitro-2(1H)-quinolinone is a quinoline derivative that has been shown to have anticancer activity against cancer cells. It can be used for the treatment of various types of cancer, including lung cancer, breast cancer, and colon cancer. This drug inhibits the growth of cancer cells by blocking the cycle at the G1 phase and inducing apoptosis. It also disrupts mitochondrial membrane potential, leading to an increase in reactive oxygen species and DNA damage. 4-Hydroxy-3-nitro-2(1H)-quinolinone is an epidermal growth factor receptor (EGFR) antagonist and blocks epidermal growth factor signaling through its inhibition of EGFR tyrosine kinase activity. It also downregulates TNFα expression in tumor cells by inhibiting NFκB activation.</p>

<p>The bicyclo[2.2.1]hept-2-ylethanone is an isomer of the bicyclo[2.2.1]heptane, with a ketone group in place of a methylene group on one ring. It is a mixture of two isomers: the cis and trans form, which are in equilibrium with each other at room temperature. The equilibrium constants for this reaction are Kcis = 6.6×10 and Ktrans = 1.4×10 at 25°C and pH 7, respectively, which means that the trans isomer predominates at low concentrations and the cis form predominates at high concentrations.</p>