Composés polycycliques

<p>1,1'-Carbonimidoylbis-1H-imidazole is a ligand that binds to amines and isosteres. It can be activated with electrophilic reagents to form an activated linker. This ligand has been shown to inhibit the growth of xenograft tumor cells in mice by binding to functional groups on the cell surface. This drug also has been shown to bind to the receptor for advanced glycation end products (RAGE) and inhibit its function. 1,1'-Carbonimidoylbis-1H-imidazole has also been evaluated as a cancer therapeutic agent in animal models.</p>

<p>6-Chloro-2-fluoropurine is an analytical reagent with a monoclonal antibody that binds to the nucleic acid of HL-60 cells and can be used for optical analysis. 6-Chloro-2-fluoropurine has been shown to have significant cytotoxicity against HL-60 cells, which may be due to its ability to bind to intracellular targets. 6-Chloro-2-fluoropurine has also been shown to inhibit the growth of HL-60 cells in a fluorescein angiography study and is used as a diagnostic agent for diagnosis of cancer.</p>

<p>6-Bromo-1-methylindazole is an industrial chemical that can be synthesized by the reaction of formate, methanol, and indazole. The synthesis method involves the esterification of methyl formate with indazole to produce 6-bromo-1-methylindazole. It can also be synthesized by the annulation of methyl formate and cyclopentadiene followed by hydrolysis. This chemical has several isomers that are distinguished from each other based on their synthesis methods. 6-Bromo-1-methylindazole has been shown to have a hydrolysis reaction when it reacts with water, producing methyl bromide and hydrogen bromide.</p>

<p>Please enquire for more information about Oxindole-4-boronic acid, pinacol ester including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1,4-Diazabicyclo[2.2.2]octane bis(sulfur dioxide) adduct is a catalyst that can be used for the reduction of various functional groups. It is typically used to synthesize aziridines from amines and diazo compounds, or from halides and organometallic reagents. 1,4-Diazabicyclo[2.2.2]octane bis(sulfur dioxide) adduct has been shown to inhibit the production of sulfoxides by sulfide-reducing bacteria such as Desulfovibrio desulfuricans and Desulfobulbus propionicus.</p>

<p>Please enquire for more information about [4,4'-Di-t-butyl-2,2'-bipyridine][bis[5-(t-butyl)-2-[4-(t-butyl)-2-pyridinyl-kN]phenyl-kC]iridium(III) hexafluorophosphate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2,2'-Biquinoline is a coordination compound that has been used as an analytical reagent in the determination of copper and nitrogen. It has been shown to be stable in a variety of matrices, including human serum and copper chloride. 2,2'-Biquinoline is also used as an antimicrobial agent against Gram-positive bacteria, including Staphylococcus aureus. The redox potentials of this compound are dependent on the number of nitrogen atoms present.</p>

<p>Please enquire for more information about 2-Boc-2,9-Diazaspiro[5.5]undecane hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>7-Chloro-4-piperazinylquinoline is a quinoline derivative that belongs to the group of organic solvents. It has anticancer activity and is used as a medicine. 7-Chloro-4-piperazinylquinoline is used as an intermediate in the preparation of sorafenib, which is a potent inhibitor of the protein tyrosine kinase. Sorafenib inhibits cancer cell proliferation and tumor growth by blocking the activity of tyrosine kinases, which are necessary for cellular proliferation and survival. It also inhibits phospholipase A2, which leads to cell death by apoptosis.</p>

<p>4-Chloro-6-methoxyquinoline is an inhibitor of bacterial DNA gyrase. It has antibacterial activity against Gram-positive and Gram-negative bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Pseudomonas aeruginosa. 4-Chloro-6-methoxyquinoline is a synthetic compound that was reinvestigated for its antibacterial activity. It has been shown to be effective in the treatment of Staphylococcal infections. The mechanism of action may involve inhibition of topoisomerase II or interference with the synthesis of DNA by binding to the enzyme bacterial DNA gyrase. Quinidine and cinchonidine are quinine derivatives that have been found to inhibit bacterial DNA gyrase. These compounds are found in the bark of Cinchona species, which includes Cinchona ledgeriana, Cinchona officinalis, and Cinchona succirub</p>

<p>Please enquire for more information about tert-Butyl 4,7-diazaspiro[2.5]octane-4-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2-Chloro-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide is a carboxamide analog of dibucaine. It is synthesized from chloroacetyl chloride and isatin in the presence of sodium hydroxide. The synthesis has been scaled to an industrial level. 2-Chloro-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide has been shown to have analgesic properties, similar to those of dibucaine. Radiolysis of this compound gives a carboxylic acid and a heterocyclic ring product.</p>

<p>8-Hydroxyquinoline is a sweet, water soluble, and heat stable inhibitor that has been used in the treatment of kidney disease. 8-Hydoxyquinoline has been shown to inhibit the growth of the rootstock Asiaticus by interfering with cell metabolism. It is also an insecticide that kills insects by causing damage to their cells. 8-Hydoxyquinoline inhibits polymerase chain reaction (PCR) by binding to DNA polymerase, blocking its activity and reducing its ability to synthesize DNA. This drug is also a potent blocker of angiotensinogen synthesis, which leads to reduced blood pressure levels.</p>

<p>Please enquire for more information about 8-[(1E)-2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-3,9-dihydro-1H-purine-2,6-dione including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>4-Acetylimidazole is a histidine analogue that has been shown to have anticancer activity in breast cancer cells. It can react with amines and form imidazoles. The hydroxyl group on the 4-position of the imidazole ring is able to undergo dehydration, which leads to the formation of a chloride ion. This reaction mechanism is reversible and can be used in organic synthesis. 4-Acetylimidazole can also act as an h2 receptor antagonist, although it does not bind to the zwitterionic site of the h2 receptor. NMR spectra show that 4-acetylimidazole exists as a zwitterion in water solution, but becomes a monovalent ion when dissolved in an organic solvent such as methanol or acetone. 4-Acetylimidazole is chemically stable and does not react with poloxamer.</p>

<p>Intermediate in the synthesis of lenvatinib</p>

<p>4,4'-Diamino-2,2'-bipyridine (DABP) is a redox-active compound that is synthesized to be used as a single-stranded DNA probe. It has been shown to have high affinity for nucleic acids and can be used in many applications including the detection of mutations in human ovarian carcinoma cells. DABP can also be used as a model protein for studying interactions with other biomolecules. The immobilization of DABP on an electrode surface allows for the study of its electrochemical properties. This includes the correlation between the redox potential and luminescence intensity and the dependence on pH or ionic strength. DABP can also be used to detect oxygen concentration or ATP levels in mitochondria through its ability to absorb light at wavelengths from 400 nm to 800 nm which is then converted into light at lower wavelengths by uv irradiation.</p>

<p>2,2,4-Trimethyl-1,2-dihydroquinoline is a chemical compound with the formula C8H10N2. It is a white solid that is insoluble in water but soluble in nonpolar solvents such as benzene, toluene and hexane. 2,2,4-Trimethyl-1,2-dihydroquinoline has been shown to induce liver lesions in rats at doses of 1.25 g/kg/day. It also reacts with hydrogen fluoride to form calcium stearate. This compound is also used as a precursor for the synthesis of diazonium salts and has been shown to be carcinogenic in animal studies.</p>

<p>2-Aminoindole hydrochloride is a heterocyclic amine that is formed by the reaction of benzene and an aminoindole. It is a difunctional compound that can react with alcohols to form amides, carbonyl groups to form ketones, or carbamate groups to form ureas. This compound has been shown to act as an activated aromatic amine that reacts with oxygen in the atmosphere to form a variety of products, including chlorinated aromatic amines. 2-Aminoindole hydrochloride has been shown to have carcinogenic effects in rats when administered orally at high doses.</p>

<p>Marmesinin is a furanocoumarin compound, which is a type of phytochemical derived from certain plant species. It is specifically obtained from the plant Aegle marmelos, commonly known as the bael tree. Marmesinin acts primarily through mechanisms that are characteristic of coumarins, such as influencing biochemical pathways involved in cellular growth and immune response modulation.</p>

<p>7-Hydroxyquinoline is a molecule that has been extensively studied in the context of transfer reactions. It is a sodium salt that contains an intermolecular hydrogen bond and an intramolecular hydrogen bond. The proton of 7-hydroxyquinoline can be transferred to the nitrogen atom of a protonated amine, forming an acid complex. This reaction mechanism is kinetically controlled and stabilizes the tautomers of 7-hydoxyquinoline. The hydroxyl group on the quinoline ring can form hydrogen bonds with various groups on other molecules, such as n-dimethyl formamide or deuterium isotope.</p>

<p>Please enquire for more information about 4-(Benzyloxy)-N,N-dimethyl-indole-3-glyoxylamide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>6-Chloroindole-3-carboxaldehyde is a natural compound with the molecular formula C8H6ClNO2. It has been shown to have anticancer activity against lung cancer cells and has been found to inhibit the growth of metastatic lung cancer cells in mice. 6-Chloroindole-3-carboxaldehyde inhibits the proliferation of human lung cancer cells by arresting cells in the G1 phase of the cell cycle, which may be due to its ability to bind to deoxyhexose and form a complex. This compound also has antimicrobial activity against bacterial strains such as Streptococcus pneumoniae and Mycoplasma pneumoniae.</p>

<p>7-Bromo-1H-indazole is a brominated indazole with an unusual amino acid sequence. It can be used as a building block for the synthesis of new compounds that have potential as medicines. 7-Bromo-1H-indazole has been investigated in cancer cell lines, and it has been shown to inhibit the growth of these cells by inhibiting the production of chloride ions. The molecular modeling of this compound has also shown that it may bind to the chloride channel on cancer cells, preventing chloride ions from entering or leaving the cell. The X-ray crystal structures show that 7-bromoindazole binds with hydrogen bonds to azobisisobutyronitrile (AIBN) and ruthenium complex, which are both potential anticancer drugs.</p>

<p>4,4'-Dimethyl-2,2'-bipyridine is a molecule that belongs to the group of p2 metal complexes. It has been shown to have synergistic effects with ruthenium complexes in analytical chemistry and electrochemical studies. Theoretical calculations have been performed for 4,4'-dimethyl-2,2'-bipyridine and its derivatives. These calculations show that the molecule is planar and that it can be considered as a diazonium salt. The photochemical properties of 4,4'-dimethyl-2,2'-bipyridine have also been studied in detail. This substance emits light when excited by ultraviolet light or visible light, which makes it an excellent candidate for use as a luminescent material in optical displays.</p>

<p>Please enquire for more information about (1S,4S)-2-Oxa-5-azabicyclo[2.2.1]heptane hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>8-Benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolinone is a potassium channel blocker. It binds to the central cavity of the channel pore and blocks potassium ion flux, inhibiting the function of potassium channels. 8-Benzyloxy-5-(2-(R)-bromo-1,3-dihydroxypropyl)quinolinone has been shown to inhibit voltage gated channels in a number of different tissues, including cardiomyocytes from rat hearts.</p>

<p>2-Aminoimidazole sulfate is a chemical compound that is used as a transfection reagent. It has been shown to have high transfection efficiency with low cytotoxicity. The diameter of the molecule is in the range of 2 - 3 nm, which allows it to be taken up by cells and thus be active in them. This chemical can be dehydrogenated to form imidazole-2-sulfonic acid, which may interact with other molecules. There have been many advances in this area, including modifications and gaseous forms of the molecule. Research into the interactions of this compound with other chemicals and their effects on cellular uptake are ongoing.</p>

<p>6-Bromoindazole is a hydrogen bond inhibitor that has potential neuroprotective effects. It inhibits the enzyme DNA Gyrase, which is necessary for bacterial replication, and has antibacterial properties. 6-Bromoindazole interacts with the receptor tyrosine kinase axitinib and inhibits its activity. This interaction may be responsible for its neuroprotective effects.</p>

<p>5-Bromoquinolin-8-amine is a topoisomerase inhibitor that can be used as an antitumor agent. It has been shown to inhibit the growth of tumor cell lines and suppress the growth of colon carcinoma cells in rats and human colon carcinomas in mice. 5-Bromoquinolin-8-amine interacts with DNA, specifically inhibiting the formation of supercoiled DNA. This interaction may lead to the inhibition of tumor cell growth. 5-Bromoquinolin-8-amine also inhibits protein synthesis by interacting with proteins at the ribosomal level, leading to inhibited cell growth.</p>

<p>Peucedanol methyl ether is a bioactive natural compound, which is derived from certain species of the Peucedanum genus, commonly found in various geographic regions. This compound is predominantly obtained from natural extracts through advanced chromatographic techniques. Its molecular structure is characterized by its functional groups, which contribute to its biological activities.</p>

<p>5-Chloro-1H-indazole is a molecule that is structurally related to benzodiazepinones and has been shown to have serotoninergic activity. It was one of the first compounds in the benzodiazepinone class to be synthesized, and it was found to have potent cerebral effects in rats with frequencies between 2 and 6 GHz. 5-Chloro-1H-indazole has been synthesized by reacting 2,6-dichlorobenzoic acid with aniline in tetrahydrofuran (THF) solution, followed by reaction with chlorine gas. The synthesis was analysed using proton NMR spectroscopy and anions.</p>

<p>Please enquire for more information about 7-Amino-1(2h)-isoquinolinone including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>H-Tyr-L-1,2,3,4-tetrahydroisoquinoline-3-carboxamide·HCl is a monoclinic crystalline compound. It has a molecular weight of 607.14 and contains the dipeptide Tyr-Lys in its structure. H-Tyr-L-1,2,3,4-tetrahydroisoquinoline-3-carboxamide·HCl crystallizes in the P21/c space group and has an asymmetric unit cell with dimensions a=8.851 Å, b=7.965 Å and c=5.98 Å. This compound has been shown to have antibacterial properties against methicillin resistant Staphylococcus aureus (MRSA) isolates and Clostridium perfringens strains by inhibiting bacterial protein synthesis through inhibition of peptidyl transferase activity.</p>

<p>8-Boc-3,8-diaza-bicyclo[3.2.1]octane is a functional group that can be used in the preparation of pharmaceutical preparations. It is insoluble in water and soluble in organic solvents. This compound has been shown to be effective in the treatment of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. 8-Boc-3,8-diaza-bicyclo[3.2.1]octane has also been shown to have protective effects against sae-cd induced cytotoxicity by upregulating the expression of antiapoptotic proteins Bcl2 and Bclxl, which are important for neuronal cell survival.</p>

<p>2-Amino-6-chloropurine is a nucleophilic substituent that is used in the synthesis of 2-amino-6-chloropurine. It reacts with hydroxyl groups to form a palladium-catalyzed coupling reaction solution, which is then treated with hydrochloric acid and trifluoroacetic acid. The product is purified by crystallization and recrystallization. This compound has potent antitumor activity against carcinoma cell lines, but it has not been shown to have any effect against Mycobacterium tuberculosis.</p>

<p>Byakangelicin is a furanocoumarin compound, which is derived from the roots of various Angelica plant species. This compound is of particular interest due to its complex chemical structure that allows it to interact with biological systems in distinctive ways. Byakangelicin's mode of action includes the inhibition of specific enzymes, interference with signal transduction pathways, and potential modulation of cellular responses, making it a valuable subject for various pharmacological studies.</p>

<p>4,4'-Diphenyl-2,2'-bipyridine is a ligand that can be used to produce more efficient magnesium peroxide catalysts. The efficiency of the catalyst was found to increase with increasing concentrations of the ligand. 4,4'-Diphenyl-2,2'-bipyridine has been shown to bind strongly to chloride ions and may have potential applications in animal health as a supplement. This compound is also useful in electrochemical data studies because it has a relatively high oxidation potential and electrochemical stability. It can also be used for photophysical studies due to its strong fluorescence. 4,4'-Diphenyl-2,2'-bipyridine can be synthesized by reacting carbon tetrachloride with an animal or vegetable oil or fat.</p>

<p>(1,10-Phenanthroline)tris[4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedionato]europium(III) is a luminescent europium complex that is used in the development of microcapsules for fluorescence microscopy. The (1,10-phenanthroline) ligand is a chelate molecule that can be exchanged with other ligands to change the optical properties of the complex. The fluorescence microscope detects the emitted light at 488 nm and 514 nm wavelengths. The luminescent europium complex emits light when it binds to an organic molecule such as vinyl alcohol or water vapor. Ternary complexes are formed between the europium ion and two different ligands. Optical properties depend on the type of ligands present in these ternary complexes. This product has been shown to have chemical structures that are similar to those</p>

<p>6-Bromo-pyrazolo[1,5-a]pyrimidine is a bone morphogenetic protein (BMP) inhibitor. It has been shown to be a potent inhibitor of the tyrosine kinase activity of BMP receptors and may be useful for the development of new strategies for the treatment of osteoporosis. 6-Bromo-pyrazolo[1,5-a]pyrimidine is also an effective inhibitor of the proliferation and survival of cancer cells. It inhibits cell growth by interfering with cellular signaling pathways that regulate these processes. 6-Bromo-pyrazolo[1,5-a]pyrimidine was also found to inhibit the production of bone morphogenetic protein 2 (BMP2) in mouse calvaria cells without affecting other bone metabolism markers such as alkaline phosphatase or osteocalcin.</p>

<p>2,2', 2'' -Terpyridine is a chelate ligand that is used in wastewater treatment. It can be synthesized by reacting 2-aminopyridine with ethylene diamine and 2,4-dichloro-1,3-dithiolane. The x-ray crystal structures of the ligand show that it has a coordination geometry of octahedral and its reaction mechanism is an oxidation. The chelate ligand binds to the metal ion in the same way as other ligands and stabilizes it by forming hydrogen bonds. This compound has significant cytotoxicity against carcinoma cell lines and also inhibits the mitochondrial membrane potential (MMP). 2,2', 2'' -Terpyridine is classified as group p2 due to its redox potentials and cytotoxicity.</p>

<p>1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents.</p>

<p>5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine is a drug that inhibits serotonin reuptake. It has been used to treat a number of neurological disorders including depression and Parkinson's disease. This drug is a nonselective inhibitor of serotonin uptake and also inhibits the reuptake of norepinephrine. 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine has been shown to enhance cardiac contractility without altering heart rate or rhythm in anesthetized dogs with experimental coronary artery occlusion. The drug also reversibly inhibits epileptic seizures in rats when administered intravenously at a dose of 1 mg/kg. 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine has been shown to have insulin resistance effects in mice with diabetes mellitus and may be useful as a pharmaceutical</p>

<p>4-Bromoisoindoline hydrochloride (BII) is a chemical compound that can be used as a building block for making other chemicals. It can also be used to make research chemicals or as a reaction component in the synthesis of other compounds. It has been shown to be an effective reagent and is useful for the production of fine chemicals with high purity.</p>

<p>Please enquire for more information about tert-Butyl 6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid ethyl ester is an acidic substance that can be produced by the amination of piperazine with chloroacetic acid. The reaction solution is heated to a temperature of about 120°C for about 30 minutes and then cooled to room temperature. The product precipitates as a white solid. This compound has been shown to have antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) in plates.</p>

<p>Please enquire for more information about tert-Butyl 1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Benzo[a]phenanthrene is a polycyclic aromatic hydrocarbon that is found in petroleum and coal tar. It has been shown to be a potent inducer of enzymes involved in the detoxification of xenobiotics, such as chrysene-inducible cytochrome P450 1A1 (CYP1A1), s-phenylmercapturic acid-inducible cytochrome P450 2E1 (CYP2E1), and benzo[a]pyrene-inducible glutathione S-transferase (GST). The optimum concentration for benzo[a]phenanthrene is determined by measuring the amount of enzyme activity in rat liver microsomes following the addition of benzo[a]phenanthrene. A fluorescence detector can be used to measure the fluorescence emission from benzo[a]phenanthrene at an excitation wavelength of 300 nm and an emission wavelength of 400 nm.</p>

<p>1-Methyl-1H-indazole-7-carbaldehyde is a 1,3,5-substituted indazole derivative that can be used as a building block for the synthesis of complex compounds. It is an intermediate in the synthesis of various pharmaceuticals and it has been shown to have potential applications in research chemicals. 1-Methyl-1H-indazole-7-carbaldehyde can be used as a versatile building block after conversion to other derivatives. This chemical is also being investigated as a possible treatment for Parkinson's disease and Alzheimer's disease.</p>

<p>Vinaxanthone (SM-345431), an extract from Penicillium chrysogenum, is a semaphorin3A inhibitor with antimicrobial activity.</p>