Ligands organométalliques

EPZ020411 2HCl is a chemical compound known as a potent selective inhibitor of the EZH2 methyltransferase, which is derived from enzymatic development processes involving high-throughput screening and medicinal chemistry optimization. With its mode of action centered on inhibiting the enzymatic activity of EZH2 (enhancer of zeste homolog 2), EPZ020411 2HCl effectively reduces the methylation of histone H3 on lysine 27 (H3K27), a critical process in gene expression regulation. This activity makes it an invaluable tool for studying epigenetic modifications and underlying oncogenic pathways.

The application of EPZ020411 2HCl is predominantly in the realm of cancer research, particularly in investigating the role of EZH2 in various malignancies, including prostate, breast, and hematopoietic cancers. By targeting and inhibiting EZH2, this compound aids in elucidating mechanisms of cancer progression, potentially leading to advancements in targeted therapeutic strategies. Additionally, it serves as a pivotal reference molecule in the structural and functional studies of histone methyltransferases, contributing to our broader understanding of epigenetic regulation.

Carbovir-13C,d2 is a stable isotope-labeled compound, specifically a version of the antiviral agent carbovir, which is a nucleoside analog. This labeled compound is derived through the incorporation of carbon-13 and deuterium atoms within the molecular structure of carbovir, a process typically achieved via synthetic organic chemistry techniques. Such isotopic labeling enables more precise investigation into the compound's pharmacokinetics and metabolic pathways.

MS37452 is an antimicrobial peptide, which is a type of biomolecule sourced from natural or synthetic origins. These peptides are known for their ability to interact with bacterial cell membranes through electrostatic interactions and hydrophobic insertions. This mode of action leads to the disruption of bacterial cell integrity, resulting in cell lysis and death.

SB 328437 is a selective 5-HT6 receptor antagonist, which is a synthetic compound developed for research purposes. It originates from a series of chemical syntheses aimed at creating ligands capable of specifically targeting serotonin receptors in the brain. The mode of action involves blocking the 5-HT6 receptor, a subtype of serotonin receptors primarily expressed in the central nervous system, thereby modulating the neurotransmission associated with this receptor.

Kamebakaurin is a diterpenoid compound, which is a bioactive natural product sourced primarily from plants of the genus Isodon. This diterpenoid has garnered attention for its significant biological activities, particularly its anticancer and anti-inflammatory properties. Kamebakaurin acts by inhibiting the activity of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway, a critical signaling pathway that regulates immune response, cell proliferation, and survival. This mode of action underpins its potential therapeutic utility in various pathological conditions.

Dimethyl sphingosine-1-phosphate (d18:1) is a bioactive lipid molecule, specifically a sphingolipid derivative, which plays a critical role in cellular signaling pathways. It is a synthetic compound derived from natural sphingosine-1-phosphate (S1P), a signaling sphingolipid found in the membranes of eukaryotic cells. This compound acts by modulating signaling pathways involving G protein-coupled receptors (GPCRs), primarily the S1P receptors, influencing a wide range of cellular processes such as proliferation, migration, and survival.

Please enquire for more information about PDD 00017272 including the price, delivery time and more detailed product information at the technical inquiry form on this page

Lifirafenib is a targeted anticancer therapy, which is a small molecule inhibitor sourced through pharmaceutical development processes. Its mode of action involves the selective inhibition of the RAF kinase family, including B-RAF, which plays a critical role in the MAPK/ERK signaling pathway. By targeting these kinases, Lifirafenib effectively disrupts the aberrant signaling that contributes to tumor growth and survival in certain cancers with mutations such as BRAF V600E.

PF 05105679 is an investigational pharmaceutical compound developed by Pfizer, classified as a selective nicotinic acetylcholine receptor (nAChR) antagonist. It is synthesized through meticulous organic chemistry techniques, representing a targeted approach to modifying neural pathways. The compound functions by selectively inhibiting specific subtypes of nAChRs, which are ligand-gated ion channels integral to synaptic transmission and neurophysiological processes.

NSC 162535 disodium is a synthetic compound, classified as a chemical agent. It is derived from chemical synthesis processes intended for research and experimental purposes. The compound acts through biochemical interactions that affect specific cellular pathways, making it of interest for a variety of investigative biological studies.

BMS 819881 is a synthetic chemical compound, classified as a pharmaceutical agent. This compound originates from synthetic processes in medicinal chemistry, developed as part of a structured drug discovery program. Its mode of action involves inhibiting specific molecular targets related to metabolic pathways, which are impactful in regulating physiological processes at the cellular level.

TAS-103 is an investigational anti-cancer drug, which is a synthetic compound with origins in advanced medicinal chemistry. It functions as a topoisomerase inhibitor with dual-action targeting both topoisomerase I and II enzymes. Topoisomerases are crucial for modulating DNA supercoiling during replication and transcription processes. By interfering with these enzymes, TAS-103 hinders the DNA replication machinery, leading to replication fork stalling and subsequent induction of DNA damage, which can trigger cell death.

UVI 3003 is a light stabilizer that functions as an ultraviolet (UV) absorber, primarily utilized in the protection of various materials from UV radiation. This product is synthesized from advanced chemical compounds designed to absorb UV light and prevent its transmission through the material. The mode of action involves converting UV radiation into harmless thermal energy, which is then dissipated, thereby protecting the underlying matrix from photodegradation.

JNJ-17203212 is a pharmacological compound, specifically a selective antagonist of the transient receptor potential vanilloid 1 (TRPV1) receptor. This compound is derived from synthetic chemical processes, emphasizing its role in modulating ion channel activity. The TRPV1 receptor is a non-selective cation channel expressed predominantly in sensory neurons.

NTRC 824 is an innovative bioactive compound, meticulously developed from natural sources, with unique properties that facilitate its mode of action. The compound is derived through an advanced extraction and purification process ensuring its optimal efficacy and stability. NTRC 824 operates by modulating specific molecular pathways, which are central to its function in targeted applications.

Pi3K/mTOR Inhibitor-2 is a synthetic small molecule, which is a highly specific chemical inhibitor. It is designed to simultaneously target and inhibit the phosphoinositide 3-kinase (Pi3K) and mechanistic target of rapamycin (mTOR) pathways. The source of Pi3K/mTOR Inhibitor-2 is entirely derived from lab-based chemical synthesis, ensuring a consistent and controlled formulation conducive to experimental reproducibility.

PRT062607 (P505-15) HCl is a small-molecule inhibitor, which is a synthetic compound with a highly specific action on the 3-phosphoinositide-dependent protein kinase-1 (PDK1). This compound is derived through rational drug design processes aimed at modulating intracellular signaling pathways. PRT062607 acts by selectively binding to the ATP-binding site of PDK1, thereby inhibiting its kinase activity. This inhibition disrupts downstream signaling mediated by the phosphoinositide 3-kinase (PI3K) pathway, which is pivotal in regulating various cellular processes, including growth, survival, and metabolism.

CYM 5541 is a selective herbicide, which is synthesized from organic chemical compounds. It functions by interfering with the metabolic processes critical to weed growth and development. Specifically, CYM 5541 targets and inhibits specific enzymes that are essential for cell division and photosynthesis in undesirable plants.

The primary application of CYM 5541 is in agricultural settings, where it is used to manage weed populations that compete with crops for light, nutrients, and water. It is particularly effective in controlling broadleaf and grassy weeds. Through its precise mode of action, CYM 5541 enables efficient, targeted suppression of non-crop vegetation, thereby maintaining the health and yield of the desired plants. Its use in integrated pest management strategies underscores its role in sustainable farming practices, minimizing the environmental impact while maximizing agricultural productivity.

Npba is a biochemical reagent, which is meticulously derived from synthesized organic compounds with high purity. This reagent acts through specific molecular interactions, primarily engaging in covalent bonding or through modulation of enzymatic activity. Its mode of action often involves facilitating or inhibiting biochemical pathways, making it a versatile tool in scientific research.

(D)-PPA, known as (D)-phenylpropanolamine, is a chiral compound frequently utilized in chemical research and synthesis. It is derived from the stereospecific synthesis of phenylpropanolamine, a known sympathomimetic compound. The mode of action of (D)-PPA involves interaction with adrenergic receptors, exhibiting a preference for specific binding characteristics associated with its stereochemistry. This interaction can influence various biochemical pathways, making it a valuable tool in the study of adrenergic functions on a molecular level.

MLT-747 is a high-performance polymer composite, which is a synthetic material derived from advanced polymerization techniques involving specific monomers and additives. Its formulation is designed to provide exceptional mechanical properties and thermal stability through the integration of reinforcing agents and proprietary chemical modifications.

Melanin probe-1 is a specialized fluorescent probe, derived from chemical synthesis, designed for the selective detection and quantification of melanin. This innovative probe operates by specifically binding to melanin pigments, resulting in a measurable fluorescence signal that correlates with the concentration of melanin present. The mode of action involves the interaction of Melanin probe-1 with melanin's chemical structure, leading to its activation and subsequent emission of fluorescence, which can be detected and quantified using standard fluorescence microscopy or spectroscopy.

(2S)-1-(7-Ethylfuro[2,3-G]indazol-1-yl)propan-2-amine is a pharmacologically active compound that acts as a synthetic amine derivative. This compound is derived from the indazole class of heterocyclic aromatic organic compounds, which are renowned for their significant biological activities. The mechanism of action primarily involves its interaction with molecular targets within cancerous cells, potentially leading to the modulation of signal transduction pathways or inhibition of specific enzymes crucial for tumor growth and survival.

IHR-1 is a peptide-based antihypertensive product, which is derived from a specific strain of yeast through fermentation processes. Its mode of action involves the inhibition of the angiotensin-converting enzyme (ACE), an important component of the renin-angiotensin system that regulates blood pressure. By inhibiting ACE, IHR-1 effectively reduces the conversion of angiotensin I to angiotensin II, thereby helping to lower blood pressure levels.

CY-09 is a fluorescent probe-based cell assay system, which is a synthetic compound designed for biomedical research. The product is developed from a combination of advanced chemical synthesis methods and molecular engineering, allowing precise interactions with cellular processes. CY-09 operates via a fluorescence-based detection mechanism, providing a highly specific and sensitive means to observe intracellular events.

PS-1145 dihydrochloride is a synthetic chemical compound that acts as a selective inhibitor of the enzyme IκB kinase β (IKK-β). This compound is typically derived through complex chemical synthesis techniques in laboratory environments. PS-1145 targets the NF-κB signaling pathway by directly binding to IKK-β, thereby inhibiting its activity. This inhibition prevents the phosphorylation and subsequent degradation of IκB proteins, which in turn retains NF-κB in the cytoplasm and prevents its transcriptional activity in the nucleus.

XL888 is a selective and potent inhibitor of heat shock protein 90 (HSP90), which is a molecular chaperone involved in the proper folding, stability, and function of many client proteins, including those critical in cancer progression. Sourced from rigorous medicinal chemistry processes, XL888 is designed to bind to the ATP-binding site of HSP90, thereby inhibiting its chaperone activity. This inhibition leads to the degradation of client proteins that are essential for tumor growth and survival.

Tubulin, GST tagged human, is a recombinant protein used extensively in cell biology research. It is derived from a human source, with genetic engineering employed to append a Glutathione S-transferase (GST) tag. This tagging facilitates purification and enhances solubility, crucial for downstream applications.

PF 06371900 is an investigational therapeutic agent, which is a synthetic small-molecule inhibitor. It is derived from advanced chemical synthesis designed to target specific molecular pathways. The mode of action involves selective binding and inhibition of a particular enzyme, which plays a critical role in the proliferation of certain cancer cells. By inhibiting this enzyme, PF 06371900 disrupts the cellular processes required for tumor growth and survival.

AMT Hydrochloride is a synthetic tryptamine compound, which is derived from chemical synthesis methods. It is an analogue of alpha-methyltryptamine (AMT), specifically the hydrochloride salt form, enhancing its stability and solubility for laboratory settings. The mode of action involves acting as a non-selective agonist at serotonin receptors, primarily targeting the 5-HT2C and 5-HT2A receptors. This interaction results in psychoactive effects through the modulation of neurotransmitter systems, impacting serotonin pathways.