Ligands organométalliques

<p>Lenalidomide is a thalidomide derivative that is used to treat multiple myeloma and anemia. This drug exerts immunomodulatory effects by altering cytokine production. Lenalidomide also directly inhibits the cullin ring E3 ubiquitin ligase complex.</p>

<p>Long-acting β2-agonist; bronchodilator</p>

<p>Prasugrel is a thienopyridine prodrug that inhibits the enzyme ADP-dependent P2Y purinergic receptor. Prasugrel inhibits platelet aggregation and the formation of blood clots by blocking the conversion of ADP to ATP on the surface of platelets, thus preventing the release of serotonin from platelets. The reaction products formed by prasugrel are similar to those formed by clopidogrel and include hydrogen sulfate ions and a thiol-containing metabolite. It has also been shown to have potent cytotoxic activity against melanoma cells and anti-inflammatory properties. <br>Prasugrel is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&amp;D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>

<p>Leflunomide is a pyrimidine synthesis inhibitor drug that is used to treat rheumatoid arthritis. Although its mechanism of action is not fully determined, this drug has shown to interfere with cell cycle progression by inhibiting dihydroorotate dehydrogenase and has shown antiproliferative activity. As a result of this, it interferes with the expansion of activated autoimmune lymphocytes. Additionally, Leflunomide is a tyrosine kinase inhibitor.</p>

<p>Ipratropium is an ammonium derivative of atropine and acts as an anticholinergic drug that is used for the control of bronchospasms in chronic obstructive pulmonary disease (COPD). This drug is an antagonist of muscarinic acetylcholine receptors and produces an inhibitor of the parasympathetic system. As a result, this leads to bronchodilation and fewer bronchial secretions.</p>

<p>Imiquimod maleate is an immune response modifier, which is a synthetic compound sourced from chemical synthesis. Its mode of action involves the activation of the immune system through the stimulation of toll-like receptor 7 (TLR7), leading to the induction of various cytokines, such as interferon-alpha, that initiate an antiviral and anti-tumor response.</p>

<p>γ-secretase inhibitor; reduces amyloid-β in brainÂ</p>

<p>Inhibitor of oxidative phosphorylation which acts on the F0F1 ATP synthase in the inner mitochondrial membrane and causes acute increase in mitochondrial membrane potential. Gboxin was shown to accumulate in mitochondria of cancer cells, to cause cellular toxicity and cell growth inhibition in mouse glioblastoma. However, Gboxin did not inhibit growth of mouse embryonic fibroblasts or neonatal astrocytes.</p>

<p>Selective A2 adenosine receptor agonist. Increases cardiac output in rats with acute heart failure, mediated by reduced venous resistance and raised heart rate. Demonstrates neuroprotective properties by lowering blood cell infiltrates and neuroinflammation in ischemic cerebral tissue.</p>

<p>Pioglitazone is a thiazolidinedione drug that is used in combination with diet change and exercise to treat glycemic levels in patients with type 2 diabetes mellitus. This drug is an agonist of peroxisome proliferator-activated receptor-gamma and increases glucose uptake. In animal studies, Pioglitazone has shown to have anti-inflammatory properties.</p>

<p>Dipeptidyl peptidase 4 (DPP4) inhibitor</p>

<p>An agonist of 5-HT1A serotonin receptors. Neurotrophic and neuroprotective activities have been demonstrated in neurodegenerative models in vivo. This is mediated by increasing the secretion of nerve growth factor (NGF), when tested in astrocytes in vitro. Anti-nociceptive activity was displayed in a model of acute tonic nociceptive and inflammatory pain.</p>

<p>Ractopamine hydrochloride is a beta-agonist that stimulates the release of fatty acids from adipose tissue, increasing food intake and weight gain in pigs. It has been shown to have significant interactions with other drugs used for bowel disease, as well as with sodium carbonate, which can be used for control analysis. Ractopamine hydrochloride is an effective drug to stimulate the release of estradiol benzoate in rats during pregnancy. The matrix effect observed when analyzing samples containing ractopamine hydrochloride may be due to its ability to bind to serum proteins or lipids. This drug has been shown to have molecular docking properties that are similar to those found in other molecules.</p>

<p>Trkc active human is a bioengineered protein, which is a synthetic derivative of the TRKC (tropomyosin receptor kinase C) receptor. This product is derived from recombinant DNA technology, utilizing expression systems to produce a functionally active protein that mimics the natural receptor found in human cells. Its mode of action involves the specific binding and activation of neurotrophin-3 (NT-3), a critical signaling molecule in the nervous system.</p>

<p>S1RA hydrochloride is a selective antagonist targeting the sigma-1 receptor, which is a type of small molecule ligand. It is synthesized chemically, enabling precise modulation of its properties for experimental use. S1RA functions by selectively inhibiting the sigma-1 receptor, a chaperone protein involved in modulating ion channels and other receptors within the endoplasmic reticulum. This modulation plays a critical role in various cellular processes, including calcium signaling and cellular stress responses.</p>

<p>Medetomidine is a synthetic compound of the benzodiazepine class. It has a variety of pharmacological effects, including sedation and muscle relaxation, and is used in veterinary medicine as an anesthetic agent for animals. Medetomidine can be administered intravenously, intramuscularly, or subcutaneously. The drug crosses the blood-brain barrier to produce its sedative effect. This agent has been shown to be effective in inducing anesthesia in experimental animals with a wide range of body weights. Medetomidine has also been shown to have cardiovascular effects such as lowering systolic pressure and heart rate. Medetomidine HCl is soluble in water and trifluoroacetic acid (TFA).<br>Medetomidine HCl is rapidly hydrolyzed by esterases at physiological pH to medetomidinol (MTM) and then further metabolized by glucuronide conjugation to form medetominol glucuronide</p>

<p>CholecystokininB (CCKB) receptor antagonist</p>

<p>Used to treat multiple sclerosis; anti-inflammatory</p>

<p>Pantoprazole is a proton pump inhibitor drug that is used to treat erosive esophagitis and promotes healing of tissue damage caused by gastric acid. It is used for the management of GERD. Through the proton pump inhibition, the formation of hydrochloric acid is inhibited thus inhibiting gastric secretion.</p>

<p>Ezetimibe is a lipid-lowering compound that inhibits cholesterol absorption. This drug helps to lower cholesterol in primary hyperlipidemia and familial cholesterolemia. Ezetimibe targets the cholesterol transport protein Niemann-Pick C1-Like 1 (NPC1L1).</p>