Ligands organométalliques

<p>ABTL-0812 is an investigational anticancer compound, which is a synthetic small molecule with a novel mechanism of action. It is derived from the research efforts focused on targeting key metabolic pathways in cancer cells. The mode of action of ABTL-0812 involves the modulation of the Akt/mTOR pathway, leading to the induction of autophagy-mediated cell death, a process that is selectively cytotoxic to cancer cells.</p>

<p>Inhibitor of dihydroorotate dehydrogenase; anti-inflammatory; immunomodulatory</p>

<p>Prostaglandin F2α receptor agonist</p>

<p>Orelabrutinib is a small-molecule Bruton’s tyrosine kinase (BTK) inhibitor, which is synthesized chemically. This selective inhibitor targets BTK, a key enzyme involved in the B-cell receptor signaling pathway. By binding covalently to cysteine-481 in BTK, orelabrutinib effectively blocks the downstream signaling, leading to apoptosis of malignant B-cells.</p>

<p>5-HT2A/C serotonin receptor antagonist; anti-migraine agent; anti-histaminic</p>

<p>Apraclonidine is an alpha adrenoreceptor agonist that is used in the treatment of raised intraocular pressure. This drug’s mechanism of action is not fully understood however, animal and human studies suggested that Apraclonidine reduces aqueous humor production and increases uveoscleral outflow.</p>

<p>Dual inhibitor of thromboxane receptor and DP2 postanoid receptor</p>

<p>CHZ868 is a chemical compound primarily used in experimental research settings. It is synthesized through a series of organic reactions, often involving specific reagents to ensure high purity and stability. The compound operates by interacting with specific cellular pathways, influencing key biochemical processes that are crucial for its intended applications.</p>

<p>Anticholinergic drug; antagonist at muscarinic acetylcholine receptors</p>

<p>Inhibitor of pan-sirtuins (IC50 = 15, 10, 33 µM for SIRT1, 2 and 3 respectively), by binding to the active catalytic site. Selectivity for sirtuins was demonstrated when tested for activity on a panel of kinases, nuclear receptors, ion channels, transporters and GPCRs.</p>

<p>Acipimox is a niacin derivative that is used as a hypolipidemic agent. Acipimox prevents the liver from producing triglycerides and from secreting VLDL, which indirectly results in a slight decrease in LDL and an increase in HDL. Also, it stimulates leptin release and improves insulin sensitivity.</p>

<p>Antagonist of proto-oncogene MDM2 and its interaction with p53</p>

<p>Inhibitor of Flk-1/KDR receptor tyrosine kinases, a vascular endothelial growth factor receptor (VEGF) receptor expressed on precursor and mature forms of endothelial cells. SU 5416 also inhibits other tyrosine kinases, including c-KIT and FLT-3. Has therapeutic potential as an anti-angiogenic agent for the treatment of cancer.</p>

<p>Inhibitor of glycogen phosphorylase and alpha-glucosidases</p>

<p>Idelalisib is a pharmaceutical drug that functions as a PI3Kδ inhibitor, developed through synthetic chemical processes. Its mode of action involves selectively targeting and inhibiting phosphatidylinositol 3-kinase delta (PI3Kδ), a lipid kinase that plays a crucial role in the signaling pathways responsible for cell proliferation, survival, and differentiation. By inhibiting this enzyme, Idelalisib effectively impedes pathways that are often hyperactivated in certain hematologic malignancies, thereby exerting antitumor effects.</p>

<p>Modulator of S1P receptor</p>

<p>Agonist of H3 and H4 receptors</p>

<p>Bexarotene is a retinoid and antineoplastic agent that is used for the treatment of solid tumours and t-cell lymphomas. It inhibits the growth in vitro of some tumor cell lines of hematopoietic and squamous cell origin and research has shown that it induces tumor regression in vivo in some animal models.</p>

<p>Moracin C is a prenylated flavonoid, which is a type of naturally occurring compound. It is derived from the Morus genus, commonly known as mulberry trees. This compound functions primarily as an antioxidant, showing activity that may protect cells from oxidative stress by neutralizing free radicals.</p>

<p>Pritelivir mesylate is an antiviral compound, which is derived from thiazolylamide class molecules, with a targeted mechanism of action against the herpes simplex virus (HSV). It functions by inhibiting the viral helicase-primase complex, which is essential for the replication of viral DNA. This distinct mode of action differentiates it from traditional treatments like acyclovir, which targets viral DNA polymerase.</p>