Ligands organométalliques

Cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor

Mots-C is a mitochondrial-derived peptide, which is encoded by the small open reading frame found within the mitochondrial 12S rRNA. This peptide functions by interacting with the cellular metabolic pathways to enhance mitochondrial bioenergetics and overall cellular metabolism. Mechanistically, Mots-C modulates the folate–methionine cycle, directly impacting glucose regulation and energy utilization, and consequently facilitating cellular adaptation to metabolic stress.

RU 58841 is a non-steroidal anti-androgen, which is a chemical compound sourced through synthetic processes in pharmaceutical laboratories. It functions by selectively binding to androgen receptors in the hair follicles, thereby inhibiting the action of androgens such as dihydrotestosterone (DHT). This mode of action prevents DHT from activating the receptor, which is a critical factor in the miniaturization of hair follicles.

HOE 33187 is a herbicide developed by Hoechst AG, which is a synthetic compound designed to interfere with plant growth. This product is an aryloxyphenoxypropionate, originating from chemical synthesis, targeting key biochemical pathways within susceptible plant species.

Palbociclib dihydrochloride is a selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6), which is derived from synthetic chemical processes. Its mode of action involves disrupting the progression of the cell cycle from G1 to S phase, thereby inhibiting cellular proliferation. By specifically targeting and inhibiting CDK4/6, Palbociclib effectively arrests the growth of cancer cells that rely on these kinases for division.

Lyn peptide inhibitor is a targeted peptide-based inhibitor derived synthetically to interact specifically with the Lyn kinase signaling pathway. As a research tool, it serves to elucidate the functional dynamics of Lyn kinase, which belongs to the Src family of tyrosine kinases involved in signal transduction processes critical to cellular differentiation, proliferation, and survival.

5-Hydroxymatrine is an alkaloid compound, which is derived from the roots of Sophora plants, notably Sophora flavescens. This compound is characterized by its structure as a quinolizidine alkaloid and is a modified form of matrine, with a hydroxyl group adding to its chemical complexity.

SR8278 is a synthetic, chemical compound that functions as a highly selective inverse agonist of the Rev-Erb nuclear receptors, which is derived from extensive biochemical research. It operates by binding to these orphan nuclear receptors, Rev-Erbα and Rev-Erbβ, inhibiting their activity. This antagonistic action disrupts the regulation of circadian rhythms, metabolism, and inflammatory responses that these receptors typically control. This modulation occurs at the transcriptional level, where SR8278 interferes with gene expression governed by Rev-Erb receptors.

PF-06658607 is an investigational drug that is classified as a small molecule inhibitor. It is developed from synthetic chemical sources with a specific mode of action targeting aggrecanases, enzymes that degrade aggrecan, a critical component of cartilage. By inhibiting these enzymes, PF-06658607 aims to prevent the breakdown of cartilage in joints.