Autres inhibiteurs

Compound 11, also known as Antitumor Photosensitizer-2, is a potent photosensitizer with remarkable photodynamic anti-tumor properties and minimal skin photo-

IDO/Tubulin-IN-2 inhibits TDO/tubulin, effective on U87, HepG2, A549, HCT-116, LO2 cancer cells; IC50 values 0.036-1.04 μM, boosts antitumor action.

Ac4GalNAlk, a weakly alkyne-labeled reagent for metabolic oligosaccharide engineering (MOE), facilitates the detection of protein glycosylation by promoting nucleotide-sugar biosynthesis and enhancing bioorthogonal cell surface markers. It is activated by cellular biosynthetic machinery into nucleotide sugars, subsequently enabling the tracing of glycoproteins in bioorthogonal chemistry [1].

LM2I, a derivative of Spinosyn A (SPA), serves both as an argininosuccinate synthase (ASS1) enzyme activator and a tumor inhibitor through direct interaction

Ifetroban sodium (BMS-180291), oral TXA2/PGH2 antagonist for researching heart, stroke, BP, thrombosis.

9,10-Phenanthrenequinone is an inhibitor of claudin-5/CLDN5, which induces apoptosis via an NO synthase/ROS-dependent mechanism. It also promotes caspase activation and DNA fragmentation while reducing CLDN5 expression and proteasome proteolysis, contributing to endothelial barrier dysfunction.

BPH-628 is a bioactive chemical.

Ifetroban is a potent and selective TxA2/PGH2 receptor antagonist.