Autres inhibiteurs

<p>Expression System: P. pastoris (Yeast)&lt;br&gt;Activity: Not Tested</p>

<p>Compound 13i is a potent PROTAC BRD4 degrader with IC50s: 29.54 nM (BD1), 3.82 nM (BD2), impedes G2/M progression, and induces apoptosis in MV-4-11 cells.</p>

<p>Fel d 1 Protein, Felis domesticus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.6 kDa.</p>

<p>2-(3-Ethoxy-4-(ethoxycarbonyl)phenyl)acetic acid is a useful organic compound for research related to life sciences. The catalog number is T67483 and the CAS number is 99469-99-5.</p>

<p>Bet v 4 Protein, Betula pendula, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 10.3 kDa and the accession number is Q39419-1.</p>

<p>Ara h 3.01 Protein, Arachis hypogaea, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 59.3 kDa.</p>

<p>4-[3-(Trifluoromethyl)diazirin-3-yl] benzoic acid N-hydroxysuccinimide ester is a valuable organic compound for life sciences research, catalog number T67028, CAS number [87736-89-8].</p>

<p>Iminodiacetic acid is a natural product for research related to life sciences. The catalog number is T65749 and the CAS number is 142-73-4.</p>

<p>(11aR)-10,11,12,13-Tetrahydro-N,N-bis[(1R)-1-phenylethyl]diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-amine is a useful organic compound for research related to life sciences and the catalog number is T66952.</p>

<p>VPC44116 is a bioactive chemical.</p>

<p>Equ c 1 Protein, Domestic horse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.1 kDa.</p>

<p>Propargyl-PEG3-Boc, a PEG-based linker for PROTACs, connects two essential ligands vital for forming PROTAC molecules, enabling selective protein degradation via the ubiquitin-proteasome system within cells.</p>

<p>3,4-Dihydroxy-5-nitrobenzaldehdye is a useful organic compound for research related to life sciences. The catalog number is T65701 and the CAS number is 116313-85-0.</p>

<p>Octyl-β-D-Selenoglucoside is a useful organic compound for research related to life sciences. The catalog number is TF0035 and the CAS number is 1423273-53-3.</p>

<p>Hydroxy-PEG8-Boc, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.</p>

<p>Ethyl 6,7-difluoro-1-methyl-4-oxo-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T65447 and the CAS number is 113046-72-3.</p>

<p>1-Amino-4,4-difluorocyclohexane-1-carboxylic acid is a fluoride analog involved in the synthesis of insecticides, herbicides, and fungicides.</p>

<p>(2R,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid hydrochloride is a useful organic compound for research related to life sciences and the catalog number is T67422.</p>

<p>PD-1/PD-L1-IN 5 is an inhibitor of PD-1/PD-L1 protein/protein interaction (IC50 of ≤100 nM).</p>

<p>PI3Kα Inhibitor 7 is a useful organic compound for research related to life sciences. The catalog number is T9312 and the CAS number is 1239978-63-2.</p>

<p>2-(Pyridin-3-yl)-4,5-dihydrooxazole is a useful organic compound for research related to life sciences. The catalog number is T66524 and the CAS number is 40055-37-6.</p>

<p>m-PEG6-amino-Mal is a PEG-based linker for PROTACs that connects two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.</p>

<p>3-(Chloromethyl)pyridine hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66829 and the CAS number is 6959-48-4.</p>

<p>(E)-3-(m-Tolyl)acrylaldehyde is a useful organic compound for research related to life sciences. The catalog number is T66436 and the CAS number is 93614-80-3.</p>

<p>Tri-n-butylphosphineoxide is a useful organic compound for research related to life sciences. The catalog number is T65487 and the CAS number is 814-29-9.</p>

<p>N-methyl-2-AI (hydrochloride) is a useful organic compound for research related to life sciences. The catalog number is T66396 and the CAS number is 10408-85-2.</p>

<p>5-hydroxy-Nω-methyl Tryptamine is a metabolite of serotonin in humans that has also been found in plants.</p>

<p>PROTAC eEF2K degrader-1 (11l) targets eEF2K, induces apoptosis in MDA-MB-231 cells, and degrades eEF2K.</p>

<p>SN50 trifluoroacetate is a useful organic compound for research related to life sciences and the catalog number is T64720.</p>

<p>Methanesulfonato(2-di-t-butylphosphino-3,4,5,6-tetramethyl-2',4',6'-tri-i-propylbiphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II) is a useful organic compound for research related to life sciences and the catalog number is T67252.</p>

<p>FFPM is a novel PDE4 inhibitor (IC50: 6 nM) and good selectivity over other PDEs. The drug also penetrates the blood brain barrier well.</p>

<p>Soybeanoil is a useful organic compound for research related to life sciences and the catalog number is T64814.</p>

<p>3,4-Difluorobenzaldehyde is a useful organic compound for research related to life sciences. The catalog number is T65937 and the CAS number is 34036-07-2.</p>

<p>(2-Butylbenzofuran-3-yl)(4-methoxyphenyl)methanone is a useful organic compound for research related to life sciences. The catalog number is T67095 and the CAS number is 83790-87-8.</p>

<p>n-Hexadecyl β-D-maltoside is a useful organic compound for research related to life sciences and the catalog number is T64463.</p>

<p>Ethyl 8-hydroxy-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T66942 and the CAS number is 131666-45-0.</p>

<p>(5R)-Platyphyllone has a wide range of applications in life science related research.</p>

<p>7-Iodopyrrolo[2,1-f][1,2,4]triazin-4-amine is a useful organic compound for research related to life sciences. The catalog number is T64496 and the CAS number is 1770840-43-1.</p>

<p>(S)-2-Hydroxyethyl 2-amino-3-methylbutanoate 4-methylbenzenesulfonate is a useful organic compound for research related to life sciences and the catalog number is T66579.</p>

<p>BKM1740 induced apoptosis in prostate cancer (PCa) cells by repressing survivin at both the mRNA and protein levels in vitro.</p>

<p>(R)-N-Benzyl-2-(3-benzylureido)-3-methoxypropanamide is a useful organic compound for research related to life sciences and the catalog number is T64816.</p>

<p>2-(2-Ethoxyphenoxy)ethanamine is a useful organic compound for research related to life sciences. The catalog number is T66134 and the CAS number is 6781-17-5.</p>

<p>ER degrader 3 targets estrogen receptor, key in cell regulation, potential for cancer research.</p>

<p>(4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T66996 and the CAS number is 104239-97-6.</p>

<p>(R)-3-([1,1'-Biphenyl]-4-yl)-2-aminopropanoic acid is a useful organic compound for research related to life sciences and the catalog number is T67381.</p>

<p>3-[2-(Trifluoromethyl)phenyl]propanoic acid is a useful organic compound for research related to life sciences. The catalog number is T65989 and the CAS number is 94022-99-8.</p>

<p>4-(Trifluoromethyl)-D-phenylalanine, catalog number T67196 and CAS number 114872-99-0, is a valuable organic compound utilized in life sciences research.</p>

<p>Diacetato[(R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]ruthenium(II) is a useful organic compound for research related to life sciences. The catalog number is T66567 and the CAS number is 325146-81-4.</p>

<p>Secretin,porcine is a useful organic compound for research related to life sciences and the catalog number is T65428.</p>

<p>Biotin-PEG8-alcohol is a PEG-based linker for PROTACs, joining two essential ligands and facilitating selective protein degradation through the ubiquitin-proteasome system within cells.</p>

<p>Thiazol-5-ylmethanol is a useful organic compound for research related to life sciences. The catalog number is T66242 and the CAS number is 38585-74-9.</p>

<p>3-Amino-4-(2-chlorophenyl)-6-nitroquinolin-2(1H)-one is a useful organic compound for research related to life sciences. The catalog number is T66852 and the CAS number is 55198-89-5.</p>

<p>CH2COOH-PEG6-CH2COOH is a PEG-based linker for PROTACs, facilitating the connection of two essential ligands vital for forming PROTAC molecules. This linker enables selective protein degradation by exploiting the ubiquitin-proteasome system within cells.</p>

<p>tert-Butyl 4-((3-fluorophenyl)amino)piperidine-1-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T67110 and the CAS number is 679409-18-8.</p>

<p>Azido-PEG2-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.</p>

<p>H-L-Photo-lysine: photo-cross-linker, diazirine-lysine for protein interaction studies in vitro/cells.</p>

<p>2-Fluoro-N-[(phenylmethoxy)carbonyl]-L-phenylalanine, with catalog number T65064 and CAS number 127862-88-8, is a valuable organic compound for research in life sciences.</p>

<p>(S)-3-(Allyloxy)-2-((tert-butoxycarbonyl)amino)propanoic acid is a useful organic compound for research related to life sciences and the catalog number is T64551.</p>

<p>(S)-2-Amino-5-((2,2,10,10-tetramethyl-4,8-dioxo-3,9-dioxa-5,7-diazaundecan-6-ylidene)amino)pentanoic acid is a useful organic compound for research related to life sciences and the catalog number is T64690.</p>

<p>(2,6-Dichlorophenyl)methanol is a useful organic compound for research related to life sciences. The catalog number is T66709 and the CAS number is 15258-73-8.</p>

<p>4-Bromo-1H-imidazole, with catalog number T65957 and CAS number 2302-25-2, is a valuable organic compound for life sciences research.</p>

<p>Ethyl 4-nitrocinnamate is a useful organic compound for research related to life sciences. The catalog number is T66286 and the CAS number is 953-26-4.</p>

<p>1,7'-Dimethyl-2'-propyl-1H,1'H-2,5'-bibenzo[d]imidazole is a useful organic compound for research related to life sciences. The catalog number is T65771 and the CAS number is 152628-02-9.</p>

<p>6-Methyleneandrost-4-ene-3,17-dione is a useful organic compound for research related to life sciences. The catalog number is T64943 and the CAS number is 19457-55-7.</p>

<p>4,6-Dichloro-2-(propylthio)pyrimidin-5-amine is a useful organic compound for research related to life sciences. The catalog number is T65622 and the CAS number is 145783-15-9.</p>

<p>2-(((3aR,4S,6R,6aS)-6-((5-Amino-6-chloro-2-(propylthio)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol is a useful organic compound for research related to life sciences. The catalog number is T66431 and the CAS number is 376608-74-1.</p>

<p>Tripao is a useful organic compound for research related to life sciences. The catalog number is TF0088 and the CAS number is 318293-46-8.</p>

<p>(Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T65586 and the CAS number is 356068-93-4.</p>

<p>(2b,3a,5a,16b,17b)-17-Acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane is a useful organic compound for research related to life sciences. The catalog number is T66654 and the CAS number is 119302-24-8.</p>

<p>IDO1-IN-20 is an enzyme that catalyzes the oxidative metabolism of tryptophan. It can immunosuppress tumors in the tumor microenvironment.</p>

<p>2-(4-Bromophenyl)quinoline-4-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T65561 and the CAS number is 103914-52-9.</p>

<p>4-Iodo-N-[(phenylmethoxy)carbonyl]-L-phenylalanine (catalog number T66874, CAS number 220400-04-4) is a valuable organic compound for life sciences research.</p>

<p>Chloro[(tricyclohexylphosphine)-2-(2'-aminobiphenyl)]palladium(II) is a useful organic compound for research related to life sciences. The catalog number is T67251 and the CAS number is 1353658-81-7.</p>

<p>Ethyl 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66601 and the CAS number is 1243308-37-3.</p>

<p>9-Azido-Neu5DAz is a non-natural bifunctional carbohydrates as imaging agent.</p>

<p>Target 5 has a wide range of applications in life science related research.</p>

<p>Glycine Sulfate is a useful organic compound for research related to life sciences and the catalog number is T64419.</p>

<p>MB07803 is an orally available prodrug of an effective, noncompetitive inhibitor of fructose 1,6-bisphosphatase (FBPase) (EC50: 140 nM and t1/2 of 7.6±2.9 h).</p>

<p>SHP099 HCl is a useful organic compound for research related to life sciences and the catalog number is T67211.</p>

<p>(R)-3-((tert-Butoxycarbonyl)amino)-4-(3-fluorophenyl)butanoic acid is a useful organic compound for research related to life sciences. The catalog number is T66938 and the CAS number is 331763-66-7.</p>

<p>Arsenazo I is a calcium-sensitive, metallochromic dye used as reagent.</p>

<p>Zinc(II) sulfate is a useful organic compound for research related to life sciences and the catalog number is T65506.</p>

<p>(S)-2-(2,6-Dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione is a useful organic compound for research related to life sciences and the catalog number is T64820.</p>

<p>2-Amino-6-(propylamino)-5,6-dihydrobenzo[d]thiazol-7(4H)-one hydrochloride is a useful organic compound for research related to life sciences and the catalog number is T64682.</p>

<p>Boc-Phe(3,4-DiCl)-OH is an amino acid derivative with diverse applications in life science research.</p>

<p>Triethyl 2-phosphonopropionate is a useful organic compound for research related to life sciences. The catalog number is T65480 and the CAS number is 3699-66-9.</p>

<p>2,3-Dimethyl-2H-indazol-6-amine is a useful organic compound for research related to life sciences. The catalog number is T66273 and the CAS number is 444731-72-0.</p>

<p>((2S,2'S)-1,1'-((2-Hydroxy-5-methyl-1,3-phenylene)bis(methylene))bis(pyrrolidine-2,1-diyl))bis(diphenylmethanol) is a useful organic compound for research related to life sciences. The catalog number is T67237 and the CAS number is 320714-00-9.</p>

<p>Magnesium silicate adsorbent(Synthetic) is a useful organic compound for research related to life sciences and the catalog number is T64727.</p>

<p>LEO-32731 is a bioactive chemical.</p>

<p>Araliadiol is a polyacetylenic compound isolated from the leaves of Aralia cordata Thunb. Araliadiol inhibits MCF-7 cell growth (IC50: 6.41 μg/mL).</p>

<p>2,4-Dihydroxy-5-methoxypyrimidine is a useful organic compound for research related to life sciences. The catalog number is T66505 and the CAS number is 6623-81-0.</p>

<p>Paromomycin (Sulfate Salt) is an aminoglycoside that is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes. Paromomycin in combination with sodium stibogluconate has proven to be effective in African and Indian VL (visceral leishmaniasis) and improves survival in African VL[3]. PS (Paromomycin Sulfate) is effective for elimination of B. coli without hematological side effects[4]. The activity of phosphoglucose isomerase was slightly inhibited by 10(-3) M paromomycin sulfate while those of hexokinase, phosphofructokinase and glucose-6-phosphate dehydrogenase were not inhibited[5]. In addition, with regard to correlation of endotoxemia with renal impairment, endogenous creatinine clearance and p-aminohippurate clearance were significantly improved (P less than 0.02) in those patients whose endotoxemia disappeared on paromomycin sulfate administration. Paromomycin sulfate seems to be effective in the prevention of endotoxemia and the associated renal impairment in cirrhosis in man[6]. Significantly higher frequencies of resistance to paromomycin, kanamycin, neomycin and tobramycin were observed in S. aureus isolates from PS (paromomycin supplemented) birds. Paromomycin supplementation resulted in resistance to aminoglycosides in bacteria of PS turkeys. Co-selection for resistance to other antimicrobial agents was observed in E. coli isolates[7].</p>

<p>BnO-PEG4-Boc is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.</p>

<p>Tenilapine is an atypical antipsychotic drug.</p>

<p>1-(Piperidin-4-yl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-one is a useful organic compound for research related to life sciences and the catalog number is T66378.</p>

<p>3-Methylbenzophenone is a useful organic compound for research related to life sciences. The catalog number is T67599 and the CAS number is 643-65-2.</p>

<p>3'-O-Angeloylhamaudol is a useful organic compound for research related to life sciences and the catalog number is T124112.</p>

<p>m-PEG-NH2 (MW 20000) is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.</p>

<p>Eleutheroside C is a glycoside isolated from the bulbs of Polianthes tuberosa.</p>