Autres inhibiteurs

<p>AM-3189: potent, selective GPR40 agonist with low CNS penetration, good pharmacokinetics, and efficacy mirroring AMG 837.</p>

<p>SML-10-70-1 is a Novel Active Site Inhibitor of Oncogenic K-Ras G12C.</p>

<p>PPARγ agonist 1 is a potent agonist of PPARγ that efficiently activates hPPARγ without causing full agonism, thereby avoiding adverse effects.</p>

<p>Skp2 inhibitor 1 is a Skp2-Cks1 interaction inhibitor (IC50: 2.8μM) with antitumor activity and can be used to study cancer.</p>

<p>OB-1 is a STOML3 inhibitor that interferes with the self-association of stomatin, inhibiting fat formation and blocking lipid droplet growth.</p>

<p>Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor that reduces the cytotoxicity induced by statins in human skeletal muscle cells.</p>

<p>Glycosyltransferase-IN-1 is a glycosyltransferase inhibitor with bacteriostatic activity, inhibiting MSSA, MRSA, Bacillus subtilis, and Enterobacteriaceae.</p>

<p>MV151 is a fluorescent proteasome inhibitor that targets all active subunits of the proteasome and immunoproteasome in living cells.</p>

<p>ELOVL1-IN-2 weakly inhibits ELOVL1 enzyme (IC50: 21 μM) and shows moderate potency in HEK293 cells (IC50: 6.7 μM).</p>

<p>NRX-1532 is a small molecule β-catenin:β-TrCP interaction enhancer.</p>

<p>PREP inhibitor-1 is a prolyl oligopeptidase (PREP) inhibitor for the study of Alzheimer's disease.</p>

<p>YTH-IN-1 is an inhibitor of the five YTH structural domains in the human.The YTH family of proteins is an N 6-methyladenosine (m6A) reader in gene expression.</p>

<p>O-Propargyl-Puromycin (OP-puro) is a potent protein synthesis inhibitor, a puromycin acetylene analog.</p>

<p>VCPIP1-IN-1 is a VCPIP1 inhibitor used in cancer research.</p>

<p>BLU2864: oral PRKACA inhibitor, IC50=0.3 nM, potential in cancer/poly. kidney disease research.</p>

<p>ARN19702: orally active, brain-penetrant, selective NAAA inhibitor, IC50 230 nM, broad analgesic profile.</p>

<p>Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.</p>

<p>Beraprost sodium is a stable and orally active prodrug of PGI2.</p>

<p>A-887826 is a selective, orally bioavailable, and voltage-dependent Na(v1.8) channel blocker (IC50: 11 nM). It attenuates neuropathic tactile allodynia in vivo.</p>

<p>Umbellulone is a natural product isolated from Umbellularia californica, and stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism.</p>

<p>β-Zearalenol, a non-steroidal estrogenic mycotoxin synthesized by Fusarium species, potentially influences transcription and affects gene expression on the translational level.</p>

<p>(8R,9S)-Talazoparib is Talazoparib enantiomer , less active than Talazoparib on the inhibition of PARP1 (IC50: 144 nM).</p>

<p>Haloxon is an organophosphorus anthelmintic. Haloxon is used against nematodes of the abomasum and small intestine in ruminants.</p>

<p>TEM1/CD248 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 73.6 kDa and the accession number is Q91V98.</p>

<p>N-Octylmaleimide is an alkylmaleimide, which can inhibit rat liver glucose 6-phosphatase.</p>

<p>BI-2545 is an autotaxin (ATX) inhibitor that significantly reduces LPA. For human ATX and rat ATX, the IC50s values are 2.2 nM and 3.4 nM , respectively.</p>

<p>Calcitriol Impurities A refers to the contaminants found in Calcitriol, the hormonally active metabolite of vitamin D3, which serves to activate the vitamin D receptor.</p>

<p>GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. GAS6 Protein, Human, Recombinant (His) is expressed in HEK293 cells.</p>

N3PT is a potent and selective inhibitor of transketolase(TK) with IC50 of 22 nM for Apo-TK)

<p>BFCAs-1 is a polyamine polycarboxylic bifunctional chelating agent (BFCAs) with a broad range of applications in biology, chemistry, medicine and diagnostic imaging.</p>

<p>CMK, an RSK2 kinase inhibitor, shows similar potency but less chemical stability compared with FMK.</p>

<p>PF-06747711 is an effective and selective retinoic acid receptor-related orphan C2 inverse agonist (IC50: 4.1 nM). PF-06747711 also has anti-skin inflammatory activity.</p>

<p>(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid, a constrained phenylalanine (Phe) analogue, can adopt beta-bend and helical structures, thereby facilitating a preferred side-chain orientation within the peptide.</p>

<p>Benzylacyclouridine (BAU) is a specific UrdPase inhibitor, uridine metabolism and potentiate toxicity of 5-Fu against human prostate cancer cells antitumor.</p>

<p>2-Selenouracil is a specialized photosensitizer for photodynamical therapy.</p>

<p>TCblR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 32-58 KDa and the accession number is Q9NPF0.</p>

<p>Demethyl 8-Epidiosbulbin E acetate is a structural analog of 8-Epidiosbulbin E acetate, a furan analog found in Dioscorea bulbifera L. 8-Epidiosbulbin E acetate is a furan analog found in Dioscorea bulbifera L. It is a structural analog of 8-Epidiosbulbin E acetate.</p>

<p>Daphnin is one of the main coumarin bioactive ingredients with antibacterial activity. Daphnine is isolated from the entire Daphne fragrance, which is a folk medicine used in China to relieve fever.</p>

<p>Metrizoic acid is an ionic contrast medium. Metrizoic acid displays high osmolality and has a risk of inducing allergic reactions.</p>

β-Apo-13-carotenone is a naturally occurring β-apocarotenoid, and is a RXRα antagonist.

<p>4',5'-Dibromofluorescein (Eosinic acid) is a fluorescent dye that can be used as a ligand for protein characterization by spectroscopic analysis.</p>

<p>sodium 4-pentynoate is a alkynylacetate analogue.</p>

<p>L-690330 inhibits human/bovine inositol monophosphatase; Ki: 0.19-0.42 μM. 10x potency vs. mouse/rat IMPase.</p>

<p>L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a KD of 1.3±0.3 µM, and a Kinact of 0.15±0.03 min-1. L-Eflornithine monohydrochloride (L-DFMO monohydrochloride) is an enantiomer of Eflornithine.</p>

<p>Tetrahydrodeoxycorticosterone(Tetrahydro-11-deoxycorticosterone) is a potent GABAA receptor orthosteric modulator (PAM) with neuroprotective activity that selectively inhibits neurosteroid-mediated enhancement of GABA-induced currents at the GABAA receptor, and can be used in the study of neurological disorders.</p>

<p>SPL-410 is a highly potent,selective and orally active inhibitor of hydroxyethylamine based SPPL2a (Signal Peptide Peptidase Like 2a)(IC50 of 9 nM).</p>

<p>Norbiotinamine, a biotin alternative, is a sulfur-containing organic compound with a structure similar to that of biotin.</p>

<p>Endogenous fatty acid glycerol ester</p>

<p>3-Acetylcoumarin as a practical ligand for copper-catalyzed CN coupling reactions at room temperature. It has neuroprotective and acaricidal properties.</p>

<p>3-Methoxyphenylacetic acid belongs to the class of organic compounds known as anisoles. 3-Methoxyphenylacetic acid is slightly soluble (in water) and a weakly acidic compound (based on its pKa).3-Methoxyphenylacetic acid (m-Methoxyphenylacetic acid), a m-hydroxyphenylacetic acid (m-OHPAA) derivative, is a phytotoxin in Rhizoctonia solani. 3-Methoxyphenylacetic acid is used to develop a toxin-mediated bioassay for resistance to rhizoctonia root rot</p>

<p>Dextromethorphan is a noncompetitive NMDA receptor antagonist and sigma-1 agonist that was approved by the FDA in 1958 for use as a cough suppressant.Cost-effective and quality-assured.</p>

<p>Isopulegol has antioxidant, and neuroactive properties. It also has gastroprotective effects induced by isopulegol appear to be mediated, at least in part, by endogenous prostaglandins, K+ATP channel opening and antioxidant proprieties related to GSH increased.</p>

<p>Anisylacetone (Anisylacetone) is an effective lure for the male melon fly.</p>

<p>4-Ethoxycoumarin has antimicrobial activity.</p>

<p>PRGL493 blocks ACSL4, halts PC3/MDA-MB-231 cancer cell spread, and inhibits MA-10 tumor progesterone. Effective in mouse PC3 tumor model at 0.25 mg/kg.</p>

<p>2-Amino-6-(propylamino)-5,6-dihydrobenzo[d]thiazol-7(4H)-one hydrochloride is a useful organic compound for research related to life sciences and the catalog number is T64682.</p>

<p>3'-O-Angeloylhamaudol is a useful organic compound for research related to life sciences and the catalog number is T124112.</p>

<p>Fos-Choline-ISO-9 is a useful organic compound for research related to life sciences. The catalog number is TF0114 and the CAS number is 869646-90-2.</p>

<p>MuRF1-IN-2 (Example 3) is a MuRF1 inhibitor used to study conditions linked to muscle wasting, encompassing both skeletal and cardiac muscle atrophy [1].</p>

<p>cbs-1114 has a wide range of applications in life science related research.</p>

<p>SingaCycle(TM)-A1 is a useful organic compound for research related to life sciences and the catalog number is T67250.</p>

<p>trans-4-Isopropylcyclohexanecarboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T64924 and the CAS number is 7077-05-6.</p>

<p>3-(2-Iodoethoxy)prop-1-yne is a useful organic compound for research related to life sciences. The catalog number is T64472 and the CAS number is 164118-56-3.</p>

<p>Enrofloxacin hydrochloride is an effective antibiotic with an MIC90 of 0.312 μg/mL for Mycoplasma bovis.</p>

<p>5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde is a useful organic compound for research related to life sciences. The catalog number is T67330 and the CAS number is 881677-11-8.</p>

<p>LEO-32731 is a bioactive chemical.</p>

<p>1-Acetyl-4-methylpiperazine hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T67190 and the CAS number is 144205-68-5.</p>

<p>1-(Piperidin-4-yl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-one is a useful organic compound for research related to life sciences and the catalog number is T66378.</p>

<p>3,4-Difluorobenzamide is a useful organic compound for research related to life sciences. The catalog number is T66971 and the CAS number is 85118-04-3.</p>

<p>2-([1,1'-Biphenyl]-4-yl)propanoic acid is a useful organic compound for research related to life sciences and the catalog number is T66534.</p>

<p>1-(4-(Trifluoromethoxy)phenyl)thiourea is a useful organic compound for research related to life sciences. The catalog number is T67168 and the CAS number is 142229-74-1.</p>

<p>N-Methyl-L-isoleucine is a useful organic compound for research related to life sciences. The catalog number is T65964 and the CAS number is 4125-98-8.</p>

<p>Podoblastin A (D-mannitol) is a useful organic compound for research related to life sciences and the catalog number is TSP-41077145.</p>

<p>5-Amino-3-(4-chlorophenyl)-5-oxopentanoic acid is a useful organic compound for research related to life sciences. The catalog number is T65689 and the CAS number is 1141-23-7.</p>

<p>Paromomycin (Sulfate Salt) is an aminoglycoside that is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes. Paromomycin in combination with sodium stibogluconate has proven to be effective in African and Indian VL (visceral leishmaniasis) and improves survival in African VL[3]. PS (Paromomycin Sulfate) is effective for elimination of B. coli without hematological side effects[4]. The activity of phosphoglucose isomerase was slightly inhibited by 10(-3) M paromomycin sulfate while those of hexokinase, phosphofructokinase and glucose-6-phosphate dehydrogenase were not inhibited[5]. In addition, with regard to correlation of endotoxemia with renal impairment, endogenous creatinine clearance and p-aminohippurate clearance were significantly improved (P less than 0.02) in those patients whose endotoxemia disappeared on paromomycin sulfate administration. Paromomycin sulfate seems to be effective in the prevention of endotoxemia and the associated renal impairment in cirrhosis in man[6]. Significantly higher frequencies of resistance to paromomycin, kanamycin, neomycin and tobramycin were observed in S. aureus isolates from PS (paromomycin supplemented) birds. Paromomycin supplementation resulted in resistance to aminoglycosides in bacteria of PS turkeys. Co-selection for resistance to other antimicrobial agents was observed in E. coli isolates[7].</p>

<p>m-PEG5-NHS ester is a PEG-based linker used in PROTACs to connect two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.</p>

<p>Ganoderic acid LM2 exhibits potent enhancement of ConA-induced mice splenocytes proliferation in vitro.</p>

<p>2,5-Dioxopyrrolidin-1-yl hept-6-ynoate is a useful organic compound for research related to life sciences. The catalog number is T64557 and the CAS number is 917222-23-2.</p>

<p>Boc-D-Tyr(2-Br-Z)-OH, with catalog number T66218 and CAS number 81189-61-9, is a valuable organic compound for life sciences research.</p>

<p>(S)-N,N-Dimethyl-1,2,4,5,6,7-hexahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-12-amine is a useful organic compound for research related to life sciences. The catalog number is T67218 and the CAS number is 443965-10-4.</p>

<p>4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile is a useful organic compound for research related to life sciences. The catalog number is T67635 and the CAS number is 103146-25-4.</p>

<p>Zinc-EDTA is a useful organic compound for research related to life sciences. The catalog number is T65166 and the CAS number is 14025-21-9.</p>

<p>Biotin-PEG8-alcohol is a PEG-based linker for PROTACs, joining two essential ligands and facilitating selective protein degradation through the ubiquitin-proteasome system within cells.</p>

<p>Cl-PEG6-acid is a PEG-based linker for PROTACs that connects two essential ligands, crucial for the formation of PROTAC molecules, enabling selective protein degradation via the ubiquitin-proteasome system within cells.</p>

<p>Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride is used as a probe for luminescent detection and quantitation of oxygen [absorption λmax=455 nm, luminescence λmax=613 nm], for fibre optic sensors, and in studies on oxygen in skin and skin tumors as well as measurement of oxygen flux through the skin.</p>

<p>5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66095 and the CAS number is 720720-96-7.</p>

<p>(R)-3-(1-(Dimethylamino)ethyl)phenyl ethyl(methyl)carbamate is a useful organic compound for research related to life sciences and the catalog number is T66465.</p>

<p>Fmoc-D-Phe(4-NO2)-OH, an amino acid derivative, finds extensive applications in life science research.</p>

<p>SH379, a 2-methylpyrimidine diterpene derivative, boosts testosterone synthesis enzymes and autophagy via AMPK/mTOR.</p>

<p>4-Hydroxyestrone, an endogenous estrogen metabolite, can strongly protect neuronal cells against oxidative damage.</p>