Autres inhibiteurs

<p>Argimicin C is an antibiotic isolated from Sphingomonas sp. It exhibits algicidal activity against various toxic cyanobacteria, with a minimum inhibitory concentration (MIC) at the micromolar level.</p>

<p>Argyrin B is a naturally occurring cyclic peptide that acts as a reversible non-competitive inhibitor of the immunoproteasome. It exhibits higher inhibitory selectivity for the β5i and β1i sites of the immunoproteasome compared to the β5c and β1c sites of the constitutive proteasome, being nearly 20 times more selective for β1i than for its homolog β1c. Additionally, Argyrin B possesses antibacterial properties.</p>

<p>Asterriquinone (ARQ) is an analog of Asterriquinone and a Grb-2 binding inhibitor. It hinders the interaction between Grb-2 and tyrosine-phosphorylated EGFR, with an IC50 of 8.37 μM. Additionally, Asterriquinone serves as an HIV1 reverse transcriptase inhibitor, with a Ki of 2.3 μM, and it also inhibits the binding activities of Grb-7 and PLC-γ.</p>

<p>Arborcandin F, a 1,3-β-glucan synthase inhibitor, serves as an antifungal antibiotic. It exhibits IC50 values of 0.012 μg/mL against Candida albicans (C. albicans) and Aspergillus fumigatus (A. fumigatus). For Candida species, the minimum inhibitory concentration (MIC) of Arborcandin F ranges from 0.25 to 1 μg/mL.</p>

<p>Tetraethyl decane-1,10-diylbis(phosphonate) is an alkyl chain-derived linker for PROTACs synthesis[1].</p>

<p>PCSK9 degrader 1 is a selective proprotein convertase substilisin-like/kexin type 9 (PCSK9) degrader. PCSK9 degrader 1 does not affect PCSK9 function.</p>

Arisugacin C is an acetylcholinesterase (AChE) inhibitor with an IC50 value of 2.5 μM.

<p>Albocycline K3 is an inhibitor of melanogenesis derived from microorganisms.</p>

<p>Actiketal is an antibiotic from the glutarimide class that can inhibit the incorporation of [3H] thymidine in EGF-stimulated Balb/MK cells.</p>

<p>Astechrome is a natural product with potent antimalarial activity, exhibiting an IC50 value of 0.94 μM. It also demonstrates cytotoxicity towards Vero cells, with an IC50 of 7.9 μM.</p>

<p>Arisugacin B is a potent, orally active selective inhibitor of acetylcholinesterase (AChE).</p>

<p>Aphidicolin 17-acetate is a selective inhibitor of eukaryotic DNA polymerase α (DNA polymeraseα) that does not inhibit DNA polymerases β and γ. It significantly suppresses DNA synthesis in sea urchin embryos and HeLa cells in vivo without affecting RNA and protein synthesis.</p>

<p>4-Benzylphenol is a phenol derivative widely used in biochemical experiments and drug synthesis research.</p>

<p>GRF (1-29) amide (rat) is a synthetic peptide that stimulates the secretion of growth hormone (GH).</p>

<p>Asticolorin B is a mycotoxic metabolite derived from the fungus Aspergillus variecolor.</p>

<p>Aspergillic acid is an antibiotic (antibiotic) found in Aspergillus species that exhibits broad-spectrum antibacterial activity.</p>

<p>Arisugacin H is a microbial metabolite and a structural analog of Arisugacin A. Unlike Arisugacin A, Arisugacin H does not exhibit activity against AChE (acetylcholinesterase).</p>

<p>2-Isopropyl-4-methylthiazole is a thiazole derivative widely used in biochemical experiments and drug synthesis research.</p>

<p>Leucylproline hydrochloride is a dipeptide that acts as an exogenous peptide to regulate the synthesis of protease in Lactococcus lactis.</p>

<p>Cyclic GMP is an endogenous second messenger that initiates interferon production in response to cytoplasmic DNA. It activates the stimulator of interferon genes (STING), triggering a signaling cascade that results in the production of type I interferons and other immune mediators. The conjugate of cyclic GMP and AMP, known as Cyclic-GMP-AMP, can induce the phosphorylation and nuclear translocation of IRF3, thereby enhancing antiviral immune responses. Additionally, Cyclic GMP may activate PDE to degrade cAMP, inhibit the myocardial calcium current ICa, and regulate cardiac contractility. The derivative 8-Br-cGMP exhibits antiplatelet activity, and Cyclic GMP is used in research related to antiviral immunity and cardiovascular diseases.</p>

<p>Argimicin B is an antibiotic isolated from Sphingomonas sp. It exhibits algicidal activity against various harmful cyanobacteria, with a minimum inhibitory concentration (MIC) at the low micromolar level.</p>

<p>Australifungin is a ceramide synthase inhibitor known for its antifungal activity.</p>

<p>Alliacol A is an antibiotic with relatively weak antibacterial and antifungal properties. It can inhibit DNA synthesis in Ehrlich ascites carcinoma cells.</p>

<p>Talaromyketide B is a polyketide compound identified in the soil bacterium Talaromyces sp. KYS-41, known for its anti-inflammatory properties. It inhibits the activation of NF-κB and MAPK signaling pathways and can dose-dependently suppress pro-inflammatory cytokines, such as IL-1β, IL-6, IL-10, and TNF-α, as well as the transcriptional activity of inflammatory mediators [including iNOS and COX-2]. Talaromyketide B shows promise for research in the fields of immunity and inflammatory diseases.</p>

<p>Propargyl-PEG1-acrylate is a polyethylene glycol (PEG) derived linker employed in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].</p>

<p>Anguibactin is an antibiotic that functions as an iron carrier, exhibiting strong affinity for Fe³⁺.</p>

<p>Aselacin B targets the endothelin-1 receptor (ET-1 Receptor) and inhibits the binding of ET-1 to both ETA and ETB receptors. It is used in cardiovascular disease research.</p>

<p>2,4,6-Trimethylpyridine is a pyridine derivative widely used in biochemical experiments and drug synthesis research.</p>

Arisugacin D is an inhibitor of acetylcholinesterase (AChE) with an IC50 of 3.5 μM.

<p>5-Methyl-2,3-cyclopentenopyrazine is a nitrogen-containing heterocyclic compound, widely used in biochemical experiments and drug synthesis research.</p>

<p>Argyrin A is a cyclic peptide and potent antitumor agent. It functions by inhibiting the proteasome (proteasome), leading to increased levels of endogenous p27kip1 by preventing protein turnover.</p>

<p>Arborcandin C is an inhibitor of 1,3-β-glucan synthase, functioning as an antifungal antibiotic. It exhibits IC50 values of 0.15 μg/mL against Candida albicans (C. albicans) and 0.015 μg/mL against Aspergillus fumigatus (A. fumigatus). The compound's minimum inhibitory concentration (MIC) for Candida species ranges from 1-2 μg/mL.</p>

<p>Paclitaxel-MVCP, with MC-Val-Cit-PAB linker, prepares conjugates for drug delivery, nanomedicine.</p>

<p>Argyrin F is a cyclopeptide with antitumor properties. It inhibits cell proliferation, migration, invasion, and colony formation by partially inducing apoptosis (apoptosis) and epithelial-mesenchymal transition (EMT). Argyrin F stabilizes p27kip, upregulates p21waf1/cip1, and reduces COX2. Argyrin F is applicable for research in pancreatic ductal adenocarcinoma (PDAC).</p>

Angiolam A is an antibiotic that can be isolated from Angiococcus disciformis. It exhibits significant antibacterial activity against Gram-positive bacteria.

<p>Actamycin is an ansamycin-class antibiotic (antibiotic) known for its antibacterial properties.</p>

<p>Kanjone is a compound discovered in Millettia peguensis, which can be used in the synthesis of protein tyrosine phosphatase 1B (protein tyrosinephosphatase1B) inhibitors. Kanjone holds potential for research in the fields of diabetes and neurological disorders.</p>

<p>Asparenomycin B is a carbapenem antibiotic (antibiotic) known for its potent β-lactamase inhibitory activity.</p>

<p>Cicutoxin is a convulsant compound. It inhibits Na+ and K+ channels and suppresses the γ-aminobutyric acid pathway. As a potent GABA antagonist, Cicutoxin induces recurrent seizures and exhibits cholinergic activity. Its primary targets are the brain and skeletal muscles. Cicutoxin can be isolated from [Cicuta maculata] and [Cicuta douglasii].</p>

<p>Asparenomycin A is a carbapenem-class antibiotic known for its potent β-lactamase inhibitory activity.</p>

<p>Asticolorin C is a mycotoxic metabolite derived from the fungus Aspergillus variecolor.</p>

<p>Arborcandin E is a 1,3-β-glucan synthase inhibitor used as an antifungal antibiotic. It exhibits IC50 values of 0.1 μg/mL against Candida albicans (C. albicans) and 0.012 μg/mL against Aspergillus fumigatus (A. fumigatus). Additionally, Arborcandin E has a MIC of 0.5-2 μg/mL for Candida species.</p>

<p>Arborcandin A is a 1,3-β-glucan synthase inhibitor, acting as an antifungal antibiotic. It exhibits IC50 values of 0.25 μg/mL against Candida albicans (C. albicans) and 0.05 μg/mL against Aspergillus fumigatus (A. fumigatus). The MIC for the Candida species is 4-8 μg/mL.</p>

<p>N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) is a PEG-based linker for PROTAC synthesis.</p>

Asperlin is an orally active marine-derived antibiotic with antifungal, anticancer, anti-inflammatory, and anti-atherosclerotic properties. It can induce apoptosis and increase reactive oxygen species (ROS) and DNA damage-related G2/M phase arrest, as well as ATM phosphorylation. Additionally, Asperlin effectively prevents HFD-induced obesity in vivo and modulates gut microbiota.

<p>Arisugacin A is a potent, orally active, and selective inhibitor of acetylcholinesterase (AChE).</p>

<p>Dimerum acid is a dihydroxamate (dihydroxamate) type iron carrier (siderophore) found in Penicillium chrysogenum. It serves as a precursor or degradation product of coprogen and significantly enhances iron uptake in Strategy I plants (such as cucumber) and Strategy II plants (such as maize). At a pH of 6.0, dimerum acid releases bioavailable Fe3+ through ligand exchange with plant-secreted phytosiderophore (phytosiderophore, PS) or EDTA, thereby improving iron supply efficiency in plants. Dimerum acid is applicable in research related to plant iron nutrition and agriculture.</p>

<p>Antiblastin is an antifungal antibiotic identified in cultures of Bacillus chrysomyxa.</p>

<p>Agrocybin is an antifungal peptide that exhibits activity against various fungi but lacks inhibitory effects on bacteria. It also attenuates the activity of HIV-1 reverse transcriptase (HIV-1 reverse transcriptase).</p>

<p>Aestivophoenin A is a microbial metabolite that serves as a neuroprotective agent.</p>