Signalisation du cytosquelette

SS28 inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase.

DM1-SMe (DM1-SSMe) potently inhibits microtubules, 3-10x stronger than Maytansine with IC50s of 0.003-0.01 nM in …

OSIP-486823(CP248) is a novel and potent microtubule disruptor with affinity for both protein kinase G …

PF-2771: potent CENP-E inhibitor, IC50 of 16.1 nM, used in cancer treatment.

AMP-PCP disodium is an ATP analogue with binding affinity to the N-terminal domain of Hsp90, …

S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin(Kd of 0.93 …

Compound 1T-0219 (SC) is a blocker of AKT1-FAK interaction reducing the stimulation of FAK phosphorylation …

Pentachloropseudilin inhibits Myosin-1 and speeds up TGF-β receptor turnover, suppressing TGF-β activity.

NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion …

Dasatinib hydrochloride is an oral Src/Bcr-Abl inhibitor with potent antitumor effects, Ki values of 16 …

Sabizabulin (ABI-231) is an effective and orally bioavailable inhibitor of α and β tubulin against …

AN-019 (NRC-019) is a Bcr-Abl kinase inhibitor with antitumor activity for the study of chronic …

SSTC3 is a casein kinase 1α (CK1α) activator with a Kd of 32 nM.SSTC3 has …

EL-102 is a HIF1α inhibitor with anticancer activity that inhibits microtubule protein polymerization and can …

SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 …

Valategrast hydrochloride (R411), a dual antagonist of integrin α4β1 (VLA-4), is used for the potential …

BMS-688521 is an LFA-1/ICAM interaction inhibitor, a small molecule antagonist of LFA-1 with potential anti-inflammatory …

Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist.Firategrast reduces the transport …

Sabeluzole (R-58735) has antiepileptic and cognitive enhancing properties and may be used in the study …

Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50=3.5 nM) and Akt2 (IC50=42 nM). …

'CCT128930, potent Akt2 inhibitor (IC50=6 nM), 28x more selective over PKA.'

AZ13705339 is an effective inhibitor of PAK1 with an IC50 of 0.33 nM and a …

Cevipabulin (TTI-237) is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to …

β-glycosidase-IN-1 is a piperidine derivative, and is an inhibitor of β-glycosidase. It has hypoglycemic activity.

PF-06651481-00 (Bosutinib Isomer I) is a Bosutinib analog and a Bcr-Abl inhibitor.

BCR-ABL-IN-1 is a BCR-ABL tyrosine kinase inhibitor (pIC50: 6.46) and may be used in the …

CID-663143 inhibits cancer cell growth and shows microtubule-binding activity.

para-Nitroblebbistatin (p-Nitroblebbistatin) is a non-cytotoxic, fluorescent, photostable and specific Myosin II inhibitor.

SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity.

HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor exhibiting antiproliferative activity, with IC50 values of 3.65 …

AJH-836 is a compound that activates Munc13-1 and PKC ε/α, demonstrating a dissociation constant (Kd) …

SMTIN-T140 (compound 6a), a potent TRAP1 (tumor-necrosis-factor-receptor associated protein 1) inhibitor with an IC50 of …

DCPLA-ME (2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid methyl ester) is the methyl ester form of DCPLA and can be …

CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 …

Defactinib hydrochloride (PF 04554878 hydrochloride) is a novel inhibitor of FAK.

CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.

Mivobulin is an inhibitor of tubulin .

Erbulozole (R 55104) is a synthetic microtubule inhibitor with anti-invasive activity that induces Wernicke's encephalopathy-like …

EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).

Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be …

DCP-LA (FR236924), linoleic acid derivatives, selective and direct activation of PKCε.

Tubulin inhibitor 7 is an inhibitor of tubulin and a potent inhibitor of multiple cancer …

KP-23172 is a inhibitor of PI3-K/Akt pathway.

Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK …

M2698 (MSC2363318A) is an inhibitor of p70S6K, Akt1 and Akt3 with IC50s of 1 nM. …

TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective …

AKT-I-1 is a selective and reversible inhibitor of Akt1.

G-5555 is a potent inhibitor of p21-activated kinase 1 (PAK1) (Kis: 3.7 nM and 11 …

Pivanex, an oral HDAC inhibitor, targets metastasis, angiogenesis, reduces Bcr-Abl protein, and promotes apoptosis.

CFI-402257 is a selective inhibitor of Mps1/TTK kinase (Mps1 Ki = 0.09 nM; EC50 = …

Roxifiban acetate(DMP 754 acetate) is a potent GP IIb / IIIa antagonist that exhibits antiplatelet …

Phenamacril (JS39919) is acyanoacrylate fungicide, has powerful inhibition against Fusarium species, especially to Fusarium graminearum.

3CAI inhibits AKT1/2, reduces mTOR/GSK3β, and triggers apoptosis in colon cancer cells.

VTX-27 is a selective inhibitor of protein kinase C θ (PKC θ) (Kis: 0.08 nM …

HSP90-IN-19 is a potent inhibitor of heat shock protein 90 (Hsp90), exhibiting inhibitory activity with …

CCT251455 is an inhibitor of mitotic kinase monopolar spindle 1 (MPS1; IC50: 3 nM).

(-)-Indolactam V: PKC activator, antitumor, Ki 3.36 nM/1.03 μM for η/γ-CRD2, Kd 5.5-213 nM for …

BI-1950: potent inhibitor of LFA-1, key in immune function and drug target.

PKC-theta inhibitor 1 is an inhibitor of PKCθ (Ki of 6 nM)

Ifebemtinib (BI-853520) is an orally active and potent inhibitor of adhesion plaque kinase (FAK) (IC50=1 …