Signalisation du cytosquelette
Les inhibiteurs de la signalisation du cytosquelette sont des composés qui perturbent les voies de signalisation régulant le cytosquelette, essentiel pour la forme, la motilité, la division des cellules et le transport intracellulaire. Ces inhibiteurs sont utilisés pour étudier la dynamique des protéines du cytosquelette, telles que l'actine et la tubuline, et leur rôle dans des processus comme la migration cellulaire, l'adhésion et la métastase du cancer. Les inhibiteurs de la signalisation du cytosquelette sont précieux dans la recherche en biologie cellulaire, en cancérologie et en neurobiologie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de la signalisation du cytosquelette de haute qualité pour soutenir vos recherches dans ces domaines.
1460 produits trouvés pour "Signalisation du cytosquelette"
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Tau ligand-1
CAS :Tau ligand-1 (Compound 75) is a ligand of aggregated tau protein that can penetrate the blood-brain barrier. In tissues affected by Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and Pick's disease, Tau ligand-1 shows high affinity for aggregated tau protein, with equilibrium dissociation constants (KD) ranging from 1 to 3.8 nM. It holds potential as a positron emission tomography (PET) tracer for imaging studies of tau-related diseases within the central nervous system.Formule :C17H16FN3OCouleur et forme :SolidMasse moléculaire :297.327RMS-07
CAS :RMS-07, a covalent MPS1/TTK inhibitor, has an IC50 of 13.1 nM, targeting a kinase hinge cysteine.Formule :C35H40N8O2Couleur et forme :SolidMasse moléculaire :604.74DDO-6691
CAS :DDO-6691 is an inhibitor of heat shock protein 90 (HSP90). It exhibits antiproliferative effects against various tumor cells, with the highest sensitivity observed in HCT-116 colon cancer cells (IC50: 1.08 μM). DDO-6691 also demonstrates potent tumor growth inhibition in HCT-116 xenograft mouse models.Formule :C22H17N3O2SCouleur et forme :SolidMasse moléculaire :387.45FAK-IN-21
CAS :<p>FAK-IN-21 (compound 9) is a FAK inhibitor with an IC50 value of 37.52 nM. It inhibits cell growth and the phosphorylation of FAK, making it useful for research into diffuse gastric cancer.</p>Formule :C22H22F2N8O3SCouleur et forme :SolidMasse moléculaire :516.52GSD-11
GSD-11: Potent, selective anti-austerity agent; blocks Akt/mTOR pathway, hinders PANC-1 cell migration & colony growth. Promising for pancreatic cancer study.Formule :C20H28O2Couleur et forme :SolidMasse moléculaire :300.44Kolavenic acid analog
CAS :KAA, an anticancer compound, inhibits centrosome clustering and targets HSET+ yeast and cancer cells.Formule :C25H38O4Couleur et forme :SolidMasse moléculaire :402.57HSN748
CAS :<p>HSN748 is an analog of ponatinib and acts as a multi-kinase inhibitor. It exhibits inhibitory activity against kinases such as FLT3, ABL1, RET, PDGFRα/β, MNK1, and MNK2. HSN748 can suppress the growth of chronic myeloid leukemia and acute myeloid leukemia cell lines, making it a useful compound in leukemia research.</p>Formule :C27H24F3N7OCouleur et forme :SolidMasse moléculaire :519.521Alfalone
CAS :<p>Alfalone (compound 9ia) is an antimitotic agent. It induces cleavage arrest and initiates the formation of tubercular eggs.</p>Formule :C17H14O5Couleur et forme :SolidMasse moléculaire :298.29Tubulin inhibitor 15
<p>Tubulin inhibitor 15 is a potent tubulin inhibitor with antiproliferative activity. Tubulin inhibitor 15 exhibits cytotoxicity in HepG2 cells [1].</p>Formule :C16H12FNO2Couleur et forme :SolidMasse moléculaire :269.27Latrunculins A
CAS :Latrunculins A is a novel marine toxin, disrupts microfilament organization in cultured cells.Formule :C22H31NO6SCouleur et forme :SolidMasse moléculaire :437.55TACC3 inhibitor 2
CAS :<p>TACC3 inhibitor 2 (Compound 13b) is a TACC3 inhibitor with an IC50 of 200 nM. It induces mitotic arrest, apoptosis (Apoptosis), and DNA damage. TACC3 inhibitor 2 is applicable for research in the field of cancer.</p>Formule :C20H22FN5O2Couleur et forme :SolidMasse moléculaire :383.419XD23
CAS :XD23 is a potent osteosarcoma inhibitor that functions by downregulating DKK1 and activating the WNT/β-catenin signaling pathway.Formule :C22H26ClN7O3Couleur et forme :SolidMasse moléculaire :471.94AKT-IN-11
AKT-IN-11 is one of the most potent antibacterial agents against human hepatocellular carcinoma Bel-7402 cell line (IC50: 1.15 μM).Formule :C27H27ClF3NO4Couleur et forme :SolidMasse moléculaire :521.96Monomethyl auristatin E intermediate-17
CAS :<p>MonomethylauristatinE intermediate-17 is an intermediate compound used in the synthesis of MonomethylauristatinE. MonomethylauristatinE (MMAE) functions as a microtubule/tubulin inhibitor with anticancer properties. It is widely utilized as the cytotoxic component in antibody-drug conjugates (ADCs).</p>Formule :C27H35NO7SMasse moléculaire :517.63AS2521780
CAS :AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).Formule :C30H41N7OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :547.76DCEM1
CAS :<p>DCEM1 binds to heat shock protein 60 (HSP60) and inhibits the interaction between HSP60 and ClpP, thereby blocking the mitochondrial unfolded protein response. Additionally, DCEM1 suppresses the expression of β-catenin and reduces ATP production in PC-3 and TKO cells. It is utilized in research related to prostate cancer.</p>Formule :C22H23N3O2SCouleur et forme :SolidMasse moléculaire :393.50Isodienestrol
CAS :Isodienestrol, a derivative of Diethylstilbestrol, acts as a microtubule (Microtubule) inhibitor. It is utilized in cancer research.Formule :C18H18O2Couleur et forme :SolidMasse moléculaire :266.3316,16-Dimethyl prostaglandin E2
CAS :<p>16,16-Dimethyl prostaglandin E2 regulates hematopoietic stem cells via EP2/EP4 and Wnt, taken orally.</p>Formule :C22H36O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :380.52OPN expression inhibitor 1
CAS :OPN expression inhibitor 1 is an osteopontin expression inhibitor used in the study of breast cancer metastasis.Formule :C25H33N3O5Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :455.55G-9791
CAS :G-9791 is an effective and selective inhibitor of group-I PAK.Formule :C26H26ClFN6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :508.98α5β1 integrin agonist-1
CAS :α5β1 integrin agonist-1 is an α5β1 integrin agonist that selectively delivers 5-FU to tumour cells and induces tumour cell death.Formule :C24H26FN5O9Couleur et forme :SolidMasse moléculaire :547.49GR 83895
CAS :GR 83895 is an antagonist of prototype fibrinogen receptor.Formule :C29H39N9O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :673.74FO-4-15
CAS :<p>FO-4-15 is an activator of mGluR1/CaMKIIα. It exhibits protective effects against H2O2 in human neuroblastoma (SH-SY5Y) cells. In mice with Alzheimer's disease, FO-4-15 enhances cognitive function by activating the mGluR1/CaMKIIα pathway, reducing Aβ accumulation, Tau hyperphosphorylation, and synaptic damage.</p>Formule :C18H20N4O4SCouleur et forme :SolidMasse moléculaire :388.44Tasidotin hydrochloride
CAS :<p>Tasidotin hydrochloride, a dolastatin 15 analog, inhibits microtubule assembly and dynamics.</p>Formule :C32H59ClN6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :643.30AMXI-5001 hydrochloride
<p>AMXI-5001 hydrochloride, an oral inhibitor of PARP1/2 and microtubules, shows greater potency and selective anti-cancer effects.</p>Formule :C25H21ClFN5O3Couleur et forme :SolidMasse moléculaire :493.92Hsp110-STAT3 interaction-IN-1
CAS :Row174336 (compound 29) serves as an efficient inhibitor of the Hsp110-STAT3 interaction, exhibiting antiproliferative activity in the HPAEC cell line with an IC50 of 22.67 μM.Formule :C23H31N3O4SCouleur et forme :SolidMasse moléculaire :445.58Lisavanbulin
CAS :<p>Lisavanbulin (BAL-101553) is a prodrug of Avanbulin (BAL 27862), a microtubule-targeting agent. It exhibits antitumor activity, particularly effective against tumors with high expression of end-binding protein 1.</p>Formule :C26H29N9O3Couleur et forme :SolidMasse moléculaire :515.57EX05
CAS :<p>EX05, an effective KIF18A inhibitor, exhibits an IC50 of 8.2 nM and holds potential for cancer research applications.</p>Formule :C26H30F2N4O5SCouleur et forme :SolidMasse moléculaire :548.60Hsp90-IN-34
CAS :Hsp90-IN-34 (compound HAM-1) is a chemical inhibitor that targets the Aha1-Hsp90 chaperone complex with high affinity (KDapp=23.5 µM). It modulates the ATPase activity of Hsp90 by affecting the interaction between Hsp90 and Aha1.Formule :C22H14F2N6OCouleur et forme :SolidMasse moléculaire :416.38Zalunfiban dihydrochloride
<p>Zalunfiban (RUC-4) is a potent αIIbβ3 platelet antagonist, IC50 45 nM, used in myocardial infarction research.</p>Formule :C16H20Cl2N8O2SCouleur et forme :SolidMasse moléculaire :459.35Tubulin inhibitor 19
Tubulin inhibitor 19 (9b), a potent indole chalcone, strongly blocks tubulin, valuable in cancer studies.Formule :C21H23NO5Couleur et forme :SolidMasse moléculaire :369.41AMG28
CAS :AMG28 is an inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 805 nM and 988 nM, respectively. Additionally, AMG28 suppresses the phosphorylation of tau protein at the Ser422 site, with an IC50 of 1.85 μM.Formule :C20H20N4OCouleur et forme :SolidMasse moléculaire :332.399Quinagolide hydrochloride
CAS :Quinagolide hydrochloride is a selective agonist of dopamine D2 receptor.Formule :C20H34ClN3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :432.02Tubulin inhibitor 22
Compound 4c: Strong tubulin inhibitor with anti-cancer & anti-angiogenic effects; halts MGC-803 cells in G2/M, triggers Caspase-mediated apoptosis.Formule :C20H17BrFNO4Couleur et forme :SolidMasse moléculaire :434.26Dictyostatin
CAS :Dictyostatin: potent microtubule stabilizer & anticancer agent with antiproliferative effects; researched for tauopathies.Formule :C32H52O6Couleur et forme :SolidMasse moléculaire :532.75FPDT
FPDT combats glioblastoma by inhibiting the AKT pathway; IC50: >100 μM (astrocytes), 45-68 μM (GBM cells).Formule :C16H12FNO2SCouleur et forme :SolidMasse moléculaire :301.34Tubulin polymerization-IN-34
"Tubulin-IN-34 inhibits oxazolylisoindole microtubule assembly, selective for VL51 lymphoma."Formule :C31H35N3O6Couleur et forme :SolidMasse moléculaire :545.63AKT-IN-10
CAS :AKT-IN-10, a potent AKT inhibitor, has potential for breast and prostate cancer research, impacting cell growth and survival pathways.Formule :C26H34ClN5O2Couleur et forme :SolidMasse moléculaire :484.03NRX-2663
CAS :NRX-2663 boosts β-catenin binding to E3 ligase SCFβ-TrCP (Kd: 54.8 nM, EC50: 22.9 nM).Formule :C20H13F3N2O5Couleur et forme :SolidMasse moléculaire :418.32Tubulin polymerization-IN-74
CAS :<p>Tubulin polymerization-IN-74 (compound 11) is an inhibitor of tubulin polymerization, with an IC50 value of 15 μM. It is applicable to cancer research.</p>Formule :C14H11NSCouleur et forme :SolidMasse moléculaire :225.309Macbecin I
CAS :Hsp90 inhibitorFormule :C30H42N2O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :558.66TTBK1/2-IN-3
CAS :<p>TTBK1/2-IN-3 (compound 10) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 579 nM and 258 nM, respectively. TTBK1/2-IN-3 can reduce the expression of primary cilia on the surface of human induced pluripotent stem cells (iPSC).</p>Formule :C21H22N4OCouleur et forme :SolidMasse moléculaire :346.426SF0166
CAS :SF0166: potent αvβ3 antagonist, IC50: 0.6 nM. Blocks cell adhesion, IC50: 7.6 pM-76 nM. Reduces neovascularization in mice.Formule :C23H27F2N5O4Couleur et forme :SolidMasse moléculaire :475.49Hsp90-IN-37
CAS :<p>Hsp90-IN-37 (Z-2) is an inhibitor of heat shock protein 90 (Hsp90), demonstrating a 69% inhibition rate on Hsp90 enzyme activity. It exhibits antitumor properties.</p>Formule :C12H15N3O2Couleur et forme :SolidMasse moléculaire :233.2666-B345TTQ
CAS :<p>6-B345TTQ is an α4 integrin inhibitor that can impede the interaction between α4 and Leupaxin. This compound is applicable for studies focused on inflammation research.</p>Formule :C22H20BrNO4Couleur et forme :SolidMasse moléculaire :442.303NRX-103094
CAS :NRX-103094 boosts β-catenin binding to SCFβ-TrCP ligase with EC50 62 nM and Kd 0.6 nM.Formule :C20H11Cl2F3N2O4SDegré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :503.28NRX-252114
CAS :NRX-252114 promotes mutant β-catenin degradation, binding it to E3 ligase SCFβ-TrCP (EC50: 6.5 nM; Kd: 0.4 nM).Formule :C22H12Cl2F3N3O2SDegré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :510.32AKT Kinase Inhibitor
CAS :AKT Kinase Inhibitor is an Akt inhibitor with antitumor activity that selectively inhibits cell proliferation in a dose-dependent manner.Cost-effective and quality-assured.Formule :C16H19N7O3Degré de pureté :97.83% - 99.13%Couleur et forme :SolidMasse moléculaire :357.37Ombrabulin
CAS :<p>Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.</p>Formule :C21H26N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :402.44ZW4864
CAS :ZW4864 is a selective inhibitor of the β-catenin/B-Cell Lymphoma 9 protein (β-catenin/BCL9 PPI) interaction, demonstrating oral activity. It inhibits β-catenin/BCL9 PPI with a K_i value of 0.76 μM and an IC_50 value of 0.87 μM.Formule :C33H43ClN6O3Couleur et forme :SolidMasse moléculaire :607.2Cercosporin
CAS :<p>Cercosporin, produced by the plant pathogen Cercospora kikuchii and the elsinochromes, is a potent photosensitizer with a short activation wavelength. Cercosporin contains perylene quinone structural features essential for PKC activity (IC50: 0.6-1.3 μM).</p>Formule :C29H26O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :534.5120-HETE
CAS :<p>20-HETE is a CYP450 product, vasoconstrictor, modulates K+ channels, affects NADPH, ROS, NF-κB, NO synthase, and cell apoptosis/proliferation.</p>Formule :C20H32O3Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :320.4724-Methylenecycloartanyl ferulate
CAS :24-Methylenecycloartanyl ferulate, a compound belonging to the γ-oryzanol family, demonstrates the ability to enhance parvin-beta expression within human breast cancer cells. Furthermore, it exhibits potential as an ATP-competitive Akt1 inhibitor, with an EC 50 value of 33.3 μM.Formule :C41H60O4Couleur et forme :SolidMasse moléculaire :616.927Methyl (6-chloro-1H-benzo[d]imidazol-2-yl)carbamate
CAS :Methyl (6-chloro-1H-benzo[d]imidazol-2-yl)carbamate is a useful organic compound for research related to life sciences. The catalog number is T65302 and the CAS number is 20367-38-8.Formule :C9H8ClN3O2Couleur et forme :SolidMasse moléculaire :225.63Sevasemten
CAS :<p>Sevasemten is an allosteric inhibitor that targets skeletal muscle myosin. It displays selectivity in its inhibition, demonstrated by IC50 values of ≤10 μM for skeletal muscle myosin and >100 μM for cardiac myosin, respectively.</p>Formule :C16H11F4N5O2Couleur et forme :SolidMasse moléculaire :381.28Tau tracer 2
CAS :Tau tracer 2 (Pl-2620) is a specific imaging agent designed to detect and visualize Tau protein aggregates, primarily used for diagnosing neurodegenerative diseases [1].Formule :C15H9FN4Couleur et forme :SolidMasse moléculaire :264.263PF-03814735
CAS :<p>PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.</p>Formule :C23H25F3N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.48Cevipabulin fumarate
CAS :Cevipabulin (TTI-237) fumarate is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell line).Formule :C22H22ClF5N6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :580.89CMX-2043
CAS :<p>CMX-2043 is a drug potentially to block oxidative damage and activate cell survival pathways.</p>Formule :C16H26N2O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.52BCR-ABL-IN-8
CAS :<p>BCR-ABL-IN-8 (compound 26f) is a BCR-ABL inhibitor featuring a trimethoxy group [1].</p>Formule :C30H33N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :571.63
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