Signalisation du cytosquelette
Les inhibiteurs de la signalisation du cytosquelette sont des composés qui perturbent les voies de signalisation régulant le cytosquelette, essentiel pour la forme, la motilité, la division des cellules et le transport intracellulaire. Ces inhibiteurs sont utilisés pour étudier la dynamique des protéines du cytosquelette, telles que l'actine et la tubuline, et leur rôle dans des processus comme la migration cellulaire, l'adhésion et la métastase du cancer. Les inhibiteurs de la signalisation du cytosquelette sont précieux dans la recherche en biologie cellulaire, en cancérologie et en neurobiologie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de la signalisation du cytosquelette de haute qualité pour soutenir vos recherches dans ces domaines.
1382 produits trouvés pour "Signalisation du cytosquelette"
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KY-02327 acetate
<p>KY-02327 acetate inhibits Dvl-CXXC5, stabilizes Wnt/β-catenin signaling, and enhances osteoblast differentiation.</p>Formule :C22H31N3O6Couleur et forme :SolidMasse moléculaire :433.5RMS-07
CAS :<p>RMS-07, a covalent MPS1/TTK inhibitor, has an IC50 of 13.1 nM, targeting a kinase hinge cysteine.</p>Formule :C35H40N8O2Couleur et forme :SolidMasse moléculaire :604.74SR121566A
CAS :<p>SR121566A is a novel non-peptide antagonist of Glycoprotein IIb/IIIa (GP IIb-IIIa).</p>Formule :C20H25N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :431.51C086
CAS :<p>C086 is a novel and potent Hsp90 inhibitor that suppresses cell cycle progression, induces apoptosis, and exhibits anti-metastatic properties by modulating various mechanisms in different cell types.</p>Formule :C29H28O8Couleur et forme :SolidMasse moléculaire :504.536-B345TTQ
CAS :<p>6-B345TTQ is an α4 integrin inhibitor that can impede the interaction between α4 and Leupaxin. This compound is applicable for studies focused on inflammation research.</p>Formule :C22H20BrNO4Couleur et forme :SolidMasse moléculaire :442.303MT-134
<p>MT-134 is a SkMII -specific inhibitor and has excellent exposure in muscles.</p>Formule :C19H16N4O3Couleur et forme :SolidMasse moléculaire :348.36Tau ligand-1
CAS :<p>Tau ligand-1 (Compound 75) is a ligand of aggregated tau protein that can penetrate the blood-brain barrier. In tissues affected by Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and Pick's disease, Tau ligand-1 shows high affinity for aggregated tau protein, with equilibrium dissociation constants (KD) ranging from 1 to 3.8 nM. It holds potential as a positron emission tomography (PET) tracer for imaging studies of tau-related diseases within the central nervous system.</p>Formule :C17H16FN3OCouleur et forme :SolidMasse moléculaire :297.327Nrf2/HO-1 activator 2
<p>Compound 13m, a difluoro derivative, activates Nrf2/HO-1, showing neuroprotective and antioxidant effects, useful in PD research.</p>Formule :C20H16F2O5Couleur et forme :SolidMasse moléculaire :374.33GR 83895
CAS :<p>GR 83895 is an antagonist of prototype fibrinogen receptor.</p>Formule :C29H39N9O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :673.74Des-ethyl-carafiban
CAS :<p>Des-ethyl-carafiban (Compound 44) is an antagonist of the fibrinogen receptor, effectively inhibiting platelet aggregation induced by various agonists. It is useful for research in thrombotic diseases.</p>Formule :C22H23N5O5Couleur et forme :SolidMasse moléculaire :437.448POSH-IN-2
CAS :<p>POSH-IN-2 (MIDI) is a mitochondrial fission inhibitor and a DRP1 inhibitor that effectively prevents mitochondrial fragmentation caused by cellular stress and genetic mitochondrial damage. It covalently interacts with DRP1-C367 to target the interaction of DRP1 with multiple receptors.</p>Formule :C22H16N2O2Couleur et forme :SolidMasse moléculaire :340.37GSK3335103
CAS :<p>GSK3335103 is a non-peptide, orally active inhibitor of αvβ6 integrin (pIC50=8), employed in the study of pulmonary fibrosis.</p>Formule :C27H36FN3O4Couleur et forme :SolidMasse moléculaire :485.59FO-4-15
CAS :<p>FO-4-15 is an activator of mGluR1/CaMKIIα. It exhibits protective effects against H2O2 in human neuroblastoma (SH-SY5Y) cells. In mice with Alzheimer's disease, FO-4-15 enhances cognitive function by activating the mGluR1/CaMKIIα pathway, reducing Aβ accumulation, Tau hyperphosphorylation, and synaptic damage.</p>Formule :C18H20N4O4SCouleur et forme :SolidMasse moléculaire :388.44NRX-2663
CAS :<p>NRX-2663 boosts β-catenin binding to E3 ligase SCFβ-TrCP (Kd: 54.8 nM, EC50: 22.9 nM).</p>Formule :C20H13F3N2O5Couleur et forme :SolidMasse moléculaire :418.32Fradafiban
CAS :<p>Fradafiban binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. Fradafiban is a non-polypeptide platelet glycoprotein IIb/IIIa antagonist.</p>Formule :C20H21N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :367.40Hsp110-STAT3 interaction-IN-1
CAS :<p>Row174336 (compound 29) serves as an efficient inhibitor of the Hsp110-STAT3 interaction, exhibiting antiproliferative activity in the HPAEC cell line with an IC50 of 22.67 μM.</p>Formule :C23H31N3O4SCouleur et forme :SolidMasse moléculaire :445.58Tubulin polymerization-IN-8
CAS :<p>Compound IIc inhibits tubulin polymerization, arrests cell cycle at G2/M in HCT116 cells, IC50 12.7 μM, potential for cancer research.</p>Formule :C21H24N4O4SCouleur et forme :SolidMasse moléculaire :428.5Ack1 inhibitor 1
CAS :<p>Ack1 inhibitor 1 is a potent and selective orally active inhibitor of ACK1 kinase, with an IC50 value of 2.1 nM. It effectively inhibits the phosphorylation of ACK1 and the activation of downstream AKT, demonstrating anti-tumor activity [1].</p>Formule :C39H40F3N7O4Couleur et forme :SolidMasse moléculaire :727.77TTBK1/2-IN-3
CAS :<p>TTBK1/2-IN-3 (compound 10) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 579 nM and 258 nM, respectively. TTBK1/2-IN-3 can reduce the expression of primary cilia on the surface of human induced pluripotent stem cells (iPSC).</p>Formule :C21H22N4OCouleur et forme :SolidMasse moléculaire :346.426ETB
CAS :<p>ETB is a potent inhibitor of Hsp60 chaperone activity. It can impede the chaperone function of both wild-type proteins and the C237A and C447A mutant proteins. ETB binds to Hsp60 at Cys442, and the C442A mutant demonstrates resistance to ETB inhibition.</p>Formule :C24H33NO6Masse moléculaire :431.52Kolavenic acid analog
CAS :<p>KAA, an anticancer compound, inhibits centrosome clustering and targets HSET+ yeast and cancer cells.</p>Formule :C25H38O4Couleur et forme :SolidMasse moléculaire :402.57Tubulin polymerization-IN-33
<p>Tubulin-IN-33, an oxazoloisoindole, hinders microtubule assembly; effective against NCI cancer cells.</p>Formule :C27H28N2O6Couleur et forme :SolidMasse moléculaire :476.52TPI-287
CAS :<p>TPI 287: synthetic taxane; may halt cancer by stabilizing microtubules, blocking cell division, inducing apoptosis.</p>Formule :C46H63NO15Couleur et forme :SolidMasse moléculaire :869.99Nrf2/HO-1 activator 1
CAS :<p>Compound 24: Potent Nrf2/HO-1 activator with neuroprotective, antioxidant properties; useful in PD research.</p>Formule :C21H18O5Couleur et forme :SolidMasse moléculaire :350.36Tubulin polymerization-IN-35
<p>Tubulin-IN-35 inhibits oxazolylisoindole microtubule formation, targeting VL51 marginal zone lymphoma.</p>Formule :C31H35N3O5Couleur et forme :SolidMasse moléculaire :529.63Onalespib lactate
CAS :<p>Onalespib lactate is a second-generation, potent and selective HSP90 Inhibitor with antitumor activity.</p>Formule :C27H37N3O6Couleur et forme :SolidMasse moléculaire :499.6Antitumor agent-200
CAS :<p>Antitumor agent-200 (Compound 2g) is a microtubule synthesis inhibitor that binds to the colchicine site on tubulin, causing G2/M cell cycle arrest and inducing reactive oxygen species (ROS) production. It demonstrates significant inhibitory activity against P-glycoprotein (P-gp) overexpressing cell lines MCF7/ADR and KBV200, with resistance indices (DRI) of 0.83 and 0.58, respectively. In an MCF-7 xenograft model, Antitumor agent-200 (at 25 mg/kg, administered intraperitoneally) achieves a 57.2% tumor growth inhibition rate. This compound is applicable for research in the field of cancer therapy.</p>Formule :C19H21FN2O3SeCouleur et forme :SolidMasse moléculaire :423.34Tubulin inhibitor 49
CAS :<p>Tubulin inhibitor 49 (Compound 18) is an inhibitor of tubulin polymerization with an IC50 of 48 μM. It disrupts the microtubule network of cells, causing cell cycle arrest in the G2 phase, and exhibits cytotoxicity with an IC50 of 8.8 μM in HeLa cells.</p>Formule :C18H14F3N3OSCouleur et forme :SolidMasse moléculaire :377.383Quinagolide hydrochloride
CAS :<p>Quinagolide hydrochloride is a selective agonist of dopamine D2 receptor.</p>Formule :C20H34ClN3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :432.02XD23
CAS :<p>XD23 is a potent osteosarcoma inhibitor that functions by downregulating DKK1 and activating the WNT/β-catenin signaling pathway.</p>Formule :C22H26ClN7O3Couleur et forme :SolidMasse moléculaire :471.94HSP90-IN-9
<p>HSP90-IN-9: potent HSP90 inhibitor, dose-dependent fungicide, impedes biofilm/morphology with FLC, reverses FLC resistance.</p>Couleur et forme :SolidAChE/GSK-3β-IN-1
CAS :<p>AChE/GSK-3β-IN-1 is a potent dual AChE/GSK-3β inhibitor that crosses the blood-brain barrier and acts on hAChE (IC50: 1.2 nM), hBChE (IC50: 149.8 nM) and hGSK-</p>Formule :C31H35N7O3SCouleur et forme :SolidMasse moléculaire :585.72SPA0355
CAS :<p>SPA0355 is a thiourea derivative with antioxidant and anti-inflammatory properties. It inhibits RANKL (receptor activator of nuclear factor κB ligand)-induced osteoclastogenesis in primary bone marrow-derived macrophages and suppresses the activation of MAPKs, Akt, and NF-κB pathways. Furthermore, SPA0355 enhances osteoblast differentiation by increasing alkaline phosphatase activity and mineralized nodule formation. It protects ovariectomized mice from bone loss by stimulating osteoblast differentiation and inhibiting osteoclast resorption, making it a potential candidate for studying postmenopausal osteoporosis.</p>Formule :C22H21N3O2SCouleur et forme :SolidMasse moléculaire :391.486SF0166
CAS :<p>SF0166: potent αvβ3 antagonist, IC50: 0.6 nM. Blocks cell adhesion, IC50: 7.6 pM-76 nM. Reduces neovascularization in mice.</p>Formule :C23H27F2N5O4Couleur et forme :SolidMasse moléculaire :475.49HSN748
CAS :<p>HSN748 is an analog of ponatinib and acts as a multi-kinase inhibitor. It exhibits inhibitory activity against kinases such as FLT3, ABL1, RET, PDGFRα/β, MNK1, and MNK2. HSN748 can suppress the growth of chronic myeloid leukemia and acute myeloid leukemia cell lines, making it a useful compound in leukemia research.</p>Formule :C27H24F3N7OCouleur et forme :SolidMasse moléculaire :519.521Ethaboxam
CAS :<p>Ethaboxam is a β-tubulin inhibitor and antifungal agent used against oomycete pathogens.</p>Formule :C14H16N4OS2Degré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :320.43AKT-IN-26
CAS :<p>AKT-IN-26 (Compound 453) is an AKT inhibitor that binds to the Pleckstrin Homology (PH) domain of AKT. It is useful for research related to cell proliferation and cancer involving the AKT pathway.</p>Formule :C21H17N5O4SCouleur et forme :SolidMasse moléculaire :435.456Hsp90-IN-38
CAS :<p>Hsp90-IN-38 (compound 20m) is an inhibitor of HSP90 (heat shock protein). It demonstrates a strong binding affinity to HSP90 with a Kd of 87 nM. The compound inhibits ATPase activity with an IC50 of 0.13 μM. Hsp90-IN-38 also shows inhibitory effects on HCT116, MCF-7, SKBr3, K562, and A549 cells with IC50 values of 0.187, 0.072, 0.105, 0.403, and 0.031 μM, respectively.</p>Formule :C28H35N3O5Couleur et forme :SolidMasse moléculaire :493.595NAP1051
CAS :<p>NAP1051, a biomimetic analog of Lipoxin A4, serves an anti-tumor role by targeting the inflammatory tumor microenvironment. It inhibits the chemotaxis of neutrophils to fMLP and stimulates macrophage efferocytosis by activating AKT. NAP1051 is utilized in research on colorectal cancer.</p>Formule :C23H34O5Couleur et forme :SolidMasse moléculaire :390.51Tubulin polymerization-IN-77
CAS :<p>Tubulin polymerization-IN-77 (Compound 15c) is a microtubule polymerization inhibitor that exhibits anti-glioblastoma activity by hindering microtubule polymerization. It demonstrates significant blood-brain barrier permeability, effectively induces G2/M phase arrest in GBM cells, and triggers apoptosis, while also markedly inhibiting tumor cell migration.</p>Formule :C22H19BrF3NO7Couleur et forme :SolidMasse moléculaire :546.288Terpendole E
CAS :<p>Terpendole E is an atypical L5 site inhibitor.</p>Formule :C28H39NO3Couleur et forme :SolidMasse moléculaire :437.61KU-32
CAS :<p>KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.</p>Formule :C20H25NO8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :407.41JC168
CAS :<p>JC168 is a phenyl analog of peloruside and functions as a microtubule inhibitor with antiproliferative and anticancer properties. It enhances tubulin polymerization, thereby disrupting microtubule dynamics, making it a useful agent in the study of microtubule-associated diseases.</p>Formule :C26H40O7Couleur et forme :SolidMasse moléculaire :464.592APN/AKT-IN-1
<p>APN/AKT-IN-1, a dual APN (IC50=0.21μM) & AKT (IC50=0.27μM) inhibitor, hinders GSK3β phosphorylation.</p>Formule :C18H27N7O3Couleur et forme :SolidMasse moléculaire :389.45Si306
CAS :<p>Si306, an Src inhibitor, exhibits antitumor activity by reducing the phosphorylation of focal adhesion kinase (FAK) and the expression of epidermal growth factor receptor (EGFR), thereby inhibiting the invasion of human glioblastoma (GBM).</p>Formule :C25H26BrClN6OSCouleur et forme :SolidMasse moléculaire :573.94Nic-15
CAS :<p>Nic-15 (compound 4n) serves as an anti-constrictive agent targeting the low vascular characteristics of pancreatic tumors. These characteristics enable cancer cells to adapt to the nutrient-deficient tumor microenvironment and develop resistance to treatment. Nic-15 modulates the PI3K/Akt/mTOR pathway and alleviates ER stress induced by Gemcitabine. It significantly inhibits migration and colony formation in MIA PaCa-2 and PANC-1 pancreatic cancer cells. When used in combination with Gemcitabine, Nic-15 effectively addresses resistance issues in pancreatic tumors. In xenograft models in vivo, Nic-15 notably enhances the efficacy of Gemcitabine.</p>Formule :C25H26F2O3Couleur et forme :SolidMasse moléculaire :412.47Myoseverin B
CAS :<p>Myoseverin B is a microtubule assembly inhibitor that impedes tubulin polymerization (IC50 = 2 μM) and generally exhibits low cytotoxicity across most cell types. It is utilized in antitumor agent research.</p>Formule :C27H32N6O2Couleur et forme :SolidMasse moléculaire :472.582β-Catenin modulator-8
CAS :<p>β-Catenin modulator-8 (Compound Ⅸa) is a specific β-catenin modulator for use in cancer research.</p>Formule :C17H20N2O2SDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :316.42Epothilone E
CAS :<p>Epothilone E, a derivative of epothilone, functions by inhibiting microtubule protein activity, thereby halting cell division and exhibiting anti-tumor</p>Formule :C26H39NO7SCouleur et forme :SolidMasse moléculaire :509.66
