Signalisation du cytosquelette
Les inhibiteurs de la signalisation du cytosquelette sont des composés qui perturbent les voies de signalisation régulant le cytosquelette, essentiel pour la forme, la motilité, la division des cellules et le transport intracellulaire. Ces inhibiteurs sont utilisés pour étudier la dynamique des protéines du cytosquelette, telles que l'actine et la tubuline, et leur rôle dans des processus comme la migration cellulaire, l'adhésion et la métastase du cancer. Les inhibiteurs de la signalisation du cytosquelette sont précieux dans la recherche en biologie cellulaire, en cancérologie et en neurobiologie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de la signalisation du cytosquelette de haute qualité pour soutenir vos recherches dans ces domaines.
1382 produits trouvés pour "Signalisation du cytosquelette"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
SIAIS100
<p>SIAIS100, a potent BCR-ABL PROTAC degrader, demonstrates a DC50 value of 2.7 nM, highlighting its efficacy.</p>Formule :C44H50ClF2N9O5SCouleur et forme :SolidMasse moléculaire :890.44TAT-Gap19 TFA
<p>TAT-Gap19 TFA is a peptide that inhibits Cx43 hemichannels but not gap junctions and may reduce liver fibrosis.</p>Formule :C121H213F3N46O28Couleur et forme :SolidMasse moléculaire :2817.272-Methylbutyrylcarnitine chloride
<p>2-Methylbutyrylcarnitine (chloride) acts as a gut microbial metabolite that targets integrin α2β1 on platelets, facilitating the activation of cytosolic phospholipase A2 (cPLA2) and enhancing platelet hyperresponsiveness. This compound further augments platelet hyperreactivity and promotes thrombus formation in mice. It is also characterized as a branched-chain acylcarnitine.</p>Formule :C12H24ClNO4Couleur et forme :SolidMasse moléculaire :281.78K34c hydrochloride
CAS :<p>K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study.</p>Formule :C26H30ClN3O4Degré de pureté :99.76% - 99.89%Couleur et forme :SoildMasse moléculaire :483.99Myelin Basic Protein
CAS :<p>Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system.</p>Formule :C60H103N21O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1390.59AB-3PRGD2
CAS :<p>AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.</p>Formule :C137H215IN30O45SCouleur et forme :SolidMasse moléculaire :3161.32Tubulin polymerization-IN-50
<p>Tubulin Polymerization-IN-50 (compound 7n) serves as an inhibitor of tubulin polymerization, exhibiting an IC50 of 5.05 μM in SK-Mel-28 cells and inducing cell</p>Formule :C24H20FN3O3Couleur et forme :SolidMasse moléculaire :417.43BCR-ABL-IN-3
CAS :<p>BCR-ABL-IN-3 irreversibly inhibits Bcr-Abl with <100 nM IC50, showing significant anti-cancer effects.</p>Formule :C20H17ClF2N4O3SCouleur et forme :SolidMasse moléculaire :466.89Fuzapladib
CAS :<p>Fuzapladib (IS-741) is a PLA2 inhibitor that reduces Mac-1 expression to prevent inflammation and pancreatitis.</p>Formule :C15H20F3N3O3SDegré de pureté :99.87%Couleur et forme :SoildMasse moléculaire :379.4Bimosiamose disodium
CAS :<p>Bimosiamose disodium (TBC-1269Z), a pan-selectin inhibitor, has IC50s: E-selectin 88 μM, P-selectin 20 μM, L-selectin 86 μM; anti-inflammatory.</p>Formule :C46H52Na2O16Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :906.88PKCε Inhibitor Peptide acetate
<p>PKCε Inhibitor Peptide acetate is a selective PKCε inhibitor containing the site for its specific receptor for activated C kinase (RACK).</p>Formule :C39H69N9O15Degré de pureté :98.93%Couleur et forme :SolidMasse moléculaire :904.02KT D606
CAS :<p>KT D606 is a PAK kinase family inhibitor with an IC50 of 4 μM. It selectively inhibits the proliferation of cancer cells transformed by oncogenic RAS mutants, making it useful for studying RAS/PAK1-induced cancers.</p>Formule :C59H50N6O10Couleur et forme :SolidMasse moléculaire :1003.06Ac-MRGDH-NH2
<p>Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru(Ph2phen)2(OH2)2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.</p>Formule :C25H41N11O8SCouleur et forme :SolidMasse moléculaire :655.727T-808
CAS :<p>T-808 is a tau tracer which may be used in radiographic labeling of Tau aggregates during Alzheimer's disease.</p>Formule :C17H19FN4Couleur et forme :SolidMasse moléculaire :298.36PKCδ Peptide Substrate
CAS :<p>PKCδ Peptide Substrate is a highly specific substrate for the δ-type of Protein kinase C, composed of a sequence that mirrors murine eEF-1α (422-443) and</p>Formule :C109H191N35O29SCouleur et forme :SolidMasse moléculaire :2487.97GSK3178022
<p>GSK3178022 is a human IgG1 monoclonal antibody (mAb) that targets LRP6. It inhibits the expression of the WNT target genes SP5 and AXIN2 and demonstrates antitumor activity in colorectal cancer RSPO fusion models. The recommended isotype control is HumanIgG1kappa, Isotype Control.</p>Couleur et forme :Odour Liquidst-Ht31
CAS :<p>Ht-31 stearate: Blocks RII subunits of PKA & AKAP interaction in cells; cell-permeable.</p>Formule :C129H217N29O39Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2798.27PROTAC HSP90 degrader BP3
CAS :<p>PROTAC BP3 selectively degrades HSP90, inhibits breast cancer growth (DC50=0.99µM), CRBN-dependent.</p>Formule :C32H29ClN8O5Couleur et forme :SolidMasse moléculaire :641.08Mps1-IN-6
<p>Mps1-IN-6 is a potent Mps1 inhibitor that demonstrates antiproliferative and antitumor activities, exhibiting an IC50 of 2.596 nM [1].</p>Formule :C35H39N9O3Couleur et forme :SolidMasse moléculaire :633.74αVβ8-IN-1
CAS :<p>αVβ8-IN-1 is an αVβ8 integrin inhibitor that suppresses the growth of multiple tumour cell lines (EMT6, CT26, KPC, TKCC-10).</p>Formule :C25H32ClN5O4Couleur et forme :SolidMasse moléculaire :502.01PDI-IN-4
<p>PDI-IN-4 (Compound 14d) is a protein disulfide isomerase inhibitor with an IC50 value of 0.48 μM. It prevents platelet aggregation and thrombosis by reducing the activation of GPIIb/IIIa, without causing significant cytotoxicity. PDI-IN-4 is applicable in thrombosis research.</p>Formule :C17H12F3NO2Couleur et forme :SolidMasse moléculaire :319.278Microtubule-associated protein tau (26-44)
<p>Microtubule-associated protein tau (26-44) is a synthetic peptide with an amino group conjugated to glutamine and a carboxyl group conjugated to lysine.</p>Formule :C83H127N25O34SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :2051.11FRATide
CAS :<p>FRATtide inhibits the phosphorylation of Axin and β-catenin, inhibits GSK-3 binding to Axin, and is a peptide derived from the GSK-3 binding protein.</p>Formule :C55H102N2O2Couleur et forme :SolidMasse moléculaire :823.433LY 379196
<p>LY 379196, a potent PKC-β inhibitor (IC 50: 50 nM for PKC βI and 30 nM for PKC βII), effectively suppresses the proliferation of bovine retinal microvascular endothelial cells (BREC) induced by VEGF, IGF-1, and bFGF. This compound serves as an antiproliferative agent for proliferative retinopathy.</p>Formule :C30H34N4O5SCouleur et forme :SolidMasse moléculaire :562.68Hypoglycemic agent 3
<p>Compound H26, a derivative of corosolic acid, functions as Hypoglycemic agent 3. It exhibits lipid-lowering and significant blood glucose-reducing properties, making it a potential hypoglycemic drug. Hypoglycemic agent 3 targets MCCC1 to mitigate insulin resistance, and may be useful in researching type 2 diabetes.</p>Formule :C32H51NO5Couleur et forme :SolidMasse moléculaire :529.751SNIPER(ABL)-044
<p>SNIPER(ABL)-044, a compound that links HG-7-85-01 (ABL inhibitor) to Bestatin (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, achieving a</p>Formule :C51H64F3N9O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1020.17Arimoclomol citrate
CAS :<p>Arimoclomol citrate boosts Hsp expression, aiding protein aggregation and neuron protection.</p>Formule :C20H28ClN3O10Couleur et forme :SolidMasse moléculaire :505.91MS5033
CAS :<p>MS5033 is a potent proteolysis-targeting chimera (PROTAC) that effectively degrades AKT (also known as protein kinase B), exhibiting a half-maximal degradation</p>Formule :C51H66ClN11O11Couleur et forme :SolidMasse moléculaire :1044.59Myosin V-IN-1
CAS :<p>Myosin V-IN-1: potent, selective Myosin V inhibitor, Ki of 6 μM; hinders actin-activated ATPase by blocking ADP release.</p>Formule :C29H26N6O3SDegré de pureté :98.64% - 98.64%Couleur et forme :SolidMasse moléculaire :538.62SNIPER(ABL)-024
CAS :<p>SNIPER(ABL)-024, a compound that conjugates GNF5 (ABL inhibitor) to an LCL161 derivative (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels,</p>Formule :C52H61F3N8O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1031.15BMP agonist 1
<p>BMP Agonist 1 (compound 2 b) is a small-molecule stimulator of bone morphogenic protein (BMP) signaling, crucial for the differentiation of C2C12 cells.</p>Formule :C21H16N2O6Couleur et forme :SolidMasse moléculaire :392.36Chemerin-9 (149-157)
CAS :<p>Chemerin-9, a nonapeptide C-terminal fragment of chemerin, retains full protein's activity as a ChemR23 agonist.</p>Formule :C54H66N10O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1063.16Rotigaptide
CAS :<p>Rotigaptide, modulates Cx43 for gap junctions, counteracts uncoupling, and maintains communication under stress.</p>Formule :C28H39N7O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :617.65Bimosiamose
CAS :<p>Bimosiamose has anti-inflammatory effects[1].</p>Formule :C46H54O16Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :862.91PROTAC BCR-ABL Degrader-1
<p>PROTAC BCR-ABL Degrader-1 (compound PROTAC 1), featuring a 2-oxoethyl linker, promotes Bcr-Abl degradation through the ubiquitin-proteasome pathway and</p>Formule :C43H40N10O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :792.84Crosstide
CAS :<p>Crosstide is a peptide analog of glycogen synthase kinase-3 (GSK-3) that functions as a natural substrate for Akt/PKB.</p>Formule :C48H77N17O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1164.23Pironetin
CAS :<p>Pironetin, from Streptomyces, inhibits microtubule polymerization and tumor growth, and causes cell cycle arrest.</p>Formule :C19H32O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :324.45ALB-109564 dihydrochloride
CAS :<p>ALB-109564 dihydrochloride: Semi-synthetic, vinblastine-derived, microtubule inhibitor, arrests tumor cells in G2/M phase.</p>Formule :C47H62Cl2N4O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :929.99para-amino-Blebbistatin
CAS :<p>para-amino-Blebbistatin is a water-soluble, stable, non-phototoxic inhibitor of non-muscle myosin II, with enhanced properties over blebbistatin.</p>Formule :C18H17N3O2Couleur et forme :SolidMasse moléculaire :307.353Aberrant tau degrader 2
CAS :<p>Aberrant tau degrader 2 (Compound 4-12) acts as a degrader of tau protein and serves as a target protein ligand for the synthesis of PROTAC degrader C004019.</p>Formule :C19H27N7O3SCouleur et forme :SolidMasse moléculaire :433.528Hsp110/sGC-modulator-1
<p>Hsp110/sGC-modulator-1 (compound 17i) is a dual-target modulator of Hsp110 and sGC with oral activity, exhibiting optimal molecular activity against both Hsp110 and sGC targets. Additionally, it demonstrates significant inhibitory effects on malignant cellular phenotypes and vasodilation. Hsp110/sGC-modulator-1 (compound 17i) alleviates pulmonary vascular remodeling and right ventricular hypertrophy by inhibiting Hsp110.</p>Couleur et forme :Odour SolidTubulin inhibitor 36
<p>Tubulin Inhibitor 36 (Compound 10) serves as a potent novel inhibitor of tubulin polymerization, which consequently induces apoptosis in glioblastoma cells,</p>Formule :C16H13ClN6SCouleur et forme :SolidMasse moléculaire :356.83PROTAC BCR-ABL1 ligand 1
CAS :<p>GMB-475 is a PROTAC ligand targeting BCR-ABL1 for degradation via E3 ligase recruitment.</p>Formule :C17H12F3N3O2Couleur et forme :SoildMasse moléculaire :347.29Mesalamine impurity P
CAS :<p>Mesalamine impurity P, a 5-Aminosalicylic acid derivative, is a PPARγ agonist, inhibiting PAK1 and NF-κB.</p>Formule :C13H11NO6SCouleur et forme :SolidMasse moléculaire :309.30JG-258
CAS :<p>JG-258 is an inactive negative control for Hsp70 inhibitors [1] .</p>Formule :C20H22ClN3OS3Couleur et forme :SolidMasse moléculaire :452.06hAChE-IN-1
<p>hAChE-IN-1 (Compound 24) is a potent inhibitor of human acetylcholinesterase (hAChE), exhibiting an inhibition concentration half-maximum (IC50) of 1.09 μM.</p>Formule :C22H24N4OCouleur et forme :SolidMasse moléculaire :360.45MPH-220
CAS :<p>MPH-220: Oral myosin-2 inhibitor, induces muscle relaxation, useful for spasticity research.</p>Formule :C20H21N3O3SCouleur et forme :SolidMasse moléculaire :383.46MS143
CAS :<p>MS143: potent AKT degrader, DC50=46 nM, GI50=0.8 µM in PC3 cells, degrades AKT via ubiquitin-proteasome, suppresses cancer growth.</p>Formule :C59H81ClN12O6SCouleur et forme :SolidMasse moléculaire :1121.87187-1, N-WASP inhibitor
CAS :<p>Inhibits N-WASP by stabilizing its autoinhibited form, blocking PIP2-induced actin assembly (IC50 ~2 μM), not directly affecting actin polymerization.</p>Formule :C96H122N18O16Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1784.13Delcasertib acetate
<p>Delcasertib acetate is a selective δ protein kinase C (δPKC) inhibitor for the study of acute myocardial infarction and pain.</p>Formule :C122H203N45O36S2Degré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :2940.33
