Molécules organiques diverses avec substitutions isotopiques

<p>Applications Labelled rac-Nicotine (N412420). Nicotine is an alkaloid isolated from plants. Nicotine is an active stimulant, having both addictive and carcinogenic properties. Nicotine can be absorbed through the alimentary canal, respiratory tract and intact skin. Nicotine is used in the treatment of smoking withdrawal syndrome. Nicotine has been used as an anthelmintic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ferretti, G., et al.: J. Med. Chem., 45, 4724 (2002), Guillen, M., et al.: J. Agric. Food Chem., 53, 1093 (2005), Ramunno, A., et al.: Bioorg. Med. Chem. Lett., 15, 3237 (2005), Alburges, M., et al.: Eur. J. Pharmacol., 573, 124 (2007),<br></p>

<p>Applications A component of garlic which revealed antiplatelet, antithrombotic activity and reduced LDL oxidation thus indicating their possible use for cardiovascular disease.<br>References Steinberg, D., et al.: J. Biol. Chem., 272, 20963 (1997), Lawson, L., et al.: J. Agric. Food Chem., 53, 6254 (2005), Gonen, A., et al.: Pathobiology, 72, 325 (2005),<br></p>

<p>Stability Very Volatile<br>Applications Isotope labelled N-Nitrosodimethylamine is a highly toxic semi-volatile organic compound and a suspected human carcinogen. It induces liver tumors in rats after chronic exposure to low doses (1,2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br>Dangerous Goods Info This compound is forbidden to ship by air under IATA regulations.<br>References 1. Peto, R. et al.: Cancer Res.1991 Dec 1;51(23 Pt 2):6415-51.2. Lee, ES. et al.: J. Pharm. Pharmacol., 2003 Aug;55(8):1169-74<br></p>

<p>Applications Active antimalarial constituent of the tradional Chinese medicinal herb Artemisia annua L., Compositae, which has been known for almost 2000 years as Qinghao. Antimalarial.<br>References Klayman, D.L., et al.: Science, 228, 1049 (1985), Price, R.N., et al.: Expert Opin. Invest. Drugs, 9, 1815 (2000), Meshnick, S.R., et al.: Int. J., Parasitol., 32, 1655 (2002),<br></p>

<p>Applications 2-Chloroethanol is used in the preparation of TTFTT (tetrathiafulvalene-2,3,6,7-tetrathiolate) and important building block in TTF syntheis. In addition, it is used in the synthesis of vinyltriazoles. This is the labeled analog.<br>Dangerous Goods Info This compound is forbidden to ship by air under IATA regulations.<br>References Svenstrup, N. et al.: Synthesis, 8, 809 (1994); Thibault, R. et al.: J. Am. Chem. Soc., 128, 12084 (2006);<br></p>

<p>Stability Unstable in Solution<br>Applications The main labelled metabolite of Artemisinin, Arteether, Artemether, Artesunate. An active antimalarial metabolite.<br>References e Vries, P., et al.: Drugs, 52, 818 (1996), Kamolrat, S., et al.: Antimicrob. Agents Chemother., 47, 3795 (2003), Mithwani, S., et al.: Br. J. Clin. Pharmacol., 57, 146 (2004),<br></p>

<p>Applications N-Methyl-d3-N-nitroso-p-toluenesulfonamide is the labeled version of Diazald; Diazomethane precursor.<br>References Takizawa, et al.: J. Pharm. Soc. Jpn., 70, 490 (1950)<br></p>