Composés deutérés

<p>Applications 1,2-Dihydrodesonide-d3 is the labeled analogue of 1,2-Dihydrodesonide (D448170), a reactant in the synthesis of 21-substituted corticosteroids which are used as topical antiinflammatory agents.<br>References Mitsukuchi, M., et. al.: Chem. Pharm. Bull, 37, 1795 (1989)<br></p>

<p>Applications (3,4,5-Trimethoxyphenyl)acetic-alpha,alpha-d2 Acid (CAS# 344299-45-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Potassium Dodecanoate-d23 (CAS# 51732-20-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Iodopropane-d7 is the isotope labelled analog of 2-Iodopropane (I718795); a reagent used in the synthesis of 4'-O-alkyl-chitobiosyl-4-methylumbelliferone as human chitinase fluorogenic substrates.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Duivenvoorden, B.A., et al.: Carbohyd. Res., no vol., no pp. (2014, ahead of print)<br></p>

<p>Applications Vinylene-D2 Carbonate is deuterium labelled analogue of Vinylene Carbonate (V375010), which is used as an additive for electrolyte solutions for Lithium-ion and Sodium-ion batteries.<br>References Aurbach, D., et al.: Electrochim. Acta, 47, 1423 (2002); Hu, Y., et al.: Angew. Chem. Int. Ed., 47, 1645 (2008); Komaba, S., et al.: Adv. Funct. Mater., 21, 3859 (2011);<br></p>

<p>Applications 1,2,4,5-Tetramethylbenzene-d14 (CAS# 15502-50-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications L-2-Aminobutyric-3,3-d2 Acid (CAS# 352431-37-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,3,5-Benzene-2,4,6-d3-tricarboxylic Acid (CAS# 62790-27-6) is a useful isotopically labeled research compound.<br></p>

<p>Stability Volatile<br>Applications Acetonitrile (15n, 98%+) (cas# 14149-39-4) is a useful research chemical.<br></p>

<p>Applications Isotope labelled analog of N-Nitrosobis(2-hydroxypropyl)amine (N525225), a compound that exhibits carcinogenicity in duct cells.<br>References Chang, P., et al.: Environ. Mol. Mutagen, 41, 43 (2003), Prohaska, J., et al.: Exp. Biol. Med., 228, 959 (2003), Abe, K., et al.: Biomed. Res., 26, 187 (2005), Abe, M., et al.: J. Toxicol. Pathol., 19, 129 (2006),<br></p>

<p>Applications Labelled N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide (F595365). Rosuvastatin intermediate.<br></p>

<p>Applications 2,6-Dimethylnaphthalene-d12 (CAS# 350820-12-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Deoxycholic Acid-24-13C (CAS# 52886-37-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled Indole derivative with anticancer activity.<br>References Lavrenov, S. et al.: Bioorgan. Med. Chem. 18, 6905 (2010)<br></p>

<p>Applications 4-n-Octyl-d17-anisole (CAS# 1219794-56-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Cyclopropylmethanol-d3, is a labeled analogue of Cyclopropylmethanol (C988605), which is used to increase selectivity of pyridyl-cinnoline phosphodiesterase 10A, inhibitors against phosphodiesterase 3 (PDE3). Also used in the synthesis of benzodiazapin-2-ones<br>References Hu, E. et al.: Bioorg. Med. Chem. Lett., 22, 6938 (2012);<br></p>

<p>Applications Pinacol-d12 is an intermediate in the synthesis of Isotope labelled Tebuconazole (T013002), which is an ergosterol biosynthesis inhibitor present in most pesticide formulations (1,2). Various uptake is observed in plants (3). Drinking water Contaminant Candidate List 3 - CCL 3 as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br></p>

<p>Applications 2-Nitrobiphenyl-2’,3’,4’,5’,6’-d5 (cas# 64420-97-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Bis(m-cresyl) o-Cresyl Phosphate-d7 is labelled Bis(m-cresyl) o-Cresyl Phosphate (B419220), an isomer of Tricresyl phosphate (TCP) which is used as an anti-wear additive in aircraft turbine engine oil.<br>References De Nola, G., et al.: J. Chrmoat. A, 1200, 211 (2008)<br></p>

<p>Applications N-4-Hydroxyphenyl-N'-1,2,3-thiadiazol-5-ylurea-d4 is labelled N-4-Hydroxyphenyl-N'-1,2,3-thiadiazol-5-ylurea (H949385) which is a substrate of cytokinin O-glucosyltransferase with position specificity related to receptor recognition. It is a metabolite of Thidiazuron (T344275) which is a non-purine containing urea derivative with cytokinin activity.<br>References Mok, M., et al.: Plant Physio., 137, 1057(2005); Benezet, H., et al.: Trans. Missouri Academy. Sci., 14, 75 (1980); Orlikowska, T., et al.: Plant Cell Tissue Org. Cult., 59, 95 (1999), Ray, T., et al.: Mol. Biol., 6, 35 (2005), Kanwar, J., et al.: Hort Sci., 2008, 35, 35 (2008),<br></p>

<p>Applications 1-Bromopentane-1,1,2,2-d4 (CAS# 1219803-61-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Phosphoric Acid-D4 Trifluoroboroane Deuterium Oxide is an intermediate in the synthesis of 3-Hydroxy Benzopyrene-d11 (H829402), which is a abelled metabolite of Benzopyrene (BaP), a carcinogenic component of tobacco smoke implicated in lung cancer.<br>References DiBiasio, K., et al.: Drug Metab. Dispos.,19, 227 (1991), Beach, J., et al.: J. Anal. Toxicol., 24, 670 (2000), Borman, S., et al.: Toxicol. Appl. Pharmacol., 167, 191 (2000), Tsai-Turton, M., et al.: Biol. Reprod., 77, 442 (2007),<br></p>

<p>Applications 2-Nitrobiphenyl-d9 (CAS# 38537-53-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications tert-Butyl Methyl Ether-d12 (CAS# 284487-64-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications (±)-Ropivacaine-d7 (propyl-d7) (CAS# 1392208-04-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled Glycerol (G598400) is used both in sample preparation and gel formation for polyacrylamide gel electrophoresis. Glycerol (5-10%) increases the density of a sample so that the sample will layer at the bottom of a gel’s sample well. Glycerol is also used to aid in casting gradient gels and as a protein stabilizer and storage buffer component.<br>References Bartsch, W., et al.: Arzeim.-Forsch., 26, 1581 (1976),<br></p>

<p>Applications Hydrocinnamic-alpha,alpha-d2 Acid (CAS# 19136-97-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,5-Dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one-d3 is the deuterated version of 2,5-Dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one (D480165), which is an impurity of Alosetron (A575500) that is a serotonin 5HT3 receptor antagonist, used in treatment of irritable bowel syndrome.<br>References Camilleri, M., et al.: Lancet, 355, 1035 (2000); Nestorov, I., et al.: Drug Metab. Dispos., 30, 276 (2002); Lewis, D., et al.: Drug Metab. Rev., 35, 1 (2003); Tang, H., et al.: J. Pharm. Sci., 95, 1783 (2006); Gleeson, M., et al.: J. Med. Chem., 50, 101 (2007);<br></p>

<p>Applications 4-Hydroxypiperidine-3,3,4,5,5-d5 (CAS# 1219799-35-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications (R)-(-)-Phenylephrine-2,4,6-d3 HCl (CAS# 1276197-50-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications (1,2,5,6-Tetramethyl-d6)naphthalene is the labeled analogue of 1,2,5,6-Tetramethylnaphthalene (T303675), a polycyclic aromatic hydrocarbon that has been found in petroleum.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Forster, P.G., et. al.: J. Chromatogr., 483, 384 (1989)<br></p>

<p>Applications 3-Hydroxy-2-naphthoic Acid-d6 is an intermediate used in the synthesis of Pamoic Acid-d10 (P173502), which is a labelled Pamoic Acid. Agonist of the orphan G protein-coupled receptor GPR35: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Used as an inhibitor in the real-time fluorescence enzymatic characterization study of specialized human DNA polymerases. Enzyme replacement therapy in pancreatic enzyme deficiency.<br>References Fonge H., et al.: Bioconjugate Chem., 18, 1924 (2007), Mayr, G.W., et al.: J. Biol. Chem., 282, 35424 (2007); Zhao, P. et al.: Mol. Pharmacol., 78, 560 (2010); Dorjsujen, D. et al.: Nuc. Acids Res., 37, e128 (2009);<br></p>

<p>Applications Ethyl N-n-Butyl-d9-carbamate (CAS# 1276197-24-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Hexylbenzene-2,3,4,5,6-d5 (CAS# 1219799-07-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Fluoro-1,3-dioxolan-2-one-d3 is the labeled version of 4-Fluoro-1,3-dioxolan-2-one (F591523)<br></p>

<p>Applications 1-Bromo-3-chloro-5-fluorobenzene-d3 (CAS# 1219805-00-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications (2,4-Dichlorophenoxy-d3)acetic-d2 Acid (CAS# 352438-69-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromopentane-1,1-d2 (CAS# 77734-75-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Methylform-d1-amide (CAS# 26103-38-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Tetradecanoic-14,14,14-d3 Acid (CAS# 62217-71-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,4-Diethylbenzene-d14 (CAS# 1219803-64-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methyl Methacrylate-d5 (CAS# 55935-46-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Malathion (Diethyl-d10) is used as one of the substances for the clean-up step in post-harvest pesticide residue analysis.<br>References Ucles, A., et al.: Talanta, 144, 51 (2015)<br></p>

<p>Applications Reagent used in the addition of labelled cyclopropane.<br></p>

<p>Applications Iodoethane-1,1-d2 is a useful reagent in synthesis of 1,4-benzoquinones.<br>References Foland, L., et al.: J. Am. Chem. Soc., 111, 975 (1989);<br></p>

<p>Applications rac Desethyl Phenyl Oxybutynin-d5 is an intermediate in the synthesis of rac Desethyl Oxybutynin-d5 Hydrochloride (D289478), a labelled metabolite of the drug Oxybutynin (D289475). Used in the treatment of incontinence.<br>References Hughes, K., et al.: Xenobiotica, 22, 859 (1992); Oki, T., et al.: Biol. Pharm. Bull., 24, 491 (2001); Fetscher, C., et al.: Br. J. Pharmacol., 136, 64 (2002); Zobrist, R., et al.: Pharm. Res., 20, 103 (2003)<br></p>

<p>Applications Fenthoxon (Dimethylphosphate-d6) is derived from Methyl Alcohol-d4 (M265107), which is the labeled analog of methyl alcohol, a common laboratory solvent used primarily in spectroscopic techniques (UV/VIS, NMR, IR). Also, it is a major metabolite of Fenthion (FEN). It is used as organophosphorus pesticides.<br>References Dawson, D.M. et al.: Phys. Chem. Chem. Phys., 15, 919 (2013); Buratti, F., et al.: Toxicol. Lett., 167, 245 (2006), Buratti, F., et al.: Drug Metab. Dispos., 33, 295 (2005), Buratti, F., et al.: Toxicology, 241, 33 (2007),<br></p>

<p>Applications Sodium 2-Methylpropionate-1-13C (CAS# 71105-51-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,2'-Binaphthyl-d14 (CAS# 210487-05-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Tetra-n-propyl-d28-ammonium Bromide (CAS# 284474-84-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Acetylpiperazine-d4 is labelled N-Acetylpiperazine-d4 which was used to prepare (aryl)sulfanyltriazoles with HIV-1 non-nucleoside reverse transcriptase inhibiting activities. It was also used to synthesize diphenylpyrazolecarboxamides as heat shock protein chaperone inhibitors and anticancer agents.<br>References Wang, Z., et al.: Bioorg. Med. Chem. Lett., 16, 4174 (2006); Brough, P., et al.: J. Med. Chem, 51, 196 (2008)<br></p>

<p>Applications Ethylene Glycol Distearate-d4 is a deuterated version of Ethylene Glycol Distearate (E917572), a component of face wash and shampoo.<br>References Kang, Daiping, et al.: Guangdong Huagong, 42(6), 60-62 (2015);Zhang, Kai, et al.: Guangdong Huagong, 42(19), 69-70 (2015);Yu, He, et al.: Guangdong Huagong, 40(1), 27, 45 (2013)<br></p>

<p>Applications 5-(N,N-Dimethyl)-amiloride-d6 Hydrochloride is an isotopic analog of 5-(N,N-Dimethyl)-amiloride Hydrochloride (D470570), which has been used to investigate biochemical processes related to the circadian clock in mouse and human cell lines. It can also inhibit sodium-hydrogen exchangers (NHE). NHEs regulate sodium and pH in various tissues.<br>References Isojima, Y., et al.: Proc. Natl. Acad. Sci. USA 106, 15744 (2009); Masereel, B., et al.: Eur J Med Chem 38, 547 (2003)<br></p>

<p>Applications N-(4-Bromo-2-picolinoylphenyl)-2-chloroacetamide-d4 is the isotope labelle danalog of N-(4-Bromo-2-picolinoylphenyl)-2-chloroacetamide. N-(4-Bromo-2-picolinoylphenyl)-2-chloroacetamide is a derivative of 2-(2-Amino-5-bromobenzoyl)pyridine (A601785); an intermediate in the preparation of Bromazepam (B678500).<br>References Panderi, I., et al.: J. Pharm. Biomed. Anal., 17, 327 (1998); El-Haj, B., et al.: J. Anal. Toxicol., 25, 316 (2001); Hansen, S., et al.: J. Pharm. Biomed. Anal., 39, 322 (2005)<br></p>

<p>Applications n-Dodecyl Alcohol-d26 (CAS# 38086-03-2) is a useful isotopically labeled research compound. It can be used for neutron spin-echo spectroscopy.<br>References Yamaguchi, T., et.al., J. Phys.Chem.B., 123, 239-246,(2019);<br></p>

<p>Applications 1-Aminonaphthalene-d9 (CAS# 78832-56-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 5-(4-Hydroxyphenyl)-5-phenyl-d5-hydantoin-15N2 (CAS# 369656-71-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Iodo-2,3-dimethoxybenzene-d6 is the isotope labelled analog of 1-Iodo-2,3-dimethoxybenzene. 1-Iodo-2,3-dimethoxybenzene is used in the preparation of fused heterocyclic amido compounds as a potential anti hepatitis C virus agents.<br>References Aoyama, H., et al.: Bioorg. Med. chem., 19, 2675 (2011);<br></p>

<p>Applications N,N-Dimethylhexadecylamine-d6 N-Oxide is an isotopic analog of N,N-Dimethylhexadecylamine N-Oxide (7128-91-8).<br></p>

<p>Applications Cardiogenol C-d4, Hydrochloride is an isotope labelled analog of Cardiogenol C, Hydrochloride. Cardiogenol C, Hydrochloride is a potent, cell permeable inducer of embryonic stem cell differentiation in cardiomyocytes displaying an Ec50 of 100nm.<br>References Wu, X., et al.: J. Am. Chem. Soc., 126, 1590 (2004)<br></p>

<p>Stability Hygroscopic<br>Applications Phenylboronic Acid-d5 is the isotope labelled analog of Phenylboronic Acid (P319590); a compound used in the organic synthesis of various pharmaceutical goods.<br>References Ainley, A.D., et al.: J. Chem. Soc., 2171 (1930)<br></p>

<p>Applications 5alpha-Androstan-3alpha-ol-17-one-16,16-d2 (CAS# 89685-22-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled 1-Naphthol (N367990). Used in the manufacturing of dyes, intermediates, synthetic perfumes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications DL-Lysine-4,4,5,5-d4 2HCl (CAS# 284664-88-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Chlorooctane-d17 (CAS# 1219803-93-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Mercaptoethanol-1,1,2,2-d4 (CAS# 284474-53-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Intermediate in the production of labelled Dutasteride<br>References Wlassoff, W., et al.: J. Pharm. Pharmacol., 59, 1549 (2007), Kumar, N., et al.: Bioorg. Med. Chem., 17, 5388 (2009),<br></p>

<p>Applications 3-Mercaptopropionic-2,2,3,3-d4 Acid (CAS# 1141488-67-6) is a useful isotopically labeled research compound. It is used for structural proteomics interactions.<br>References Petrotchenko, E., et.al., Mol. Cell Proteomics, 8,273-286,(2009);<br></p>

<p>Applications Propionic Acid (1-13c, 99%) (cas# 6212-69-7) is a useful research chemical.<br></p>