Composés deutérés

<p>Applications Ethyl-1-d1 Alcohol (CAS# 1624-36-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromo-2,5-difluorobenzene-d3 (CAS# 1219795-54-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethyl-2,2,2-d3-triphenylphosphonium Bromide (CAS# 1560-55-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Aminopiperidine-3,3,4,5,5-d5 (CAS# 1219803-60-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications trans-1,4-Dibromo-2-butene-d6 (CAS# 118886-18-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled Formamide is a compound that is used in biochemistry to prevent RNA samples from degradation due to RNAses. Formamide is also used as a plasticizer to prepare thermoplastic starch (TPS), a special type of starch that can be mixed with other synthetic polymers because of its unique ability to “flow”.<br>References Chomczynski, P.: Nuc. Acids Res., 20, 3791 (1992); Ma, X. &amp; Yu, J.: Acta Polym. Sinica 2, No vol. given, 240 (2004); Rodriguez-Gonzalez, F., et al.: Polymer, 44, 1517 (2003); Shi, Q., et al.: Polym. Degrad. Stabil., 96, 175 (2011)<br></p>

<p>Applications Reagent used to make labelled Catechol.<br></p>

<p>Applications 2-Bromofluorobenzene-d4 (CAS# 50592-35-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Eicosapentaenoyl Ethanolamide-d4 is labelled Eicosapentaenoyl Ethanolamide (E477960) which inhibits dietary-restriction-induced lifespan extension in wild type and TOR pathway mutant nematodes.<br>References Lucanic, M., et al.: Nature, 473, 226 (2011)<br></p>

<p>Applications Ethanol-13C2 is a labelled analogue of Ethanol, which is used in alcoholic beverages in suitable dilutions and as solvent in laboratory and industry, in the manufacture of denatured alcohol, pharmaceuticals, in perfumery, and in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wiberg, G.S., et al.: Toxicol. Appl. Pharmacol., 16, 718 (1970); Brown, N.A., et al.: Science, 206, 573 (1979);<br></p>

<p>Applications 4-tert-Butylbenzyl Bromide-D13 is the labeled form of 4-tert-Butylbenzyl Bromide (B692457), which was used as a reagent in the organic synthesis of several compounds including that of C(5)-substituted analogs of inhibitor BRP-7. Also used in the preparation of hydroxy-based sphingosine kinase inhibitors;Also, it is an intermediate used in the synthesis of Pyridaben-d13 (P991262), which is deuterium labelled Pyridaben. Pyridaben is a pyridazinone derivative used as an insecticide and acaricide. In the European Union, Pyridaben has been authorized for use as an insecticide and acaricide from 1 May 2011. In Germany, Austria and Switzerland, no plant protection products containing this active substance are authorized. Pyridaben is a colorless solid that is practically insoluble in water. Cann<br>References Levent, S., et al.: Eur. J. Med. Chem., 122, 510 (2016); Xi, M., et al.: Bioorgan. Med. Chem., 24, 3218 (2016);<br></p>

<p>Applications 4-(3’,6’-Dimethyl-3’-heptyl)phenol diethoxylate-13C6 (cas# 1173019-36-7) is a compound useful in organic synthesis.<br></p>

<p>Applications Oleic Acid Methyl Ester-d3 is labelled Oleic Acid Methyl Ester (M330110) which is an intermediate used to prepare cis-9,10-Epoxystearic Acid Methyl Ester, an inhibitor of soybean lipoxygenase.<br>References Wright, S., et al.: Bioorg. Med. Chem. Lett., 2, 1385 (1992)<br></p>

<p>Applications p-Nitrophenyl Acetate-13C,d3 (cas# 1794766-80-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Acetanilide-d3 is the deuterium labelled form of Acetanilide (A168330).<br></p>

<p>Applications Thymine-alpha,alpha,alpha,6-d4 (CAS# 156054-85-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-(2-Aminoethoxy)anisole-d3 (cas# 1189881-28-4) is a compound useful in organic synthesis.<br></p>

<p>Applications (Z,Z)-5,11-Eicosadienoic Acid Methyl Ester-d3 is the isotope labelled analog of (Z,Z)-5,11-Eicosadienoic Acid Methyl Ester (E476810); the methyl ester derivative of (Z,Z)-5,11-Eicosadienoic Acid (E476800) which is a biomarker for trophic transfer.<br>References Koussoroplis, A., et al.: Lipids, 43, 461 (2008); Nguyen, J., et al.: Drug Dev. Res., 51, 233 (2000)<br></p>

<p>Applications Thiazole Orange-d3 is the isotope labelled analog of Thiazole Orange (T344135); a fluorescent DNA staining dye used for reticulocyte analysis.<br>References Lee, L.G., et al.: Cytometry, 7, 508 (1986); Cho, H., et al.: ACS Nano, 7, 2032 (2013)<br></p>

<p>Applications Isotope labelled 1-Pyrenyl Potassium Sulfate is used as a biomarker of exposure to polycyclic aromatic hydrocarbons.<br>References Woudneh, M. et al.: J. Chrom. A., 1454, 93 (2016);<br></p>

<p>Applications Acenaphthene-d10 is an isotopic analog of Acenaphthene (1,2-Dihydro Acenaphthylene)(D448330), which is a polycyclic aromatic hydrocarbon.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hansen, B., et al.: Environ. Toxicol. Chem., 18, 772 (1999), Czub, G., et al.: Environ. Sci. Technol., 38, 2406 (2004),<br></p>

<p>Applications N,N-Diethyl-2-hydroxyacetamide-d10 is a derivative compound of N,N-Diethyl-2-hydroxyacetamide (D444580), a reactant used in the synthesis of phosphonate prodrugs to increase the oral bioavailability of an antiviral agent 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA).<br>References Starrett, J. E., et al.: J. Med. Chem., 37, 1857-64 (1994)<br></p>

<p>Applications n-Hexane-1,1,1,2,2,3,3-d7 (CAS# 32740-31-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethyl-d5-methylamine (CAS# 1219804-73-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-tert-Butyldimethylsilyloxyethanol-d4 (cas# 764650-43-3) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Butyl sodium sulfate-D9 is a labelled analogue of Butyl sodium sulfate (B693875). Butyl sodium sulfate is the sulfate salt of Monobutyl sulfate (M525130). Monobutyl sulfate is used as a wetting agent in the mercerization (a treatment that gives cotton its shiny appearance and also functions to increase its strength) of cotton. Monobutyl sulfate is also used in the polymerization of tetrahydrofuran.<br>References Pruckmayr, G. &amp; Wu, T.: Macromolecules, 11, 662 (1978); Shenai, V., Int. Dyer Text. Print. Bleach. Finish., 158, 246 (1977)<br></p>

<p>Applications Ethyl 2-(3-((1R,3R)-3-(((R)-2-(3-Chlorophenyl)-2-hydroxyethyl)amino)cyclohexyl)phenoxy)acetate-d5 is a labeled analogue of Ethyl 2-(3-((1R,3R)-3-(((R)-2-(3-Chlorophenyl)-2-hydroxyethyl)amino)cyclohexyl)phenoxy)acetate which is used in the preparation of phenylethanolamine compounds as β3-agonists.<br></p>

<p>Applications 4-n-Pentylphenol-2,3,5,6-d4,OD (CAS# 126839-95-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled 3-(Methylnitrosamino)propionitrile (MNPN) (M325715). It was detected for the 1st time in the saliva of betel quid chewers and is a potent carcinogen.<br>References Bartsch, H., et al.: Mutat. Res., 250, 103 (1991), Su, T., et al.: Drug Metab. Dispos., 24, 884 (1996), Guengerich, F., et al.: Chem. Res. Toxicol., 14, 611 (2001),<br></p>

<p>Applications Sodium Propionate-d5 (CAS# 202529-18-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled analogue of D-Allose (A548006) is a rare naturally occurring monosaccharide, known to exert anti-proliferative effects on cancer cells.<br>References Jeong, R.U., et al.: Anal. Bioanal. Chem., 401, 689 (2011); Yamada, K., et al.: Nut. Res., 32, 116 (2012);<br></p>

<p>Applications rac-trans-N-Desmethyl Sertraline-d3 Hydrochloride is deuterium labelled rac-trans-N-Desmethyl Sertraline Hydrochloride (D292117), which is a metabolite of Sertraline. rac-trans-N-Desmethyl Sertraline-d3 Hydrochloride can be used for treating CNS disorders.<br>References Welch, W.M., et al.: J. Med. Chem. 27, 1508 (1984)<br></p>

<p>Applications Cyclopropane-1-d1-carboxylic Acid (CAS# 19136-94-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications p-Tolyl-d7 Isocyanate (CAS# 1219798-59-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications TRIS Maleate-d15 (CAS# 1219806-43-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Benzyl 2-(2-Hydroxy-3-morpholinopropyl)hydrazinecarboxylate-d5 is an intermediate for the synthesis of 2-NP-AMOZ-d5 (N894952), which is a labelled derivatized of AMOZ (A634600), a metabolite of Nitrofuran.<br>References Vroomen, L., et al.: Toxicol. Appl. Pharmacol., 95, 53 (1988), Delatour, T., et al.: J. Agric. Food Chem., 51, 6371 (2003), Stadler, R., et al.: Analyst, 129, 276 (2004),<br></p>

<p>Applications Octylamine-d17 is the isotope labelled analog of Octylamine. Octylamine is used as a reactant in the synthesis of 2H-indazoles and 1H-indazolones which are used as myeloperoxidase(MPO) inhibitor.<br> E0<br>References Roth, A., et al.: Bioorg. Med. Chem., 22, 6422 (2014);<br></p>

<p>Applications 2-Fluorobenzonitrile-d4 (CAS# 2256740-46-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications trans,trans-2,4-Nonadienal-D2 is a labelled analogue of trans,trans-2,4-Nonadienal (N649315). trans,trans-2,4-Nonadienal is an unsaturated aldehyde that is responsible for the bean odour of soymilk. trans,trans-2,4-Nonadienal has also been identified as a potentially mutagenic substance by inducing oxidative DNA damage.<br>References Sjaastad, A. &amp; Svendsen, K.: Ann. Occ. Hyg., 52, 739 (2008); Vara-Ubol, S., et al.: J. Sens. Stud., 19, 15 (2004); Yang, C., et al.: Chin. J. Physiol., 52, 151 (2009)<br></p>

<p>Applications trans-4-Hydroxy-2-hexenal-5,5,6,6,6-d5 Dimethyl Acetal (CAS# 1219806-40-2) is a useful isotopically labeled research compound.<br></p>

<p>Stability Hygroscopic, Light Sensitive, Temperature Sensitive<br>Applications 3-Deoxyglucosone-13C6, is the labeled anologue of 3-Deoxyglucosone (D239150), an intermediate in the Maillard reaction of proteins with glucose, which is metabolised to 3-Deoxyfructose. An intermediate in the formation of pyrraline, which might contribute to a pathological effect, such as carcinogenesis.<br>References Kato, H. et al.: Agric. Biol. Chem., 51, 683 (1987), Hayase, F. et al.: J. Biol. Chem., 264, 3758 (1989), Kato, H. et al.: Biochimica et Biophysica Acta, 1035, 71 (1990)<br></p>

<p>Applications (±)-Fluoxetine-d5 Oxalate (phenyl-d5) (CAS# 1219804-82-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Eicosanyl-d41 Alcohol (CAS# 349553-89-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Tri-p-tolylamine-15N (CAS# 311761-87-2) is a useful isotopically labeled research compound. This compound has been used in structural studies relating to photoconductivity of various polymers.<br>References Kesling, B., et.al., J Labelled Compd Rad., 43,1059-1068,(2000);<br></p>

<p>Applications 1-Phenylpentadecane-d36 (CAS# 352431-31-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Chlorobenzene-d5 is the labeled analogue of Chlorobenzene (C364530). Chlorobenzene-d5 is used to increase quantification of data from gas chromatography and mass spectrometric analysis of micropollutants in water.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References James, H.A., et. al.: Adv. Mass Spec., 8B, 1429 (1980)<br></p>

<p>Applications Potassium Tetradecanoate-2,2-d2 (CAS# 352438-85-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Indole-3-pyruvic Acid Methyl Ester-D5 is an intermediate used in the synthesis of Indole-3-pyruvic Acid-d5 (I627182), which is an isotope labelled compound of Indole-3-pyruvic Acid (I627189). Indole-3-pyruvic Acid is a compound involved in the biosynthesis of Indole-3-acetic acid, a plant hormone which plays important roles in regulating growth and responses to environmental changes.<br>References Kong, W., et al.: Plant Cell Physiol, 56, 715-726 (2015)<br></p>

<p>Applications Isotope labelled 2,2,4-Trimethyl-1,3-pentanediol used in the synthesis of monoisobutyrate derivatives used in film forming auxilleries in paint substances.<br>References Li, Y. et al.: Chem. Papers, 68, 422 (2014);<br></p>

<p>Applications 5-Ethyl-3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-1H-indole-d5 is an isotope labelled impurity of Eletriptan (E505000), a serotonin 5-HTIB/ID receptor agonist and an antimigraine agent.<br>References Madasu, S. B., et al.: Beilstein. J. Org. Chem., 8, 1400 (2012); Willems, E., et al.: Arch. Pharmacol., 358, 212 (1998), Napier, C., et al.: Eur. J. Pharmacol., 368, 259 (1999), Goadsby, P.J., et al.: Neurology, 54, 156 (2000)<br></p>

<p>Applications Iodoethane-2-d1 (CAS# 57460-45-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Bis(1,3-dithian-2-yl)methane-d2 (cas# 105479-87-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Isotope Labelled Adipodinitrile is used in the preparation of alkyl/arylthiazolines in the efficient synthesis of bacillamide A. Also used in the preparation of arylketones via insertion of nitriles.<br>References Fache, F. et al.: Synth. Comm., 42, 2098 (2012); Hsieh, J. et al.: Org. Lett., 14, 1282 (2012);<br></p>

<p>Applications 2,2,3,5-Tetramethylhexanoic Acid-d3 is the isotope analog of 2,2,3,5-Tetramethylhexanoic Acid. 2,2,3,5-Tetramethylhexanoic Acid is used in analytical studies as a method to quantitatively determine the total organic acid content in aqueous coolant.<br>References Lynn, T.B., et al.: PCT Int. Appl., 2012:1561111 (2012)<br></p>

<p>Applications D-Mannose is a carbohydrate that is important in the glycosylation of molecules in a variety of cellular processes. It is involved in N and O glycosylation of bovine why protein products, used in infant formulas. It is also responsible for the O-glycosylation of the T helper cell-derived cytokine interlukin-17A, an important cell-signaling molecule. This is the labeled analog.<br>References Van Leeuwen, S. et al.: J. Agri. Food Chem., 60, 12553 (2012); Geoghegan, K. et al.: Prot. Express. Purif., 87, 27 (2013);<br></p>

<p>Applications Nilvadipine-d3 is labelled Nilvadipine (N475150) which is used as an antihypertensive and antianginal.<br>References Gross, G.J., et al.: Gen. Pharmacol., 14, 677 (1983); Molyvdas, P.A. and Sperelakis, N.: J. Cardiovasc. Pharmacol., 8, 449 (1986); Mizuno, K., et al.: Res. Comm. Chem. Pathol. Pharmacol., 52, 3 (1986)<br></p>

<p>Applications N-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide -d4 is labelled N-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide (C988880) which was shown to exhibit regulatory effects towards the expression of pH sensing G protein-coupled receptor-68 and is now a new drug target for ischemic heart disease.<br>References Russell, J.L., et al.: ACS. Chem. Biol., 7, 1077 (2012); Schneider, J.W., et al.: ACS. Chem. Neurosci., 3, 557 (2012);<br></p>

<p>Applications Isotope labelled 1,4-Dichlorobenzene is labelled 1,4-Dichlorobenzene (D431875), a versatile building block and a small bioactive molecule, used in various organic synthesis. It is also used as disinfectant, deodorant, and pesticide.<br>References Fahey, D. R., et al.: Macromolecules, 24 (15), 4242 (1991); Rossberg, M., et al.: Ullmann's Encyclopedia of Industrial Chemistry, (2006);<br></p>

<p>Applications 1-(2-Furyl)ethanol-d3 is the isotope labelled analog of 1-(2-Furyl)ethanol (F865260), which is an intermediate in the synthesis of 2H-Furo[2,3-c]pyran-2-one derivatives of their germination-promoting activity.<br>References Singh, V., et al.: Synthetic. Commun., 40, 1280 (2010);<br></p>

<p>Applications Pyrrolidine-2,2,5,5-d4 (CAS# 42403-25-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Iodoethane-1-d1 (CAS# 3652-81-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications DL-Phenyl-d5-alanine (CAS# 284664-89-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications (±)-2-Aminohexane-1,1,1,2,3,3-d6 (CAS# 1219802-28-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Hydroxyacetonitrile-13C2 is an intermediate in the synthesis of Indole-3-carboxaldehyde-13C8 (I614993), the labelled version of Indole-3-carboxaldehyde (I615020) which is a tryptophan (T947200) metabolite from Streptomyces staurosporeus and it is chemical constituent from Inula wissmanniana. Indole-3-carboxaldehyde and other tryptophan metabolites play an important role in mammalian gut immune homeostasis.<br>References Yang, S., et al.: J. Nat. Prod., 60, 44 (1997); Cheng, X. et al.: Chem. Nat. Compd., 49, 815 (2013); Zelante, T., et al,: Immunity, 39, 372 (2013)<br></p>

<p>Applications Ethyl-d5-benzene (CAS# 38729-11-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Deuterium labelled analog of (±)-α-Bisabolol, which is found in a variety of beauty and skin care products, including compositions for skin lightening cosmetic creams, color change cosmetic compositions for makeup fused with antioxidant function and oil-to-gel makeup removing compositions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ma, P. et al.: Faming Zhuanli Shenqing 11pp. Patent 2017 CODEN:CNXXEV; Son, T.; et al.: Repub. Korean Kongkae Taeho Kongbo 14pp.; Chemical Indexing Equivalent to 167:543596 (WO) Patent 2017 CODEN:KRXXA7; Lin, X.; et al.; Faming Zhuanli Shenqing 8pp. Patent 2017 CODEN:CNXXEV<br></p>

<p>Applications n-Hexyl-5,5,6,6,6-d5 Alcohol (CAS# 64118-18-9) is a useful isotopically labeled research compound.<br></p>