Composés deutérés

<p>Applications Fluorene-13C6 is a labelled polycyclic aromatic hydrocarbon.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Di Toro, D., et al.: Environ. Toxicol. Chem., 19, 1971 (2000), Vines, C., et al.: Aquat. Toxicol., 51, 225 (2000), Incardona, J., et al.: Toxicol. Appl. Pharmacol., 196, 191 (2004), Junghans, M., et al.: Aquat. Toxicol., 76, 93 (2006),<br></p>

<p>Applications 1-Iodopropane-2,2,3,3,3-d5 (CAS# 1095269-04-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Vinyl Acetate-d6 (CAS# 189765-98-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Boc-piperazine-d4 is a deuterium labelled analogue of N-Boc-piperazine (B662000).<br></p>

<p>Applications 2-Ethyl-d5-naphthalene (CAS# 1219805-14-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications rac 3-Hydroxybutyric Acid-d2 Sodium Salt is the labeled analogue of rac 3-Hydroxybutyric Acid Sodium Salt (H833020), an optically active 3-hydroxybutyric acids are key intermediates of the biosynthesis and metabolism of fatty acids and exist widely in biological systems.<br>References Freeman, J., et al.: Pediatrics, 102, 1358 (1998), Thio, L., et al.: Neurology, 54, 325 (2000), Rho, J., et al.: Epilepsia, 43, 358 (2002)<br></p>

<p>Applications trans-2,cis-6-Nonadienal-D2 is a labelled analogue of trans-2,cis-6-Nonadienal (N649365). trans-2,cis-6-Nonadienal is an unsaturated aldehyde that is responsible for the cucumber smell of Synura petersenii, a freshwater colonial flagellate. trans-2,cis-6-Nonadienal is also a common natural and drinking water contaminant.<br>References Berra, T., et al.: Trans. Am. Fish. Soc., 111, 78 (1982); Kynclova, A., et al.: Nova Hedw. Bei., 136, 283 (2010); Ömür-Özbek, P. &amp; Dietrich, A.: Environ. Sci. Tech., 39, 3957 (2005)<br></p>

<p>Applications 4-Fluoroanisole-2,3,5,6-d4 (CAS# 1219802-94-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Sodium Acetate-13C2,D3 (cas# 123333-80-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Used in the preparation of cosmetic and pharamceutical products.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Glyceryl Tri(hexadecanoate-2,2-d2) (CAS# 241157-06-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Hydroxy-1,4-naphthoquinone-5,6,7,8-d4 is the isotope labelled analog of 2-Hydroxy-1,4-naphthoquinone (Lawsone) (H949535); the active ingredient of Lawsonia inermis (henna) leaves extract. Lawsone has potential antimicrobial activity and can be used for the detection of latent fingermarks on paper surfaces.<br>References Tekin, V., et al.: J. Radioanal. Nucl. Ch., (2014); Rahmoun, N.M., et al.: Am. J. Med. Biol. Res., 1, 16 (2013); Jelly, R., et al.: Chem. Commun., 30, 3513 (2008)<br></p>

<p>Applications Anisole-d3 (methyl-d3) (CAS# 4019-63-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Testosterone Laurate-d23 is the isotopic analog of Testosterone Laurate. Testosterone Laurate is a derivative of testosterone(T155000), which is used in analytical studies to determine testosterone and nandrolone esters in race horse plasma for doping control through UPLC-ESI-MS-MS.<br>References You, Y., et al.: J. Chromato., 1218, 3982 (2011); Guan, F., et al.: Mass Spectrom., 45, 1270 (2010)<br></p>

<p>Applications 5-Hydroxy-N-methyl-2-pyrrolidinone-d3 is an isotopically labelled analogue of the metabolite of N-methylpyrrolidone (NMP, M326120).<br>References Payan, J., et al.: Drug Metab. Dispos., 30, 1418 (2002), Carnerup, M., et al.: Food Chem. Toxicol., 43, 1441 (2005), Angerer, J., et al.: Toxicol. Sci., 93, 3 (2006),<br></p>

<p>Applications 2,6-Dimethyl-d6-nitrobenzene (CAS# 285138-83-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications (2S,2'S)-Ethambutol-d10 (1,1,1',1',2,2'-d6; ethylene-d4) (CAS# 1129526-24-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromononane-6,6,7,7-d4 (CAS# 1219805-44-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Propyl-d7-amine HCl (CAS# 344298-88-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromohexane-1,1-d2 (CAS# 78904-38-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Pyrrole-2,3,4,5-d4 (CAS# 17767-94-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Bromoethane-2-d1 (CAS# 23705-67-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Dimethyl Sulfoxide (13c2, 99%) (cas# 136321-15-8) is a useful research chemical.<br></p>

<p>Applications Phenyl Ether-13C12 is an intermediate used in the synthesis of Decabromodiphenyl Ether-13C12 (D212852), which is the labeled analogue of Decabromodiphenyl Ether (D212850), which is a brominated flame retardant that is used in conjunction with antimony trioxide in high impact polystyrene.<br>References Keum, Y.S., et al.: Environ. Sci. Technol., 39, 2280 (2005); Egeback, A.L., et al.: Chemosphere., 86, 264 (2012);<br></p>

<p>Applications Isopropyl Diphenyl Phosphate-d10 is a labelled analogue of Isopropyl Diphenyl Phosphate (I824470) which is a chemical reagent used in the synthesis of H-phosphonate synthesis of oligonucleotides. Also used in the preparation of flame retardants.<br>References Butt, C. et al.: Env. Sci. Tech., 48, 10432 (2014); Powles, N. et al.: Prg. Biomol. Chem., 10, 5940 (2012);<br></p>

<p>Applications 4-Chloroanisole-2,3,5,6-d4 (CAS# 1219804-86-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromopropane-d7 is the isotope labelled analog of 1-Bromopropane (B687135); a solvent used for the cleaning of metal surfaces and removal of soldering residues from electronic circuit boards. It is anticipated to be a human carcinogen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lingyo, Zh., et al.: Toxicology, 304, 76 (2013); Samukawa, M., et al.: Archives Internal Med., 172(16), 1257 (2012)<br></p>

<p>Applications Decyltrimethylammonium-d9 Iodide is an intermediate used in the synthesis of n-Decyltrimethylammonium-d9 Chloride (D525512), which is an isotope labelled quaternary ammonium salt used to study ionic interactions of detergents with lipid membranes.<br>References Beck, A., et al.: J. Phy. Chem., 48, 15862 (2010);<br></p>

<p>Applications Benzilic-d10 Acid (rings-d10) (CAS# 1219799-12-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Used for the preparation of labelled benzene derivatives as non-steroidal androgen receptor modulators.<br>References Xiao, H.-Y., et al.: Bioorg. Med. Chem. Lett., 20, 4491 (2010),<br></p>

<p>Applications Isopropanol (2-13c, 99%) (cas# 21388-65-8) is a useful research chemical.<br></p>

<p>Applications 4-(Oxiranylmethyl)morpholine-d5 Hydrochloride is an intermediate for the synthesis of 2-NP-AMOZ-d5 (N894952), which is a labelled derivatized of AMOZ (A634600), a metabolite of Nitrofuran.<br>References Vroomen, L., et al.: Toxicol. Appl. Pharmacol., 95, 53 (1988), Delatour, T., et al.: J. Agric. Food Chem., 51, 6371 (2003), Stadler, R., et al.: Analyst, 129, 276 (2004),<br></p>

<p>Applications Benzene-1,2,4-d3 (CAS# 14941-53-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethyl 2-Cyanoacetate-13C 15N, is the labeled analogue of Ethyl Cyanoformate (E907820), which can be used as an intermediate for insecticide, such as Fipronil (F342202).<br>References Cole, L., et al.: Pestic. Biochem. Physiol., 46, 47 (1993), Cole, L., et al.: Life Sci., 56, 757 (1995), Hosie, A., et al.: Br. J. Pharmacol., 115, 909 (1995),<br></p>

<p>Applications Fumaric Acid Monomethyl Ester-13C4, is the labeled analogue of Fumaric Acid Monomethyl Ester (F500390). monomethyl ester is one of the most bioactive anti-psoriatic fumaric acid ester metabolite.<br>References de Jong, R. et al.: Eur. J. Immunol., 26, 2067 (1996); Litjens, N.H.R. et al.: Br. J. Dermatol., 154, 211 (2006); Schimrigk, S., et al.: Eur. J. Neurol., 13, 604 (2006); Tang, H. et al.: Biochem. Biophys. Res. Comm., 375, 562 (2008);<br></p>

<p>Applications L-Homocystine-3,3,3’,3’,4,4,4’,4’-d8 is the labeled form of L-Homocysteine (H591360), an increased levels lead to hyperhomocysteinemia; a cardiovascular risk factor in prediction of coronary heart disease as well as being associated with congenital birth defects, pregnancy complications and cancer.<br>References Geisel, J. et al.: Clin. Chem. Lab. Med., 41, 1513 (2003); Geisel, J. et al.: Clin. Chem. Lab. Med., 41, 1513 (2003);<br></p>

<p>Applications Methyl trans-Cinnamate-d7 (CAS# 2022152-96-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid-d15 (CAS# 1219794-63-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications [4-(4-Aminophenoxy)(2-pyridyl)]-N-(methyl-d3)carboxamide (cas# 1189975-18-5) is a compound useful in organic synthesis.<br></p>

<p>Applications N,N-Dibutyl-4,6-dichloro-1,3,5-triazin-2-amine-d4 is an intermediate used in the synthesis of 6-(Dibutylamino)-1,3,5-triazine-2,4-dithiol-d4 (D462764), which is a labelled form of 6-(Dibutylamino)-1,3,5-triazine-2,4-dithiol (D462763), which is a compound capable of electrochemical polymerization on magnesium alloy plates.<br>References Mori, K.; et al.: Materials Science Forum, 350, 223 (2000).<br></p>

<p>Applications p-Toluidine-d3 (methyl-d3) (CAS# 23346-25-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,4'-Dibromoacetophenone-2-13C (CAS# 335081-05-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Dipotassium Cyclobutane-1,1-dicarboxylate-D2 is an intermediate in the synthesis of Carboplatin-d4 (C177502), which is an analog of Cisplatin with reduced nephrotoxicity. Antineoplastic.<br>References Harland, S.J., et al.: Cancer Res., 44, 1693 (1984), Smith, I.E., et al.: Cancer Treat. Rep., 69, 43 (1985), Lygidakis, N.J., et al.: Interferon Cytokine Res., 15, 467 (1995),<br></p>

<p>Applications (2-Bromoethyl-1,1,2,2-d4)-benzene is an intermediate used in the synthesis of Phenelzine-d4 Sulfate (P295902), which is a labeled hydrazine derivative that is a non-selective and irreversible monoamine oxidase inhibitor (MAOI) and also inhibits GABA-transaminase (GABA-T), markedly increasing brain GABA levels. It is an antidepressant and anxiolytic used in the treatment of major depressive disorder (MDD) as well as other neural disorders.<br>References MacKenzie, E.M. et al.: Neurochem. Res., 33, 430 (2008);Chiche, F. et al.: Mol. Pharmacol., 75, 1052 (2009); McKenna, K.F, et al.: J. Neural Trans., 41, 115 (1994);<br></p>

<p>Applications 4-Nitrobiphenyl-d9 (CAS# 350818-59-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications D,L-Azetidine-2-carboxylic Acid-d5 is a useful synthetic intermediate.<br></p>

<p>Applications 1-(4-Nitrophenyl)cyclopentanecarbonitrile-d8 is an intermediate used in the synthesis of Apatinib-d8 Hydrochloride (A726152), which is labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.<br>References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);<br></p>

<p>Applications 6-Dodecanoate-1,4-anhydro-D-glucitol-d23 is the isotopic form of 6-Dodecanoate-1,4-anhydro-D-glucitol (D494710). 6-Dodecanoate-1,4-anhydro-D-glucitol is used in the synthetic preparation of nonionic surfactant.<br>References Giacometti, J. et al.: J. Agr. Food Chem., 44, 3950 (1996)<br></p>

<p>Applications Labelled analogue trans-1,2-Dihydroxy-1,2-dihydronaphthalene, a metabolite of Naphthalene.<br>References Sun, Y. et al.: Arch. Toxicol., 80, 280 (2006); Cho, T. et al.: Drug Metab. Drug Interact., 22, 235 (2007); Iwamoto, N. et al.: J. Biol. Chem., 282, 33396 (2007);<br></p>

<p>Applications 1-Bromoeicosane-20,20,20-d3 (CAS# 202480-72-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Acetyl-3,4,5,6-tetrahydropyridine-d4 Hydrochloride, is the labeled analogue of 2-Acetyl-3,4,5,6-tetrahydropyridine Hydrochloride (A188500), the most important bread flavor component.<br>References Buttery, R.G., et al.: J. Agric. Food Chem., 43, 1878 (1995),<br></p>

<p>Applications Isotope labelled Hexadecyltrimethylammonium Bromide (CTAB) (H293860), is a cationic surfactant used as a template in the synthesis of Mesoporous γ-Fe2O3.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yu, H.-h., et al.: Gongneng Cailiao, 42, 2005 (2011),<br></p>

<p>Applications Isotope labelled Indene is an organic building block that has been used in the synthesis of isatins as selective inhibitors of carboxylesterases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hyatt, J.L., et. al.: J. Med. Chem., 50, 1876 (2007)<br></p>

<p>Applications 5-Bromohexahydro-2,6-dioxo-4-pyrimidinecarboxylic Acid-15N2 is an intermediate used in the synthesis of Orotic Acid-15N2 Monohydrate (O691504), which is a labeled analogue of Orotic Acid Monohydrate (O691500) that is used in the preparation of therapeutic agents for chronic obstructive pulmonary disease (COPD) treatment. Also, it is the labeled form of 5-Bromohexahydro-2,6-dioxo-4-pyrimidinecarboxylic Acid (B699363), an intermediate in synthesizing Orotic Acid Monohydrate (O691500), which is used in the preparation of therapeutic agents for chronic obstructive pulmonary disease (COPD) treatment.<br></p>

<p>Applications 1-Bromooctane-3,3,4,4-d4 (CAS# 1219803-37-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications (4S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazine-d2 ,13C1, is the labeled analogue of (4S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazine (C365935), used for the synthesis of Efavirenz (E425000), which is a nonnucleoside HIV-1 reverse transcriptase inhibitor.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995),<br></p>

<p>Applications 4-Chlorobenzyl-2,3,5,6-d4 Cyanide (CAS# 1219804-00-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Lombazole-d9 is deuterium labelled form of Lombazole (L470205), which is imidazole based antimicrobial agent with some antifungal activity.<br>References Barug, D., De Groot, K.: Antimicrob. Agents Chemother., 28, 643 (1985); Barug, D., et al.: Antimicrob. Agents Chemother., 30, 238 (1986);<br></p>

<p>Applications D-​Valine-​2,​3,​4,​4,​4,​4',​4',​4'-​d8 is one of the analytes used to validate high resolution mass spectrometry-based approach for metabolomic fingerprinting of human gut phenotype.<br>References Vanden Bussche, J., et al.: Anal. Chem., 87, 10927 (2015);<br></p>