Composés deutérés

Applications 4,4'-Dimethoxybenzophenone-d8 (rings-d8) (CAS# 350818-55-2) is a useful isotopically labeled research compound.

Applications Methylphloroglucinol is used for the formation of insoluble azo dyes on blended fabrics. It is also used in the synthesis of inhibitory dihydroxyxanthone derivatives that are active against human tumor cell lines. This is the labeled analog.
References Tarakanova, L. et al.: Fiber Chem., 42, 254 (2011); Castanheiro, R. et al.: Bioorg. Med. Chem., 15, 6080 (2007);

Applications A labelled isomeric impurity of 7-(2-Hydroxypropyl)guanine (H952590).

Applications 1,3-Dibromo-5-fluorobenzene-d3 (CAS# 1219805-87-4) is a useful isotopically labeled research compound.

Applications Ursolic Acid-d3 is labelled Ursolic Acid(U850100) which is a Triterpene acid used in cosmetics. It also has STAT3 pathway inhibiting properties.
References Lee, C., et al.: Bioorg. Med. Chem. Lett., 20, 7354 (2010), Lee, A., et al.: J. Agric. Food Chem., 58, 12941 (2010), Pethakamsetty, L., et al.: J. Pharm. Res., 3, 193 (2010),

Applications 1,3-Dichlorobenzene (D4, 98%) (cas# 2199-70-4) is a useful research chemical.

Applications 4-Bromochlorobenzene-d4 (CAS# 134415-42-2) is a useful isotopically labeled research compound.

Applications n-Pentyl-2,2,3,3,4,4,5,5,5-d9 Alcohol (CAS# 148587-12-6) is a useful isotopically labeled research compound.

Applications Cuprous Cyanide-15N is an intermediate in the synthesis of Bictegravir-15N, d2 (B382096), which is the labeled version of Bictegravir, which is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.
References Tsiang M. et al.: Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097;

Applications Diethyl-d10-amine HCl (CAS# 285132-87-8) is a useful isotopically labeled research compound.

Applications A trapping agent used in the desulfenylation of 3-indolyl sulfides.
References Miller, C., et al.: Environ. Sci. Technol., 43, 8548 (2009), Mecinovic, J., et al.: Anal. Biochem., 393, 215 (2009), Zarghi, A., et al.: Bioorg., Med., Chem., 17, 5369 (2009),

Applications (±)-2-Ethylhexanoic-d15 Acid (CAS# 352431-38-0) is a useful isotopically labeled research compound.

Applications Benzyl Octyl Adipate-d17, is the labeled analogue of Benzyl Octyl Adipate (B285580), which is used as plasticizer. It can also be used for the synthesis of orally effective acid prodrugs of the β-Lactamase inhibitor Sulbactam (S699185).
References Sorokin, G. A., Plasticheskie Massy, 25 (1976); Kraus, A., Farbe + Lack,60, 185 (1954); English, A. R., et al.: J. Med. Chem., 33, 344 (1990);

Applications N-(2,6-Dimethylphenyl)-2,2-dichloroacetamide-d9 is labelled N-(2,6-Dimethylphenyl)-2,2-dichloroacetamide (D434405) which is an intermediate used to prepare Ranolazine (R122500), an antianginal agent.
References Aalla, S., et al.: Org. Proc. Res. Dev.,16, 748 (2012)