Composés deutérés

Applications Labelled Tolazamide, an antidiabetic.
References Welling, et al.: J. Pharmac. Sci., 71, 1259 (1982);

Applications Ethylbenzene-13C6 is the labeled form of Ethylbenzene (E899745), which is used in the industrial production of stryrene trough various organic processes.
References Weiss, W. et al.: Prog. Surf. Sci., 70, 1 (2002); Cavani, F. et al.: App. Catal. A., 133, 219 (1995);

Applications Pyruvic Acid-13C2 is an intermediate in synthesizing L-Lactic Acid-d3 Sodium Salt (L113503), a labelled sodium salt of L-Lactic Acid (L113500). L-Lactic Acid occurs in small quantities in the blood and muscle fluid of man and animals. The lactic acid concentration increases in muscle and blood after vigorous activity. L-(+)-Lactic acid is also present in liver, kidney, thymus gland, human amniotic fluid, and other organs and body fluids.
References Wenzel, A., et al.: J. Neurosci., 21, 53 (2001); Martinez., et al.: Development, 6, 851 (2002); Nakayama, K., et al.: J. Biochem., 146, 757 (2009); Tanaka, T., et al.: J. Pharmacol. Sci., 109, 24 (2009)

Applications Octadecylamine-d37 is the isotope labelled analog of Octadecylamine. Octadecylamine is used in biological studies for the formation of ion pairing as alternative to improve encapsulation and stability and to reduce skin irritation of retinoic acid loaded in solid lipid nanoparticles.
References Castro, G.A., et al.: Int. J. Pharma., 381, 77 (2009);

Stability Unstable in Solution, Hygroscopic
Applications Used in nucleophilic substitution.
References Genicot, C., et al.: Bioorg. Med. Chem. Lett., 13, 437 (2003),

Applications Labelled N-Nitrosopiperidine (N545370). A carcinogenic nitrosocompound.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bos, J., et al.: Cancer Res., 49, 4682 (1989), Wong, H., et al.: Carcinogenesis, 24, 291 (2003), Gonzalez-Mancebo, S., et al.: Mutat. Res., 558, 45 (2004), Gonzalez, M., et al.: Bioorg. Med. Chem., 13, 601 (2005),

Applications Aminoguanidine-13C Bicarbonate is a compound useful in organic synthesis.

Applications Carbetamide-D5 is the labelled analogue of Carbetamide (C178028). Carbetamide is used in the determination of pesticides.
References Jia, W., et al.: Journal of Chromatogr. A., 1395, 160-166 (2015)

Applications N-Hexadecanol (2,2,3,3...16,16,16-D31, 98%) (cas# 203633-15-2) is a useful research chemical.

Applications N-Desmethyl Regorafenib (Pyridine)-N-oxide-d3 is the isotope labelled analog of N-Desmethyl Regorafenib (Pyridine)-N-oxide (D293280); a synthetic metabolite of Regorafenib (R143000) used for treatment and prevention of cancer.
References Wilhelm, S.: PCT Int. Appl. WO 2011130728 A1 20111020. Oct 20, 2011

Applications Labelled 2,3-Butanedione (B690030). 2,3-Butanedione (Diacetyl), the molecule implicated in the disease known as popcorn lung, has now been implicated in amyloid-β peptide toxicity associated with Alzheimer’s disease. Diacetyl accelerates amyloid-β aggregation-a hallmark of Alzheimer’s disease. These preliminary finding raise the possibility of long-term neurological toxicity mediated by DA.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wang, J., et al.: Exp. Neurol., 158, 328 (1999); Brown, M., et al.: Cell, 100, 391 (2000); Heinitz, K., et al.: J. Neurochem., 98, 1930 (2006); Brody, D., et al.: Science, 321, 1221 (2008); More, S., et al.: J. Med. Chem., 52, 4650 (2009);

Applications S-Methyl-d3-thioacetaminophen is deuterium labeled S-Methyl-3-thioacetaminophen (M330610), a metabolite of Acetaminophen (A161220). Acetaminophen is an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).
References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)

Applications Diglyme-d14, is the labeled analogue of Diglyme (D446300), a solvent, that is used as reaction medium for Grignard and similar synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Merck Index, 11th Edition, 3148.

Applications Isotope labelled 1,3-Dibromopropane is a substrate specificity of haloalkane dehalogenases.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Koudelakova, T., et al.: Biochem. J., 435, 345 (2011),

Applications Labelled Fenfluramine. Anorexic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Pinder, et al.: Drugs, 10, 241 (1975), Caccia, S., et al.: Eur. J. Clin. Pharmacol., 29, 221 (1985), Finner, N., et al.: Curr. Ther. Res., 38, 847 (1985),

Stability Hygroscopic
Applications N-Acetylneuraminic Acid-13C,d3 is a labelled Neuraminic Acid derivative.
References Oetke, C., et al.: J. Biol. Chem., 277, 6688 (2002)

Applications 2,7-Diisopropyl-9,9-dimethyl-9,10-dihydroacridine-d6 (Major) is a labeled analogue of 2,7-Diisopropyl-9,9-dimethyl-9,10-dihydroacridine (D455760), a useful chemical reagent. Also, it is derived from 9,9-Dimethyl-9,10-dihydroacridine (D474300), which are currently being used in the development of thermally activated delayed fluorescence (TADF) molecules which are being researched for their possible efficient deep-​blue TADF emitting potential.
References Kwon, D.Y., et al.: J. Nanosci. Nanotechnol., 15, 7828-31 (2015); Wada, Y., et al.: Adv. Mater., 30 (2018).

Applications Benzoic Acid-13C6 (cas# 125945-98-4) is a compound useful in organic synthesis.

Applications Methyl-d3 Methanesulfonate (CAS# 91419-94-2) is a useful isotopically labeled research compound.

Applications Wittig Reagent