Composés deutérés

Applications A labelled metabolite of the pesticide Glyphosphate (G765000).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Siehl, D.L. et al.: J. Biol. Chem., 282, 11446 (2007); Env. Prot. Agen. EPA: Fed. Reg., 74, 67129 (2009);

Applications Morpholine-d8 Hydrochloride is used as a reactant in the synthesis of Moclobemide-d8 (M481002), the labeled analogue of Moclobemide (M481000), a reversible monoamine oxidase inhibitor.
References Wiesel, F.A., et al.: Eur. J. Clin. Pharmacol., 28, 89 (1985), Burkard, W.P., et al.: J. Pharmacol. Exp. Ther., 248, 391 (1989)

Applications Bis(o-cresyl) p-Cresyl Phosphate-d7 is labelled Bis(o-cresyl) p-Cresyl Phosphate (B419205), an isomer of Tricresyl phosphate (TCP) which is used as an anti-wear additive in aircraft turbine engine oil.
References De Nola, G., et al.: J. Chrmoat. A, 1200, 211 (2008)

Applications Labelled Tiglic acid (T440050). Tiglic acid is the stable isomer of angelic acid. Tiglic acid was found as glyceride in croton oil, as butyl ester in the oil of the Roman camomile, and as geranyl tiglate in oil of geranium. Tiglic acid is formed during the charcoaling of maple wood.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bueding, et al.: J. Biol. Chem., 202, 505 (1953),

Applications Labelled Propionic Acid, used in the synthesis of novel inhibitors of signal transducer and activator of transcription 3 signaling pathway in the potential treatment of human cancers. In addition it is used in the synthesis of morphans.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Zhang, M. et al.: Eur. J. Med. Chem., 62, 301 (2013); Bradshaw, B. et al.: Org. Lett., 15, 2458 (2013);

Stability Very Hygroscopic
Applications rac Tenofovir-d6 Diphosphate Triethylamine Salt is an isotopic analog of Tenofovir Diphosphate Triethylamine Salt (T018525), which is a metabolite of Tenofovir (T018500).
References Hazra, R., et al.: Antimicrob. Agents Chemother., 48, 124 (2004), Piketty, C., et al.: Antivir. Ther., 11, 213 (2006), Molto, J., et al.: Ther. Drug Monit., 29, 648 (2007),

Stability Volatile
Applications 2,​2,​3,​3,​3-​Pentafluoropropanoic Acid-13C is the labeled analogue of 2,​2,​3,​3,​3-​Pentafluoropropanoic Acid (P227235), which is used in the analysis of gentamicin with Gemini column by liquid chromatographic (LC) methods. It was also used to prepare [(R)-(amino)(oxo)(fluorophenyl)butyl]tetrahydro(fluoroethyl)-1,2,4-triazolo[4,3-a]pyrazine using (fluoro)propanoic acid.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Manyanga, V., et al.: J. Pharm. Biomed. Analysis, 45, 257 (2007); Kim, D., et al.: J. Med. Chem., 48, 141 (2005)

Applications Chlorpromazine-d6 Oxalate (N,N-dimethyl-d6) (CAS# 1276197-23-9) is a useful isotopically labeled research compound.

Applications Labelled Hydrazine Hydrate, used as a reactant in the cyclizations of pyridinones. It is also used in the study of nanocrystal semiconductors, participating in the functionalization and passivation of surface states.
E0
References Smolyar, N. et al.: Rus. J. Org. Chem., 44, 1205 (2008); Traub, M. et al.: J. Am. Chem. Soc., 130, 955 (2008);

Stability Volatile
Applications The labelled version of Bromobenzene (B680145), used as a general reagent in palladium-catalyzed reactions and in the synthesis of Grignard reagents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Miyaura, N. et al.: Synth. Commun., 11, 513 (1981); Nahm, S. et al.: Tetra. Lett., 22, 3815 (1981);

Applications Labelled Formic Acid is used to improve NMR profiling of amino metabolites in biofluids.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ye, T. et al.: Anal. Chem., 82, 2303 (2010); Gowda, G.A., Anal. Chem., 82, 8983 (2010);

Applications Butyric-2,2-d2 Acid (CAS# 19136-92-6) is a useful isotopically labeled research compound.

Applications Labelled Physcion. A natural anthraquinone derivative, on the infection process of Blumeria graminis on wheat. Physcion is one of the important active ingredients of ethanol extract from the roots of Chinese rhubarb (Rheum officinale) for controlling powdery mildew.
References Thiericke, R., et al.: Nat. Prod. Rep.,10, 265 (1993), Lin, C., et al.: J. Nat. Prod., 58, 1934 (1995), Julia, S., et al.: J. Biotechnol., 124, 690 (2006), Wang, W., et al.: J. Antibiot., 60, 603 (2007),

Applications Dihexylphthalate-d4 is an labeled analog of Dihexylphthalate (B185430), which is a phthalic ester, which is used as a plasticizers for vinyl plastics. Phthalates may be associated with reproductive toxicity in humans and animals.
References Saido, K., et al.: ?J. Am. Oil Chem. Soc 61, 945 (1984); Foghmoes, S., et al.: J. Eur. Ceram. Soc. 36, 3441 (2016); Przybyli?ska, P. A. and Wyszkowski, M.: Ecol. Chem. Eng., S 23,347 (2016)

Applications Irbesartan-d6 is deuterium labelled Irbesartan (I751000) which is an angiotensin II type 1 (AII1)-receptor antagonist.
References Gillis, J.C. and Markham, A.: Drugs, 54, 885 (1997); Chando, T.J., et al.: Drug. Metabol. Dispos., 26, 408 (1998),

Applications Labelled Resorcinol. A benzene derivative used as keratolytic and antiseborrheic. Also used in veterinary medicine as a topical antipruritic and antiseptic (has been used as intestinal antiseptic).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications A labelled metabolite of Nitrofuran.Environmental contaminants; Food contaminants; Heat processing contaminants
References Tribalat, L., et al.: Anal. Bioanal. Chem., 386, 2168 (2006), Chu, P., et al.: J. Agric. Food Chem., 55, 2129 (2007),

Stability Light Sensitive
Applications Isotope labelled N-Nitrosodiethylamine (N525465) (DEN) is a widely occurring nitrosamine that is one of the most important environmental carcinogens (1) primarily inducing tumors of liver (2,3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.NDMA and NDEA were found as an impurity in generic versions of valsartan, losartan and irbesartan.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References 1. Farber, E. et al.: Cancer Res. 1984 Oct;44(10):4217-23.2. el-Demerdash, E. et al.: Anticancer Res. 2002 Mar-Apr;22(2A):977-84.3. Kweon, S. et al.: Life Sci. 2003 Sep 26;73(19):2515-26.

Applications Labelled analogue of Diphenyl Phosphate, an organophosphate diester and metabolite of the flame retardant Triphenyl phosphate (T808990) and also a metabolite of 2-Ethylhexyl diphenyl phosphate.
References Cooper, E.M. et al.: Anal. Bioanal. Chem., 401, 2123 (2011); Nishimaki-Mogami, T. et al.: Arch. Toxicol., 61, 259 (1988);

Stability Hygroscopic
Applications (±)-Albuterol-d3 (3-hydroxymethyl-d2; alpha-d1) (CAS# 1219798-60-3) is a useful isotopically labeled research compound.