Composés deutérés

<p>Stability Hygroscopic<br>Applications N-Ethyl Benzamid-3-carboxylate-d5 is the isotope labelled analog of N-Ethyl Benzamid-3-carboxylate. N-Ethyl Benzamid-3-carboxylate is an impurity of Deet (D228500) which is an insect repellent.<br>References Gilbert, I.H., et al.: J. Econ. Entomol., 48, 741 (1955), Ambrose, A.M., et al.: Toxicol. Appl. Pharmacol., 1, 97 (1959), Blomquist, L., Acta Pharmacol. Toxicol., 41, 235 (1977), Yeung, J.M., et al.: Drug Metab. Dispos., 16, 600 (1988),<br></p>

<p>Applications Sodium Acetate-d3, is the labeled analogue of Sodium Acetate, the sodium salt of acetic acid, with a wide range of uses. Sodium Acetate is used in the textile industry to neutralize sulfuric acid waste streams, and as a photoresist while using aniline dyes. Sodium Acetate may be added to foods as a seasoning.<br>References Clayden, j., et al.: Org. Chem., 1st ed. (2001);<br></p>

<p>Applications Labeled Sucrose (S697000). Yuanzhen sugar is a polysaccharide polymer, containing a certain amount of fructooligosaccharides.<br>References Watanabe, T., et al.: Biosci. Biotech. Biochem., 72, 3167 (2008), You, Y., et al.: J. Agric. Food Chem., 57, 709 (2009),<br></p>

<p>Applications Labeled Chlorotriphenylstannane, which is used in the synthesis of nanoparticles which bear triamide ligands.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shariatinia, Z. et al.: Beil. J. Nanotech., 4, 94 (2013);<br></p>

<p>Applications 1,4-Dihydro-1-methyl-4-oxo-3-pyridinecarboxamide-d3 is the isotope labelled analog of 1,4-Dihydro-1-methyl-4-oxo-3-pyridinecarboxamide (D453415); a compound that has been shown to be one of the potential novel biomarkers of peroxisome proliferation in the rat.<br>References Ringeissen, S., Biomarkers, 8, 240 (2003); Shibata, K., et al.: Biosci. Biotech. and Biochem., 77, 2105 (2013)<br></p>

<p>Stability Hygroscopic<br>Applications Labelled nucleotide.<br>References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010), Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010),<br></p>

<p>Applications Labelled Aldicarb Sulfone (A514660). Aldicarb Sulfone is an analog of Aldicarb (A514650) detected in agricultural products as pesticide residue.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ashby, J., et al.: Environ. Mutagen., 7, 919 (1985), Ashby, J., et al.: Mutat. Res., 257, 229 (1991), Kazius, J., et al.: J. Med. Chem., 48, 312 (2005), Benigni, R., et al.: Mutagenesis, 25, 335 (2010),<br></p>

<p>Applications Isotope labelled 2-Bromoethanol is an widely used intermediate in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tian, Z., et al.: Int. J. Quant. Chem., 111, 631 (2011); Thayer, F.K., et al.: Org. Syntheses., 6, (1926);<br></p>

<p>Applications Labelled analogue of Adenosine (A280400), a purine nucleoside that plays an important role in various biochemical processes.<br>References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010); Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010)<br></p>

<p>Applications Isotope labelled 9-Bromophenanthrene (B687200), a halogenated polycyclic aromatic hydrocarbon that has been seen to have a room temperature phosphorescence that can be induced by β-cyclodextrin (β-CD) in the presence of cyclohexane; however, trace Fe(III) causes a decrease of the RTP emission.<br></p>

<p>Applications Carbamazepine-D10 is used to study occurrence of emerging trace organic chemicals in wastewater effluents in Saudi Arabia.<br>References Alidina, M., et al.: Sci. Total Environ., 478, 152 (2014);<br></p>

<p>Applications β-Alanine-13C3,15N is the isotope labeled analogue of β-Alanine (A637320), which is a naturally occurring beta amino acid. β-Alanine is formed in vivo by the degradation of Dihydro Uracil (D449990) and Carnosine. β-Alanine is also the rate-limiting precursor of Carnosine, as a result supplementation with β-Alanine increases the concentration of Carnosine in muscles.<br>References Derave, W. et al.: J. Appl. Physiol., 103, 1736 (2007); Xia, J.-F. et al.: J. Chrom. B Anal. Technol. Biomed. Life Sci., 977, 1930 (2009); Artioli, G.G. et al.: Med. Sci. Sports Exer.,42, 1162 (2010);<br></p>

<p>Applications Labelled Fenhexamid (F247650). Hydroxyanilide fungicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yamashita, M., et al.: J. Phys. Chem., 88, 4451 (1984), Kende, A., et al.: Microchem. J., 84, 63 (2006),<br></p>

<p>Applications Hydantoin-5-13C,1-15N (cas# 1189697-61-7) is a compound useful in organic synthesis.<br></p>

<p>Applications Cyanamide-​15N2 is an intermediate in the synthesis of 5-Azacytidine-15N4 (A796002), which is a labelled Azacytidine (A796000), a potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by inhibiting DNA methyltransferase.<br>References Kusaba, H., et al.: Eur. J. Biochem., 262, 924 (1999), Broday, L., et al.: Mol. Cell Biol., 19, 3198 (1999), Qian, X., et al.: Am. J. Pathol., 153, 1475 (1999), Canova, C., et al.: Mech. Ageing Dev., 101, 153 (1998)<br></p>

<p>Applications Isotope labelled analogue of Isobutyric Acid, a carboxylic acid found in vanilla. Isobutryic Acid was used as an intermediate in the synthesis of novel inhibitors of signal transducer and activators of transcription 3 signaling pathway.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhang, M.M., et al.: Euro. J. Med. Chem., 62, 301 (2013);<br></p>

<p>Applications Labelled Trimethylamine. Trimethylamine is a versatile building block used in the synthesis of various compounds ranging from cholines, plant growth regulators, strongly basic anion exchange resins, dye leveling agents as well as a number of basic dyes.<br>References Miroshnichenko, E.A. et al.: Zhur. Obshch. Khim., 63, 2375 (1993); Liu, X. et al.: Jiang. HUag., 33, 173 (2005); Xu, J. et al.: Color. Technol., 120, 316 (2004);<br></p>

<p>Applications Isotope labelled 2-Toluidine (T536205) is a carcinogenic and toxic aromatic amine and is a potential bladder cancer risk, surmised from urine assessment and analysis (1). It is contained in hair dye, henna and dyed hair samples (2,3). Possible mutagen (4). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. El-Bayoumy, K. et al.: Cancer Res. 1986 Dec;46(12 Pt 1):6064-7.2. Turesky R. et al.: Chem. Res. Toxicol. 2003 Sep;16(9):1162-73.3. Andrew, A. et al.: Int. J. Cancer. 2004 Apr 20;109(4):581-6.4. Kirkland, D. et al.: Mutat. Res. 2005 Dec 30;588(2):88-105.<br></p>

<p>Applications Adipic Acid-13C6 is labelled Adipic Acid (A291590) which is primarily used in the synthesis of nylon. It has been used as a reagent in the solid-state polymerization of nylon analogs.<br>References Kim, Y. et al.: Ind. Eng. Chem. Res., 51, 15801 (2012)<br></p>

<p>Applications Pinoxaden-d3 is a deuterized labeled form of Pinoxaden (P469505), which is derived from Diethylene Glycol Dimethanesulfonate (D444275), an intermediate in the production of alkylating agents.<br>References Wong, I., et al.: J. Med. Chem., 52, 5311 (2009); Muehlebach, M., et al.: Bioorg. Med. Chem., 17, 4241 (2009)<br></p>