Composés deutérés

Applications 1,4-Di(hydroxymethyl)benzene-d4 (cas# 1158734-28-1) is a compound useful in organic synthesis.

Applications Potassium Azide-15N is a labelled intermediate in the synthesis of Tazobactam Sodium Salt-13C2,15N1, which is the labeled analogue of Tazobactam Sodium Salt (T010100), which is a β-Lactamase inhibitor, used with β-lactam antibiotics to enhance their effect.
References Gould, I.M., et al.: Drugs Exp. Clin. Res., 17, 187 (1991), Roland, R.K., et al.: J. Infect. Dis., 4, 226 (2000), Bonomo, R.A., et al.: Biochim. Biophys. Acta, 1547, 196 (2001),

Applications Intermediate for the preparation of isotope Labelled Amantadine.

Applications Reagent used in the addition of labelled cyclopropane.
References Cave, C., et al.: Eur. J. Med. Chem., 25, 75 (1990), Kiyama, R., et al.: Chem. Pharm. Bull., 43, 960 (1995), Humphries, P., et al.: Bioorg. Med. Chem. Lett., 16, 6120 (2006)

Applications Isotope labelled ammonium hydroxide is in numerous household cleaning agents.
References Lokshin, E.P., et al.: Russ. J. App. Chem., 86, 450 (2013); Alghamdi, A.A., et al.: J. Material. Chem. A. Mater. Energy. Sustain., 1, 5165 (2013);

Applications 1,2,3,9-Tetrahydro-9-(methyl-d3)-4H-carbazol-4-one is used in the preparation of 5-HT3 modulators useful in the treatment and prevention of 5-HT3 receptor-mediated diseases.
References Huang, W. et al.: Zhong. Yao. Dax. Xueb., 30, 1 (1999); Kim, M. et al.: Heterocycles, 45, 2041 (1997);

Applications Imidazol-1-yl-acetic Acid-15N2,13C2 (cas# 1184983-00-3) is a compound useful in organic synthesis.

Applications Monomethyl Glutarate-1,5-13C2 (cas# 1189708-76-6) is a compound useful in organic synthesis.

Applications 3,4-Di(methoxy-d3)-benzoic Acid Methyl Ester is an intermediate used in the synthesis of Veratric Acid-d6 (V127562), which is labelled Veratric Acid, a derivative of Protocatechuic Acid. Veratric Acid is a reagent used in the production of antimicrobial agents, antifeedants, and a variety of other biologically active compounds.
References Alissandrakis, E. et al.: Eur. Food Res. Technol., 229, 365 (2009); Spaccini, R. et al.: Soil Biol. Biochem., 41, 1164 (2009); Narasimhan, B. et al.: Eur. J. Med. Chem., 44, 689 (2009); Pereira, L. et al.: J. Biotechnol., 139, 68 (2009);

Applications 4-Chloro-N-[2-(4-hydroxyphenyl)ethyl]benzamide-d4 (cas# 1189464-84-3) is a compound useful in organic synthesis.

Applications 2,2-Difluoroethylamine-d2 Hydrochloride is an intermediate used in the synthesis of Flupyradifurone-d5 (F598616), which is the labeled form of Flupyradifurone (F598615), can be used as an insecticide.
References Anon, IP.com J., 12, 19 (2011)

Applications (S)-1-Nitrosopiperidin-3-ol-d4 is an intermediate in synthesizing Ibrutinib-d4 (I124971), a labelled analogue of Ibrutinib (I124970). Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.
References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011)

Applications N-[1-(3’-Benzyloxyphenyl)ethyl]-N-(methyl-d3)amine (cas# 1189957-44-5) is a compound useful in organic synthesis.

Applications Indole-2,4,5,6,7-d5 is the intermediate in the synthesis of Indole-d6 (I577322), which is a labelled Indole (I577320). Can be used in perfumes and in the synthesis of tryptophan.
References Kawano, T. et al.: Gen. Hypo. 60, 664 (2003);

Applications Intermediate in the preparation of labelled Trimebutine metabolites.

Applications A deuterated intermediate in the synthesis of Carisoprodol.

Applications 1’-Hydroxy N-Trityl Medetomidine-d3 is an intermediate in the synthesis of Dexmedetomidine-d4 L-Tartrate (d4-Major) (D299006). Dexmedetomidine-d4 L-Tartrate is the labeled salt analogue of Dexmedetomidine (D299000), an α2-Adrenergic agonist; (+)-isomer of Medetomidine; sedative; analgesic.
References Rajala, R., et al.: Eur. J. Pharm. Sci., 1, 219 (1994); Jalonen, J., et al.: Anesthesiology, 86, 331 (1997); Talke, P., et al.: Anesth. Analg., 85, 1136 (1997); Bhana, N., et al.: Drugs, 59, 263 (2000)

Applications 3,5-Diamino-4-chlorobenzonitrile-15N2 is an intermediate in synthesizing Lodoxamide-15N2,d2 (L469367), a labelled form of Lodoxamide. It is an antiallergic drug that acts as a mast cell stabilizer. It is effective in the treatment of allergic conjunctivitis and in decreasing vascular permeability.
References Ciprandi, G., et al.: Allergy, 51(12), 946-951 (1996); Bayer, Atilla., et al.: Ophthalmologica, 217(2), 119-123 (2003)

Applications rac-N-Benzyl-3-(4-methoxyphenyl)-2-propylamine-d6 (cas# 1174538-53-4) is a compound useful in organic synthesis.
References Jozwiak, K., et al.: J. Med. Chem., 50, 2903 (2007),

Applications 2-(Formylamino)-3-hydroxy-2-propenoic-13C2 Acid Ethyl Ester (cas# 1391062-48-8) is a compound useful in organic synthesis.