Composés deutérés

Applications N-Cyanoacetylurethane-13C3,15N2 is an intermediate for the synthesis of Diclazuril-13C3,15N2 (D436202), which is the labelled analogue of Diclazuril (D436200). Diclazuril is a nucleotide analogue with broad-spectrum anticoccidial activity and a coccidiostat.
References Maes, L., et al.: J. Parasitol., 74, 931 (1988)

Applications D-Aspartic Acid-d3 L-Alanine Copper(II) Complex is an intermediate in the synthesis of D-Aspartic-2,3,3-d3 Acid (A790019) which is derived from D-Asparatic Acid (A790020), which is a non-essential amino acid found in food sources. Its conjugate base D-aspartate has potential use as an therapeutic agent in the treatment of schizophrenia-related symptoms.
References Errico, F. et al.: J. Neurosci., 28, 10404 (2008); Denu, J.M. et al.: Biochem., 34, 3396 (1995); Chen, P.E. et al.: Mol. Pharmacol., 67, 1470 (2005);

Applications 3,4-Di(methoxy-d3)-benzoic Acid Methyl Ester is an intermediate used in the synthesis of Veratric Acid-d6 (V127562), which is labelled Veratric Acid, a derivative of Protocatechuic Acid. Veratric Acid is a reagent used in the production of antimicrobial agents, antifeedants, and a variety of other biologically active compounds.
References Alissandrakis, E. et al.: Eur. Food Res. Technol., 229, 365 (2009); Spaccini, R. et al.: Soil Biol. Biochem., 41, 1164 (2009); Narasimhan, B. et al.: Eur. J. Med. Chem., 44, 689 (2009); Pereira, L. et al.: J. Biotechnol., 139, 68 (2009);

Applications Reagent used in the addition of labelled cyclopropane.
References Cave, C., et al.: Eur. J. Med. Chem., 25, 75 (1990), Kiyama, R., et al.: Chem. Pharm. Bull., 43, 960 (1995), Humphries, P., et al.: Bioorg. Med. Chem. Lett., 16, 6120 (2006)

Applications Ethyl Cyanoacetate-13C2 (cas# 93664-96-1) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Dimethyl-d6 Carbonate is the labeled analogue of Dimethyl Carbonate (D446705), which is used in the synthesis of phosphine-boranes in the preparation of new bidentate ligands. Also used in the synthesis of flavonoid analogs.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Imamoto, T. et al.: J. Am. Chem. Soc., 112, 5244 (1990); Cushman, M. et al.: J. Med. Chem., 34, 798 (1991)

Applications Ethyl Geranylgeranate-d6 is an isotope labelled geranylgeranylacetone derivative with potential in treating neurodegenerative diseases including paralysis.
References PCT Int. Appl. (2014), WO 2014163643 A1 20141009.; PCT Int. Appl. (2014), WO 2014151719 A1 20140925.

Applications α,α-Diphenyl-1-azabicyclo[2.2.2]octane-4-methanol-d10 is an intermediate in the synthesis of Umeclidinium Bromide-d5, which is considered as a potentially long-acting antimuscarinic agent.
References Cazzola, M., et al.: Pharmacol., Rev., 64, 450 (2012); Laine, D., et al.: J. Med. Chem., 52, 2493 (2009)

Applications Reagent used in the preparation of labelled cyclopropane derivatives.
References Antipenko, L., et al.: Chem. Pharm. Bull., 57, 580 (2009), Kumar, A., et al.: Bioorg. Med. Chem., 17, 5285 (2009),

Applications Chemical building block used in the synthesis of more complex structures.

Applications An intermediate of Rosuvastatin (R700500).

Applications An intermediate in the synthesis of the Daspone metabolite.

Applications Diethyl Cromoglycate-D5 is an intermediate used in the synthesis of Cromolyn-d5 Disodium Salt (C815002), which is a chromone complex which blocks mast cell degranulation.
References Ashton, M.J., et al.: Toxicol. Appl. Pharmacol., 26, 319 (1973), Friday, G.A., et al.: Am. J. Ophthalmol., 95, 169 (1983)

Applications Loratadine-d4 Epoxide N-Oxide (cas# 1794754-14-5) is a compound useful in organic synthesis.

Applications A labelled biodegradation product of Malathion (M111000).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kim, Y. et al.: Chemosphere, 60, 1349 (2005); Yoshii, K. et al.: J. Health Sci., 54, 535 (2008); Hayasaka, M. et al.: Jap. J. Forensic Toxicol., 12, 15 (1994);

Applications Indole-2,4,5,6,7-d5 is the intermediate in the synthesis of Indole-d6 (I577322), which is a labelled Indole (I577320). Can be used in perfumes and in the synthesis of tryptophan.
References Kawano, T. et al.: Gen. Hypo. 60, 664 (2003);

Applications O-Methyloxime Guanosine-13C15N2 is an isotope labelled intermediate in the preparation of nucleotide analogs.
References Robins, M. J., et al.: J. Am. Chem. Soc., 105, 4059 (1983);

Applications Ethyl (Z)-[2-amino-4-thiazolyl](methoxyimino)acetate-d3 is an intermediate used in the preparation of ceftriaxone-d3 (C245002), which is a labelled antibacterial.
References Reiner, R., et al.: J. Antibiot., 33, 783 (1980)

Applications A useful reactant in the preparation labelled Carbazeran (C175792), a phosphodiesterase inhibitor drug.

Applications 4-N-Acetylaminobenzene-13C6-sulfonyl Chloride (cas# 1216418-07-3) is a compound useful in organic synthesis.
References Tashiro, T., et al.: Bioorg. Med. Chem., 16, 8896 (2008), Alcalde, E., et al.: J. Med. Chem., 52, 675 (2009),