Composés deutérés

Applications 5H-Pyrido[1,2,3-de]-1,4-benzoxazine-D3 Boron Derivative is an intermediate in the synthesis of (R)-Ofloxacin-d3 (O245742), which is a labelled fluorinated quinolone antibacterial. An enantiomer of Levofloxacin (L360000).
References Hwangbo, H.J. et al.: Eur. J. Pharmac. Sci., 18, 197 (203); Gascon, A.R. et al.: J. Clin. Pharmacol, 40, 869 (2000); Monk, J.P., et al.: Drugs, 33, 346 (1987); Drlica, K., Curr. Opin. Microbiol. 2, 504 (1990);

Applications 2,6-Dichloroaniline-3,4,5-d3 (CAS# 77435-48-4) is a useful isotopically labeled research compound.

Applications Rabeprazole-D4 Sulfide is an intermediate in the synthesis of Rabeprazole-d4 (R070492). Rabeprazole-D4 Sulfide is an isotope-labeled analogue of Rabeprazole Sulfide (Rabeprazole EP Impurity B), which is a metabolite of Rabeprazole (R070500).
References Morii, M., and Takeguchi, N.: J. Biol. Chem., 268, 21553 (1993); Yasuda, S., et al.: Int. J. Clin. Pharmacol. Ther., 32, 466 (1994); Cloud, M.L., et al.: Dig. Dis. Sci., 43, 993 (1998)

Applications (-)-(2S,3S)-Viridifloric Acid Ethyl Ester is an intermediate in the synthesis of (+)-amabiline, an unsaturated pyrrolizidine alkaloid from Cynoglossum amabile.
References Senter, T. J., et al.: Org. Lett., 14, 1869 (2012);

Applications An intermediate in the synthesis of the Daspone metabolite.

Applications 3,5-Dimethyl-1-hexyn-3-ol-d5 is an isotope labelled intermediate in the synthesis of acetylene glycol derivative used in water-based coatings and has both antifoaming and surfactant properties.
References Schwartz, J. et al.: J. Coat. Tecnhol., 67, 21 (1995); Chinoy, N.F. et al.: Polym. Paint Colour J., 175, 438 (1985);

Applications 5-Hydroxy-7-methoxy-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one-d3 is an intermediate for the synthesis of Alternariol Monomethyl Ether-d3 (A575771), labelled methyl este analog fo Alternariol. An alternaria mycotoxin and genotoxin, found in common edible crops. It inhibits the activity of various DNA-topoisomerases, increasing the rate of DNA strand breaks.
References Asam, S., et al.: J. Agric. Food Chem., 57, 5152 (2009); Fehr, M., et al.: Mol. Nut. Food Res., 53, 441 (2009); Tiemann, U., et al.: Toxicol. Lett., 186, 139 (2009)

Applications 2-​Pyrimidin-​4,​6-​d3-​amine is a byproduct in the synthesis of 2-Chloropyrimidine-d3 (C380852), which was used in the study of IR vibrational spectroscopy of [Ru(bpy)2(bpm)]2+ and [Ru(bpy)3]2+ in the excited triplet state.
References Mukuta, T., et al.: Inorg. Chem., 53, 2481 (2014)

Applications Isotope labelled 6-Amino-5-nitrosouracil is used in the preparation of palladium(II) complexes with 5-nitrosopyrimidines which display antiproliferative effects. Useful heterocyclic reagent in the synthesis of substituted purine derivatives displaying anti-thyroid activity.
References Illan-Cabeza, N. et al.: J. Inorg. Biochem., 126, 118 (2013); Fatima, I. et al.: J. Mexi. Chem. Soc., 54, 227 (2010);

Applications 1,3-Dihydro-N-nitro-1,3-dioxo-2H-isoindole-2-carboximidothioic acid Methyl Ester-13C is an intermediate used in the synthesis of Clothianidin-d3,13C1 (C588502), which is the isotope labelled analog of Clothianidin. Clothianidin is a neonicotinoid insecticide for use in food crops.
References Kamel, A., et al.: J. Agric. Food Chem., 58, 5926 (2010), Lynd, L., et al.: Energy Environ. Sci., 3, 1150 (2010), Cresswell, J., et al.: Ecotoxicology, 20, 149 (2011),

Applications (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone-D3 is an intermediate in the synthesis of (S)-3-Hydroxy-2-methylpropanoic Acid-d3 sodium salt (H997291), which is the labelled version of 3-hydroxy-2-methyl-Propanoic acid sodium salt (CAS# 1893416-17-5), a useful building block used in the synthesis of aminotriazine derivatives.
References Du, Z.; et al.: WO 2016049211 (2016).

Applications Intermediate in the production of labelled Cyclophosphamide metabolites.
References Takamizawa, A., et al.: Chem. Pharm. Bull., 20, 1612 (1972),

Applications Methyl 4-(Dimethylamino)benzoate-D4 is an intermediate in the synthesis of DMABA-d4 NHS Ester (D678402), which is a labelled DMABA NHS ester (D678400). DMABA NHS ester is a reagent that reacts with the primary amine group of PE lipids. DMABA NHS ester has been used in combination with DMABA NHS ester-d4, -d6, and -d10 to study relative changes in PE lipid abundance before and after radical oxidation.
References Wester, H., et al.: Nucl. Med. Bio., 23, 365 (1996), Frees, D., et al.: Mol. Microbiol., 48, 1565 (2003), Michel, A., et al.: J. Bacteriol., 188, 5783 (2006), Voelker, T., et al.: Bioorg. Med. Chem., 17, 2047 (2009),

Applications Glycine-13C2,15N p-Toluenesulfonate is a by-product of an intermediate during the synthesis of m-Hydroxyhippuric Acid-13C2, 15N (H943127), a labelled m-Hydroxyhippuric Acid (H943125) which is a metabolite of caffeic and chlorogenic acids in human.
References Booth, A., et al.: J. Biol. Chem., 229, 51 (1957); Gonthier, M., et al.: Biomed. Pharmacother., 60, 536 (2006)

Applications (Methoxymethoxy)benzene-13C6 is an intermediate in the synthesis of 2,6-Dimethylphenol-13C8 (D465859), an isotope labelled analog of 2,6-Dimethylphenol-13C8. Similar to other xylenol compounds, 2,6-dimethylphenol is used in the synthesis of anti-oxidant compounds due to the phenol moiety in the structure. In addition, this compound is used as a a reactant in the synthesis of polyphenylene ether polymers.
References Carrillo, A. et al.: ANTEC. Soc. Plas. Eng., 69, 945 (2011); Guillen, M. et al.: J. Agri. Chem., 47, 3016 (1999); Guillen, M. et al.: J. Agri. Chem., 46, 1276 (1999)

Applications Isotope labelled Dimethyl Diglycolate is an starting material in the manufacture of unsaturated polyester resins and plasticizers.
References Hilker, I., et al.: Euro. Poly, J., 44, 1441 (2008);

Applications 1-Ethoxyethanimine-D3 Hydrochloride is an intermediate in the synthesis of Secnidazole-d3 (S225003), which is a labelled Secnidazole (S225000). Analog of Metronidazole. Antiamebic. Antiprotozoal (Trichomonas).
References Cosar, C., et al.: Arzneim.-Forsch., 16, 23 (1966), Videau, D., et al.: Br. J. Vener. Dis., 54, 77 (1978), Symonds, J., et al.: J. Antimicrob. Chemother., 5, 484 (1979),

Applications Labelled Doxylamine intermediate.
References Rennison, D., et al.: Bioorg. Med. Chem., 15, 2963 (2007),

Applications 2,4,6-Trifluorobenzonitrile-15N is an intermediate in the synthesis of Bictegravir-15N, d2 (B382096), which is the labeled version of Bictegravir, which is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.
References Tsiang M. et al.: Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097;

Applications 3,5-Dimethylbenzoic-d9 Acid is labelled 3,5-Dimethylbenzoic Acid which is a a reagent used to synthesize 5-Benzoyl-m-xylene (B209800). It can also be used to prepare quinoline inhibitors of Dengue viral NS2B-NS3 protease.
References Tachibana, Y., et al.: J. Org. Chem., 71, 5093 (2006); Deng, J., et al.: J. Med. Chem., 55, 6278 (2012)