Composés deutérés

Applications Isotope labelled Hexahydro-1,3-isobenzofurandione is used in the synthesis of hypotensive agents, pyridazinones. Also used in the synthesis of selective PDE4 inhibitors.
References Curran, W. et al.: J. Med. Chem., 17, 273 (1974); Van der Mey, M. et al.: J. Med. Chem., 44, 2511 (2001);

Applications Reactant in the preparation of CB1 cannabinoid receptor agonists and brain imaging agents.
References Deng, H. et al; J. Med. Chem. 48, 6386 (2005)

Applications 2-Chloro-ethanamine-d4 Hydrochloride (cas# 172333-26-5) is a compound useful in organic synthesis.

Applications Labelled intermediate for the synthesis of Thiouric Acid.
References Levin, G., et al.: J. Org. Chem., 25, 1752 (1960), Piper, J., et al.: J. Med. Chem., 36, 4161 (1993).

Applications An intermediate for the synthesis of labelled thiazolidinedione anti-diabetic drugs
References Cantello, B., et al.: Bioorg. Med. Chem. Lett., 4, 1181 (1994),

Applications A labelled intermediate of Irbesartan (I751000).
References Gillis, J., et al.: Drugs, 54, 885 (1997), Chando, T., et al.: Drug Metab. Disps., 26, 408 (1998), Hines, J., et al.: Eur. J. Pharmacol., 384, 81 (1999)

Applications Farnesalacetone-d6 is an labelled intermediate in the synthesis of intermediates in the biosynthesis of carotenoids.
References Natarajan, R. K., et al.: Adv. Biol. Res., 7, 95 (2013);

Applications O-2-Amino-2-methylpropyl Bilastine-d6 is an intermediate used in the synthesis of Bilastine-d6 (B385002), which is labelled Bilastine. It is a novel, nonsedating H1-antihistamine developed for symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria.
References Van Cauwenberge, P., et al.: Clin. Exp. Allergy, 30, 891 (2000), Bauchau, V., et al.: Eur. Respir. J., 24, 758 (2004), Lehman, J., et al.: Drugs, 66, 2309 (2006),

Applications 3-Aminobenzoic-d4 Acid (A591492) derivative. It increases attractiveness when combines with sex pheromones.
References Maekawa, M. et al.: Appl. Entomol. Zool., 34, 9 (1999)

Applications An intermediate in the preparation of labelled Pipradrol Hydrochloride

Applications 2-(Cyanomethyl)-1H-indole-1-carboxylic Acid tert-Butyl Ester-13C,15N is an isotope labelled intermediate in the synthesis of endothelial lipase inhibitors.

Applications 5-[4-Bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-2-chloro-4-fluorobenzoic Acid-d3 is an intermediate in the synthesis of Fluazolate (F407500), the active ingredient in the preparation of agrochemicals and drugs in amorphous form.

Applications (4-((3-Acetamidopropyl)(tert-butoxycarbonyl)amino)butyl)(3-((tert-butoxycarbonyl)amino)propyl)carbamic Acid-d3 tert-Butyl Ester is an intermediate in the synthesis of derivatives of Spermine (S680510) which is a biogenic polyamine formed from Spermidine (S680400) that occurs in almost all tissues.
References Theoharides, T.C., et al.: Life Sci., 27, 703 (1980); Horn, Y., et al.: Cancer Res., 42, 3248 (1982)

Applications Benzophenone-2,3,4,5,6-d5 is derived from Benzene-d6 (B185282), which is an isotope labelled benzene, an organic compound that is a natural constituent of crude oil and one of the most basic petrochemicals.
References Feng, Z.X.. et al.: J. Phys. Chem. Lett. 4, 285 (2013); Pilling. M., et al.: Chem. Eng. Prog., 108, 32 (2012);

Applications N-Methyl-o-phenylenediamine-d3, Dihydrochloride (cas# 1246820-22-3) is a compound useful in organic synthesis.

Applications Acetyl-13C2 Chloride is a labelled derivative of Acetyl chloride (A164496).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications N-[(Ethylamino)thioxomethyl]-N'-phenylpropanimidamide-d5 is an intermediate in the synthesis of Ethaboxam (E675700), a fungicide used against fungal infections in crops.

Applications Iodobenzene-d5 (cas# 7379-67-1) is a useful research chemical.

Applications 2-Butoxyethanol-d9 is an intermediate in the synthesis of Tris(2-butyloxyethyl)phosphate-d27 (T875032), which is the isotope analog of Tris(2-butyloxyethyl)phosphate. Tris(2-butyloxyethyl)phosphate,is an organophosphate, that can be used in the preparation of flame retardant, such as viscose fiber.
References Wang, Y., et al.: Fangzhi Xuebao, 33, 16 (2012); Xiaoshan, L. et al.: Aquatic Toxicology, 114, 173 (2012);

Applications N-Phenethylbenzamide-d5 is an isotope labelled intermediate in the synthesis of deteurerium-labeled amides within microreactors.
References Hooper, J., Watts, P.: J. Labelled Compd. Rad., 50, 189 (2007)