Composés deutérés

<p>Applications (±)-1-Phenylethan-1-d1-ol (CAS# 3101-96-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Decane-d21-thiol (CAS# 239090-36-9) is a useful isotopically labeled research compound. This compound has been used in experiments to directly measure water permeation using neutron reflectometry.<br>References Fies, W., et.al., Langmuir, 35, 5647-5662,(2019);<br></p>

<p>Applications Piperazine-d10 (CAS# 362049-61-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications m-Cresol-d8 (CAS# 302911-90-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications DL-Leucine-d7 (iso-propyl-d7) (CAS# 259225-40-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications (2S)-1-(2-Chloroacetyl)-2-9-pyrrolidinecarbonitrile-d1 is the deuterated form of (2S)-1-(2-Chloroacetyl)-2-9-pyrrolidinecarbonitrile (C363780), which is a key intermediate for dipeptidyl peptidase IV inhibitor Vildagliptin (V305000).<br>References Singh, S.K., et al.: Beil. J. Org. Chem., 4, 20 (2008);<br></p>

<p>Applications N-Methylacetamide-2,2,2-d3 (CAS# 3669-69-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-[(Tetrahydro-2H-pyran-2-yl)oxy]-2-butyn-1-ol-1,2,3,4-13C4 is an intermediate in the synthesis of N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine-13C4 (A173713). N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine-13C4 is labelled N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine (A173710), which is a metabolite of butadiene.<br>References Heavner, D., et al.: J. Pharm. Biomed. Anal., 40, 928 (2006); Carmella, S., et al.: Chem. Res. Toxicol., 22, 734 (2009)<br></p>

<p>Applications Isotope labelled benzyl bromide is a compound used in organic synthesis for the introduction of the benzyl protecting group for alcohols and carboxylic acids.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kudou, N., et al.: Euro. J. Med. Chem., 60, 76 (2013); Cahiez, G., et al.: Advan. Synthesis. Catalysis., 354, 1519 (2012);<br></p>

<p>Applications 1-Bromotridecane-d27 (CAS# 349553-91-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Decanoyl-d3 Chloride is an intermediate in the synthesis of Decanoyl-10,10,10,d3-L-carnitine Chloride (D212582), a labelled metabolite of L-Carnitine (C184110) which is an essential cofactor of fatty acid metabolism. Also required for the transport of fatty acids through the inner mitochondrial membrane.<br>References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978); Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001); Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002); Karlic, H., et al.: Nutrition, 20, 709 (2004)<br></p>

<p>Applications Octahydro-1H-pyrrolo[3,4-b]pyridine-d2 Di-trifluoroacetate is an intermediate in the synthesis ofhybrid antibacterial agents that exhibits inhibitory activities towards DNA Polymerase-Topoisomerase.<br>References Zhi, C.X., et al.: J. Med. Chem., 49, 1455 (2006);<br></p>

<p>Applications N,N'-Bis(3-aminopropyl-d6)-1,3-propanediamine (CAS# 1219804-74-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-tert-Butyl-2-chlorophenol-d9 is the labelled analogue of 4-tert-Butyl-2-chlorophenol.<br></p>

<p>Applications p-O-Methyl-isoproterenol-d3 Hydrochloride is an isotopic analog of p-O-Methyl-isoproterenol Hydrochloride (M314735), which can be synthesized from 2-Chloro-1-(3,4-dihydroxyphenyl)ethanone (C365325).<br></p>

<p>Applications N-Methyl-d3-acetamide (CAS# 3669-71-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Dibutyl Phenyl Phosphate-d5 is the deuterated form of Dibutyl Phenyl Phosphate (D429478), which is a phosphorus flame retardant additive.<br>References Sundkvist, A. M., et al.: Environ Monit Assess., 12, 943 (2010),<br></p>

<p>Applications Decanoic-2,2-d2 Acid (CAS# 62716-49-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Bromopropane-1,1,1,2-d4 (CAS# 1219799-22-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Octanol-d17, is the labeled analogue of 1-Octanol (O237900), which is an fatty acid alcohol that is used industrially to form various synthetic intermediate and pharmaceuticals.<br>References Nagaraja, N., et al.: J. Entomol. Res., 37, 29 (2013); Luang, S., et al.: J. Biol. Chem., 288, 10111 (2013);<br></p>

<p>Applications A labelled impurity of the anti-viral Lamivudine (L172500).<br>References Dwyer, O.: Synlett, 11, 1163 (1995);<br></p>

<p>Applications Cholesterol-3-d1 (CAS# 51467-57-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Wittig Reagent<br></p>

<p>Applications Naphthalene-1-d1 (CAS# 875-62-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled 4-Bromoaniline is a brominated aniline used as a building block in the preparation or pharmaceutial and organic compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Abdel-M. et al.: J. Org. Chem., 61, 3849 (1996); Sridhar, S.. et al.: Eur. J. Med. Chem., 36, 615 (2001);<br></p>

<p>Applications (±)-1-Phenylethan-2,2,2-d3-ol (CAS# 17537-32-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,3-Dimethylparabanic Acid-d6 is the labelled form of 1,3-Dimethylparabanic Acid (D474715). Chronic exposure to 1,3-Dimethylparabanic Acid can cause inhibition of growth population on rotifers while algae seems to be unaffected. Furthermore, 1,3-Dimethylparabanic Acid is a derivative of Caffeine (C080100).<br>References Zarrelli, a., et al.: Sci. Total Environ., 470, 453 (2014)<br></p>

<p>Applications 1-Bromo-2,3-dichlorobenzene-d3 (CAS# 1219805-59-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Vilazodone N-Oxide-d4 is the isotope labelled analog of Vilazodone N-Oxide (V265020); a metabolite of Vilazodone (V265000) which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression. Also an antidepressant.<br>References Bartoszyk, G., et al.: Eur. J. Pharmacol., 322, 147 (1997); Heinrich, T., et al.: J. Med. Chem., 47, 4684 (2004)<br></p>

<p>Applications Phenyl 4-Bromo-2-(ethyl-d3)pyridine-1(2H)-carboxylate is an intermediate in the synthesis of Ethionamide-d3 (E890422), a labelled antibacterial (tuberculostatic) agent.<br>References Banerjee, A., et al.: Science, 263, 227 (1994), Newton, G., et al.: J. Bacteriol., 178, 1990 (1996), Baulard, A., et al.: J. Biol. Chem., 275, 28326 (2000), Koledin, T., et al.: Arch. Microbiol., 178, 331 (2002), Cardoso, R., et al.: Antimicrob. Agents Chemother., 48, 3373 (2004),<br></p>

<p>Applications 2-Furamide-3,4,5-d3 (CAS# 1219799-31-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromohexadecane-16,16,16-d3 (CAS# 284474-40-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethynylbenzene-13C2, is the labeled analogue of Ethynylbenzene (E932150), which is an aromatic hydrocarbon, is important in the petrochemical industry as an intermediate in the production of styrene, which in turn is used for making polystyrene, a common plastic material.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Xiang, J., et al.: Tetrahedron Lett, 37, 5269 (1996);<br></p>

<p>Applications Sodium Butyrate-4,4,4-d3 (CAS# 347840-05-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Sodium Butyrate-3,3,4,4,4-d5 (CAS# 204244-79-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-(3-Methylbutyryl)glycine-2,2-d2 (CAS# 1219795-09-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Aminodihydro-​d2-2(3H)​-​thiophenone-​4,​5-​d2 is an intermediate in the synthesis of Erdosteine-d4 (E596052), which is the isotope labelled analog of Erdosteine (E596050); a mucolytic developed for the treatment of chronic obstructive bronchitis.<br>References Kuvandik, G., et al.: Toxicol. Pathol., 36, 714 (2008); Koyu, A., et al.: Mol. Cell. Biochem., 331, 43 (2009); Fourches, D., et al.: Chem. Res. Toxicol., 23, 171 (2010)<br></p>

<p>Applications 2-Nitroaniline-4,6-d2 (CAS# 1276197-41-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Fluorotoluene-alpha-d1 (CAS# 131088-90-9) is a useful isotopically labeled research compound. This compound can be used in to detect isotopic effects, and can be detected using NMR spectroscopy.<br>References Langen, H.,et.al., Z. Naturforsch.A., 46,1123-1130,(1991); Holland, H., et.al., J.Chem.Soc. Perkin Trans.1., 36,1107-1165,(2008);<br></p>

<p>Applications Tolcide 2230-d4 is derived from 2-Benzothiazolethiol-d4 (B206652), which is a useful building block in the synthesis of various pharmaceuticals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1,8-Dimethylnaphthalene-d12 (CAS# 104489-29-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Benzo[b]thien-2-yl ketone-D10 is a labelled analogue of Benzo[b]thien-2-yl ketone (B207710). Benzo[b]thien-2-yl ketone is an impurity of Zileuton (Z420000), an inhibitor of 5-lipoxygenase that is used to treat patients with asthma. Benzo[b]thien-2-yl ketone is used as a reagent to synthesize Bis(1H-2-indolyl)methanone, compounds that inhibit the activity of growth factor receptor kinase. Benzo[b]thien-2-yl ketone is also used as a reagent to prepare annulated oligothiophenes, compounds that are used in organic light-emitting devides (OLEDs).<br>References Israel, E., et al.: JAMA, 275, 931 (1996); Mahboobi, S., et al.: J. Med. Chem., 45, 1002 (2002); Mitschke, U. &amp; Bäuerle, P.: J. Chem. Soc. Perk. Trans., 1, 740 (2001); Nenajdenko, V., et al.: Russ. Chem. Bull., 61, 1456 (2012)<br></p>

<p>Applications 1,3-Di(methyl-d3)-naphthalene is the labeled analogue of 1,3-Dimethylnaphthalene (D476385), a polycyclic aromatic hydrocarbon (PAH) that has been shown to have cytochrome P 450 2A6 and 2A5 inhibitory activities.<br>References Wammer, K.H., Peters, C.A.: Environ. Sci. Technol., 39, 2571 (2005); Roy, K., Roy, P.P.: Eur. J. Med. Chem., 44, 1941 (2009)<br></p>

<p>Applications Bromocyclopropane-d4 is labelled Bromocyclopropane (B682760) which is used as a reagent to synthesize substituted (carboxycyclopropyl)glycines as potent and selective group II metabotropic glutamate receptor antagonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ornstein, P., et al.: J. Med. Chem., 41, 358 (1998)<br></p>

<p>Applications p-Xylene-d4 (ring-d4) (CAS# 16034-43-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 6-Amino-5-nitrosouracil-13C,15N2 is an intermediate in the synthesis of Xanthine-13C15N2 (X499952), which is an isotope labelled analog of Xanthine (X499950), a substance that can be found in animal organs, yeast, potatoes, coffee beans, tea. Xanthine can be used to relax and widen certain breathing passages of the lungs. It is also found that a large number of derivatives that exhibits adenoside receptor antagonist properties.<br>References Mueller, C. et. al: Handbook Exp. Pharmacol. 200,151(2011)<br></p>

<p>Applications Isotope labelled Nitrobenzene (N493000), used mainly in the production of the chemical precursor aniline as well as in azobenzene synthesis (1). Also may be reduced through magnetic iron oxide nanocrystals (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References Cantillo, D. et al.: J. Org. Chem. 2013 May 3;78(9):4530-42.Yadav, G. et al.: Chem. Eng. J. 2013 Aug:221(1) pp500-511<br></p>

<p>Applications Bromobenzene-2,3,5,6-d4 (CAS# 64646-03-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Cyclohexane-d11 (CAS# 1520-59-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled 2-Chloropyridine (C380605). (2-CPY) has been identified as a trace organic chemical in process streams, wastewater and even drinking water. Furthermore, it appears to be formed as a secondary pollutant during the decomposition of specific insecticides. 2-CPY was found to be genotoxic agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Demsia, G., et al.: Mutat. Res., 634, 32 (2007), Stapleton, D., et al.: Water Res., 43, 3964 (2009),<br></p>

<p>Applications (±)-1-Phenylethanol-d10 (CAS# 219586-41-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-(Trifluoromethoxy)benzoic Acid-13C is labeled 4-(Trifluoromethoxy)benzoic Acid (T790720) which is a substituted benzoic acid used in the preparation of a various biologically active compounds such as antifungal and antimalarial agents.<br>References Jiang, Y. et al.: Bioorg. Med. Chem. Lett., 21, 4471 (2011); Herrin, T.R. et al.: J. Med. Chem., 18, 1216 (1975);<br></p>

<p>Applications 2-Hexanone-1,1,1,3,3-d5 (CAS# 4840-82-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Octatriacontane-d78 (CAS# 1219803-25-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Phenyl-d5-ethylamine (CAS# 912627-99-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,6-Dinitrotoluene-alpha,alpha,alpha-d3 (CAS# 93951-90-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled (6R,7S)-Cefoperazone (C242890). (6R,7S)-Cefoperazone is the enantiomer of Cefoperazone (C242900) as an impurity.<br>References Fabre, H., et al.: J. Pharm. Sci., 73, 611 (1984), Strasters, J., et al.: Anal. Chem., 63, 2503 (1991), Chen, Z., et al.: World Notes Antibiot., 25, 249 (2004),<br></p>

<p>Applications Labelled analogue of Diethyl Hexyl Phosphate, an alkylphosphoric acid used in the extraction of uranium from molybednum. Diethyl Hexyl Phosphate is also used as a solid dispersing agent in certain food and beverage containers.<br>References Li, Z.: Youkuangye, 5, 14 (1986);<br></p>

<p>Applications 1,1-Dichloroethane (2,2,2-D3, 98%) (cas# 56912-77-7) is a useful research chemical.<br></p>

<p>Applications DL-4-Hydroxyphenylalanine-3,3-d2 (CAS# 35693-18-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,3,5-Trimethylphenol-d11 (CAS# 362049-46-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications T-705 Ribofuranose-13C5 is the labeled analog of T-705 Ribofuranose (T003200), a reagent used for the preparation of pyrazine-ribofuranose derivatives as antiviral agents that are useful in the treatment of viral infections.<br>References Zhong, B., et al.: Faming Zhuanli Shenqing, 2014:924257 (2014)<br></p>

<p>Applications 1-Iodobutane-d9 is the d9 labelled analog of 1-Iodobutane (I693895) which is one of the most universally useful substrates in the assessment of haloalkene dehalogenase activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Koudelakova, T., et al.: Biochem. J., 435, 345 (2011);<br></p>

<p>Applications Tri(n-octyl-1,1-d2)amine (CAS# 1219798-90-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Haloxyfop-methyl-d4 is the isotope labelled analog of Haloxyfop-methyl (H104050); a herbicide used for selective post-emergence control of annual and perennial grasses in broadleaf crops.<br>References Buhler, D.D., et al.: Weed Sci., 32, 824 (1984); Gronwald, J.W.: Weed Sci., 34, 196 (1986)<br></p>

<p>Applications (2,2',3,3',4',5,5',6,6'-d9-[1,1'-Biphenyl]-4-yl)boronic Acid acts as a reagent in the preparation of anthracene derivatives used as organic electroluminescent materials.<br>References Kim, T. H., et al.: From Repub. Korean Kongkae Taeho Kongbo (2013), KR 2013124775 A 20131115<br></p>

<p>Applications Di-n-propyl-d7-amine (mono-propyl-d7) (CAS# 63220-61-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methyliminodiacetic-d4 Acid (CAS# 1219803-27-6) is a useful isotopically labeled research compound.<br></p>