Composés deutérés

Applications iso-Propyl 4-Hydroxybenzoate-2,3,5,6-d4 (CAS# 1219798-72-7) is a useful isotopically labeled research compound.

Applications Labelled Norflurazon (N684500). Pesticide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References El-Nahhal, Y., et al.: J. Agric. Food Chem., 46, 3305 (1998),

Applications (±)-3-Amino-iso-butyric-2,3,3-d3 Acid is the labeled version of DL-3-Aminoisobutyric Acid (A603043(P)), which is a useful compound for suppressing atherosclerosis in apolipoprotein E-knockout mouse.
References Shimba, Y., et al.: Bio. Pharma. Bull., 43, 1016 (2020)

Applications 1,10-Decanedioic-2,2,9,9-d4 Acid (CAS# 339080-77-2) is a useful isotopically labeled research compound.

Applications 1-Naphthoic Acid-d7 (cas# 634179-80-9) is a compound useful in organic synthesis.

Applications Acetaminophen-13C2, 15N1 is doubly labeled Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).
References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)

Applications Metabolite of Salicylic Acid (S088125).
References Jurkowski, W., et al.: Current Drug Metab., 10, 448 (2009), Appeldoorn, M., et al.: J. Agric. Food Chem., 57, 7693 (2009), van Oijen, M., et al.: Pharmacol., 83, 237 (2009),

Applications Undecanoic-d21 Acid (CAS# 60658-40-4) is a useful isotopically labeled research compound.

Applications Di-n-decyl Phthalate-3,4,5,6-d4 (CAS# 1276197-18-2) is a useful isotopically labeled research compound.

Applications A labelled form of Pirimicarb (P508768) which is a pesticide which is useful in cannabis testing kits as a component of pesticide mixes (P698240).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Tsuchiyama, T.; et al.: Journal of Chromatography A, 1524, 233 (2017).

Applications Labelled Creatinine. The end product of creatine catabolism. Normal constituent of urine. Also found together with creatine in muscle tissues and blood. Occurs in all soils and in grain seeds and other vegetable matter. Has been found in certain fish and in crab meat extract.
References Folin, et al.: J. Biol. Chem., 17, 463 (1914),

Applications Butanoic-d7 Acid is a deuterated version of Butanoic Acid (B692235). Butanoic Acid, is found in milk, especially goat, sheep and buffalo milk. It can be used for the preparation of various esters, such as methyl butyrate, which has pleasant aromas or tastes and thus can be used as food and perfume additives.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lupton, J. R., et al.: J. Nutrition, 134 (2), 479 (2004); Grummer, R. R., et al.: J Dairy. Sci., 74 (9),3244 (1991)

Applications Labelled analogue of Hydrocinnamic Acid, a cinnamic acid derivative used in the compositions for the treatment of blood disorders using α-methylhydrocinnamic acid.
References Migliaccio, A., et al.: Blood, 76, 1150 (1990); McDonagh, K., et al.: J. Biol. Chem., 266, 11965 (1991);

Applications Labelled Resorcinol. A benzene derivative used as keratolytic and antiseborrheic. Also used in veterinary medicine as a topical antipruritic and antiseptic (has been used as intestinal antiseptic).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Labelled Physcion. A natural anthraquinone derivative, on the infection process of Blumeria graminis on wheat. Physcion is one of the important active ingredients of ethanol extract from the roots of Chinese rhubarb (Rheum officinale) for controlling powdery mildew.
References Thiericke, R., et al.: Nat. Prod. Rep.,10, 265 (1993), Lin, C., et al.: J. Nat. Prod., 58, 1934 (1995), Julia, S., et al.: J. Biotechnol., 124, 690 (2006), Wang, W., et al.: J. Antibiot., 60, 603 (2007),

Stability Hygroscopic
Applications Hexanoyl-L-carnitine-(N-methyl-d3) Chloride, is the labeled analogue of Hexanoyl-L-carnitine Hydrochloride (H294440), which is used as reactant in the synthesis of carnitine benzyl esters as prodrugs.
References Gong, X., et. al.: J. Chem. Res., 6, 327 (2008)

Applications Labelled Formic Acid is used to improve NMR profiling of amino metabolites in biofluids.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ye, T. et al.: Anal. Chem., 82, 2303 (2010); Gowda, G.A., Anal. Chem., 82, 8983 (2010);

Applications Morpholine-d8 Hydrochloride is used as a reactant in the synthesis of Moclobemide-d8 (M481002), the labeled analogue of Moclobemide (M481000), a reversible monoamine oxidase inhibitor.
References Wiesel, F.A., et al.: Eur. J. Clin. Pharmacol., 28, 89 (1985), Burkard, W.P., et al.: J. Pharmacol. Exp. Ther., 248, 391 (1989)

Applications Glyburide-d3 (methoxy-d3) (CAS# 1219803-02-7) is a useful isotopically labeled research compound.

Applications Labelled N-nitrosopiperazine derivative; shows strong nasal carcinogenicity and genotoxicity after low dose inhalation.
References Sabadie, N., et al.: Cancer Res., 40, 119 (1980), Kuchenmeister, F., et al.: Toxicol. Lett., 88, 29 (1996), Mathison, B., et al.: Mutat. Res., 380, 77 (1997),

Applications Labelled Glycerol (G598400). Glycerol is used both in sample preparation and gel formation for polyacrylamide gel electrophoresis. Glycerol (5-10%) increases the density of a sample so that the sample will layer at the bottom of a gel’s sample well. Glycerol is also used to aid in casting gradient gels and as a protein stabilizer and storage buffer component.
References Bartsch, W., et al.: Arzeim.-Forsch., 26, 1581 (1976),

Applications L-Valine (1-13c, 99%) (cas# 81201-85-6) is a useful research chemical.

Applications Labelled Hexanal. Used in the enzymic synthesis of (R)- and (S)-1-deuteriohexanol.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Tsai, A., et al.: J. Biol. Chem., 267, 17753 (1992), Glickman, M., et al.: Biochemistry, 35, 12882 (1996),

Applications Betaine-d3 Hydrochloride is a useful gastric acidifier.
References Wilcken, D.E., et al.: N. Engl. J. Med., 309, 448 (1983),

Stability Volatile
Applications Labelled 2,5-Dimethylfuran (D473050). It is an ideal marker for detecting cigarette smoke.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Spitzer, W., et al.: Clin. Invest. Med., 13, 17 (1990), Alonso, M., et al.: Anal. Bioanal. Chem., 396, 2989 (2010),

Stability Volatile
Applications Assignments of far-IR (FIR) laser lines have been found for optically pumped Methanol-13C.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Moraes, J.C.S., et. al.: J. Mol. Spec., 177, 302 (1996)

Applications Bis(2-butoxyethyl) 2-Hydroxyethyl-d4 Phosphate Triester is a labeled form of Bis(2-butoxyethyl) 2-Hydroxyethyl Phosphate Triester (B415190), which is a metabolite of Tris(2-butyloxyethyl)phosphate (T875030), an organophosphate, that is used in the preparation of flame retardant, such as viscose fiber.
References Wang, Y., et al.: Fangzhi Xuebao, 33, 16 (2012); Xiaoshan, L. et al.: Aquatic Toxicology, 114, 173 (2012);

Applications L-Methionine Sulfoxide 13C1 is a labelled analogue of L-Methionine Sulfoxide ( M260450). L-Methionine Sulfoxide ( M260450) an intermediate in the synthesis of the acyclic amino carboxylic acid L-Methionine sulfoximine.
References Lee, B., et al.: J. Biol. Chem., 283, 28361 (2008), Nordqvist, A., et al.: Bioorg. Med. Chem., 16, 5501 (2008);Balog, E., et al.: Biochem., 48, 3005 (2009);

Applications Labelled Mecoprop (M203052). Herbicide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gagne, F., et al.: Environ. Res., 103, 238 (2007), LaChapelle, A., et al.: Reprod. Toxicol., 23, 20 (2007),

Applications Benzonitrile-D5 is a labelled analogue of benzonitrile, commonly used as a precursor to synthesize a wide range of aromatic compounds and also forms stable coordination complexes with transition metals.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Anderson, G., et al.: Inorg. Syn., 28, 60 (1990); Cui, D., et al.: Angew. Chem. Int. Edit., 117 981 (2005)

Applications 2,2′,4,4′-Tetrahydroxybenzophenone-d4 is an isotopic analog of 2,2′,4,4′-Tetrahydroxybenzophenone (T295900), a benzophenone-type UV filter with known or suspected endocrine disrupting properties detected in surface waters, sunscreens, personal care products, clothing and food packaging. It is used to protect the skin and materials from the adverse effects of UV-radiation.
References Wu, M., et al.: Ecotoxicol. Environ. Saf., 141, 235-241 (2017); Krause, M., et al.: Environ. Int., 99, 177-184 (2017); Jimenez-Diaz, I., et al.: J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 1035, 57-66 (2016)

Applications Diphenyl-2,2',4,4',6,6'-d6-amine (CAS# 99234-91-0) is a useful isotopically labeled research compound.

Applications tert-Butyl-d9 4-Nitrophenyl Carbonate (cas# 1190006-35-9) is a compound useful in organic synthesis.

Applications 4-Ethylphenyl-d4 Sulfate Potassium Salt is the isotope labelled analog of 4-Ethylphenyl Sulfate Potassium Salt (E925865); a newly identified uremic substance.
References Kaori, K., et al.: J. Chromatogr. B, 878, 2997 (2010)

Applications AOZ-HN-d4 is the isotope labelled analog of AOZ-HN (A699000); a metabolite of 3-Amino-2-oxazolidinone (AOZ, A618570) and 1-Formylnaphthalen-2-ol (F700825) which is a novel fluorescence agent.
References Sheng, L., et al.: Food Addit. Contam., 30, 2114 (2013); Du, N., et al.: J. Chromatogr. A, 1327, 90 (2014)

Applications 2,3,4-Trihydroxybenzophenone-2’,3’,4’,5’,6’-d5 is the isotope labelled analog of 2,3,4-Trihydroxybenzophenone; a trihydroxy derivative of Benzophenone (B204980) which is a compound used in the manufacturing of antihistamines, hypnotics, and insecticides.
References Wallace, W., et al.: Environ. Toxicol. Chem., 19, 962 (2000); Hayashi, T., et al.: Toxicol. Lett., 167, 1 (2006); Bechard, K., et al.: Aquat. Toxicol., 90, 310 (2008)

Applications Dimethyl-d6-cyanamide (cas# 72142-88-2) is a compound useful in organic synthesis.

Applications 2-Amino-ethan-1,1,2,2-d4-ol is labelled Ethanolamine (E676500) which is used in the preparation of various pharmaceutical compounds and inhibitors. Substituted carboxamides are synthesized using Ethanolamine that show potent antitumor activity. Also used in the synthesis of aminoquinolones which display anti-plasmodial activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lombardo, L. et al.: J. Med. Chem., 47, 6658 (2004); Egan, T.: J. Med. Chem., 43, 283 (2000);

Applications 5-(4-Chlorobutyl)-1-cyclohexyltetrazole-d11 (cas# 1073608-19-1) is a compound useful in organic synthesis.

Applications 2-Benzothiazolethiol-d4 (cas# 1346598-64-8) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications A labelled metabolite of 4-t-nonylphenol
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ye, X., et al.: Drug Metab. Disposition, 35, 1269 (2007), Gabriel, F., et al.: Env. Sci. Technol., 42, 6399 (2008), Liedtke, A., et al.: Env. Toxicol., 23, 59 (2008),

Applications n-Triacontane-d62 is the labeled compound of Triacontane (CAS #: 638-68-6). Triacontane releases selective material in thermally degradable capsule. It also, increases charge carrier mobility and molecular packing of a solution sheared Diketopyrrolopyrrole-based donor-acceptor copolymer by Alkyl side chain modification.
References Shkolnikov, V., et al.; PCT Int. Appl., (2018); Hambsch, M., et al.: Journal of Materials Chemistry C: Materials for Optical and Electronic Devices, 7, 3665-3674, (2019);

Applications 4-Cumylphenol-d2 is a deuterated isotope of 4-Cumylphenol (C834580) which is a useful building block for polymers.

Applications Methoxyfenozide-d9 is deuterium labelled Methoxyfenozide (M262765). It is used primarily as an insecticide, and pesticide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Zhao, Q., et al.: J. Agricul, Food Chem., 56, 10799 (2008);

Applications 17beta-Estradiol-2,4,16,16,17-d5 (CAS# 221093-45-4) is a useful isotopically labeled research compound.

Applications Labelled analogue of Sulfachlorpyridazine, an antibacterial compound.
References Wammer, K.: Environ. Toxicol. Chem. 25, 1480 (2006);

Applications Geraniol-D6 is the deuterium labeled analog of Geraniol, which is used in the synthesis of insect repellant. It is also used in the synthesis of Angelicoin A and Herecinone J, which inhibit collagen-induced platelet aggregation.
References Barnard, D. et al.: J. Med. Entomol., 41, 726 (2004); Mori K. et al.: Phytomedicine, 17, 1082 (2010);

Applications 3-Pentanone-d6 is labelled 3-Pentanone (P273600) which is a simple, symmetrical dialkyl ketone. It is mainly used as a solvent in paint and a precursor to vitamin E. It is a useful synthetic intermediate. It can be used as a reagent to synthesize Ethyl 2-Cyano-3,3-diethylacrylate (E907600) by Knoevenagel condensation. It also shows anticonvulsant effect in several types of mouse seizure models.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hasebe, N., et al.: Eur. J. Pharma., 642, 66 (2010); Siegel, H., et al.: Ullmann's Encyclopedia of Industrial Chemistry, (2002)

Stability Volatile
Applications tert-Butylamine is common reagent in pharmaceuticals syntheses. Used in the preparation of aminoBODIPY compounds for chemical analyses. Also it aids in the synthesis of benzylurea-based insecticides containing amide and sulfonate groups. It has also been used in the synthesis of BPTES analogs, that act as glutaminase inhibitors, which can attenuate the growth of human lymphoma B cells. This is the labeled analog.
E0
References Osorio-Martinez, C. et al.: J. Org. Chem., 77, 5434 (2012); Sun, R. et al.: J. Agri. Food, Chem., 61, 517 (2013); Shukla, K. et al.: J. Med. Chem., 55, 10551 (2012);