Composés deutérés

<p>Applications N,N-Diisopropyl-3-(2-methoxy-5-methyl-phenyl)-3-phenylpropylamine-d14 (cas# 1795031-80-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,3-Dichlorobenzamidyl Guanidine-13C2 (cas# 1185047-08-8) is a compound useful in organic synthesis.<br></p>

<p>Applications N,N'-Dimethyl-3,3'-dithiodipropionamide is an disulfide linked compound found in antifouling coatings and is also an intermediate in the synthesis of antimicrobial agents and biocides.<br>References Easton, C.J., et al.: J. Chem. Soc., 1, 153 (1985);<br></p>

<p>Applications 1,1,2-Trimethyl-3-(4-sulfobutyl)benz[e]indolium-d6 Inner Salt is a labelled analogue of 1,1,2-Trimethyl-3-(4-sulfobutyl)benz[e]indolium Inner Salt (T796740). It is a reactant used in the preparation of liposomally formulated indocyanine green (LP-ICG) derivatives for near infrared fluorescence imaging of lymph nodes.<br>References Toyota, T., et. al.: Bioorg. Med. Chem., 22, 721 (2014)<br></p>

<p>Applications Intermediate in the production of labelled Lapatinib.<br>References Godeneche, D., et al.: Drug Metab. Disposition, 21, 93 (1993),<br></p>

<p>Applications Benzoic Acid-d5 Ethyl Ester (cas# 54354-03-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Reagent used in labelled pyrimidine and purine synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Das, S., et al.: J. Med. Chem., 52, 5937 (2009), Kim, K., et al.: Bioorg. Med. Chem. Lett., 19, 5225 (2009),<br></p>

<p>Applications 2,5-Dihydro-2-hydroxy-5-nitro-2-furanmethanediol-d3 Triacetate (cas# 1346604-22-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Hydrazine derivative.<br></p>

<p>Applications Methyl nicotinate-2,4,5,6-d4 is a labelled form of methyl nicotinate (M323240), a useful synthetic intermediate, which can be used to prepare biarylcarboxamide inhibitors of phosphodiesterase IV and tumor necrosis factor-α in treatment of rheumatoid arthritis.<br>References Chambers, R., et al.: Bioorg. Med. Chem. Lett., 7, 739 (1997).<br></p>

<p>Applications 4-Benzyloxyphenylacetonitrile-d2 is an intermediate in synthesizing N-Iodoacetyltyramine-d4 (I685882), an isotope labelled N-Iodoacetyltyramine (I685880). It is used in iodine-125 labelling of various molecules for chemical analysis.<br>References Lin, C. et al.: Anal. Biochem., 179, 389 (1989);<br></p>

<p>Applications Intermediate in the production of labelled Medetomidine<br>References Kagechika, H., et al.: J. Med. Chem., 32, 1098 (1989),<br></p>

<p>Applications [3-(Dimethylamino)propyl]triphenylphosphonium-d6 Bromide is a compound useful in organic synthesis.<br></p>

<p>Applications Anticonvulsant against audiogenic convulsion.<br>References Goeres, E., et al.: Acta Biol. Med. Ger., 23, 679 (1969)<br></p>

<p>Applications α,α-Dimethyl-1H-indole-2-acetonitrile-13C315N is an isotope labelled intermediate in the synthesis of serotonin-3 receptor antagonists.<br>References Kato, M., et al.: Chem. Pharma. Bull., 42, 2556 (1994);<br></p>

<p>Applications Imidazol-1-yl-acetic Acid-15N2,13C2 (cas# 1184983-00-3) is a compound useful in organic synthesis.<br></p>

<p>Applications Ammonium-15N hydroxide Solution is a solution prepared from ammonium-15N sulfate for studying fertilizer use efficiency and is an important fertilizer for soil fertilization of the sugarcane crop in Brazil.Ammonium-15N hydroxide Solution is also used in the preparation of isotope-labeled oligonucleotides for their use in NMR studies of protein-DNA complexes.Ammonium-15N hydroxide Solution is the 15N-labeled compound for A634020, which is used in numerous household cleaning agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bendassolli, Jose Albertino., Scientia Agricola (Piracicaba, Brazil), 59, 595-603, (2002)Kellenbach, E. R., Nucleic Acids Research, 20, 653-7, (1992)Lokshin, E.P., et al.: Russ. J. App. Chem., 86, 450 (2013)<br></p>

<p>Applications Labelled analogue of Potassium Cyanide, a reagent widely used in organic synthesis for the preparation of nitriles and carboxylic acids, particularly in the von Richter reaction.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kollenz, G. et al.: Org. Prep. Proc. Int., 12, 244 (1980); Subramanian, L. R.: Sci. Synth., 19, 173 (2004);<br></p>

<p>Applications Fluorene-D10 is a labelled analogue of Fluorene (F462000). Fluorene is a polycyclic aromatic hydrocarbon that is ubiquitous in the urban environment, and is also a suspected carcinogen. Fluorene is used as a component of fluorescent probes that bind to human serum albumin, allowing researchers to study internal mechanisms more closely.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Harrison, R., et al.: Env. Sci. Tech., 30, 825 (1996); Park, K., et al.: Org. Biomol. Chem., 7, 4225 (2009); Weissenfels, W., et al.: Appl. Micro. Biotech., 32, 479 (1990)<br></p>

<p>Applications Ethyl (5-Ethyl-2-pyridinyl)-1,1-d2-acetate (cas# 1189654-25-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Intermediate in the synthesis of labelled heteroarotinoids.<br>References Dawson, M.I. et al.; J. Med. Chem. 27, 1516 (1984); Waugh, K.M. et al.; J. Med. Chem. 28, 116 (1985); Spruce, L.W. et al.; J. Med. Chem. 30, 1474 (1987)<br></p>

<p>Applications 7-Fluoro-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione-d3 is the isotope labelled analog of 7-Fluoro-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione,. 7-Fluoro-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione, is used as a reactant in the synthetic preparation of 18F-labeled radiotracers for γ-aminobutyric acid A (GABAA) receptor positron emission tomography (PET) imaging.<br>References Jackson, A., et al.: Bioorg. Med. Chem. Lett., 23, 821 (2013); Tedesco, R. et al.: J. Med. Chem., 49, 471 (2006);<br></p>

<p>Applications 2-Amino-4,6-dichloropyrimidine-13C2 (cas# 1346605-11-5) is a compound useful in organic synthesis.<br></p>

<p>Applications A deuterated intermediate in the synthesis of the metabolite of Terbinafine, an orally active, antimycotic allylamine related to naftifine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4-Amino-1-pentanol-d4 Hydrochloride Salt (cas# 1216414-18-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,2-Dimethoxybenzene-3,4,5,6-d4 (CAS# 126840-15-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Amino-1-pentanol-d4 Benzyl Ether is an intermediate in the synthesis of Hydroxychloroquine-d4 Sulfate (H916902), which is an antimalarial; antirheumatic; lupus erythematosus suppressant.<br>References Yarden, Y., et al.: Nature, 323, 226 (1986), Seifert, R., et al.: J. Biol. Chem., 264, 8771 (1989), Gahl, W., et al.: Mol. Genet. Metab., 76, 234 (2002), Card, J., et al.: Toxicol. Sci., 75, 169 (2003),<br></p>

<p>Stability Volatile<br>Applications 1-Bromobutane-d3 is used in the synthesis of specifically-deuterated procaine and tetracaine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Boulanger, Y., et al.: J. Labelled Comp. Radiopharm., 18, 1197 (1981),<br></p>

<p>Applications Uridine 5′-Monophosphomorpholidate 4-Morpholine-N,N′-dicyclohexylcarboxamidine Salt-13C, 15N2 is an intermediate in the synthesis of Trilithium UDP-glucuronic Acid-13C1, 15N2 (T886287), which is an isotope labelled analog of Trisodium UDP-glucuronic Acid (T886285). Trisodium UDP-glucuronic Acid is a reactant used in the enzymatic preparation of β-glucuronides.<br>References Stevenson, D.E., et. al.: Collect Czech. Chem. C., 65, 117 (2000); Robotham, S.A., Brodbelt, J.S.: Biochem. Pharmacol., 82, 1764 (2011); Kren, V., et. al.: Drug Metab. Dispos., 28, 1513 (2000)<br></p>

<p>Applications Isotope labelled analogue of tert-Pentyl Chloride, an alkyl chloride used as a starting material in various organic synthesis.<br></p>

<p>Applications (S)-1-Boc-3-hydroxypiperidine-d4 is an intermediate in synthesizing Ibrutinib-d4 (I124971), a labelled analogue of Ibrutinib (I124970). Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011)<br></p>

<p>Applications Substrate for alcohol dehydrogenase<br>References Burkhard, P., et al.: J. Mol. Biol., 295, 953 (2000), Ferreira, A., et al.: J. App. Microbiol., 91, 67 (2001), Johnson, B., et al.: J. Comp. Neurol., 502, 468 (2007),<br></p>

<p>Applications Farnesyl Pyrophosphate Triammonium Salt-13C3 is labelled Farnesyl Pyrophosphate Triammonium Salt (F102470) which is an isoprenoid from the intracellular mevalonate pathway used for prenylation of several low molecular mass G proteins, including Ras.<br>References Correll, C., et al.: J. Biol. Chem., 269, 17390 (1994), Moura, I., et al.: Antimicrob. Agents Chemother., 45, 2553 (2001), Gana-Weisz, M., et al.: Clin. Cancer Res., 8, 555 (2002),<br></p>

<p>Applications O-TBS 2'-Deoxy-N-methyl-cytidine-d3 is an intermediate used in the synthesis of 2'-Deoxy-N-methyl-cytidine-d3 (D242412), which is the labelled form of 2'-Deoxy-N-methyl-cytidine (D242410). 2'-Deoxy-N-methyl-cytidine is a nucleotide derivative used as an analytical reagent.<br>References Dupret, D.: Biomed. Health. Res., 23(Human Genome Analysis), 244-255 (1998)<br></p>

<p>Applications An intermediate for the synthesis of Tamoxifen.<br>References Ruenitz, P.C., et al.: Biochem. Pharmacol., 34, 2807 (1985), Gilbert, J., et al.: J. Med. Chem., 40, 1104 (1997), Lashley, M.R., et al.: Bioorg. Med. Chem., 10, 4075 (2002),<br></p>

<p>Applications 2-(Formylamino)-3-hydroxy-2-propenoic-13C2 Acid Ethyl Ester (cas# 1391062-48-8) is a compound useful in organic synthesis.<br></p>

<p>Applications α-Methyl-2-piperidinemethanol-13C2 is a labelled analogue of α-Methyl-2-piperidinemethanol (M324830), which can be used in the preparation of substances with herbicidal activity. α-Methyl-2-piperidinemethanol-13C2 is also an intermediate in synthesizing 2-Acetyl-3,4,5,6-tetrahydropyridine-13C2 Hydrochloride (A188502), which is a labelled 2-Acetyl-3,4,5,6-tetrahydropyridine (A188500), the most important bread flavor component.<br>References Buttery, R.G., et al.: J. Agric. Food Chem., 43, 1878 (1995)<br></p>

<p>Applications Methyl Valerimidate-d9 Hydrochloride (cas# 1030939-72-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-(2-Bromoethyl-d4)-2,3-dihydrobenzofuran (cas# 1189652-25-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-Hydroxy-8-methoxy-octanoic Acid Methyl Ester-d5 is a compound useful in organic synthesis.<br></p>

<p>Applications Methyl-(4-nitrophenylethyl)-4-(nitrophenoxyethyl)amine-d4 (cas# 1189869-42-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Glutaronitrile-d6 (cas# 1346598-53-5) is a compound useful in organic synthesis.<br></p>

<p>Applications (4E)-Octenedinitrile-1,8-13C2 (cas# 1185245-34-4) is a compound useful in organic synthesis.<br></p>

<p>Applications Reproduction of Sindbis virus strains sensitive and resistant to 1-adamantanecarboxamide.<br>References Erice, A., et al.: N. Engl. J. Med., 320, 289 (1989), Andronova, V.L., et al.: Bull. Exper. Bio. Med., 129, 74 (2000).<br></p>

<p>Applications 2,2-Difluoroethylamine-d2 Hydrochloride is an intermediate used in the synthesis of Flupyradifurone-d5 (F598616), which is the labeled form of Flupyradifurone (F598615), can be used as an insecticide.<br>References Anon, IP.com J., 12, 19 (2011)<br></p>

<p>Applications Possible inhibitor of Superoxide Dismutase.<br>References Sanchez-Moreno, M., et al.: Pharmacol., 52, 61 (1996),<br></p>

<p>Applications N3-Tritylpyridine-2,3-diamine-d3 is an intermediate in the synthesis of Pentosidine-d3 TFA Salt which is a biochemical marker of bone turnover for management of metabolic bone diseases.<br>References Turner, W., et al.: Biol. Psychiatry, 14, 177 (1979), Miyata, T., et al.: Kidney Int., 60, 2351 (2001), Politi, P., et al.: Neurosci. Lett., 396, 163 (2006),<br></p>

<p>Applications Eugenol-d3 Methanesulfonate is an intermediate in the synthesis of Labelled Eugenol (E935640), a dental compound which shows cytotoxicity to human oral squamous cell carcinoma and oral cells. When glucosylated, this compound exhibits anti-inflammatory activity.<br>References Koh, T. et al.: In Vivo, 27, 85 (2013); Zhang, P. et al.: Arch. Pharm. Res., 36, 109 (2013);<br></p>