Composés deutérés

Applications Aceclofenac-d4 is deuterium labelled Aceclofenac (A130400), which is an anti-inflammatory and analgesic drug.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yscla, A., et al.: Drugs Exp. Clin. Res., 14, 491 (1988); Ballesteros, R., et al.: Clin. Trials J., 27, 12 (1990)

Applications Butyronitrile-d7 (CAS# 352431-11-9) is a useful isotopically labeled research compound.

Applications Ethyl (±)-2-Bromopropionate-3,3,3-d3 (CAS# 1398066-14-2) is a useful isotopically labeled research compound.

Applications 1-Bromodecane-1,1,2,2-d4 (CAS# 1219805-58-9) is a useful isotopically labeled research compound.

Applications Cyproheptadine Hydrochloride-d3 is the isotope labelled analog of Cyproheptadine (C989200, HCl,H2O); a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. Also a 5-HT2/5-HT1C serotonin receptor antagonist, H1 histamine receptor antagonist, and antipruritic.
References Marchei, E., et al.: J. Pharm. Biomed. Anal., 41, 1633 (2006); de-Benedictis, F., et al.: Allergy, 63, 1395 (2008); Feas, X., et al.: J. Pharm. Biomed. Anal., 50, 1044 (2009); Yu, C., et al.: Talanta, 2011, 83, 1376 (2011)

Applications Labelled analogue 4-(2-Hydroxyethyl)morpholine, a morphiline derivative used in the preparation of ester prodrugs of naproxen. 4-(2-Hydroxyethyl)morpholine was also shown to induce repair in rat hepatocyte primary culture/DNA.

Applications 1,2-Dibromobenzene-d4 (CAS# 1643577-34-7) is a useful isotopically labeled research compound.

Applications p-Toluic-2,3,5,6-d4 Acid (CAS# 1219798-71-6) is a useful isotopically labeled research compound.

Applications Labelled Mebeverine Alcohol, a metabolite of Mebeverine (M202490), an antispasmodic.
References Greenwood, B. et al.: Eur. J. Pharmacol., 211, 143 (1992); van Outryve, M. et al.: J. Clin. Pharm. Ther., 20, 277 (1995); Kraemer, T. et al.: Drug Metab. Disp., 28, 339 (2000);

Applications Dimethyl N,N-Diisopropylphosphoramidite-d6 is an isotope labelled reagent for the efficient phosphorylation of alcohols.
References Tatsumi, S., et al.: Tetrahedron. Lett., 54, 3731 (2013);

Applications 2-(1-Oxo-2(1H)-naphthalenylidene)-hydrazinecarboxamide-d4 is labelled 2-(1-Oxo-2(1H)-naphthalenylidene)-hydrazinecarboxamide (N359270) which is a novel anti-anflammatory agent as well as an anti-proliferative agent due to its 1,2-napthoquinone substructure.
References Marrero-Ponce, Y. et al.: Eur. J. Med. Chem., 46, 5736 (2011);

Applications Isotope labelled 1-Bromo-3-chloropropane can be used safer and equally efficient alternative to chloroform as a phase-separation agent in the 1-step method of RNA isolation from biological samples such as animal and plant tissue.
References Chomczynski, P. et al.: Anal. Biochem., 225, 163 (1995); Chey, S. et al.: Anal. Biochem., 411, 164 (2011);

Applications Estrone-2,4-d2 (CAS# 350820-16-5) is a useful isotopically labeled research compound.

Applications 8-Nitro-1-pyrenol is a urinary hydroxylated metabolites used as a biomarkers of exposure of polycyclic aromatic hydrocarbons. This is the labeled analog.
References Toriba, A., et al.: J. Health. Sci., 53; 631 (2007); Chae, Y.H., et al.: Cancer Res., 59, 1473 (1999); Sangaiah, R., et al.: Poly. Aro. Comp., 11, 283 (1996);

Applications Isotope labelled Isopropyl DL-Mandelate is used in nonporous silica/alumina amorphous material. Pregabalin (P704800) impurity.
References Wang, Z. et al.:; ACS Catal., 3, 1573 (2013);

Applications N-Didesmethyl Loperamide-d4 is the isotope labelled analog of N-Didesmethyl Loperamide (D441135); a metabolite of the antidiarrheal Loperamide (L469450, HCl). Also a new and improved PET radiotracer for imaging P-gp function.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Stokbroekx, et al.: J. Med. Chem., 1, 782 (1973); Carter, J.E., et al.: Anal. Profiles Drug Subs., 19, 341 (1990); Rahman, A., et al.: Cancer Res., 54, 5543 (1994); Sai, Y., et al.: Xenobiotica, 30, 327 (2000); Eneroth, A., et al.: Eur. J. Pharm. Sci., 12, 205 (2001); Kim, K., et al.: Drug Metab. Dispos., 31, 1090 (2003)

Applications N-Boc-(p-Aminobenzoyl)-L-glutamic Acid Dimethyl Ester-13C5 is an intermediate used in the synthesis of Folic Acid-13C5 (F680303), which is a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.
References Xu, L., et al.: Mol. Pharm., 7, 1311 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010), Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010), McKay, D., et al.: Nut. J., 9 (2010),

Applications 4-Bromomethcathinone-D3 hydrochloride is a labelled analogue of 4-Bromomethcathinone hydrochloride (B686080). 4-Bromomethcathinone is part of a family of synthetic cathinone compounds called aminopropiophenones (which have high potential for abuse). Aminopropiophenones have potential psychoactive effects, can lead to death, and are labelled as highly controlled substances in many countries.
References Foley, K. & Cozzi, N.: Drug Dev. Res., 60, 252 (2003); Mas-Morey, P., et al.: J. Pharm. Pract., 26, 353 (2013); Penders, T., et al.: Gen. Hosp. Psych., 34, 647 (2012); Spiller, H., et al.: Clin. Toxicol., 49, 499 (2011)

Applications Tolan-d10 (CAS# 19339-46-9) is a useful isotopically labeled research compound.

Applications 1-Bromobutane-1,1,2,2-d4 (CAS# 1219805-80-7) is a useful isotopically labeled research compound.

Applications 8,9-Dihydro-2-methyl-9-(4-methylphenyl)-8-oxo-7H-purine-6-carboxamide-d7 is a compound useful in organic synthesis.

Applications Isotope labelled 1-Pentene, used in the synthesis of iminosugars such as d-xylitol and l-arabinitol. Also usd in the synthesis of hydrazones of substituted salicylaldehydes.
E3
References Biela, A. et al.: Tetrahedron, 69, 3348 (2013); Ding, S. et al.: J. Coord. Chem., 66, 2023 (2013);

Applications n-Heptylbenzene-d20 (CAS# 634897-84-0) is a useful isotopically labeled research compound.

Applications Ursodeoxycholic Acid-24-13C is the labeled compound of Ursodeoxycholic Acid (U850000). It is used as an anticholelithogenic. Epimer with Chenodiol with respect to the hydroxyl group at C7.

Applications 2-Ethyl-1-hexanol-D5 is an intermediate in the synthesis of Alexidine-d10 Dihydrochloride (A525002), which has antibacterial, antiplaque properties against Streptococcus mutans, Actinomyces ciscosus, and Actinomyces naesludii.
References Coburn, R.A., et al.: J. Med. Chem., 21, 8, 829 (1978), Takayama, K., et al.: J. Biol. Chem., 269, 2241 (1994), Faure, P., et al.: Biochimie, 86, 411 (2004),

Applications 3,3-Dimethyl-2-butanol-d3 is an isotopic analog of 3,3-Dimethyl-2-butanol (D471480), a reagent used in the synthesis of 2,4-dicarboxy-pyrroles as selective non-competitive mGluR1 antagonists. 3,3-Dimethyl-2-butanol is also used in the preparation of dihydropyrrole derivatives containing N-sulfanyl, sulfinyl, and sulfonyl moieties which have insecticidal activity.
References Ito, M., et al.: Bioorg. Med. Chem., 11, 489 (2003); Micheli, F., et al.: Bioorg. Med. Chem., 11, 171 (2003)

Applications 1-Iodopropane-1,1,2,2-d4 (CAS# 1219804-45-1) is a useful isotopically labeled research compound.

Applications (±)-2-Chlorobutane-d9 (CAS# 175540-77-9) is a useful isotopically labeled research compound.

Applications Pyridine-4-d1 (CAS# 10259-15-1) is a useful isotopically labeled research compound.

Applications 1,2-Bis(4-hydroxyphenyl)-2-hydroxypropane-d3 is labelled 1,2-Bis(4-hydroxyphenyl)-2-hydroxypropane (B447367) which is a metabolite of bisphenol A (B519495). It works as an endocrine disruptor.
References Krishnan, A.V., et al.: Endocrinology, 132, 2279 (1993), Steinmetz, R., et al.: Trends Endocrinol. Metab., 9, 124 (1998); Kitamura, S., et al.: Toxicol. Sci., 84, 249 (2005)

Applications 2,3-Pentanedione-1,1,1,4,4-d5 is deuterated form of 2,3-Pentanedione which is a diketone that is used as a building block in organic chemistry. It is also a volatile flavour compound found in coffee, cheese and other foods.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Engels, W., et al.: Int. Dairy J., 7, 255 (1997); Roberts, D., et al.: J. Agric. Food Chem., 48, 2430 (2000);

Applications Vinblastine-d3 Methiodide is the labeled analogue of Vinblastine Methiodide (V314015), an adduct of Vinblastine (V314000), an antitumor alkaloid isolated from periwinkle, Vinca rosea Linn., Apocynaceae; inhibits microtubule assembly. An antineoplastic.
References Dorman, D.E., Paschal, J.W.: Org. Magnetic Resonance, 8, 413 (1976); Lu, C., et al.: Cancer Research, 39, 3575 (1979); Gobbi, P.G., et al.: J. Clin. Oncol., 14, 527 (1996); Muhtadi, F.J., et al.: Anal. Profiles Drug Subs. Excip., 21, 611 (1992)

Applications 3-Aminobenzotrifluoride-D4 is a labelled analogue of 3-Aminobenzotrifluoride (A591720).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 3-Nitroaniline acts as an azo dye used in analytical toxicity studies. 3-Nitroaniline-2,4,5,6-d4 is the labeled version.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Garner, R.C. et al.: Mut. Res., et al 44, 9 (1977);

Applications D,L-Carnitine-d3 Chloride is the isotope labelled analog of D,L-Carnitine Chloride (C184100); a vitamin (enzyme cofactor). It is an essential cofactor of fatty acid metabolism and is required for the transport of fatty acids through the inner mitochondrial membrane. Synthetized primarily in the liver and kidney with the highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado.
References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978); Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001); Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002); Karlic, H., et al.: Nutrition, 20, 709 (2004)

Applications 4-tert-Butylaniline-d15 (CAS# 1219794-71-4) is a useful isotopically labeled research compound.