Composés deutérés

<p>Applications Methyl Acetate-d3 (CAS# 21300-54-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications tert-Butyl-d9 Acrylate (CAS# 928163-00-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Butyric-4,4,4-d3 Acid (CAS# 36789-14-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 17beta-Dihydroequilin-2,4,16,16-d4 (CAS# 350819-99-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Phenyl-d5-ethyl Isothiocyanate (CAS# 912627-98-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Glyceryl-d5 Trihexadecanoate (CAS# 60763-98-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,4,6-Trimethylbenzeneamine-d11 (cas# 1126138-13-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,3-Dibromo-1-propan-1,1,2,3,3-d5-ol is a labelled analogue of 2,3-Dibromo-1-propanol (D425522), which is a metabolite of the flame retardant tris(2,3-dibromopropyl) phosphate (T775560), previously shown to be a mutagen and carcinogen in experimental animals. It is also an intermediate in synthesizing Bis(2,3-dibromopropyl) Phosphate-d10 (B426237), which an isotope labelled analog of Bis(2,3-dibromopropyl) Phosphate. Bis(2,3-dibromopropyl) Phosphate is a derivative of Tris(2,3-dibromopropyl) Phosphate, a widely used flame retardant in plastic and textiles.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pandith, A.H., et al.: Org. Chem. Int., 17, (2010); Dixon, D., et al.: Toxicol. Pathol., 36,428 (2008);Eustis, S.L., et al.: Toxiciol. Sci., 26, 41 (1994); Elliott, W.C., et al.: Life. Sci., 7, 1107 (1983);<br></p>

<p>Applications 4-Fluorobenzyl-d6 Alcohol (CAS# 1071809-48-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methylcycloheptane-d3 is the isotope analog of Methylcycloheptane. It is synthesized form cycloheptanone (C989555), which is a common reagent used as the precursor for the synthesis of various pharmaceuticals including NF-κB-inducing kinase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, K., et al.: Bioorg. Med. Chem. Lett., 23, 1238 (2013); Hayden, M., et al.: Cell, 132, 344 (2008); Mackay, F., et al.: Annu. Rev. Immunol., 21, 231 (2003)<br></p>

<p>Applications 1-Phenyldodecane-d30 (CAS# 352431-29-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 5-Bromo-2,4-pyrimidinedione-13C,15N2 is the isotope labelled analogue of Bromouracil, a halogenated nitrogenous base on RNA nucleosides.<br>References Morinaga, H., et al.: Bioorg. Med. Chem., 21, 466 (2013);<br></p>

<p>Applications Carcinogenic compound commonly found in hair dyes and henna ink, also a commonly used synthetic intermediate<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mulyono; T., et al.: J. Biosci. Bioeng., 103, 147 (2007), Mosley-Foreman, C., et al.: Food Chem. Toxicol., 46, 3780 (2008), Patel, A.K., et al.: J. Agric. Food Chem., 56, 9236 (2008), Akyuz, M., et al.: J. Pharm. Biomed. Anal., 47, 68 (2008),<br></p>

<p>Applications Labelled Cortisol-d4 21-Sulfate (C696320). Cortisol 21-Sulfate is a phase II metabolite of Cortisol (H714615).<br>References Spielgelhalder, B., et al.: J. Steroid Biochem., 7, 749 (1976), Vanluchene, E., et al.: J. Chromatogr., 456, 175 (1988), Choi, M., et al.: Steroids, 65, 54 (2000),<br></p>

<p>Applications Choline-d9 Bromide (N,N,N-trimethyl-d9) (CAS# 285979-71-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Tetracontane-d82 (CAS# 1219802-99-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isobutylsuccinic Acid-d9 is labelled Isobutylsuccinic Acid (I780660) which was used to synthesize succinimide derivatives as inhibitors of human leukocyte elastase, cathepsin G and proteinase 3.<br>References Groutas, W., et al.: Bioorg. Med. Chem., 3, 375 (1995);<br></p>

<p>Applications 1-Iodopropane-1,1-d2 (CAS# 25493-14-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Dodecanoic-2,2-d2 Acid (CAS# 64118-39-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Phenyl-d5-acetylene (CAS# 25837-46-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Cyclopropane-d5-carboxylic Acid (CAS# 1219804-09-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Acetamide-d5 (CAS# 33675-83-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Methyl Lacosamide-d3 is the labeled analogue of N-Methyl Lacosamide (M315210), a methly analogue of Lacosamide (L098500), a medication used for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Lacosamide is a potent anticonvulsant.<br>References Lees, G., et al.: Brain Res., 612, 190 (1993), Kuo, C., et al.: Mol. Pharmacol., 51, 1077 (1997); Barton, M., et al.: Epilepsy Res., 47, 217 (2001); Beyreuther, B., et al.: Eur. J. Pharmacol., 539, 64 (2006); Beyreuther, B., et al.: CNS Drug Rev., 13, 21 (2007)<br></p>

<p>Applications (4S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazine-d2 ,13C1, is the labeled analogue of (4S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazine (C365935), used for the synthesis of Efavirenz (E425000), which is a nonnucleoside HIV-1 reverse transcriptase inhibitor.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995),<br></p>

<p>Applications 1-Chlorohexane-d13 (CAS# 1219798-45-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Aminobenzoic-​2,​3,​5,​6-​d4 Acid Methyl Ester is an intermediate in the synthesis of DMABA-d4 NHS Ester (D678402), which is a labelled DMABA NHS ester (D678400). DMABA NHS ester is a reagent that reacts with the primary amine group of PE lipids. DMABA NHS ester has been used in combination with DMABA NHS ester-d4, -d6, and -d10 to study relative changes in PE lipid abundance before and after radical oxidation.<br>References Wester, H., et al.: Nucl. Med. Bio., 23, 365 (1996), Frees, D., et al.: Mol. Microbiol., 48, 1565 (2003), Michel, A., et al.: J. Bacteriol., 188, 5783 (2006), Voelker, T., et al.: Bioorg. Med. Chem., 17, 2047 (2009),<br></p>

<p>Applications 2-Phenylpropane-1,1,1,3,3,3-d6 (CAS# 20201-29-0) is a useful isotopically labeled research compound.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Labeled 1,4-cyclohexanedione with high isotopic purity.<br>References Stibbe, W.; et al.: J. Labelled Compounds Radiopharmaceuticals, 16, 567 (1979),<br></p>

<p>Applications 2,2-Dimethyloctanoic Acid-d3 is the isotope analog of 2,2-Dimethyloctanoic Acid. 2,2-Dimethyloctanoic Acid is used in biological studies as benzyl dimethyloctanoate metabolite of sewage bacteria.<br>References Millier, A., et al.: Bull. Environ. Contam. Toxicol., 28, 113 (1982);<br></p>

<p>Applications cis-8,11,14-Eicosatrienoic Acid Ethyl Ester-d5 is the isotope labelled analog of cis-8,11,14-Eicosatrienoic Acid Ethyl Ester (E477920); the ethyl ester derivative of cis-8,11,14-Eicosatrienoic Acid (E477930) which is a fatty acid with selective tumoricidal activity.<br>References Das, U., et al.: Cancer Lett., 56, 235 (1991); Rudra, P., et al.: Anticancer Res., 21, 29 (2001); Menendez, J., et al.: Breast Cancer Res. Treat., 72, 203 (2002)<br></p>

<p>Applications Glyceryl Tri(pentadecanoate-d29) (CAS# 352431-43-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Propyl-d5-amine is labelled 1-Propylamine (P833700) which is used in the synthesis of pyrimidine derivatives as novel and highly potent PDE4 inhibitors. It is also used in the preparation of fluorenone analogs with DNA topisomerase I inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>