Composés deutérés

<p>Applications Isotope labelled Propyl Paraben Sulfate (P838355) is the sulfate conjugate of Propyl Paraben (P838285), an antimicrobial agent used in cosmetic products.<br>References Kim, D.H., et al.: Biol. Pharma. Bull., 17, 1326 (1994);<br></p>

<p>Applications It is a stable isotopically labelled analog of Tasimelteon (T007740) which is a novel drug, used in the treatment of non-24 hour sleep-wake disorder. It helps to correct the circadian rhythm disorder often seen in patients who are visually impaired.<br>References Lahon, J. et al.: World. J. Pharm. Res., 3, 1521 (2014)<br></p>

<p>Applications Ammonium Formate-d5 (CAS# 65387-23-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Benzene-1,2,3,5-d4 (CAS# 14941-52-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Iodoacetic Acid-d3 (CAS# 1219799-36-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Tetracosanoic-12,12,13,13-d4 Acid (CAS# 1219794-59-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Acetylglycine-13C2,15N is a labelled derivative of N-Acetylglycine (A178260(P)), which is a derivative of Glycine (G615990). Glycine is a useful intermediate for synthesizing rac 3-O-Methyl DOPA (M303805), which is an impurity of Levodopa.<br>References Tabar, et al.: Pharmacol. Biochem. Behav., 33, 139 (1989), De Souza Silva, et al.: J. Neurochem., 68, 233 (1997), Feigin, A., et al.: Neurology, 57, 2083 (2001), Perera, A., et al.: J. Labelled Comp. Radiopharm., 46, 389 (2003)<br></p>

<p>Applications Adenosine-2-d1 (CAS# 109923-50-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Dicyclohexyl Carbonate-d22 is the isotope labelled analog of Dicyclohexyl Carbonate (D438505); a reagent in the synthesis of colon specific reduction sensitive polymers for pharmaceuticals.<br>References Schacht, E. and Wilding, I.: PCT Int. Appl. WO 9610994 A1 19960418. Apr 18, 1996<br></p>

<p>Applications Hexanenitrile-6,6,6-d3 (CAS# 1219805-03-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,4-Di(methyl-d3)-naphthalene has been used in the preparation of di(trideuteriomethyl)naphthalene derivatives. 1,4-Di(methyl-d3)-naphthalene is a labeled analogue of 1,4-Dimethylnaphthalene (D476380), a polycyclic aromatic hydrocarbon (PAH) that has been found to retard the development of epidermoid carcinomas in hamster buccal pouch and alter the genes associated with the maintenance of a G1/S phase block possibly through the induction of the cell cycle inhibitors KRP1 and KRP2 in potatoes.<br>References Dizabo, P., et. al.: J. Labelled Compd., 2, 272 (1966); Malament, D.S., Shklar, G.: Carcinogenesis, 2, 723 (1981); Campbell, M.A., et. al.: Fuct. Interg. Genomics, 12, 533 (2012); Andrysik, Z., et. al.: Mutat. Res-Fund. Mol. M., 714, 53 (2011)<br></p>

<p>Applications (±)-2-Chlorobutane-d9 (CAS# 175540-77-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Tridecanoic-2,2-d2 Acid (CAS# 64118-44-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications o-Tolyl-d7 Isocyanate (CAS# 1219802-73-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethyl 2-Bromo-2-methyl-d3-propionate-3,3,3-d3 (CAS# 64768-38-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,3-Diethylbenzene-d14 (CAS# 1219803-40-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Diethyl Oxalacetate-13C4 is an intermediate used in the synthesis of (O845032), which is labelled form of Oxaloacetic Acid (O845030) which is a four carbon dicarboxylic acid that is an intermediate in the citric acid cycle and glucogenesis. It has been shown to inhibit succinate dehydrogenase.<br>References Zeylemaker, W.P. et al.: Biochim. Biophys. Acta Enzymol., 132, 210 (1967); Dalla-Betta, P. et al.: Int. J. Mol. Sci., 10, 2809 (2009);<br></p>

<p>Applications 1,3-Di-iso-propylbenzene-d18 (CAS# 1398065-59-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Cholesten-3-one-3,4-13C2 (CAS# 82938-09-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethyl 4-Isocyanatobenzoate-2,3,5,6-d4 (CAS# 1219802-91-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Glyceryl-d5 Trioctadecanoate (CAS# 55256-03-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Fluorobenzyl-d6 Chloride (CAS# 1219804-13-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Chlorobenzene-3,4,5-d3 (CAS# 59164-11-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Ethyl-3,4,5,6-tetrahydropyridine Hydrochloride-d3 is the isotope labelled analog of 2-Ethyl-3,4,5,6-tetrahydropyridine Hydrochloride (E926330); a compound that is produced by lactic acid bacteria (LAB) and can cause mousy off-flavor in wines.<br>References Snowdon, E.M., et al.: J. Agr. Food Chem., 54, 6465 (2006); Costello, P.J., et al.: J. Agr. Food Chem., 50, 7079 (2002); Craig, J.T., et al.: Am. J. Enol. Viticult., 35, 46 (1984)<br></p>

<p>Applications 1-Iodooctane-1,1-d2 (CAS# 89232-08-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications p-​Tolunitrile-d7 is an isotopic analog of p-​Tolunitrile (T536235), a reagent used in the preparation of 1H-Indazoles from imidates and nitrosobenzenes.<br>References Wang, Q. et al.: Org. Lett., 18, 2102 (2016);<br></p>

<p>Applications DL-Alanine-2-d1 (CAS# 31024-91-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethylene Glycol Dipalmitate-d4 is the deuterated version of Ethylene Glycol Dipalmitate (E917565), a component of phase change materials for thermal energy storage.<br>References Aydin, Ahmet A.: Solar Energy Mat. &amp; Solar Cells, 108, 98-104 (2013)<br></p>

<p>Applications Labelled analogue of 2-Butanone 2,4-Dinitrophenylhydrazone, a dinitrophenylhydrazone (DNPH) derivative of an aliphatic ketone found in mainstream cigarette smoke.<br>References Delgado, B. et al.: J. Liq. Chrom. Rel. Technol., 31, 361 (2008); Miller, J.H. et al.: J. Chrom. Sci., 48, 12 (2010);<br></p>

<p>Applications rac-3-Hydroxyheptanoic acid-D7 is a labelled analogue of rac-3-Hydroxyheptanoic acid (H943075).<br></p>