Composés deutérés

Applications 1,5-Dibromopentane-1,1,5,5-d4 (CAS# 1219803-90-3) is a useful isotopically labeled research compound.

Applications 3-Bromopropionic-2,2,3,3-d4 Acid is the labeled analog of 3-Bromopropionic acid (B687705). 3-Bromopropionic Acid is used as a reagent in the synthesis of nitrogen containing diselenides which exhibit antioxidant activity. Also used as a reagent in the synthesis of indolin-2-one-based multi-targeted receptor tyrosine kinase inhibitors as potential anticancer agents.
References Nascimento, V., et al.: Eur. J. Med. Chem., 87, 131 (2014); Zhang, L., et al.: Eur. J. Med. Chem., 82, 139 (2014)

Applications 2-(Ethyl-d3) Isonicotinamide is an intermediate in the synthesis of Ethionamide-d3 (E890422), a labelled antibacterial (tuberculostatic) agent.
References Banerjee, A., et al.: Science, 263, 227 (1994), Newton, G., et al.: J. Bacteriol., 178, 1990 (1996), Baulard, A., et al.: J. Biol. Chem., 275, 28326 (2000), Koledin, T., et al.: Arch. Microbiol., 178, 331 (2002), Cardoso, R., et al.: Antimicrob. Agents Chemother., 48, 3373 (2004),

Applications α-Naphthyl-d7 Glycidyl Ether is an intermediate in the synthesis of rac-Propranolol-d7 (P831803) which is the labeled analogue of Propranolol (P831800), a β−Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).
References Bond, et al.: Nature, 213, 721 (1967), Hansteen, V., et al.: Br. Med. J., 284, 155 (1982), Diamond, S., et al.: J. Clin. Pharmacol., 28, 193 (1988),

Applications Isotope labelled D-Glucitol is a sugar alcohol obtained from the reduction of glucose and is naturally found in various fruits such as apples, pears and peaches. D-Glucitol has been widely used as a sweetener, laxative, various medical applications and in cosmetic products.
References Wang, Z.J., et al.: Anal. BIoanal. Chem., 405, 3899 (2013); Vinarta, S.C., et al.: Carb. Poly., 92, 1107 (2013); Kaumanu, M.L., et al.: Soil. Biol. Biochem., 57, 644 (2013); Hailu, T., et al.: Anal. Biochem., 434, 181 (2013);

Applications Labelled Maleic Anhydride. A heterocyclic compound used in the manufacture of unsaturated polyester resins. Maleic Anhydride has a wide range of other applications; it is used in synthetic tensides, insecticides, herbicides and fungicides.
References Hanafi, W.Z.A. et al.: Plast. Rub. Comp. Proc. Appl., 19, 175 (1993); Noma, K. et al.: Shik. Kyok., 36, 225 (1963); Augustin, M. et al.: Wissen. Zeitsch., 25, 5 (1976); Jiang, Q. et al.: Nongyao, 49, 257 (2010);

Applications 1-Dodecane-d25-thiol (CAS# 869563-00-8) is a useful isotopically labeled research compound.

Applications Carbon 13 Labelled analogue of Adenosine (A280400), a purine nucleoside that plays an important role in various biochemical processes.
References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010); Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010)

Applications N-Hexadecanoyl-2-amino-1,3-propane-d5-diol (CAS# 949524-35-2) is a useful isotopically labeled research compound.

Applications N,N-Bis(2-chloroethyl)benzenesulfonamide-d5 is the isotope labelled analog of N,N-Bis(2-chloroethyl)benzenesulfonamide (B418910); a novel intermediate in the synthesis of Cetirizine (C281100).

Applications Tetrahydro-4H-pyran-4-ol-3,3,4,5,5-d5 (CAS# 1219795-46-6) is a useful isotopically labeled research compound.

Applications 2-Nitropropane-1,1,1,3,3,3-d6 (CAS# 52809-86-6) is a useful isotopically labeled research compound.

Applications 1-(2-Pyridinyl)benzotriazole-15N3 (cas# 1189465-04-0) is a compound useful in organic synthesis.

Applications Ethylene Glycol Dimyristate-d4 is a deuterated version of Ethylene Glycol Dimyristate (E917560), a pearling agents for cosmetics.
References Onozaki, T., et al.: Journal of SCCJ, 15, 38-44 (1981)

Applications Sulfolane-d8 is the labeled analogue of Sulfolane (S689220), which is used in lithium-ion batteries.
References Lewandowski, A., et. al.: J. Power Sources, 266, 132 (2014); Xing, L., et. al.: Electrochim. Acta, 133, 117 (2014)

Applications Ethyl β-Alanine-2,2,3,3-d4 Ester is an intermediate used in the synthesis of N-(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)-β-alanine-d4 (C424342), which is an isotope labelled N-(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)-β-alanine is a metabolite of Tianeptine (T436800), a tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant.
References Malen, C., et al.: Experientia, 28, 811 (1972), Safa, A., et al.: J. Biol. Chem., 262, 7884 (1987), Ford, J.M., et al.: Pharmacol. Rev., 42, 155, (1990), Pierre, A., et a.: Cancer Res., 51, 2312 (1991), Nair, M. et al.: Analyst, 123, 2267 (1998)

Applications 5-Methyl-2(1H)-pyridinone-d6 is a reagent used in the preparation of substituted N-aryl pyridinones as fibrotic inhibitors.

Applications 1-Bromotridecane-1,1,2,2-d4 (CAS# 284474-45-9) is a useful isotopically labeled research compound.

Applications Terconazole-d4 is the isotope labelled analog of Terconazole (T110600); a compound used for topical treatment of mycotic vaginitis. Terconazole may also be used in vitro as a potent antifungal agent to prevent the morphogenetic transformation of yeast into the (pseudo-)mycelium form of Candida albicans.
References Cauwenbergh, G., Vanden Bossch H.: J. Reprod. Med., 34, 588 (1989); Del Palacio-Hernanz, A., et. al.: Chemioterapia, 3, 192 (1984); Van Cutsem, J., et. al.: Chemotherapy, 29, 322 (1983)

Applications 3,4-Difluoroaniline-2,6-d2 (CAS# 1061566-62-8) can be used in its derivative form as an antiviral agent for Hepatitis B.
References Qiu, Y.L., et.al., U.S. Pat. Appl. Publ., 187,(2019);

Applications Methyl 3-Bromopropionate-2,2,3,3-d4 (CAS# 1219803-82-3) is a useful isotopically labeled research compound.

Applications Anteisoheneicosanoic acid-d3 is labelled Anteisoheneicosanoic acid which is used in cosmetics as it allows hair fiber to lie flat and parallel with respect to each other while its removal formed coarse tangled bundles, aligned in disorderly manner.
References Tanamachi, H., et al.: J. Cosmetic Sci., 61, 147 (2010); Breakspear, S., et al.: PMSE Preprints, 90, 276 (2004)

Applications 4-Fluorobenzyl-alpha,alpha-d2 Chloride (CAS# 1219804-18-8) is a useful isotopically labeled research compound.

Applications n-Nonyl-6,6,7,7-d4 Alcohol (CAS# 33975-46-1) is a useful isotopically labeled research compound.

Applications Benzene-1,2,4,5-d4 (CAS# 14919-17-6) is a useful isotopically labeled research compound.

Applications L-Lysine-DL-amphetamine-d6 2HCl (propane-1,1,2,3,3,3-d6) (CAS# 1276056-89-3) is a useful isotopically labeled research compound.

Applications L-4-Hydroxyphenyl-3,5-d2-alanine (CAS# 30811-19-9) is a useful isotopically labeled research compound.

Applications 13-cis-Retinoic Acid-d5, is the labeled analogue of 13-cis-Retinoic Acid (R250000) used as a treatment for severe acne. Presently being studied in conjuction with the treatment of photoaged skin.
References Lerche, C., et al.: Exp. Dermatol., 17, 972 (2008), Sato, T., et al.: J. Med. Chem., 51, 7705 (2008), Gan, J., et al.: Chem. Res. Toxicol., 22, 690 (2009), Macejova, D., et al.: Toxicol. Lett., 184, 114 (2009), Chen, P., et al.: Toxicol. App. Pharmacol., 234, 143 (2009),

Applications n-Hexyl 4-Hydroxybenzoate-2,3,5,6-d4 is the isotope labelled analog of n-Hexyl 4-Hydroxybenzoate; a phenolic acid alkyl ester/paraben that shows antimicrobial activity and antioxidant properties.
References Merkl, R., et al.: Czech J. Food Sci., 28, 275 (2010)

Applications 1,2-Dimethoxybenzene-d10 (CAS# 362049-43-2) is a useful isotopically labeled research compound.