Composés deutérés

Applications Bis(4-cyanophenyl)methanol-d4 is labelled Bis(4-cyanophenyl)methanol (B422852) which is a metabolite of Letrozole (L330100), a nonsteroidal aromatase inhibitor structurally related to Fadrozole.
References Bhatnagar, A.S., et al: J. Steroid Biochem. Mol. Biol., 37, 1021 (1990), Pfister, C.U., et al.: J. Pharm. Sci., 83, 520 (1994), Lipton, A., et al.: Cancer, 75, 2132 (1995)

Applications 4-(4-Fluorobenzoyl)-3-hydroxymethylbenzonitrile-D4 is a labelled analogue of 4-(4-Fluorobenzoyl)-3-hydroxymethylbenzonitrile (F588365).

Applications 4-Nitrofluorobenzene-13C6 is an intermediate for the synthesis of Flufenacet-13C6 (F599422), labelled Flufenacet (F599420) which is an anilide based herbicide that is applied to the soil surface or incorporated before the crop is emerged. Flufenacet is often used in field corn, corn grown for silage or soybeans to control annual grasses and broadleaf weeds.
References Hulting, A.G., et al.: Weed. Technol., 26, 230 (2012); Bailly, G.C., et al.: Crop Protect., 34, 96 (2012)

Applications Trandolaprilat-d3 Monohydrate, is the labeled analogue of Trandolaprilat Monohydrate (T713520), a metabolite of Trandolapril, an antihypertensive.
References Blankley, C.J., et al.: J. Med. Chem., 30, 992 (1987)

Applications 3-(N-Morpholino)propanesulfonic Acid-d15 (CAS# 1219799-30-0) is a useful isotopically labeled research compound.

Applications Dihydro-3-(3-pyridoyl)-2-(3H)-furanone-d4 is an intermediate in the synthesis of 1-(3-Pyridyl-d4)-1,4-butanediol (P992504). 1-(3-Pyridyl-d4)-1,4-butanediol is the labeled analogue of 1-(3-Pyridyl)-1,4-butanediol (P992500), a metabloite of NNK (M325750), a carcinogen that readily produces cancer in rats and hamsters.
References Koenigs, L., et al.: Drug Metab. Dispos., 25, 1407 (1997); Gu, J., et al.: Toxicol. Appl. Pharmacol., 165, 158 (2000); Jalas, J., et al.: Chem. Res. Toxicol., 18, 95(2005); Zhu, L., et al.: Drug Metab. Dispos., 34, 1672(2006)

Applications N-Methylacetamide-N-d1 (CAS# 3669-70-3) is a useful isotopically labeled research compound.

Applications n-Tetratriacontane-d70 (CAS# 1219805-47-6) is a useful isotopically labeled research compound.

Applications Diethylamine-13C4 Hydrochloride is the labelled salt of Diethylamine (D443485).

Applications 4-Chlorotoluene-2,3,5,6-d4 (CAS# 85577-24-8) is a useful isotopically labeled research compound.

Applications 2-[2-(Methyl-d3-thio)ethyl-1,1,2,2-d4]-1H-isoindole-1,3(2H)-dione is an intermediate used in the synthesis of Lapatinib-d7 Dihydrochloride (L175807), which is a labeled Lapatinib (L175800), a reversible dual inhibitor of ErbB1 and ErbB2 tyrosine kinases. Antineoplastic;Also, it is used in the preparation of 4-Aminoquinazolines as EGFR and HER-2 inhibitors.
References Kim, T.E., et al.: Drugs, 6, 886 (2003); Wood, E.R., et al.: Cancer Res., 64, 6652 (2004); Spector, N.L., et al.: J. Clin. Oncol., 23, 2502 (2005); Tung, R.: PCT Int. Appl. (2008), WO 2008024439 A2 20080228

Stability Volatile
Applications Isopropyl-d7-amine may act as a potential protease inhibitor but also takes part in numerous organic chemical reactions such as amide synthesis.
E0
References Dam, J.H. et al.: Chem. A. Eur. J., 16, 6820 (2010); Latli, B. et al.: J Labelled. Compd. Radiopharm., 48, 447 (2005);

Applications Used in the preparation of antiviral agents.

Applications Tetramethyl-d12-urea (CAS# 51219-89-7) is a useful isotopically labeled research compound.

Applications Labelled Isoproturon. Pre-and post-emergence herbicide for control of annual grasses and broad-leaved weeds. Herbicide.
References Fournier, J.-C., et al.: Chemosphere, 4, 207 (1975), Gonzales, P., et al.: Weed Res., 23, 39 (1983),

Applications Hexanedioic-d8 Acid Dihydrazide (CAS# 1202865-37-9) is a useful isotopically labeled research compound.