Composés deutérés

<p>Applications DL-Histidine-alpha,beta,beta-d3 (CAS# 344299-50-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Cefepime-D8 sulfate is a labelled analogue of Cefepine sulfate, a cephalosporin that has antibacterial effects against Gram-positive and Gram-negative bacteria. Cefepime sulfate is used to treat mild to severe bacterial infections.<br>References Neu, H.: Am. J. Med., 100, 68S (1996); Sanders, C.: Clin. Infect. Dis., 17, 369 (1993); Sanders, W., et al.: Clin. Infect. Dis., 23, 454 (1996); Yahav, D., et al.: Lancet Infect. Dis., 7, 338 (2007)<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Cyromazine (C989300). Insect growth regulator. Insecticide.<br>References Hall, R.D., et al.: J. Econ. Entomol., 73, 564 (1980), Hart, R.J., et al.: Aust. Vet. J., 59, 104 (1982),<br></p>

<p>Applications cis-7,10,13,16-Docosatetraenoic Acid Ethyl Ester-d5 is an isotopic analog of cis-7,10,13,16-Docosatetraenoic Acid Ethyl Ester. cis-7,10,13,16-Docosatetraenoic Acid Ethyl Ester is an ethyl analog of cis-7,10,13,16-Docosatetraenoic Acid (D494510). cis-7,10,13,16-Docosatetraenoic Acid has been identified as a protein kinase inhibitor, affecting serotonin levels in studies.<br>References Mirnikjoo, B. et al.: J. Biol. Chem., 276, 10888 (2001);<br></p>

<p>Stability Light Sensitive<br>Applications Isotope labelled N-Nitrosodiethylamine (N525465) (DEN) is a widely occurring nitrosamine that is one of the most important environmental carcinogens (1) primarily inducing tumors of liver (2,3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.NDMA and NDEA were found as an impurity in generic versions of valsartan, losartan and irbesartan.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Farber, E. et al.: Cancer Res. 1984 Oct;44(10):4217-23.2. el-Demerdash, E. et al.: Anticancer Res. 2002 Mar-Apr;22(2A):977-84.3. Kweon, S. et al.: Life Sci. 2003 Sep 26;73(19):2515-26.<br></p>

<p>Stability Hygroscopic<br>Applications Myristoyl-L-carnitine-d3 Hydrochloride is labelled Myristoyl-L-carnitine Hydrochloride (M884745), a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Lauroyl-L-carnitine can be diagnostic for a number of ß-oxidation defects.<br>References Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)<br></p>

<p>Applications N-Methyl-2,4-dinitroaniline-d3 (cas# 91808-45-6) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Theobromine-d3 (7-methyl-d3) is deuterium labelled theobromine, which is a metabolite of caffeine.<br>References Suto, M., et al.: Anticancer Drug Des., 6, 107 (1991); Burkart, V., et al.: Nat. Med., 5, 314 (1999); Hassa, P., et al.: J. Biol. Chem., 278, 45145 2003); Veres, B., et al.: J. Pharmacol. Exp. Ther., 310, 247 (2004)<br></p>

<p>Applications A labelled active ingredient formulation to prepare agrochemicals and drugs in amorphous form.<br>References Blair, A.M., et al.: J. Agr. Sci., 139, 385 (2002),<br></p>

<p>Applications Labelled Aldicarb Sulfone (A514660). Aldicarb Sulfone is an analog of Aldicarb (A514650) detected in agricultural products as pesticide residue.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ashby, J., et al.: Environ. Mutagen., 7, 919 (1985), Ashby, J., et al.: Mutat. Res., 257, 229 (1991), Kazius, J., et al.: J. Med. Chem., 48, 312 (2005), Benigni, R., et al.: Mutagenesis, 25, 335 (2010),<br></p>

<p>Applications Chloroform-13C is a ubiquitous trichlorinated organohalide solvent. It is used in the preparation of stable isotope-labeled precursors for the synthesis of capsaicinoids, capsinoids and capsiconinoids.<br>References Kobata, K., et al.: Biosci., Biotechnol., Biochem., 75, 1611 (2011)<br></p>

<p>Applications Labelled analogue of Phosphorylethanolamine (P360900). Phosphorylethanolamine is used in the synthesis of Sphingomyelin, a type of sphingolipid found in animal cell membrane.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Myller, A.T. et al.: Appl. Surf. Sci., 257, 1616 (2010);<br></p>

<p>Stability No Data Avaialble<br>Applications 2-Chlorophenol (Ring-D4, 99%) was an analyte in a study looking to optimize ultrasonic extraction for efficient detection of polycyclic aromatic hydrocarbons (PAHs) in soil.<br>References Stankov Jovanovic, V., et al.: Anal. Lett., 50, 2491 (2017)<br></p>

<p>Stability Hygroscopic<br>Applications N-Ethyl Benzamid-3-carboxylate-d5 is the isotope labelled analog of N-Ethyl Benzamid-3-carboxylate. N-Ethyl Benzamid-3-carboxylate is an impurity of Deet (D228500) which is an insect repellent.<br>References Gilbert, I.H., et al.: J. Econ. Entomol., 48, 741 (1955), Ambrose, A.M., et al.: Toxicol. Appl. Pharmacol., 1, 97 (1959), Blomquist, L., Acta Pharmacol. Toxicol., 41, 235 (1977), Yeung, J.M., et al.: Drug Metab. Dispos., 16, 600 (1988),<br></p>

<p>Applications Isotope labelled analogue of p-Tolyl Sulfate Potassium Salt (T536805), a representative retained toxin that shows a high level of toxicity.<br>References Cuoghi, A., et al.: Anal. Bioanal. Chem., 404, 2097 (2012); Wu, I.W., et al.: Nehphrol. Dial. Transplan., 27, 1169 (2012);<br></p>

<p>Applications A labelled isomer of dichloropropanol; shows metabolite toxicity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Omura, M., et al.: Bull. Environ. Contam. Toxicol., 55, 1 (1995),<br></p>

<p>Applications Labelled Octopamine (O239750). A biogenic amine that is the phenol analog of Noradrenaline. It is a neurosecretory product found in several vertebrates and invertebrates. Adrenergic.<br>References Pisano, et al.: Biochim. Biophys. Acta., 43, 566 (1960), Breen, C.A., et al.: Nature, 303, 716 (1983)<br></p>

<p>Applications A labelled acetylene glycol derivative. It is used in water-based coatings and has both antifoaming and surfactant properties. It is highly toxic and have been found in acrylic adhesives used for food packaging multilayers manufacturing.<br>References Schwartz, J. et al.: J. Coat. Tecnhol., 67, 21 (1995); Chinoy, N.F. et al.: Polym. Paint Colour J., 175, 438 (1985);<br></p>

<p>Applications Sodium Acetate-d3, is the labeled analogue of Sodium Acetate, the sodium salt of acetic acid, with a wide range of uses. Sodium Acetate is used in the textile industry to neutralize sulfuric acid waste streams, and as a photoresist while using aniline dyes. Sodium Acetate may be added to foods as a seasoning.<br>References Clayden, j., et al.: Org. Chem., 1st ed. (2001);<br></p>

<p>Applications rac-3-Hydroxypentanoic acid-D3 is a labelled analogue of rac-3-Hydroxypentanoic acid (H949470), a useful synthetic intermediate that is used in the fine chemical and pharmaceutical industries.<br>References Kuhara, T. &amp; Matsumoto, I.: Biomed. Mass Spec., 7, 424 (1980); Rinaldo, P., et al.: Perspect. Inherit. Metabol. Dis., 7, 57 (1987); Tseng, H., et al.: Microb. Cell Fact., no Vol. given, 96 (2010)<br></p>