Composés deutérés

<p>Applications Carbetamide-D5 is the labelled analogue of Carbetamide (C178028). Carbetamide is used in the determination of pesticides.<br>References Jia, W., et al.: Journal of Chromatogr. A., 1395, 160-166 (2015)<br></p>

<p>Applications N-Hexadecanol (2,2,3,3...16,16,16-D31, 98%) (cas# 203633-15-2) is a useful research chemical.<br></p>

<p>Applications N-Desmethyl Regorafenib (Pyridine)-N-oxide-d3 is the isotope labelled analog of N-Desmethyl Regorafenib (Pyridine)-N-oxide (D293280); a synthetic metabolite of Regorafenib (R143000) used for treatment and prevention of cancer.<br>References Wilhelm, S.: PCT Int. Appl. WO 2011130728 A1 20111020. Oct 20, 2011<br></p>

<p>Applications Labelled 2,3-Butanedione (B690030). 2,3-Butanedione (Diacetyl), the molecule implicated in the disease known as popcorn lung, has now been implicated in amyloid-β peptide toxicity associated with Alzheimer’s disease. Diacetyl accelerates amyloid-β aggregation-a hallmark of Alzheimer’s disease. These preliminary finding raise the possibility of long-term neurological toxicity mediated by DA.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, J., et al.: Exp. Neurol., 158, 328 (1999); Brown, M., et al.: Cell, 100, 391 (2000); Heinitz, K., et al.: J. Neurochem., 98, 1930 (2006); Brody, D., et al.: Science, 321, 1221 (2008); More, S., et al.: J. Med. Chem., 52, 4650 (2009);<br></p>

<p>Applications S-Methyl-d3-thioacetaminophen is deuterium labeled S-Methyl-3-thioacetaminophen (M330610), a metabolite of Acetaminophen (A161220). Acetaminophen is an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).<br>References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)<br></p>

<p>Applications Diglyme-d14, is the labeled analogue of Diglyme (D446300), a solvent, that is used as reaction medium for Grignard and similar synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Merck Index, 11th Edition, 3148.<br></p>

<p>Applications Isotope labelled 1,3-Dibromopropane is a substrate specificity of haloalkane dehalogenases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Koudelakova, T., et al.: Biochem. J., 435, 345 (2011),<br></p>

<p>Applications Labelled Fenfluramine. Anorexic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pinder, et al.: Drugs, 10, 241 (1975), Caccia, S., et al.: Eur. J. Clin. Pharmacol., 29, 221 (1985), Finner, N., et al.: Curr. Ther. Res., 38, 847 (1985),<br></p>

<p>Stability Hygroscopic<br>Applications N-Acetylneuraminic Acid-13C,d3 is a labelled Neuraminic Acid derivative.<br>References Oetke, C., et al.: J. Biol. Chem., 277, 6688 (2002)<br></p>

<p>Applications 2,7-Diisopropyl-9,9-dimethyl-9,10-dihydroacridine-d6 (Major) is a labeled analogue of 2,7-Diisopropyl-9,9-dimethyl-9,10-dihydroacridine (D455760), a useful chemical reagent. Also, it is derived from 9,9-Dimethyl-9,10-dihydroacridine (D474300), which are currently being used in the development of thermally activated delayed fluorescence (TADF) molecules which are being researched for their possible efficient deep-​blue TADF emitting potential.<br>References Kwon, D.Y., et al.: J. Nanosci. Nanotechnol., 15, 7828-31 (2015); Wada, Y., et al.: Adv. Mater., 30 (2018).<br></p>

<p>Applications Benzoic Acid-13C6 (cas# 125945-98-4) is a compound useful in organic synthesis.<br></p>

<p>Applications Methyl-d3 Methanesulfonate (CAS# 91419-94-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Wittig Reagent<br></p>

<p>Applications 1,6-Hexane-1,1,6,6-d4-diamine (CAS# 115797-49-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled Butylparaben. An antimicrobial agent used in cosmetic products.<br>References Gilliland, D. et al.: J. Appl. Bacteriol., 72, 258 (1992); Routledge, E. et al.: Toxicol. Appl. Pharmacol., 153, 12 (1998); Miller, C. et al.: J. Biol. Chem., 272, 32824 (1997); Nakagawa, Y. et al.: Biochem. Pharmacol., 55, 1907 (1998);<br></p>

<p>Applications Benzoic Acid-d5 is a compound useful in organic synthesis. A pentadeuterated form of benzoic acid for proteomics research.<br>References Kurogochi, M., et al.: Molecules, 19, 9944 (2014); Liang, X., et al.: Asian J. Org. Chem., 6, 1063 (2017)<br></p>

<p>Applications N,N-Dimethyldodecylamine-d6 is the isotope labelled analog of N,N-Dimethyldodecylamine. N,N-Dimethyldodecylamine is used as a reagent in the synthesis of epoxy quaternary ammonium salt surfactants which exhibit potential antibacterial activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liu, Y., et al.: J. Disper. Sci. Technol., 35, 1460 (2014)<br></p>

<p>Applications A labelled metabolite of 2’-Deoxy-6-thio Guanosine (D281650) and 6-Thioguanine. An effective immunosuppressant and anticancer agent, however chronic exposure can be mutagenic in human cells as long-term use of thiopurines was found to be associated with a significantly increased risk of various types of cancer.<br>References Loo, T.L. et al.: Cancer Chemother. Pharmacol., 6, 131 (1981); Yuan, B. et al.: ACS Chem. Biol., 5, 1021 (2010); Kroplin, T. et al.: Adv. Exp. Med. Biol., 431, 741 (1998);<br></p>

<p>Applications Metabolite of oleic and linoleic acids.<br>References Jin, S.J., et al.: Biochem., 29, 8540 (1990).<br></p>

<p>Applications Isotope labelled 9-Bromophenanthrene (B687200), a halogenated polycyclic aromatic hydrocarbon that has been seen to have a room temperature phosphorescence that can be induced by β-cyclodextrin (β-CD) in the presence of cyclohexane; however, trace Fe(III) causes a decrease of the RTP emission.<br></p>